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Zebrafish : Methods and protocols
Introduces new tools, models, and analytic insights that position the zebrafish even more strongly as an engine of discovery for developmental and disease biology. Beginning with a section exploring detailed methods for use of zebrafish to model a variety of human diseases, the book continues by illuminating the key ongoing role of the fish model in studies of the vertebrate nervous system, tools and approaches using zebrafish to study stem cell and regenerative biology, as well as techniques in genetics and genomics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls.
Promoting Self-Change from Addictive Behaviors : Practical Implications for Policy, Prevention, and Treatment
Many are addicted. Few are treated. Yet many who are not treated recover. Promoting Self-Change from Addictive Behaviors examines natural recovery as a clinical phenomenon, a field of inquiry, and a vital component of therapy. It also brings clinicians and counselors to a new understanding of addiction and recovery. One of the few books on the topic, this volume offers alternatives to disease models of addiction by exploring personal pathways to recovery. Focusing on alcohol and drug problems, it provides a literature review of 40 years of studies on self-change with particular emphasis on the current decade and methodological issues (starting with how much or how little treatment constitutes "treatment"). The 24 experts keep the coverage consistently readable, and dozens of brief narratives from individuals who have successfully recovered from an addictive behavior without formal help lend valuable personal perspectives.
Organ on a chip for drug development and disease modeling
“Organ-on-a-chip” systems integrate microengineering, microfluidic technologies, and biomimetic principles to create key aspects of living organs faithfully, including critical microarchitecture, spatiotemporal cell–cell interactions, and extracellular microenvironments. This creative platform and its multiorgan integration recapitulating organ-level structures and functions can bring unprecedented benefits to a diversity of applications, such as developing human in vitro models for healthy or diseased organs, enabling the investigation of fundamental mechanisms in disease etiology and organogenesis, benefiting drug development in toxicity screening and target discovery, and potentially serving as replacements for animal testing.
Mathematics for Life Science and Medicine
Dynamical systems theory in mathematical biology has attracted much attention from many scientific directions. The purpose of this volume is to present and discuss the many rich properties of the dynamical systems that appear in life science and medicine. The main topics include cancer treatment, dynamics of paroxysmal tachycardia, vector disease models, epidemic diseases and metapopulations, immune systems, pathogen competition and coexistence and the evolution of virulence and the rapid evolution of viruses within a host. Each chapter will serve to introduce students and scholars to the state-of-the-art in an exciting area, to present new results, and to inspire future contributions to mathematical modeling in life science and medicine.
In the Pursuit of Winning : Problem Gambling Theory, Research and Treatment
Poker websites. State lotteries. Sports betting. As gambling outlets become easier to find, more—and younger—people are risking their finances, family lives, and health. In the Pursuit of Winning brings together an international panel of 35 experts to present theoretical, clinical, sociological, historical, and spiritual perspectives on problem gambling, and test popular addiction and disease models in the field. Early chapters examine the general psychology of gambling, before moving on to the irrational ideas associated with compulsive wagering, from belief in luck to illusions of control. The seven chapters in the second half are devoted to evidence-based interventions from a variety of clinical orientations. Case examples, Q&A sections, and a glossary add extra readability to the coverage.
Etiology and Morphogenesis of Congenital Heart Disease : From Gene Function and Cellular Interaction to Morphology
This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration
Dictyostelium discoideum : Methods and protocols
Discusses the latest advancements and techniques used to study Dictyostelium discoideum. The chapters in this book cover topics such as cytokinesis, membrane function and damage, and nutrient/bacterial processing; autophagy activation and function; protein localization, interaction, and activation; cell migration and contact guidance for quantification of cytoskeletal dynamics; and global mutational screening, transcriptome analyses, and proteomics that apply to all stages of the Dictyostelium life cycle and that may generalize to human disease models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Conditional Mutagenesis : An Approach to Disease Models
Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.
Chemokine biology : Basic research and clinical application ; Vol.2 : Pathophysiology of chemokines
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
