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Molecular Basis of Symbiosis
Symbiotic associations involving prokaryotes occur ubiquitously and are ecologically highly significant. In symbiotic associations, co-evolution of the partner organisms has led to specific mechanisms of signal exchange and reciprocal regulation, and resulted in novel physiological capabilities of the association as compared to those of the individual partners. Symbiosis research has recently entered an exciting era because molecular biology techniques are available for studying partner organisms in association and in a culture-independent manner. It is the goal of this book to contribute towards a broader perspective and an understanding of the function of symbiotic systems. 14 different model systems have been chosen, comprising well known symbioses as well as novel experimental systems which have only recently become amenable to experimental manipulation.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Molecular analysis of B lymphocyte development and activation
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Molecular analyses : Medical genomics and proteomics
Methods for extraction, manipulation, and characterization of nucleic acids, peptides, and proteins have been rapidly developed. Extraction from a variety of tissues and samples have become routine and automated. Next generation sequencing (NGS) methods have been developed. This book focuses on medically-focused methods
Modulation of host gene expression and innate immunity by viruses
This book is reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases.
Modern Magnetic Resonance ; Part 1 : Applications in Chemistry, Biological and Marine Sciences ; Part 2 : Applications in Medical and Pharmaceutical Sciences ; Part 3 : Applications in Materials Science and Food Science
Modern Magnetic Resonance provides a unique and comprehensive resource on up-to-date uses and applications of magnetic resonance techniques in the sciences, including chemistry, biology, materials, food, medicine, pharmaceuticals and marine sciences.The widespread appeal of MMR methods for revealing information at the molecular and microscopic levels is noted and examples are provided from the chemical and other sciences.Until now, there has been no single publication that covers all the areas encompassed by "Modern Magnetic Resonance", by bringing together the various techniques and their applications in many scientific areas, the internationally renowned Editors have created a resource of broad appeal to the scientific community.
Modern implant dentistry
A comprehensive look at the state of implant dentistry today, equipping beginners and seasoned clinicians alike to improve their skills and practice implant dentistry safely and predictably. The early chapters focus on the biology of dental implants as well as medical considerations required prior to placing them, followed by chapters dedicated to documentation, treatment planning, and digital workflow. Surgical concepts are then described in detail, from single-tooth extraction to guided All-on-X treatment, followed by detailed discussion of the prosthetic options available in implant dentistry. The final chapters include relevant topics such as soft tissue management in implant dentistry, treatment of peri-implant disease, the socket shield technique, and marketing of dental implant therapy. Written by experienced clinicians from all over the world, the book includes over 60 surgical and clinical videos (linked via QR codes) to demonstrate what the procedures and techniques and products look like in real life, not in a photograph taken in ideal conditions, so readers can be confident in their understanding.
Modern Hematology : Biology and Clinical Management
The first chapters of this book contain a self-contained introduction to path integrals in Euclidean quantum mechanics and statistical mechanics. The resulting high-dimensional integrals can be estimated with the help of Monte Carlo simulations based on Markov processes. The most commonly used algorithms are presented in detail so as to prepare the reader for the use of high-performance computers as an “experimental” tool for this burgeoning field of theoretical physics. Several chapters are then devoted to an introduction to simple lattice field theories and a variety of spin systems with discrete and continuous spins, where the ubiquitous Ising model serves as an ideal guide for introducing the fascinating area of phase transitions. As an alternative to the lattice formulation of quantum field theories, variants of the flexible renormalization group methods are discussed in detail. Since, according to our present-day knowledge, all fundamental interactions in nature are described by gauge theories, the remaining chapters of the book deal with gauge theories without and with matter.
Modern Genome Annotation : The Biosapiens Network
An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.
Modern Formal Methods and Applications
Formal methods are a robust approach for problem solving. It is based on logic and algebraic methods where problems can be formulated in a way that can help to find an appropriate solution. This book shows the basic concepts of formal methods and highlights modern modifications and enhancements to provide a more robust and efficient problem solving tool.Applications are presented from different disciplines such as engineering where the operation of chemical plants is synthesized using formal methods. Computational biology becomes easier and systematic using formal methods. Also, hardware compilation and systems can be managed using formal methods.
Modern Food Microbiology
With 30 revised and updated chapters, the new edition of this classic text brings benefits to professors and students alike who will find new sections on proteobacteria, bottled water, food sanitizers (eletrolyzed oxidating water, ozone, chlorine, activin, chitosans, endolysins, etc.), bicontrol, biosensors quorum sensing, molecular genetic methods of analysis, food safety objectives, noroviruses, and prions. The book builds on the trusted and established sections on food preservation by modified atmosphere, high pressure and pulsed electric field processing, food-borne pathogens, food regulations, fresh-cut produce, new food products, and risk assessment and analysis. In-depth references, appendixes, illustrations, index and thorough updating of taxonomies make this an essential for every food scientist.
Modern Deep Learning Design and Application Development : Versatile Tools to Solve Deep Learning Problems
Learn how to harness modern deep-learning methods in many contexts. Packed with intuitive theory, practical implementation methods, and deep-learning case studies, this book reveals how to acquire the tools you need to design and implement like a deep-learning architect. It covers tools deep learning engineers can use in a wide range of fields, from biology to computer vision to business. With nine in-depth case studies, this book will ground you in creative, real-world deep learning thinking. You will: Improve the performance of deep learning models by using pre-trained models, extracting rich features, and automating optimization. Compress deep learning models while maintaining performance. Reframe a wide variety of difficult problems and design effective deep learning solutions to solve them. Use the Keras framework, with some help from libraries like HyperOpt, TensorFlow, and PyTorch, to implement a wide variety of deep learning approaches.
Models, Mysteries, and Magic of Molecules
Molecular behaviour, which is no less than magical, holds the key to the understanding, not only of chemistry, but of all biology and of life itself. It is a mystery why molecular behaviour should remain poorly understood and why the authoritative theories of physics have produced no more than superficial models to elucidate this vital issue. This book explores the common ground to guide chemists, biologists, crystallographers, spectroscopists and theorists into a deeper recognition of their individual relevance towards painting a holistic picture of scientific endeavour. This effort to stimulate interest in multidisciplinary research is rare, if not unique.
Models of the Atomic Nucleus
Models of the Atomic Nucleus is a largely non-technical introduction to nuclear theory – an attempt to explain the nucleus in a way that makes nuclear physics as comprehensible as chemistry or cell biology. Unlike many other scientific fields, the "popularization" of nuclear physics has not previously been successful because many fundamental issues remain controversial and a unified theory of nuclear structure has not yet been established. The theme developed in this book is that the many models of nuclear theory each provide a partial perspective on the nucleus and that the many models can in fact be integrated into a coherent whole and expressed in terms of a lattice of nucleons.
Modelling, Analysis and Optimization of Biosystems
Mathematical models in biology and medicine cannot be based on natural laws as it is the case with physics and chemistry. This is due to the fact that biological and medical processes are concerned with living organisms. Mathematical models, however, can be used as a language by which certain aspects of biological or medical processes can be expressed. In general, several mathematical models can be designed in order to describe a biological or medical process and there is no unique criterion which model gives the best description. This book presents several of these models and shows applications of them to different biological and medical problems. The book shows that operations research expertise is necessary in respect to modeling, analysis and optimization of biosystems.
Modelli Matematici in Biologia = Mathematical Models in Biology
This text is addressed first of all to the students of the Specialist Degrees in Biology of the Universities, but it will also be of interest to students of Natural Sciences and Medicine. The topics covered include the most classic mathematical models of biological phenomena (population dynamics, spread of infectious diseases, simple physiology models), but a relevant part of the text is dedicated to the mathematical approach to the theory of natural evolution. The only prerequisites required of the reader are those provided by the basic courses of Mathematics of the Bachelor's Degree in Biology, Natural Sciences or Medicine.
Modelli Dinamici Discreti = Discrete Dynamic Models
Discrete mathematical modeling is one of the driving factors in modern mathematics research, and has played a role of synthesis between different disciplines, becoming a tool for qualitative and quantitative analysis in applied sciences. This volume provides an introduction to the analysis of discrete dynamic systems, following a modeling approach. An examination of a wide range of examples, models, and motivations drawn from Biology, Demography, Engineering and Economics, is followed by the presentation of the tools for the study of linear and non-linear scalar dynamical systems, with particular attention to stability analysis. The linear difference equations are studied in detail and an elementary introduction to the Z and DFT transforms is provided. One chapter is devoted to the study of bifurcations and chaotic dynamics. One-step vector dynamical systems and the applications of Markov chains are the subject of three chapters.
Modeling, Simulation and Optimization of Complex Processes ; Proceedings of the Third International Conference on High Performance Scientific Computing, March 6–10, 2006, Hanoi, Vietnam
This proceedings volume contains a selection of papers presented at the Third International Conference on High Performance Scientific Computing held at the Hanoi Institute of Mathematics, Vietnamese Academy of Science and Technology (VAST), March 6-10, 2006. The conference has been organized by the Hanoi Institute of Mathematics, Interdisciplinary Center for Scientific Computing (IWR), Heidelberg, and its International PhD Program ``Complex Processes: Modeling, Simulation and Optimization'', and Ho Chi Minh City University of Technology. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and control, parallel computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site location, communication networks, production scheduling, industrial and commercial problems.
Modeling, Simulation and Optimization of Complex Processes ; Proceedings of the International Conference on High Performance Scientific Computing, March 10-14, 2003, Hanoi, Vietnam
This proceedings volume contains a selection of papers presented at the symposium "International Conference on High Performance Scientific Computing'' held at the Hanoi Institute of Mathematics of the Vietnam National Center for Natural Science and Technology (NCST). The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and optimal control, parallel computing, symbolic computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site location, communication networks, production scheduling, industrial and commercial problems.
Modeling with Itô Stochastic Differential Equations
This modeling procedure is thoroughly explained and illustrated for randomly varying systems in population biology, chemistry, physics, engineering, and finance. Introductory chapters present the fundamental concepts of random variables, stochastic processes, stochastic integration, and stochastic differential equations. These concepts are explained in a Hilbert space setting which unifies and simplifies the presentation. Computer programs, given throughout the text, are useful in solving representative stochastic problems. Analytical and computational exercises are provided in each chapter that complement the material in the text.
