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Life - As a Matter of Fat : The Emerging Science of Lipidomics
Lipids are as important for life as proteins, sugars, and genes. The present book gives a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. The book is aimed at undergraduate students and young research workers within physics, chemistry, biochemistry, molecular biology, nutrition, as well as pharmaceutical and biomedical sciences. The emphasis is on the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Furthermore, it is shown how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.
Leveraging Data Science for Global Health
Explores ways to leverage information technology and machine learning to combat disease and promote health, especially in resource-constrained settings. It focuses on digital disease surveillance through the application of machine learning to non-traditional data sources.
Level Crossing Methods in Stochastic Models
Since its inception in 1974, the level crossing approach for analyzing a large class of stochastic models has become increasingly popular among researchers. This volume traces the evolution of level crossing theory for obtaining probability distributions of state variables and demonstrates solution methods in a variety of stochastic models including: queues, inventories, dams, renewal models, counter models, pharmacokinetics, and the natural sciences. Results for both steady-state and transient distributions are given, and numerous examples help the reader apply the method to solve problems faster, more easily, and more intuitively.
Les fonctions sphinctériennes = Sphincter functions
This book on Sphincter functions provides an update on a very topical subject, urinary and anal incontinence. Divided into three parts, it first deals with fundamental aspects, whether anatomical, physiological or clinical. The explorations of the various urinary and anorectal functions are described with electrophysiological, manometric, urodynamic tests as well as imaging. The second part is devoted to the pathology with all the dysfunctions that we encounter in daily practice. Urinary and anal incontinence, dysuria and retention, neurological sphincter disorders, dysfunctions in pregnant women and children are discussed. The last part takes stock of treatments, whether pharmacological, rehabilitative or surgical. This work, which contains a considerable amount of information, will undoubtedly be of interest to many medical specialists (physicians in physical medicine and rehabilitation, neurologists, gastroenterologists, gynecologists, general practitioners, pediatricians), surgeons (urologists, gynecological surgeons, surgeons). digestive) whether they are in training or already involved in the management of perineal disability. Other health professionals will find reference material there (nurses, physiotherapists, midwives).
Lehninger Principles of Biochemistry
Help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry.
Legitimacy Needs as Drivers of Business Exit
A diversified firm’s withdrawal from a business unit, i.e. business exit, is a significant phenomenon in management practice. Although divestitures are highly relevant in practice, the acquisition of business units attracts much more attention in strategic management research. Carolin Decker develops and empirically applies a framework in which business exits serve the purpose of re-establishing a firm’s previously harmed legitimacy. She suggests four types of legitimacy needs that are to be satisfied with the divestiture of a business unit and the simultaneous pursuit of strategic reorientation. The author tests the theoretical framework with secondary data on 213 business exits. Her findings support the idea that legitimacy needs drive the likelihood of fit-enhancing business exits in divesting firms.
Legitimacy in International Law
In recent years the question of the legitimacy of international law has been discussed quite intensively. Such questions are, for example, whether international law lacks legitimacy in general; whether international law or a part of it has yielded to the facts of power; whether adherence to international legal commitments should be subordinated to self-defined national interests; whether international law or particular rules of it – such as the prohibition of the use of armed force – have lost their ability to induce compliance (compliance pull); and what is the relevance of non-enforcement or failure to obey for the legitimacy of that particular international norm? This book contains fresh perspectives on these questions, offered at an international and interdisciplinary conference hosted by the Max Planck Institute for Comparative Law and International Law.
Legitimacy In European Nature Conservation Policy : Case Studies In Multilevel Governance
Focuses on the issue of legitimacy in the context of European nature conservation policy. It provides insights in the way in which democratic legitimacy is being ‘produced’ at different levels of governance. Building forth upon recent developments in democracy theory that have identified multiple forms of legitimacy, the volume observes a EU-wide shift from output legitimacy to input and throughput legitimacy. Top down policy making is increasingly meeting
Learning Theory ; Vol. 4005 ; 19th Annual Conference on Learning Theory, COLT 2006, Pittsburgh, PA, USA, June 22-25, 2006, Proceedings
Constitutes the refereed proceedings of the 19th Annual Conference on Learning Theory, COLT 2006, held in Pittsburgh, Pennsylvania, USA in June 2006. The 43 revised full papers presented together with 2 articles on open problems and 3 invited lectures were carefully reviewed and selected from a total of 102 submissions. The papers cover a wide range of topics including clustering, un- and semisupervised learning, statistical learning theory, regularized learning and kernel methods, query learning and teaching, inductive inference, learning algorithms and limitations on learning, online aggregation, online prediction and reinforcement learning.
Learning Theory ; Vol. 3559 : 18th Annual Conference on Learning Theory, COLT 2005, Bertinoro, Italy, June 27-30, 2005, Proceedings
The technical program contained 45 papers selected from 120 submissions, 3 open problems selected from among 5 contributed, and 2 invited lectures. The invited lectures were given by Sergiu Hart on “Uncoupled Dynamics and Nash Equilibrium”, and by Satinder Singh on “Rethinking State, Action, and Reward in Reinforcement Learning”. These papers were not included in this volume. The Mark Fulk Award is presented annually for the best paper co-authored by a student. The student selected this year was Hadi Salmasian for the paper titled “The Spectral Method for General Mixture Models” co-authored with Ravindran Kannan and Santosh Vempala. The number of papers submitted to COLT this year was exceptionally high. In addition to the classical COLT topics, we found an increase in the number of submissions related to novel classi?cation scenarios such as ranking. This - crease re?ects a healthy shift towards more structured classi?cation problems, which are becoming increasingly relevant to practitioners.
Learning theory ; 20th Annual Conference on Learning theory, COLT 2007, San Diego, CA, USA, June 13-15, 2007, Proceedings
It covers unsupervised, semisupervised and active learning, statistical learning theory, inductive inference, regularized learning, kernel methods, SVM, online and reinforcement learning, learning algorithms and limitations on learning, dimensionality reduction, as well as open problems.
Learning in Modern International Society : On the Cognitive Problem Solving Abilities of Political Actors
Claudia Hofmann engages in a theoretical modelling of international learning processes and the substantiation of this model through three cases from international politics. She answers two questions: How may international actors learn as a collective? And how may the lessons learned influence actor behaviour and problem solving processes? As a foundation for answering these questions she examines the nature of actor behaviour within a social international system and integrates the diffusion of norms and values among macro-level actors.
Learning in Economic Systems with Expectations Feedback
Recently economists have more and more focussed on scenarios in which agents' views of the world may be erroneous. These notes introduce the concept of perfect forecasting rules which provide best least-squares predictions along the evolution of an economic system.
Learning Classifier Systems in Data Mining
Just over thirty years after Holland first presented the outline for Learning Classifier System paradigm, the ability of LCS to solve complex real-world problems is becoming clear. In particular, their capability for rule induction in data mining has sparked renewed interest in LCS. This book brings together work by a number of individuals who are demonstrating their good performance in a variety of domains.
Learning and Teaching for the Twenty-first Century : Festschrift for Professor Phillip Hughes
This book stresses learning and teaching, rather than teaching and learning. The contention of the contributors is that the focus in all educational endeavours should not be primarily on teachers and teaching, but on learners; how to best facilitate learning, in the most effective, enjoyable, relevant and cost-effective ways for learners, whether they be children, youth or adults. The focus is therefore on how learning can be enhanced, through effective teaching; and how individuals can be best prepared to be excellent teachers.
Learning and Intelligent Optimization ; 2nd International Conference, LION 2007 II, Trento, Italy, December 8-12, 2007. Selected Papers
The papers cover current issues of machine learning, artificial intelligence, mathematical programming and algorithms for hard optimization problems and are organized in topical sections on improving optimization through learning, variable neighborhood search, insect colony optimization, applications, new paradigms, cliques, stochastic optimization, combinatorial optimization, fitness and landscapes, and particle swarm optimization.
Learning and Adaption in Multi-Agent Systems ; 1st International Workshop, LAMAS 2005, Utrecht, The Netherlands, July 25, 2005, Revised Selected Papers
Contains selected and revised papers of the International Workshop on Lea- ing and Adaptation in Multi-Agent Systems (LAMAS 2005), held at the AAMAS 2005 Conference in Utrecht, The Netherlands, July 26. An important aspect in multi-agent systems (MASs) is that the environment evolves over time, not only due to external environmental changes but also due to agent int- actions. For this reason it is important that an agent can learn, based on experience, and adapt its knowledge to make rational decisions and act in this changing environment autonomously. Machine learning techniques for single-agent frameworks are well established. Agents operate in uncertain environments and must be able to learn and act - tonomously. This task is, however, more complex when the agent interacts with other agents that have potentially different capabilities and goals. The single-agent case is structurally different from the multi-agent case due to the added dimension of dynamic interactions between the adaptive agents. Multi-agent learning, i.e., the ability of the agents to learn how to cooperate and compete, becomes crucial in many domains. Autonomous agents and multi-agent systems (AAMAS) is an emerging multi-disciplinary area encompassing computer science, software engineering, biology, as well as cognitive and social sciences. A t- oretical framework, in which rationality of learning and interacting agents can be - derstood, is still under development in MASs, although there have been promising ?
Learn to Tango with D
Learn to Tango with D introduces you to the powerful D language, with special attention given to the Tango software library. A concise yet thorough overview of the language's syntax and features is presented, followed by an introduction to Tango, the popular general–purpose library you'll find invaluable when building your D applications.
Leading Pharmaceutical Innovation : Trends and Drivers for Growth in the Pharmaceutical Industry
Pharmaceutical giants have doubled their investments in drug development in the past decade only to see new drug approvals remain constant. This book investigates and highlights a set of proactive strategies aimed at generating sustainable competitive advantage based on value-generating business practices. We focus on three sources of pharmaceutical innovation: new management methods in the drug development pipeline, new technologies as enablers for cutting-edge R&D, and new forms of cooperation and internationalization, such as open innovation in the early phases of R&D. Our findings are illustrated by cases from Europe, the US, and Asia.
Leading edge technologies in fashion innovation : Product design and development process from materials to the end products to consumers
Offers cutting-edge knowledge on various design and product development related technologies, and applications of these technologies in fashion. Further, it envisions the future of these technologies when designing and engineering apparel-related products.
