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Ocular Transporters in Ophthalmic Diseases and Drug Delivery
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.
Object-Oriented Data Structures Using Java ; 4th ed.
an essential resource for students learning data structures using the Java programming language. It presents both the traditional and modern data structure topics with an emphasis on problem-solving and object-oriented software design. Beginning early and continuing throughout the text, it introduces and expands upon the use of many Java features such as classes, objects, generics, polymorphism, packages, interfaces, library classes, inheritance, exceptions, and threads.
Nitrogen-fixing Actinorhizal Symbioses
This book is the self-contained sixth volume of a comprehensive series on nitrogen fixation. It presents the state-of-the-art in regards to actinorhizal symbioses. Like legumes, actinorhizal plants form root nodules that host nitrogen-fixing soil bacteria. However, because the macrosymbionts are, with one exception, woody plants rather than crop plants, actinorhizal symbioses are less well-known than legume symbioses to which they are phylogenetically related. Actinorhizal plants come from eight different families. This volume includes chapters that deal with all these aspects of the symbiosis and both symbionts plus their ecological role and use. Other chapters tackle the global distribution of different actinorhizal plants and their microsymbionts and how this impacts the question of co-evolution of the micro- and macrosymbionts as well as comparing the actinorhizal and leguminous symbioses.
Neurobiology of Exceptionality
Nurture or nature? Biology or environment? Why are some people intelligent, or personable, or creative and others obtuse, or shy, or unimaginative? Although each human being is a unique mixture of positive and negative traits and behaviors, the question remains: What is the neurobiological basis for each individual’s makeup? For example, why does one person suffer from a disorder (e.g., ADHD, autism, mental retardation) and another lives free of maladies?
National security exceptions in international trade and investment agreements : Justiciability and standards of review
provides a comprehensive analysis of national security exceptions in international trade and investment agreements. The subject has gained particular relevance in the past few years, as both the United States and the Russian Federation have invoked national security as justification for trade-restrictive measures in the context of WTO dispute settlement proceedings. describes the evolution of security exceptions in international economic law, from the GATT 1947 to the most recent economic treaties, such as the 2017 Buenos Aires Protocol for Intra-Mercosur Investment and the 2018 USMCA.
Multilingual Information Access for Text, Speech and Images ; 5th Workshop of the Cross-Language Evaluation Forum, CLEF 2004, Bath, UK, September 15-17, 2004, Revised Selected Papers
The ?fth campaign of the Cross-Language Evaluation Forum (CLEF) for Eu- pean languages was held from January to September 2004. Participation in the CLEF campaigns has increased each year and CLEF 2004 was no exception: 55 groups submitted results for one or more of the di?erent tracks compared with 42 groups in the previous year. CLEF 2004 also marked a breaking point with respect to previous campaigns. The focus was no longer mainly concentrated on multilingual document retrieval as in previous years but was diversi?ed to include di?erent kinds of text retrieval across languages (e. g. , exact answers in the question-answering track) and retrieval on di?erent kinds of media (i. e. , not just plain text but collections containing image and speech as well). In ad- tion, increasing attention was given to issues that regard system usability and user satisfaction with tasks to measure the e?ectiveness of interactive systems or system components being included in both the cross-language question - swering and image retrieval tasks with the collaboration of the coordinators of the interactive track. The campaign culminated in a two-and-a-half-day workshop held in Bath, UK, 15–17 September, immediately following the 8th European Conference on Digital Libraries. The workshop was attended by nearly 100 researchers and s- tem developers.
Models in Software Engineering ; Workshops and Symposia at MoDELS 2006, Genoa, Italy, October 1-6, 2006, Reports and Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of 11 international workshops held as satellite events of the 9th International Conference on Model Driven Engineering Languages and Systems, MoDELS 2006, in Genoa, Italy, in October 2006 (see LNCS 4199). The 32 revised full papers were carefully selected for inclusion in the book.
Migration and Pandemics : Spaces of Solidarity and Spaces of Exception
This book discusses the socio-political context of the COVID-19 crisis and questions the management of the pandemic emergency with special reference to how this affected the governance of migration and asylum. The book offers critical insights on the impact of the pandemic on migrant workers in different world regions including North America, Europe and Asia.
Microsoft Visual C# Step by Step
Guide to Microsoft Visual C# fundamentals with Visual Studio. Expand your expertiseand teach yourself the fundamentals of programming with the latest version of Visual C# with Visual Studio. If you are an experienced software developer, you'll get all the guidance, exercises, and code you need to start building responsive, scalable, cloud-connected applications that can run almost anywhere. Discover how to: Quickly start creating Visual C# code and projects with Visual Studio Work with variables, operators, expressions, methods, and program flow Build more robust apps with error, exception, and resource management Spot problems fast with the Visual Studio debugger Make the most of improvements to C# methods, parameters, and switch statements Master the C# object model, and create your own functional data structures Leverage advanced properties, indexers, generics, and collection classes Create Windows 10 apps that share data, collaborate, and use cloud services Integrate Cortana to voice-enable your applications Perform complex queries over object collections with LINQ
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2005 ; 8th International Conference, Palm Springs, CA, USA, October 26-29, 2005, Proceedings, Part I
This paper presents a method for classification of medical images, using machine learning and deformation-based morphometry. A morphological representation of the anatomy of interest is first obtained using highdimensional template warping, from which regions that display strong correlations between morphological measurements and the classification (clinical) variable are extracted using a watershed segmentation, taking into account the regional smoothness of the correlation map which is estimated by a crossvalidation strategy in order to achieve robustness to outliers. A Support Vector Machine-Recursive Feature Elimination (SVM-RFE) technique is then used to rank computed features from the extracted regions, according to their effect on the leave-one-out error bound. Finally, SVM classification is applied using the best set of features, and it is tested using leave-one-out. The results from a group of 61 brain images of female normal controls and schizophrenia patients demonstrate not only high classification accuracy (91.8%) and steep ROC curves, but also exceptional stability with respect to the number of selected features and the SVM kernel size
Intrinsic Molecular Mobility and Toughness of Polymers II
The series Advances in Polymer Science presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science . the authors highlight the dual role of segmental jumps and displacements to improve toughness by energy dissipation and relaxation of critical stresses and to influence without exception all damage mechanisms. The dynamic response of a chain segment to thermo-mechanical excitation strongly depends on in-chain cooperative motions. By combining the powerful techniques of multi-dimensional Nuclear Magnetic Resonance and of dielectric and dynamic mechanical analysis Monnerie,
Intrinsic Molecular Mobility and Toughness of Polymers I
The series Advances in Polymer Science presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science . the authors highlight the dual role of segmental jumps and displacements to improve toughness by energy dissipation and relaxation of critical stresses and to influence without exception all damage mechanisms. The dynamic response of a chain segment to thermo-mechanical excitation strongly depends on in-chain cooperative motions. By combining the powerful techniques of multi-dimensional Nuclear Magnetic Resonance and of dielectric and dynamic mechanical analysis Monnerie,
International comparative studies in mathematics : Lessons for improving students’ learning
It argues that the main purpose of educational research is to improve student learning, and that international comparative studies are no exception.
Integrated Molecular and Cellular Biophysics
Biophysics represents perhaps one of the best examples of interdisciplinary research areas, where concepts and methods from disciplines such as physics, biology, b- chemistry, colloid chemistry, and physiology are integrated. It is by no means a new ?eld of study and has actually been around, initially as quantitative physiology and partly as colloid science, for over a hundred years. For a long time, biophysics has been taught and practiced as a research discipline mostly in medical schools and life sciences departments, and excellent biophysics textbooks have been published that are targeted at a biologically literate audience. With a few exceptions, it is only relatively recently that biophysics has started to be recognized as a physical science and integrated into physics departments’ curr- ula, sometimes under the new name of biological physics.
Innovations in rehabilitation sciences education : Preparing Leaders for the future
We are most fortunate to be housed in an institution that embraces risk taking and innovation in education. Part of the joy of working at McMaster University is the sense that you will be supported in your efforts to develop new ways of facilitating learning even if these are not always successful. We are privileged to work with a group of exceptional colleagues who embrace - novation and strive for ongoing excellence in education.
Il bizzarro mondo dei quanti = The bizarre world of quanta
Written before the final exams by an exceptionally talented young woman, this book bridges the gap between the popular literature on quantum physics, which normally avoids any mathematical formula, and specialized literature, well filled with advanced mathematics.
High-Grade Gliomas : Diagnosis and Treatment
This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response.
Geometric Data Analysis : From Correspondence Analysis to Structured Data Analysis
Geometric Data Analysis (GDA) is the name suggested by Stanford University to designate the approach to Multivariate Statistics initiated.as Correspondence Analysis, an approach that has become more and more used and appreciated over the years. This book presents the full formalization of GDA in terms of linear algebra - the most original and far-reaching consequential feature of the approach - and shows also how to integrate the standard statistical tools such as Analysis of Variance, including Bayesian methods. Chapter 9, Research Case Studies, is nearly a book in itself; it presents the methodology in action on three extensive applications, one for medicine, one from political science, and one from education (data borrowed from the Stanford computer-based Educational Program for Gifted Youth ). Thus the readership of the book concerns both mathematicians interested in the applications of mathematics, and researchers willing to master an exceptionally powerful approach of statistical data analysis.
Fractures du genou = Knee fractures
Provides a comprehensive yet practical overview of the management of knee fractures and their complications. The editorial team comprises specialists from France, Switzerland, Belgium, the United States, and Ireland, many of whom are members of the AO group. Imaging strategies, assessment, classification, and anatomical variations are reviewed for each anatomical location. All therapeutic approaches are discussed without exception: conventional implants, intramedullary nailing, minimally invasive techniques, including the role of external fixation, and newer technologies such as the LISS. These approaches are subjected to critical analysis to identify the best options based on the indications and individual circumstances. The patellar apparatus is addressed in its functional unity. Postoperative management, influenced by functional prognosis, is also covered, as is the management of malunion, stiffness, and other complications. Finally, very specific problems are discussed, such as pediatric injuries, patellectomies, periprosthetic fractures, often complex projectile injuries, the role of immediate arthroplasty and massive grafts, but also associated injuries which sometimes have a heavy impact on the final prognosis.
Founders at Work : Stories of Startups' Early Days
These stories are exceptionally interesting, because they're about the early stages, when the founders were younger and inexperienced. Most readers know startup founders only as confident millionaires.
