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Cancer : Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related.
Cancer
The last decade has seen a dramatic shift in anticancer drug research towards agents that aim to target selectively key regulatory and signaling processes known to drive tumorigenesis. A number of these newer agents have now been introduced into clinical practice. This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-nvasives. Each chapter aims to cover the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Canadian Semantic Web
This book covers a variety of well known topics of interest to practitioners in industry and research scientists. The range of topics includes languages, tools and methodologies for the semantic Web, semantic Web-based ontology management and engineering, semantic Web services, practical applications of the semantic Web techniques, artificial intelligence methods and tools for the semantic Web, software agents on the semantic Web, visualization and modeling of the semantic Web. The goal of this book is to provide a state-of-the-art review of the research as well as to introduce topics of interest to experts.
CADD and informatics in drug discovery
Updates knowledge on recent advances in computational and bioinformatics tools/techniques and their practical applications in modern drug design and discovery programme. Also it encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas / presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, RandD personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, De-novo drug design, Pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and system biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to different stakeholders working in the pharmaceutical and biotechnology industries (RandD), the academic as well as research sectors. .
Business Intelligence for the Real-Time Enterprises ; 1st International Workshop, BIRTE 2006, Seoul, Korea, September 11, 2006, Revised Selected Papers
The book includes different aspects in the lifecycle of business intelligence on very large enterprise-wide operational real-time data sets. In today’s competitive and highly dynamic environment, analyzing data to und- stand how the business is performing, to predict outcomes and trends, and to improve the effectiveness of business processes underlying business operations has become critical. The traditional approach to reporting is not longer adequate; users now - mand easy-to-use intelligent platforms and applications capable of analyzing real-time business data to provide insight and actionable information at the right time. The end goal is to improve the enterprise performance by better and timelier decision making, enabled by the availability of up-to-date, high-quality information.
Business Information Systems ; 11th International Conference, BIS 2008, Innsbruck, Austria, May 5-7, 2008. Proceedings
This book contains the refereed proceedings of the 11th International Conference on Business Information Systems, BIS 2008, held in Innsbruck, Austria, in May 2008.
Building a Data Warehouse : With Examples in SQL Server
The book is organized as follows. In the beginning of this book (chapters 1 through 6), you learn how to build a data warehouse, for example, defining the architecture, understanding the methodology, gathering the requirements, designing the data models, and creating the databases. Then in chapters 7 through 10, you learn how to populate the data warehouse, for example, extracting from source systems, loading the data stores, maintaining data quality, and utilizing the metadata. After you populate the data warehouse, in chapters 11 through 15, you explore how to present data to users using reports and multidimensional databases and how to use the data in the data warehouse for business intelligence, customer relationship management, and other purposes. Chapters 16 and 17 wrap up the book: After you have built your data warehouse, before it can be released to production, you need to test it thoroughly. After your application is in production, you need to understand how to administer data warehouse operation.
Browning Agents and Active Particles : Collective Dynamics in the Natural and Social Sciences
Lays out a vision for a coherent framework for understanding complex systems'' (from the foreword by J. Doyne Farmer). By developing the genuine idea of Brownian agents, the author combines concepts from informatics, such as multiagent systems, with approaches of statistical many-particle physics. This way, an efficient method for computer simulations of complex systems is developed which is also accessible to analytical investigations and quantitative predictions. The book demonstrates that Brownian agent models can be successfully applied in many different contexts, ranging from physicochemical pattern formation, to active motion and swarming in biological systems, to self-assembling of networks, evolutionary optimization, urban growth, economic agglomeration and even social systems.
Brown and Mulholland’s drug calculations
A realistic practice problems and unique "proof" step in the answer key that allows you to double-check your answers to avoid medication errors. This edition continues to promote critical thinking, clinical judgment, and patient safety with respect to accurate drug dosages. Helpful worksheets, assessment tests, and Clinical Alerts call attention to situations in actual practice that have resulted in drug errors — giving you extensive hands-on practice for the Next Generation NCLEX® and beyond.
Brilliantguard : AI-powered healthcare prototype for mobile & automotive integration
Brilliantguard is an AI-powered healthcare and safety prototype designed to support individuals with special needs, the elderly users, and patients with chronic conditions such as alzheimer’s disease. The system integrates augmented reality (AR), an AI based chatbot, and bitcoin-based payments into a unified platform combining mobile apps, smartwatches, and automotive sensors. It enables real-time health monitoring, predictive alerts with preliminary health suggestions, medication reminders, initial fault detection, and geofencing-based tracking for alzheimer’s patients. Emergency alerts are automatically triggered in response to abnormal health readings or car crashes.
Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries ; 7th International Workshop, BrainLes 2021, Held in Conjunction with MICCAI 2021, Virtual Event, September 27, 2021, Revised Selected Papers, Part I
The content of thebook covers the current state-of-the-art literature on federated learning applications for cancer research and Vclinical oncology analysis, as well as an overview of the deep learning approaches improving the current standard of care for brain lesions and current neuroimaging challenges. It is also focusing on the accepted BrainLes workshop submissions, is to provide an overview of new advances of medical image analysis in all the aforementioned brain pathologies. It brings together researchers from the medical image analysis domain, neurologists, and radiologists working on at least one of these diseases. The aim is to consider neuroimaging biomarkers used for one disease applied to the other diseases.
Brain-inspired computing ; 4th International Workshop, BrainComp 2019, Cetraro, Italy, July 15–19, 2019, Revised Selected Papers
The 11 papers presented in this volume were carefully reviewed and selected for inclusion in this book. They deal with research on brain atlasing, multi-scale models and simulation, HPC and data infra-structures for neuroscience as well as artificial and natural neural architectures.
Brain, vision, and artificial intelligence ; 1st International Symposium, BVAI 2005, Naples, Italy, October 19-21, 2005, Proceedings
This book constitutes the refereed proceedings of the First International Symposium on Brain, Vision and Artificial Intelligence, BVAI 2005, held in Naples, Italy in October 2005. The 48 revised papers presented together with 6 invited lectures were carefully reviewed and selected from more than 80 submissions for inclusion in the book. The papers are addressed to the following main topics and sub-topics: brain basics - neuroanatomy and physiology, development, plasticity and learning, synaptic, neuronic and neural network modelling; natural vision - visual neurosciences, mechanisms and model systems, visual perception, visual cognition; artificial vision - shape perception, shape analysis and recognition, shape understanding; artificial inteligence - hybrid intelligent systems, agents, and cognitive models.
Brain Dynamics : Synchronization and Activity Patterns in Pulse-Coupled Neural Nets with Delays and Noise
This book addresses a large variety of models in mathematical and computational neuroscience.He devotes the main part to the synchronization problem. He presents neural net models more realistic than the conventional ones by taking into account the detailed dynamics of axons, synapses and dendrites, allowing rather arbitrary couplings between neurons. He gives a complete stabile analysis that goes significantly beyond what has been known so far. He also derives pulse-averaged equations including those of the Wilson--Cowan and the Jirsa-Haken-Nunez types and discusses the formation of spatio-temporal neuronal activity pattems. An analysis of phase locking via sinusoidal couplings leading to various kinds of movement coordination is included.
Brain dynamics : An introduction to models and simualtions
Brain Dynamics serves to introduce graduate students and nonspecialists from various backgrounds to the field of mathematical and computational neurosciences. Some of the advanced chapters will also be of interest to the specialists. The book approaches the subject through pulse-coupled neural networks, with at their core the lighthouse and integrate-and-fire models, which allow for the highly flexible modelling of realistic synaptic activity, synchronization and spatio-temporal pattern formation. Topics also include pulse-averaged equations and their application to movement coordination. The book closes with a short analysis of models versus the real neurophysiological system.
Braid Groups
Braids and braid groups have been at the heart of mathematical development over the last two decades. Braids play an important role in diverse areas of mathematics and theoretical physics. The special beauty of the theory of braids stems from their attractive geometric nature and their close relations to other fundamental geometric objects, such as knots, links, mapping class groups of surfaces, and configuration spaces. In this presentation the authors thoroughly examine various aspects of the theory of braids, starting from basic definitions and then moving to more recent results. The advanced topics cover the Burau and the Lawrence--Krammer--Bigelow representations of the braid groups, the Alexander--Conway and Jones link polynomials, connections with the representation theory of the Iwahori--Hecke algebras, and the Garside structure and orderability of the braid groups.
Boosting Collaborative Networks 4.0 ; 21st IFIP WG 5.5 Working Conference on Virtual Enterprises, PRO-VE 2020, Valencia, Spain, November 23–25, 2020, Proceedings
This book constitutes the refereed proceedings of the 21st IFIP WG 5.5 Working Conference on Virtual Enterprises, PRO-VE 2020, held in Valencia, Spain, in November 2020. The conference was held virtually. The 53 full papers were carefully reviewed and selected from 135 submissions. They provide a comprehensive overview of major challenges and recent advances in various domains related to the digital transformation and collaborative networks and their applications with a strong focus on the following areas related to the main theme of the conference: collaborative business ecosystems; collaborative business models; collaboration platform; data and knowledge services; blockchain and knowledge graphs; maintenance, compliance and liability; digital transformation; skills for organizations of the future
Bone remodeling and osseointegration of implants
Provides an insight into the latest advances in bone fracture healing and remodeling algorithm and their incorporation into patient-specific finite element models and the use of machine learning and artificial intelligence to predict the bone regeneration and osseointegration process with a certain degree of accuracy. It also examines the applications of numerical models to simulate the fracture healing process, which may prove to be advantageous in determining the optimal mechanical-based treatment or reconstruction after an accident or illness.
Blockchain, artificial intelligence, and the internet of things : Possibilities and opportunities
Provides basic concepts and deep knowledge about various security mechanisms that can be implemented in IoT through Blockchain technology. This book aids readers in gaining insight and knowledge about providing security and solutions to different challenges in IoT using Blockchain technology. This book primarily focuses on challenges to addressing the integration of the IoT with Blockchain with respect to potential benefits for IoT. This book gives descriptive analysis of Blockchain integrated with IoT applications and platforms for the development of IoT solutions along with possible topologies to that integration. Several application examples are included in a variety of industries / Provides the latest on secure IIoT communication using Blockchain technology for Industry 4.0 / Includes updates on using Blockchain technology in secure vehicular communication (VANET), healthcare, retail, and gaming / Provides the latest on secure IIoT communication using Blockchain technology for Industry 4.0
Blockchain, artificial intelligence and financial services : Implications and applications for finance and accounting professionals
Blockchain technology and artificial intelligence (AI) have the potential to transform how the accounting and financial services industries engage with the business, stakeholder and consumer communities. Presenting a blend of technical analysis with current and future applications, this book provides professionals with an action plan to embrace and move forward with these new technologies in financial and accounting organizations.
