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Cancer drug resistance
In Cancer Drug Resistance, leading scientists from the best academic institutions and industrial laboratories summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to a wide variety of anticancer therapeutics, as well as suggest new approaches to the biology of drug resistance that may afford new therapeutic opportunities.
Cancer
The last decade has seen a dramatic shift in anticancer drug research towards agents that aim to target selectively key regulatory and signaling processes known to drive tumorigenesis. A number of these newer agents have now been introduced into clinical practice. This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-nvasives. Each chapter aims to cover the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Calixarenes in the Nanoworld
Calixarenes have been widely exploited in all areas of supramolecular chemistry over the past three decades and many recent developments have concerned their applications in the production of chemical entities with the dimensions of nanometres, as in "nanochemistry".Calixarenes in the Nanoworld Relates calixarenes to nanochemistry – key information for industries engaged in the production of high-tech materials. Provides a timely review of both what is known and the exciting prospects provided by calixarenes, Contains several review articles which define the importance of calixarenes as reagents in nanochemistry.
CADD and informatics in drug discovery
Updates knowledge on recent advances in computational and bioinformatics tools/techniques and their practical applications in modern drug design and discovery programme. Also it encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas / presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, RandD personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, De-novo drug design, Pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and system biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to different stakeholders working in the pharmaceutical and biotechnology industries (RandD), the academic as well as research sectors. .
C++ mit Visual Studio 2019 : C++17 für Studierende und erfahrene Programmierer
C++ hat sich in den letzten Jahren rasant entwickelt: C++11, C++14, C++17 und C++20 haben viele Verbesserungen und neue Möglichkeiten gebracht. Vieles, was vor 10 Jahren noch gut und empfehlenswert war, kann heute besser und sicherer gemacht werden. Dieses Buch stellt C++ mit Visual Studio 2019 auf dem Stand von Mai 2020 umfassend dar. Das ist nicht nur der Umfang von C++17, sondern auch schon ein Teil von C++20.
Business ethics from the 19th century to today : An economist's view
Combines elements of economic and business history to study business ethics from the nineteenth century to today. It concentrates on American and British business history, delving into issues such as slavery, industrialization, firm behavior and monopolies, and Ponzi schemes. This book draws on the work of economists and historians to highlight the importance of changing technologies, religious beliefs, and cultural attitudes, showing that what is considered ethical differs across time and place.
Burning mouth disease : A guide for patients
Prepared for patients who suffer from 'Burning mouth disease', also referred to as 'Burning mouth syndrome'. It gives a comprehensive overview of the disease, its symptoms and management. Readers will learn about the terminology and definition of 'Burning mouth disease', and its suggested causes. Attention is paid to symptoms of various diseases that may mimic those of burning mouth disease. Neurological and psychogenic aspects are well covered, as are the many reported pharmacological and non-pharmacological treatment modalities.
Building a Cashless Society : The Swedish Route to the Future of Cash Payments
This book tells the story of how Sweden is becoming a virtually cashless society. Its goal is to improve readers’ understanding of what is driving this transition, and of the factors that are fostering and hampering it. In doing so, the book covers the role of central banks, political factors, needs for innovation, and the stakeholders involved in developing a cashless ecosystem. Adopting a historical standpoint, and drawing on a unique dataset, it presents an academic perspective on Sweden’s leading role in this global trend. The global interest in the future of cash payments makes the Swedish case particularly interesting. As a country that is close to becoming a cashless economy, it offers a role model for many other countries to learn from - whether they want to stimulate or reduce the use of cash. This highly topical book will be of interest to politicians, researchers, businesses, financial service providers and payment service providers, as well as fintech start-ups, regulators and other authorities.
Brown and Mulholland’s drug calculations
A realistic practice problems and unique "proof" step in the answer key that allows you to double-check your answers to avoid medication errors. This edition continues to promote critical thinking, clinical judgment, and patient safety with respect to accurate drug dosages. Helpful worksheets, assessment tests, and Clinical Alerts call attention to situations in actual practice that have resulted in drug errors — giving you extensive hands-on practice for the Next Generation NCLEX® and beyond.
Brilliant light in life and material sciences
This book aim to create a synchrotron radiation facility, CANDLE, as an international laboratory for advanced research in life and material sciences. About 50 researchers from NATO, partner countries and Armenia gathered at Yerevan to discuss modern trends in developments of advanced light sources with high spectral brilliance and applications in basic and applied research in a wide range of fields. Research with high brilliant photon beams are used, for example for practical applications in pharmacy, electronics and nanotechnology. Such practical relevance promoted the design and construction of now more than 50 such facilities worldwide. Overview and specialized talks on the status and highlights of newly constructed light sources (ALBA, SPEAR3, European XFEL Facility, Siberian Synchrotron Radiation Center, CANDLE), on instrumentation and development of experimental techniques, and frontier research in life and material sciences using synchrotron radiation have been presented.
Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries ; 7th International Workshop, BrainLes 2021, Held in Conjunction with MICCAI 2021, Virtual Event, September 27, 2021, Revised Selected Papers, Part I
The content of thebook covers the current state-of-the-art literature on federated learning applications for cancer research and Vclinical oncology analysis, as well as an overview of the deep learning approaches improving the current standard of care for brain lesions and current neuroimaging challenges. It is also focusing on the accepted BrainLes workshop submissions, is to provide an overview of new advances of medical image analysis in all the aforementioned brain pathologies. It brings together researchers from the medical image analysis domain, neurologists, and radiologists working on at least one of these diseases. The aim is to consider neuroimaging biomarkers used for one disease applied to the other diseases.
Brain-inspired computing ; 4th International Workshop, BrainComp 2019, Cetraro, Italy, July 15–19, 2019, Revised Selected Papers
The 11 papers presented in this volume were carefully reviewed and selected for inclusion in this book. They deal with research on brain atlasing, multi-scale models and simulation, HPC and data infra-structures for neuroscience as well as artificial and natural neural architectures.
Brain thoughts recognition
Humans controlling machines with their minds may sound like something from a scifi movie, but it’s becoming a reality through brain-computer interfaces BCI. Where BCI technology allows a human brain and an external device to talk to each other—to exchange signals. It gives humans the ability to directly control machines, without the physical constraints of the body. There are two ways to implement the BCI: Noninvasive tools often use sensors applied on or near the head to track and record brain activity, or Invasive BCI would require surgery. Electronic devices would need to be implanted beneath the skull, directly into the brain, to target specific sets of neurons. In order to implement a non-invasive BCI in a mobile phone, this study developed a mobile application to help paralyzed people who do not have the ability to use their phones to spend their basic daily needs, such as using the keyboard and interacting with PDF, etc.
Brain Death : A Reappraisal
This text is intended to provide an overview of brain death. The topics explored in this book are the concept and historical approach of human death, clinical examinations of brain-dead patients, ancillary tests in coma and brain death, bioethical discussions of brain death and its relationship with some consciousness disturbances, and the legal considerations of human death.
Brain Control of Wakefulness and Sleep
The book is rich in references and leaves no aspect of the problem untouched. The morphological, pharmacological, physiological and mathematical modeling aspects of different components of the subject are treated to exhaustion...the book is richly illustrated and down-right comprehensive. It will delight those interested in the field, will inform those who need a context for their research efforts and is a must for graduate and medical libraries.
Brain and Heart Dynamics
Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling.
Botanical drug products : Recent developments and market trends
Botanicals, which have been part of human food and medicine for thousands of years, are perceived as being safer than synthetic pharmaceuticals. The global botanical drug market was expected to reach $26.6 billion by 2017. In terms of FDA regulations, botanical drugs are no different from non-botanical products, having to meet the safety and effectiveness standards of a new drug in accordance. This book comprises a complete start-to-end process from drug-idea conception, to drug development process.
Bone remodeling and osseointegration of implants
Provides an insight into the latest advances in bone fracture healing and remodeling algorithm and their incorporation into patient-specific finite element models and the use of machine learning and artificial intelligence to predict the bone regeneration and osseointegration process with a certain degree of accuracy. It also examines the applications of numerical models to simulate the fracture healing process, which may prove to be advantageous in determining the optimal mechanical-based treatment or reconstruction after an accident or illness.
Bone Morphogenetic Proteins : From Local to Systemic Therapeutics
Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.
Bonding in Microsystem Technology
Bonding in Microsystem Technology starts with descriptions of terminology, kinds of microsystems and market analysis. Followed by the presentation of mechanisms of wet etching, set of process parameters, description of micromachining methods, examples of procedures, process flow-charts and applications of basic micromechanical structures in microsystems are shown. Next, high-temperature, low temperature and room-temperature bonding and their applications in microsystem technology are presented. The following part of the book contains the detailed description of anodic bonding, starting from analysis of properties of glasses suitable for anodic bonding, and discussion of the nature of the process. Next all types of anodic bonding and sealing procedures used in microsystem technology are presented.
