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Forensic pathology reviews ; Vol. 3
Maintaining the high quality achieved in earlier volumes, leading national and international forensic pathologists provide in Forensic Pathology Reviews, Volume 3 evidence-based accounts of special topics of current interest from various fields of forensic pathology and death-scene investigation. The authors offer cutting-edge insights into the medicolegal investigation of bodies found in water, the forensic aspects of the human immunodeficiency virus (HIV)-1 infection of the central nervous system, deaths in a head-down position, and forensic bitemark analysis. Additional chapters address taphonomic changes in human bodies during the early postmortem interval, arrhythmogenic ventricular dysplasia that produces sudden death in young people, the postmortem diagnosis of death in anaphylaxis, and iatrogenic deaths. The forensic aspects of suicide, murder-suicide, and suicide trends in the United States are also discussed, along with the evaluation of fatal pulmonary thromboembolism and the use of radiology in medicolegal investigations. A comprehensive, up-to-date review of the international literature is given for each chapter. Evidence-based and state-of-the-art, Forensic Pathology Reviews, Volume 3 synthesizes the practical advances made in a variety of important subspecialties of forensic pathology, demonstrating how the latest medical and scientific advances are being applied to solve current problems of high interest to forensic pathologists today.
Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Apitherapy and therapeutic properties
Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central nervous system diseases, such as Parkinson’s disease, and Alzheimer’s disease and autoimmume diseases like reumatic and atherosclerosis .Bee venom (BV) is usually associated with pain since, when humans are stung by bees,local inflammation and even an allergic reaction can be produced. It also consists of a mixture of proteins and peptides, including enzymes such as Melittin and phospholipase A2 (PLA2) are the most abundant and studied compounds of BV Stings of hymenoptera can induce IgE-mediated hypersensitivity reactions in venom-allergic patients, ranging from local up to severe systemic reactions and even fatal anaphylaxis. skin is larger than any other organ in humans.
Anafilassi in pediatria = Anaphylaxis in pediatrics
Anaphylaxis is defined as an immediate systemic reaction due to the rapid IgE mediated release of potent mediators from tissue mast cells and peripheral blood basophils and represents a generalized clinical condition that includes skin, respiratory, cardiovascular and gastrointestinal signs and symptoms. It includes various clinical pictures, which derive from the association of symptoms such as urticaria, angioedema, vomiting, diarrhea, asthma, dyspnoea, edema of the glottis, hypotension, shock, etc., not always easy to identify, which however require a timely and correct diagnostic approach. .
Allergy in Practice
This book reflects the rich personal experience of a German allergist with international training and reputation, who is active in immunology and allergy research and practice for almost 30 years. In this book, not only IgE-mediated allergic reactions are covered but all other kinds of allergies such as atopic eczema, contact dermatitis, drug eruptions, anaphylaxis and food allergies are equally represented as well as psychosomatic aspects and problems of environmental intolerances.
