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Basic concepts in medicinal chemistry
Designed to help students incrementally build their knowledge of fundamental concepts of medicinal chemistry and their applications to therapeutic decisions, it is progressively organized. Specific sections of the text have been updated to make potentially confusing concepts easier to understand. Numerous examples and review questions further reinforce learning and analytical skills.
Basic & Clinical Pharmacology
Covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters
Barile's clinical toxicology : Principles and mechanisms ; 3rd ed.
Examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. Special emphasis is placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. Includes the source, pharmacological and toxicological mechanism of action, detection and identification in body fluids, and treatment of exposure. An overview of protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology, are discussed. In addition, effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered
Banking Sector Liberalization in India : Evaluation of Reforms and Comparative Perspectives on China
Banking Sector Liberalization in India explores in detail the changes in the Indian banking sector over the last 20 years, and puts them into a comparative perspective with the Chinese banking sector. For this purpose, the author develops a detailed indicator-based framework for assessing the liberalization of a banking sector along various process steps based on financial liberalization and transformation studies. This framework, along with the indicators for the process and the results of liberalization, is applied to the banking sectors in India and China to test for the effects of liberalization on the sector and the macro level. The key finding is that while liberalization has improved the sectoral performance, it has so far had no effect on the macro level. The book features a detailed description of recent reforms in the Indian banking sector, a set of indicators for evaluating banking sector reforms, and a large number of graphs with key figures for the banking sectors in India and China.
Bacteriophage therapy : a potential solution for antibiotic resistance crisis
For many years, humans have been fighting with bacteria, in a matter of fact, bacteria have been winning for the last decade, becoming resistant to every weapon we have; The antibiotics. In order to win the fight humans had to think of alternative ways, like viruses. There is a special type of viruses that have been in a war with bacteria for millenniums, Bacteriophages. Bacteriophages (or phages), the most abundant viral entity of the planet. On the basis of their unique characteristics and anti-bacterial property, phages are being the freshly evaluated taxonomically. Phages replicate inside the host either by lytic or lysogenic mode after infecting and using the cellular machinery of a bacterium. Phage became an important agent for combating pathogenic bacteria in clinical treatments and its related research gained momentum. However, due to recent rise of bacterial resistance on antibiotics, applications of phage (phage therapy) become an unavoidable option of research. In this dissertation, the advantage and limitations of Bacteriophages for use in humans will be discussed. Furthermore, this dissertation deals with recent development of its application in the areas of biotechnology.
Bacterial signal transduction : Networks and drug targets
Interactions among different TCSs enable one system to respond to multiple signals, which is important for bacteria to minutely adjust themselves to complex environmental changes. Such interactions are found or predicted in various bacteria in this book. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these develop› ments have been put together in this book, Bacterial Signal Transduction: Networks andDrug Targets. This book Offers an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs.
Axon growth and guidance
The complexarchitectureofneuronal networks togetherwith the extraordinary associated functions make the nervous system a fascinating biological structure. The considerable work performed to explore this cellular machinery is nowadays successfulbecause the mysteryofnervous system developmentisbeing unravelled. As described in their outstanding review published 10 years ago in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular era of axon guidance-summarized the assembly of nervous system connections as a subtle game of attraction and repulsion of neuronal growth cones. The cellular ballet ensuring the formation of billions of synapses, which ultimately gives rise to the highest cognitive functions, is primarily orchestrated by a step-by-step mechanism of growth driven by multiple molecular cues. While our general concept of axon guidance remains identical, a profound evolution ofour knowledge ofthe molecular identityofthe guidance cues together with their interactions and signalling pathways occurred over the past ten years.
Axial flux permanent magnet brushless machines
This book deals with the analysis, construction, design, control and applications of AFPM machines. The authors present their own research results, as well as significant research contributions made by others.
Axial flux permanent magnet brushless machines
Axial Flux Permanent Magnet (AFPM) brushless machines are modern electrical machines with a lot of advantageous merits over their conventional counterparts. They are increasingly used in power generation, domestic appliances, industrial drives, electric vehicles, and marine propulsion drives and many other applications. This book deals with the analysis, construction, design, optimisation, control and applications of AFPM machines. The authors present their own research results, as well as significant research contributions made by others. This monograph will be of interest to electrical engineers and other engineers involved in the design and application of AFPM brushless machine drives. It will be an important resource for researchers and graduate students in the field of electrical machine and drives.
Autonomy : In the Law
Autonomy in the Law considers one of the most important benefits of the rule of law. Juxtaposing European and American conceptions of autonomy in the law of families, capital punishment and, criminal trials reveals the common values that justify all legal systems. Law protects the autonomy of individuals and associations by defending the boundaries of their own self-rule. This book illuminates the fundamental purpose of law by examining how European and American lawyers, judges and citizens do and should apply legal autonomy to the practical circumstances of litigation, legislation and the law.
Automatic Autocorrelation and Spectral Analysis
It takes advantage of greater computing power and robust algorithms to produce enough candidate models to be sure of providing a suitable candidate for given data. Improved order selection quality guarantees that one of the best (and often the best) will be selected automatically. The data themselves suggest their best representation. Should the analyst wish to intervene, alternatives can be provided. Written for graduate signal processing students and for researchers and engineers using time series analysis for practical applications ranging from breakdown prevention in heavy machinery to measuring lung noise for medical diagnosis.
Automated technology for verification and analysis ; 18th International Symposium, ATVA 2020, Hanoi, Vietnam, October 19–23, 2020, Proceedings
This book constitutes the refereed proceedings of the 18th International Symposium on Automated Technology for Verification and Analysis, ATVA 2020, held in Hanoi, Vietnam, in October 2020. The 27 regular papers presented together with 5 tool papers and 2 invited papers were carefully reviewed and selected from 75 submissions.
Automated machine learning : Methods, systems, challenges
This book presents the first comprehensive overview of general methods in Automated Machine Learning (AutoML), collects descriptions of existing systems based on these methods, and discusses the first series of international challenges of AutoML systems. The recent success of commercial ML applications and the rapid growth of the field has created a high demand for off-the-shelf ML methods that can be used easily and without expert knowledge. However, many of the recent machine learning successes crucially rely on human experts, who manually select appropriate ML architectures (deep learning architectures or more traditional ML workflows) and their hyperparameters. To overcome this problem, the field of AutoML targets a progressive automation of machine learning, based on principles from optimization and machine learning itself.
Autoimmunity : Methods and protocols
Brings together a comprehensive and up-to-date collection of protocols that reflect the diverse experimental strategies. Chapters detail T-cell, macrophage characterization, neutrophil functional assays, organoid culture methods, spatial transcriptomics, RNA FISH, microRNA profiling, and ribosome profiling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Aulton's pharmaceutics : The design and manufacture of medicines
A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. Pharmaceutics in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture and the elimination of micro-organisms from the products.
Aulton's pharmaceutics : The design and manufacture of medicines
Offers a complete course in one book for students in all years of undergraduate pharmacy and pharmaceutical sciences degrees. Thoroughly revised, updated and extended by experts in their fields and edited by Professors Kevin Taylor and Michael Aulton, this new edition includes the science of formulation, pharmaceutical manufacturing and drug delivery. All aspects of pharmaceutics are covered in a clear and readily accessible way and extensively illustrated throughout, providing an essential companion to the entire pharmaceutics curriculum from day one until the end of the course. Fully updated throughout, with the addition of new chapters, to reflect advances in formulation and drug delivery science, pharmaceutical manufacturing and medicines regulation Designed and written for newcomers to the design and manufacture of dosage forms Relevant pharmaceutical science covered throughout Includes the science of formulation and drug delivery Reflects current practices and future applications of formulation and drug delivery science to small drug molecules, biotechnology products and nanomedicines Key points boxes throughout Over 400 online multiple choice questions
Atmospheric Aerosol Properties : Formation, Processes and Impacts
An increasing interest in studies of atmospheric aerosols in the context of their impact on the formation of climate, heterogeneous chemical reactions in the atmosphere affecting in particular the environmental quality, problems of visibility and human health is the cause of unusual scales of developments connected with studies of atmospheric aerosols. The necessity has arisen to analyze the latest results concerning, first of all, three aspects of the problems considered: 1. aerosol properties from data of complex field observational experiment; 2. processes of aerosol formation and interaction of aerosol with clouds, 3. aerosol as a climate-forming atmospheric component (including the problem of long-range transport). The monograph in hand is dedicated mainly to the problems of the impact of aerosol on climate processes in the atmosphere, from microphysical processes of formation and evolution of aerosol properties to the formation of macro-scale cloud sytems on aerosol particles.
Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery
Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery covers in detail the technical aspects of all important procedures of the upper abdomen (esophagus, duodenum, stomach, liver, biliary system, pancreas, portal hypertension and spleen) including general, oncologic and transplantation surgery. Each chapter has been written by an expert renowned in his or her field and been reviewed by a second expert. All of the approximately 900 illustrations have been drawn by the same team of three artists of notable experience. The liver section follows the internationally accepted terminology of the Brisbane 2000 conference of the IHPBA. In this atlas experts of upper abdominal surgery share their experience and show how they do it - step by step.
Atlas of fundus autofluorescence imaging
During recent years, FAF (Fundus autofluorescence) imaging has been shown to be useful in various retinal diseases with regard to diagnostics, documentation of changes, identification of disease progression, and monitoring of novel therapies. Hereby, FAF imaging gives additional information above and beyond conventional imaging tools.This unique atlas provides a comprehensive and up-to-date overview of FAF imaging in retinal diseases. It also compares FAF findings with other imaging techniques such as fundus photograph, fluorescein- and ICG angiography as well as optical coherence tomography. General ophthalmologists as well as retina specialists will find this a very useful guide which illustrates typical FAF characteristics of various retinal diseases.
At the crossroads : The world trading system and the Doha Round
Since its foundation in 1995 the legitimacy of the WTO – and herewith the notion of organising global trade on the basis of herewith the notion of organising global trade on the basis of concepts like trade-liberalisation, treaty-based rule of law and concepts like trade-liberalisation, treaty-based rule of law and enforceability – is challenged for very different reasons this volume not only documents the proceedings of this conference but, against the backdrop of the ongoing efforts to revive the Doha Round wants to be understood as some sort of stocktaking: What did really go wrong in Cancún? Where does the WTO stand today? Has there been any progress made since? And, finally: Is there any chance left to reach the ambitions goals postulated by the Doha Development Agenda? These and other, related questions are being discussed in the volume at hand.
