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Molecular Sensors for Cardiovascular Homeostasis
This book reveals state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases.It offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.
Medical data processing and analysis
Medical data can be defined as obtaining information from patients (such as signals, images, sounds, chemical components and their concentration, body temperature, respiratory rate, blood pressure, and different treatment measurements) to quantify the patient’s status and disease stage. Computer-aided diagnostic (CAD) systems use classical image processing, computer vision, machine learning, and deep learning methods for image analysis. Using image classification or segmentation algorithms, they find a region of interest (ROI) pointing to a specific location within the given image or an outcome of interest in the form of a label pointing to a diagnosis or prognosis. Computer science, with the evolution of artificial intelligence and machine learning techniques, facilitates the modeling and interpretation of results—from carrying out measurements to experiments and observations.
Insights into Receptor Function and New Drug Development Targets
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function. The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions.
Hypertension in the Elderly
Topics range from basic concepts, epidemiology and trials, and evaluation and management, to pharmacological treatment, special populations, and adherence, all presented with an emphasis on the optimal management of patients. The authors examine in detail the mechanisms of hypertension in the elderly, particularly age-related changes in vascular stiffness, and methodically review the lifestyle and outcomes trials that were conducted in older persons. The problems of clinical evaluation, secondary hypertension, and target organ damage are also fully addressed, and a practical approach is provided for correctly determining blood pressure, one of the most important tasks in evaluating an older patient. Extensive discussions of pharmacological therapy detail the role of individual drug classes, including diuretics and b-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium antagonists, a-1 blockers, and combination drug therapies. Additional chapters focus on special populations, such as African Americans, patients with diabetes, and patients with arthritis, as well as on the clinician's role in improving therapeutic adherence in older patients. Offers family practitioners and general internists an up-to-date, user-friendly reference on the diagnosis, treatment, and complications of hypertension in the elderly.
Effect of Cranberry in the Treatment of E. Coli
Escherichia coli (E. coli) bacteria normally live in the intestines of healthy people and animals. It may cause severe stomach cramps, bloody diarrhoea, vomiting and UTI. You may be exposed to E. coli from contaminated water or food especially raw vegetables and undercooked ground beef. Healthy adults usually recover from infection with E. coli within a week. Young children and older adults have a greater risk of developing a life-threatening form of kidney failure. Cranberries are a popular superfood. People can consume them in the form of a sauce or a juice. They can also add them to stuffing, casseroles, or dessert. In fact, research has linked the nutrients in cranberries to a lower risk of urinary tract infection (UTI), the prevention of certain types of cancer, improved immune function, and decreased blood pressure
Earthquake alert with smartwatch = تنبيه الزلازل باستخدام الساعة الذكية
After the recent events and earthquakes that affected the region, resulting in the deaths of many individuals due to the lack of timely emergency response, the idea for this project emerged Earthquake Alert with Smartwatch. Initially, our application gathers information about the user, such as age, family members, and any existing medical conditions. In the event of an earthquake, the application sends an alert to the user. It receives earthquake information, such as ‘magnitude, time, location…’ from United States Geological Survey “USGS” through an API. If the user is within the geographical area affected by the earthquake, the application will assist the Smartwatch in calculating vital signs such as ‘heart rate and blood pressure’. Additionally, there is another artificial intelligence model that receives the user's audio recordings and converts them into written texts. All this information, along with the user's geographical location, will be sent to the nearest emergency point for the purpose of aiding those individuals trapped under the rubble.
Consequences of Unawareness in Usage of Some Medicines and Diet Routine
In the short term, imbalanced nutrition can contribute to stress, tiredness and our capacity to work, and over time, it can contribute to the risk of developing some illnesses and other health problems such as: being overweight or obese, tooth decay, high blood pressure. Such habits cause considerable damage to human existence such as loss of potential and motivation, premature aging of the human body and the acquisition of diseases of various kinds. Such habits include the consumption of the following substances and medications which we will focus on in our research project in order to contribute to the public health awareness and to provide people with the best way to eat, on the other hand as an effect, pharmacologist we will also include the possible therapy of such diseases. However, with their side and some other commune drugs we are used to take on daily terms or very often but it may have a toxic side effect.
Living with Heart Disease
The media are full of terms like angina, heart failure, coronary artery disease, thrombosis, but what do these mean to you? Gerry Coghlan and Clive Handler are experienced heart doctors who have written this book for people who have or might get coronary heart disease.
Kidney Diseases
Kidney diseases is a “hidden epidemic” affecting 850 million people worldwide. It occurs when the kidneys become damaged and can’t perform their function. Damage may be caused by diabetes, high blood pressure, and various other chronic conditions. Kidney diseases can lead to other health problems, including weak bones, nerve damage, and malnutrition. There are two main types of kidney diseases: short-term (acute kidney failure) and lifelong (chronic kidney failure). If the diseases get worse over time, the kidneys may stop working completely. This means that dialysis will be required to perform the function of the kidneys or kidney transplant. Dialysis is a treatment that filters and purifies the blood using a machine. It can’t cure kidney diseases, but it can prolong the life.
Chronic kidney disease and its complications and treatment
Our research focuses on the relationship of chronic diseases in the kidney and complications resulting from these diseases, as we focused on three chronic diseases that affect the kidneys by identifying hypertension disease and its genetic role in affecting the kidney and the relationship between the kidney and high blood pressure that affects the long term and leads to kidney failure and identifying the indicators that Indicates the kidney function in patients with hypertension, high potassium values, and its direct effect on renal function, and treatment measures for hypertensive patients who suffer from a kidney problem.
Cardiac Mechanotransduction
For about hundred years the investigation of heart physiology has had one central guiding principle, the "law" of Frank and Starling. This connects the return of blood into the heart and the blood pressure with cardiac con traction force. The "law" does it in a way that enables the cardiovascular system to react to perturbations without major malfunctions. This book is a compilation of reviews of prominent scientists on this subject. The differ ence of the original formulation of the Frank-Starling principle is that mechanotransduction is the central theme that leads the reader through the book. Since the discovery of the "law" the scope of topics related to this subject has broadened enormously, as can be seen easily by glancing at the contents of this book. Mechanotransduction in the heart has many faces that range from molecules to humans and their diseases.
Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics
In this newly updated second edition of Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics, William B. White, MD, and a panel of highly distinguished clinicians give a critical review of every aspect of the evaluation of high blood pressure. This includes home and ambulatory blood pressure monitoring, the relationship between whole-day blood pressure and the cardiovascular disease process, and the effects of antihypertensive therapies on these blood pressure parameters. World-class contributors describe the significant advances in our understanding of the circadian pathophysiology of cardiovascular disorders and demonstrate that ambulatory blood pressure values are independent predictors of cardiovascular morbidity and mortality.
Angiotensin converting enzyme inhibitors and application
It is now a little over 10 years since the introduction of drugs that inhibit the angiotensin converting enzyme (ACE). Angiotensin converting enzyme inhibitors are a class of oral medications that act primarily through blockade of the angiotensin converting enzyme. This enzyme converts angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction increasing afterload, thus increasing systemic blood pressure. Angiotensin contributes to the production of aldosterone, which normally acts to retain sodium and water.
Adrenomedullin in Cardiovascular Disease
Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease.
