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Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Oncology : An Evidence-Based Approach
Reflect the principles and current practice of oncology with contributors from the fields of medical, surgical, and radiation oncology. The textbook will incorporate an evidence-based approach, enabling the reader to make decisions on the basis of concrete data. Sections on solid tumors, hematologic malignancies and the practice of oncology address the natural history and therapy for the full spectrum of neoplastic diseases in the adult. Further sections present fundamentals of supportive care of the cancer patient, the management of oncologic emergencies and acute toxicities of therapy, as well as care of metastatic disease and the terminally-ill patient. Breaking new ground, the textbook features thoughtful, in-depth sections on cancer prevention and control, cancer surviorship, the economics of cancer care, and cancer informatics. Cancer imaging is covered with an organ system-based approach, with an additional chapter on the especially intriguing potential of PET. Furthermore, a comprehensive section on translational basic science reviews the fundamentals of molecular biology, the cell cycle and signal transduction, carcinogenesis, cancer genetics, the biology of invations and metastasis, and tumor immunology.
Olfactory knows the truth
Olfaction, the sense of smell detects and discriminate odors as well as social cues which influence our innate responses. The olfactory system in human beings is found to be weak as compared to other animals; however, it seems to be very precise. It can detect and discriminate millions of chemical moieties (odorants) even in minuscule quantities. The sense of smell is greatly underappreciated, despite the fact that it monitors the intake of airborne agents into the human respiratory system and determine to a large degree the flavor and palatability of foods and beverage. In addition to enhancing quality of life, this primary sensory system warns of spoiled foods, leaking natural gas, polluted air and smoke, and mediates basic elements of communication (e.g., mother-infant interaction). It is now apparent that smell dysfunction is among the first clinical signs of such neurodegenerative diseases as Alzheimer’s disease and sporadic Parkinson’s disease.
Odell's clinical problem solving in dentistry
Explores care planning and treatment alternatives and evaluates their advantages and disadvantages as well as medico-legal implications Integrates material from all the dental disciplines in order to cover an extensive range of clinical problems which will be encountered in daily practice A practical approach to learning - includes a large number of real-life clinical cases including those relevant to new techniques and issues such as implantology, use of CAD-CAM, CBCT (cone beam computed tomography) Designed to help the reader use the knowledge gained in a clinically useful, practically applied format Highly visual guide with more than 350 colour illustrations, artwork and tables presenting clinical, diagnostic and practical information in an easy-to-follow structure
Ocular Transporters in Ophthalmic Diseases and Drug Delivery
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.
Ocular Angiogenesis : Diseases, Mechanisms, and Therapeutics
Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches. Comprehensive and multidisciplinary, Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics offers a novel view of the clinical features of pathological angiogenesis in the eye, the molecular and environmental switches that govern vessel growth, and the tremendous opportunities for and progress made in the development of new therapeutics.
Oceans and Health: Pathogens in the Marine Environment
The importance of combating infectious diseases has received international attention, p- viding the opportunity for a multidisciplinary approach that combines medicine with other scientist candtechnological capabilities,notably information technology,nanotechnology,and biotechnology. In fact, it has been predicted that the future will bring a merging of these te- nologies with the cognitive and behavioral sciences.. The connection between infectious diseases and the oceans provides a paradigm for this perspective. A stark global context indisputably frames all human health issues in the twenty century: the world wide movement of people and goods. Throughout the past half century, international travel has skyrocketed; there are more than 500 million international arrivals per year. The greatest increase has taken place since the mid-1990s. The world has become integrated and global; consequently, the notion that it is possible to successfully eradicate a disease from the face of the planet has become simplistic. Infectious disease is a moving target and climate shifts will affect any disease that has an environmentally sensitive stage or vector.
Occlusal splints for painful craniomandibular dysfunction
Bridges that gap, presenting a practical guide for the treatment of craniomandibular dysfunction (CMD)—a functional disorder that affects the muscles of mastication, temporomandibular joints, and/or occlusion—in patients with related pain. The first half of the book provides detailed but simple clinical instructions and examples of occlusal splint therapy, including splint fabrication and coordinative training for painful CMD, based entirely on a high level of evidence. The second half delves deeper into the etiology, advanced diagnostic techniques, neurobiology, and pathophysiology of painful CMD and splint therapy.
Obstetric life support manual
A comprehensive review in normal and abnormal pregnancy physiology, the most common etiologies of maternal medical emergencies, recognition of maternal deterioration and pending cardiopulmonary arrest, modifications to cardiopulmonary resuscitation in pregnant and postpartum patients, special procedures that can assist in diagnosing and treating maternal medical emergencies tailored to the setting (e.g., point-of-care ultrasound, resuscitative cesarean delivery, extracorporeal cardiopulmonary resuscitation), treatment of trauma/stroke in pregnancy, and postpartum maternal medical emergencies. There are streamlined algorithms and cognitive aids designed to improve a team’s ability to successfully implement techniques unique to treating maternal medical emergencies and car..
Obesity and Diabetes
The increasing prevalence of diabetes and obesity in western societies today makes these two diseases the leading epidemics of the 21st century. Closely linked with the development of serious complications, including cardiovascular disease and several malignancies, the morbidity and mortality associated with obesity and diabetes will continue to escalate as the population ages and becomes more sedentary. In Obesity and Diabetes, international experts from world-renowned medical schools comprehensively review for practicing clinicians and scientists alike the latest understanding of the epidemiology, causation, and consequences of diabetes and obesity.
Nuucleic acids in medicinal chemistry and chemical biology : Drug development and clinical applications
Delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field
Nutrition, diet and healthy aging
Over the last 100 years, the numerous advances in science, the improved sanitary conditions and a decline in poverty have led to an increase in life expectancy. As a result, in the coming years, the number of over-65s will triple, and the over-80s will be the fastest growing portion of the population. However, an increased lifespan is associated with an increase in chronic diseases, such as cardiovascular disease, diabetes, cancer, sarcopenia, and degenerative disorders. Therefore, ideally, increased lifespan should be associated to a better healthspan, which is the period one individual is living in good health
Nutrition and Rheumatic Disease
It is difficult, if not impossible, for health care providers to remain at the forefront of knowledge for all aspects of nutrition and rheumatic diseases. In Nutrition and Rheumatic Disease, experts provide a comprehensive review of current knowledge regarding nutrition and dietary management for the complex set of rheumatic conditions. Within the disease-specific chapters, the authors present a historical perspective, a discussion of the major clinical features, current management and treatment, a review of the literature related to nutritional status and diet, and dietary recommendations, based on current scientific evidence. The field of rheumatic diseases includes a wide variety of pathologic processes. Adequate reviews of the scientific literature on each of the rheumatic diseases in Nutrition and Rheumatic Disease alleviate the inherent confusion surrounding the risks and benefits of various dietary therapies.
Nutrition and Physical Activity : Health Information Sources in EU Member States, and Activities in the Commission, WHO, and European Networks
Awareness of the importance of nutrition and physical activity for good health has given rise to a multitude of projects with different scopes and methodologies. This book aims to summarize the activities carried out by the EU countries to address these determinants of health.
Nutrition and Oral Health
Explores in depth the relationships between nutrition and oral health across all age groups. Discusses the latest knowledge on the consequences of poor diet for tooth loss and progression of oral diseases . Explains the importance of a disease-free and functional dentition for nutritional well-being
Nutrition and Health in Developing Countries
Nutrition and Health in Developing Countries, Second Edition was written with the underlying conviction that global health and nutrition problems can only be solved through a firm understanding of the different levels of causality and the interactions between the various determinants. This volume provides policy makers, nutritionists, students, scientists, and professionals with the most recent and up-to-date knowledge regarding major health and nutritional problems in developing countries.
Nutrition and diet in health: Principles and applications
Food provides us with essential nutrients involved in many physiological activities and biological processes in the body including growth and development, metabolism, immune function, and overall well-being. Nutrition and Diet in Health: Principles and Applications reviews and discusses the issues related to the roles of nutrition and diets in human health and diseases. The book contains two sections - one section features principles, the other, covers applications. Part One provides information on sustainable use of nutrition and diets in health and diseases; advanced biotechnological approaches to improve nutritional content of food; trace elements in nutrition; drug and nutrient interactions; functional foods and nutraceuticals in health maintenance; and Bio markers of functional foods and nutraceuticals in health maintenance. Part Two discusses the significance of nutrition in selected human diseases, including cardiovascular diseases, cancer, infection, neurodegenerative diseases, and metabolic co-morbidities. It also discusses optimal nutrition for wellness, fitness, pregnancy, mental health, aging, and longevity.
Nutraceuticals in respiratory and pulmonary diseases
Explores nutraceuticals that have been found to be effective in managing and treating respiratory and pulmonary diseases. It explains nutritional supplements that function as adjuvants for respiratory health and which may be useful targets for developing innovative nutraceutical-active respiratory products. The book also discusses the role of vitamins, minerals, and functional foods in the prevention and treatment of respiratory illnesses such as asthma, bronchitis, airway constriction, chronic obstructive pulmonary disorder (COPD), etc. It also explores the potential role of various herbs and foods in the treatment of lung illnesses through the Ayurvedic practices. The effectiveness of various natural and dietary supplements as well as plant and animal-based nutritional supplements for respiratory health are also considered.
Nutraceuticals in cardiac health management
Cardiovascular diseases (CVDs) constitute the major cause of death worldwide, claiming nearly 18 million lives each year. Multiple foods and nutraceuticals have been proven to reduce the risk of cardiovascular disease. This new book offers an informative update on the most recent scientific evidence addressing the use of nutraceuticals in the prevention and management of heart disease. It summarizes the functional foods that are involved in preventing the risk of CVDs, the mechanisms of the bioactive components that lower the risk of chronic illnesses, as well as the dietary patterns that are involved in the prevention of CVDs. It also covers specific nutraceuticals, including probiotics, dietary fibers, garlic, green tea, vitamins, tomatoes and other lycopene-rich fruits and vegetables, dietary supplements, bee products, and more. In addition, it focuses on detailing the endothelial effects of marine- and plant-derived omega-3 fatty acids and marine-derived natural flavonoids in hypertension and CVDs.
Nutraceuticals in arthritis and psoriasis : Management and prevention of diseases
Explores plant-derived nutraceuticals that can be used as crucial therapeutic tools in the prevention and treatment of arthritis and psoriasis, providing detailed information on the use of plant-derived nutraceuticals, such as microalgae and other marine botanicals, omega polyunsaturated fatty acids, glucosamine and chondroitin sulphate, plant-based gum, vitamins and oils, probiotic supplements, and others in the treatment and management of arthritis and psoriasis. The book relates the recent scientific evidence on the effectiveness of each of these nutraceutical treatments, offering case studies, results of clinical studies, and more.
