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Les thérapies ciblées = Targeted therapies
We are at the start of the development of new therapeutic classes, directed against new molecular targets (EGFR, VEGF, IGFR, Rank, etc.) Several diseases such as kidney, colon or breast cancer, GIST, have a natural history now modified thanks to these therapies. This practical book takes stock of the current use of these molecules.
Lectins
In the intervening years well over 10,000 articles have appeared with lectins as the main subject, and more than twice as many in which they were touched upon, as well as around 20 books. In particular, great strides have been made in several areas of lectin research, about which little was known until the late 1980s. One prominent example is animal lectins, many of which have been discovered only during the last decade and the functions of several of which have been clarified, especially as to their key role in innate immunity.
Algorithms in Bioinformatics ; 8th International Workshop, WABI 2008, Karlsruhe, Germany, September 15-19, 2008. Proceedings
This book constitutes the refereed proceedings of the 8th International Workshop on Algorithms in Bioinformatics, WABI 2008, held in Karlsruhe, Germany, in September 2008 as part of the ALGO 2008 meeting.
Life in the Universe : Expectations and Constraints
Energy, chemistry, solvents, and habitats -- the basic elements of living systems - define the opportunities and limitations for life on other worlds. This class-tested text examines each of these parameters in crucial depth and makes the argument that life forms we would recognize may be more common in our solar system than many assume. It also considers, however, exotic forms of life that would not have to rely on carbon as basic chemical element, solar energy as a main energy source, or water as primary solvent. Finally the question of detecting bio- and geosignature of such life forms is discussed, ranging from Earth environments to deep space. While speculative considerations in this emerging field of science cannot be avoided, the authors have tried to present their study with the breadth and seriousness that a scientific approach to this issue requires. They seek an operational definition of life and investigate the realm of possibilities that nature offers to realize this very special state of matter and avoid scientific jargon wherever possible to make this intrinsically interdisciplinary subject understandable to a broad range of readers.
Amino acids and the asymmetry of life : Caught in the act of formation
This book describes how the basic building blocks of life, the amino acids, formed. After a comprehensible introduction into stereochemistry, the author addresses the inherent property of amino acids in living organisms, namely the preference for left-handedness. What was the cause for violation of parity of amino acids in the emergence of life on Earth? All the fascinating models proposed by physicists, chemists and biologist are vividly presented including the scientific conflicts.
