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Snake and spider toxins : Methods and protocols
Explores techniques and protocols, across various biological disciplines, used to study snake and spider peptide toxins. The chapters in this book are organized into four parts and cover topics such as the use of toxins in drug development; analysis of bioactivity of complex mixtures like venom; extraction of venom glands and the production of toxins; characterization of toxins from the RNA level to the peptide structure; and the determination of the toxin’s biological function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Snake and Spider Toxins: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.
Smart micro - and nanomaterials for pharmaceutical applications
Smart drug delivery refers to a targeted drug delivery or precision drug delivery system that allows drugs to be administered to a specific location in the body or at a specific time with enhanced precision and control. This approach has several advantages, including maximizing the therapeutic effects of a drug while minimizing side effects.
Small Animal Imaging : Basics and Practical Guide
A practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Sleep and Sleep Disorders : A Neuropsychopharmacological Approach
This timely book serves to present updated information about the neuropsychopharmacology of sleep as this field enters mainstream psychiatry, neurology and medicine This volume has assembled articles that summarize and review carefully, a chosen selection of the latest discoveries concerning sleep medicine, sleep physiology and sleep pharmacology. Outstanding contributions have been sought from acknowledged experts in their respective fields. The goal of the volume is to present the more recent developments and advances in the fields of sleep and neuropsychopharmacology, as well as to provide a context for considering them both in depth and from multidisciplinary perspectives.
Sjögren's Syndrome and Oral Health : Disease Characteristics and Management of Oral Manifestations
Provides a thorough update on Sjögren’s syndrome (SS) and its adverse impacts on oral health. The opening section focuses on the clinical and laboratory characteristics of SS and its current management. The final section details important advances in SS diagnosis and therapy. The differential diagnoses of recurrent glandular swelling, glandular irrigation and sialendoscopy, and salivary gland ultrasound for SS in children are explained, along with the pharmacological management for SS, clinical care for dry eyes, and gene therapy.
Single-Use Technology in Biopharmaceutical Manufacture
This authoritative guide contains the basic knowledge and information about disposable equipment. The author also discusses biopharmaceuticals’ applications through the lens of case studies that clearly illustrate the role of manufacturing, quality assurance, and environmental influences. This updated second edition revises existing information with recent developments that have taken place since the first edition was published. The book also presents the latest advances in the field of single-use technology and explores topics including applying single-use devices for microorganisms, human mesenchymal stem cells, and T-cells.
Sindrome Coronarica Acuta, un nuovo modo di fare diagnosi, un nuovo modo di impostare la terapia = Acute Coronary Syndrome : Anew way of diagnosing and setting therapy
Aims to provide the reader with a concise yet comprehensive and up-to-date overview of the issue of acute coronary syndrome, in light of the enormous body of literature published on the subject over the past decade. Introduction to the concepts of electrocardiography and histophysiopathology, the nosological reclassification of acute coronary disease resulting from the introduction of new myocardial necrosis markers into clinical practice is addressed. It also emphasizes the need for physicians to assess the intrinsic risk of the disease by calculating specific scores proposed by clinical studies. Based on these new concepts, the various therapeutic approaches that should be implemented are analyzed, including both purely pharmacological and more "aggressive" approaches in terms of effectiveness. Ample space is therefore given to the use of new antithrombotic treatments and the choice between pharmacological therapy and invasive approaches using coronary angiography and angioplasty. a crossroads that sometimes puts the doctor in difficulty, but which can imply, if the options are faced rationally, a radical change in the patient's destiny.
Signal Transduction in the Cardiovascular System in Health and Disease
This book has addressed the contributions of several key signal transduction pathways which are central to our understanding of cardiovascular physiology and pathophysiology. Aberrations in these signaling events have been suggested to be involved in a host of cardiovascular pathologies, such as cardiac arrhythmias, congenital heart failure and hypertension. All the chapters have been written by well known leaders in the fields, which cover a wide range of intracellular events that regulate various aspects of cardiovascular functions. This book will be of interest to both basic as well as clinical scientists seeking to understand the molecular basis of cardiovascular diseases, and also to those interested in defining targets for cardiovascular pharmacotherapy.
Shargel and Yu's applied biopharmaceutics and pharmacokinetics
Includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas. Shargel and Yu's Applied Biopharmaceutics and Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development.
Serotonin and Sleep : Molecular, Functional and Clinical Aspects
Serotonin and Sleep: Molecular, Functional, and Clinical Aspects covers the complete spectrum of the field and explores the link between the latest basic molecular, functional, and clinical aspects of serotonin and the practice of sleep medicine. The volume focuses on 24 different areas of research, with special emphasis relating the state of basic and clinical research to potential applications: changing concepts in serotonin research, topographic organization and chemoarchitecture, receptor mechanisms – its organization and regulation of behavioral states, electrophysiological mechanisms – in vitro, in vivo, and behaving animals and other areas of molecular neurobiology. Also highlighted are studies related to the circadian control of behavioral states, and mechanisms involved in the serotonergic inhibition of REM sleep. Such discussion has profound implications for the basic biology of serotonin.
Sensitization of Cancer Cells for Chemo/immuno/Radio-therapy
Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.
Semi-critical assisted extraction : Applications and commercialization in biotechnology, food, and pharmacy
Compiles empirical and traditional extraction methods applied to cutting-edge critical extraction research in the areas of food science, phytochemistry, pharmacy, fragrance, cosmetology, and folk medicine. It presents extraction technology as an interdisciplinary area that applies the principles of physics and chemistry as tools to develop engineered models for the construction of more advanced extraction devices. It includes examples and problems related to data treatment in normal laboratory research work that will facilitate undergraduate- and graduate-level students, as well as operators working in the area, in solving real problems.
Selective Digestive Tract Decontamination in Intensive Care Medicine : a Practical Guide to Controlling Infection
More than 20 years ago it was recognized by Stoutenbeek and colleagues that patients in the intensive care unit suffered from infections developed whilst being treated. Moreover, the majority of these infections appeared to originate from bacteria that were acquired in the intensive care leading to pathologic colonisation and overgrowth in the gut, subsequently leading to organ site infections. Selective decontamination of the digestive tract (SDD) is an antibiotic strategy which aims to prevent secondary infections in critically ill patients. This book provides both the scientific rationale and the practical approach to nurses, physicians, pharmacists and microbiologists to design a SDD treatment strategy tailored to each individual patient and the local hospital situation.
Secondary Metabolites in Soil Ecology
Secondary Metabolites in Soil Ecology focuses on the role of bacterial, fungal and plant secondary metabolites in soil ecosystems. Our understanding of the biological function of secondary metabolites is surprisingly limited, considering our knowledge of their structural diversity and pharmaceutically relevant activities. This volume reviews functional aspects of secondary metabolite production, with a focus on interactions among soil organisms. Topics such as truffle metabolites and burnt phenomenon, ecology of mycotoxins in soil, root exudates, and chemical interactions between Streptomyces and mycorrhiza fungi are treated. Further aspects are the role of microbial metabolites as quorum sensing signals, their role in protecting plants against pathogens and the effect of volatiles on soil invertebrates. Chapters describing techniques for the detection of antibiotics in soil and the application of metabolomics to rhizosphere research, which has advanced rapidly in recent years, complement the book.
Secondary Analysis of Electronic Health Records
This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence.
Scientific Pharmaceutical Research and Competition : Between Doctors and Pharmacists
The profession of pharmacist and pharmacology is a science that researches drugs, their properties, the composition of drugs and what is related to them.we will describe in our study the differences between the pharmacsit and Physicians,and how the pharmacsit outperforms the Physicians in many things, including pharmacology and presecbting. Pharmacists and physicians need to work together to provide pharmaceutical care, but differences in the ‘language’ of the two disciplines often impair this collaboration. Pharmacy students have a better knowledge of basic pharmacology, but not of the application of pharmacology knowledge, than medical students, whereas medical students are better at writing prescriptions.
RNA nanotechnology and therapeutics
Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, immunorecognition of RNA nanomaterials, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.
RNA as a drug target : The next frontier for medicinal chemistry
Provides the concepts and tools for developing drug-like small molecules that selectively target RNA rather than proteins, including the first successful examples from the development pipeline of big pharma.
Risk-sharing in the Pharmaceutical Industry : The Case of Out-licensing
The costs of developing a new drug have reached record levels in the pharmaceutical industry. As any failure of a new drug candidate can lead to significant losses, many pharmaceutical companies are looking for new approaches to reduce their exposure to R&D risks. In this context, the book deals with the topic of out-licensing as a novel form of risk-sharing collaborations. The phenomenon of out-licensing is illustrated by three major case studies of Novartis, Schering and Roche as well as several smaller case studies. In addition, the Noble Prize awarded economic theory of Adverse Selection is applied to analyze the topic theoretically. The gained insights allow identifying the critical parameters of out-licensing collaborations and thereby provide R&D managers with recommendations on how to conclude and manage this type of deals more effectively.
Rhinosinusitis : A Guide for Diagnosis and Management
Rhinosinusitis is one of the most common health care complaints, with many millions of cases managed annually by a variety of practitioners, from family care physicians and pediatricians to allergists, pulmonologists, and otolaryngologists. Rhinosinusitis: A Guide for Diagnosis and Management provides a comprehensive, practical guide to treating this widespread condition. Medical, surgical, and pharmacological management of both acute and chronic forms are discussed by experts with a wealth of clinical experience. Pediatric considerations and the role of allergies, asthma, and systemic diseases such as cystic fibrosis are discussed. A special chapter is devoted to alternative medicine in recognition of its increasing role in health care management. Diagnostic imaging techniques such as MRI and CT are discussed in detail.
