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Evolution Algebras and their Applications
Behind genetics and Markov chains, there is an intrinsic algebraic structure. It is defined as a type of new algebra: as evolution algebra. This concept lies between algebras and dynamical systems. Algebraically, evolution algebras are non-associative Banach algebras; dynamically, they represent discrete dynamical systems. Evolution algebras have many connections with other mathematical fields including graph theory, group theory, stochastic processes, dynamical systems, knot theory, 3-manifolds, and the study of the Ihara-Selberg zeta function. In this volume the foundation of evolution algebra theory and applications in non-Mendelian genetics and Markov chains is developed, with pointers to some further research topics.
Epigenome editing : Methods and protocols
This second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Epigenetics in oncology
Covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years. Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
Epigenetics and chromatin
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility.
Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Enhancing Smallholder Farmers' Access to Seed of Improved Legume Varieties Through Multi-stakeholder Platforms : Learning from the TLIII project Experiences in sub-Saharan Africa and South Asia
This book shares the experiences of Tropical Legumes III (TLIII) project in facilitating access to seed of improved legume varieties to smallholder farmers through innovation platforms. It highlights practices and guiding principles implemented in eight developing countries of sub-Saharan Africa and South Asia. This book details key processes that respective teams employed to create an innovation space that delivers seed, other inputs, knowledge and financial services to agricultural communities and most importantly, the underserved farmers in remote areas of the drylands
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine
This is the most authoritative and wide-ranging reference yet assembled on Functional Genomics (the systematic analysis and identification of genes and their function) and Proteomics (the study of the complex structures and functions of proteins) in the rapidly expanding field of Molecular Medicine. The two-volume reference work offers a comprehensive overview of the terms, topics and issues in both molecular biology and molecular medicine, with particular emphasis placed on the molecular causes of diseases. It provides up-to-the minute information about developments in the field, including pharmacogenetics and pharmacoproteomics, gene regulation and gene therapy. The Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine is an invaluable tool for clinical scientists in academia and industry, and all who need fast and user-friendly access to key information in this dynamically developing field.
Encyclopedia of Genetics, Genomics, Proteomics and Informatics
It includes about 56% more words than the 1,392-page 2nd edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. Cross-references among entries are expanded. The statements are supported by references; more than 14,000 journal papers and more than 3,000 books are listed. The book includes ~1,800 current databases and web servers. Retractions and corrigenda are pointed out.It covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, patents, etc. Similar integrated information is not available in textbooks or on the Internet. The journal reviews called it the best, high-quality resource for researchers, instructors and students of basic and applied biology, as well as for physicians and lawyers or even for interested laymen because of the clarity of presentation.
Encyclopedia of Entomology
Brings together the expertise of more than 450 distinguished entomologists from 40 countries to provide a worldwide overview of insects and their close relatives. Combining the basic science of an introductory text with accurate, comprehensive detail, the Encyclopedia is a reliable first source of reference for students and working professionals. Coverage includes insect classification, behavior, ecology, genetics and evolution, physiology, and management, and references to relevant literature. All the major arthropod groups are addressed, along with many important families and species. The Encyclopedia places special emphasis on insect relationships with people, medical entomology, biological control and insect pathology. This important work also presents biographical sketches of hundreds of entomologists who have made important contributions to the discipline since its origin. The new Second Edition is fully indexed, and includes more than 120 color plates.The four-volume Encyclopedia of Entomology is a handy desk-top reference for entomologists, and a valuable source of information for scientists and students in agronomy, botany, disease biology, ecology, evolutionary biology, forestry, genetics, horticulture, parasitology, toxicology, and zoology. It is also available as an easily accessible, fully searchable online reference.
Emergent Computation : Emphasizing Bioinformatics
Emergent Computation is concerned with recent applications of Mathematical Linguistics or Automata Theory. This subject has a primary focus upon ""Bioinformatics"" (the Genome and arising interest in the Proteome), but the closing chapter also examines applications in Biology, Medicine, Anthropology, etc. The book is composed of an organized examination of DNA, RNA, and the assembly of amino acids into proteins. Rather than examine these areas from a purely mathematical viewpoint (that excludes much of the biochemical reality), the author uses scientific papers written mostly by biochemists based upon their laboratory observations. Thus while DNA may exist in its double stranded form, triple stranded forms are not excluded. Similarly, while bases exist in Watson-Crick complements, mismatched bases and abasic pairs are not excluded, nor are Hoogsteen bonds. Just as there are four bases naturally found in DNA, the existence of additional bases is not ignored, nor amino acids in addition to the usual complement of 20. Can there be more than ""64"" possible codons? RNA is examined from the point of view of Nussinov plots.
Electrical Diseases of the Heart : Genetics, Mechanisms, Treatment, Prevention
Electrical Diseases of the Heart is a thorough clinical reference on the current status of cardiac electrophysiological disease,emphasizing common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology, and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science.
Efficient Screening Techniques to Identify Mutants with TR4 Resistance in Banana : Protocols
The Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture implemented a Coordinated Research Project (CRP) ‘Efficient Screening Techniques to Identify Mutants with Disease Resistance for Coffee and Banana” (2015-2020). This CRP brought together experts from Asia, Europe and Africa in addition to experts of the Joint FAO/IAEA Centre to develop resistance against TR4 through mutation-assisted breeding. Induced mutagenesis is particularly attractive in case of banana since most cultivated bananas are seedless, thus hampering conventional cross breeding
Early Life Origins of Health and Disease
Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a ‘must’ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the ‘optimal’ way in which to investigate these phenomena.
Drug Metabolism: Current Concepts
The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development.
Drug Addiction : From Basic Research to Therapy
Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, genetic and behavioral pathways underlying drug addiction. Focusing on fundamental neurophysiological processes that overlap between drug addiction and other CNS disorders, this volume covers the translation of basic research into novel therapies, not only of drug addiction but a spectrum of related CNS disorders, including pain. Chapters are written by leading scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and development, drug targeting, and quantitative therapeutics, providing an unprecedented overview of a complex field of high societal signficance.
Double Fertilization : Embryo and Endosperm Development in Flowering Plants
Double Fertilization" provides a comprehensive overview of all aspects of this central event in the reproduction and development of flowering plants. Written by Val Raghavan, The Ohio State University, an acknowledged expert in plant developmental biology, the book vividly describes the molecular and cellular steps of the unique and complex fertilization process that culminates in the formation of embryo and endosperm, focusing on the latest results from the model plant Arabidopsis. The text is complemented by excellent illustrations, including 16 color plates.
Doing integrated history and philosophy of science : A case study of the origin of genetics
offers an integrated historical and philosophical examination of the origin of genetics. The author contends that an integrated HPS analysis helps us to have a better understanding of the history of genetics, and sheds light on some general issues in the philosophy of science. consists of three parts. It begins with historical problems, revisiting the significance of the work of Mendel, de Vries, and Weldon. Then it turns to integrated HPS problems, developing an exemplar-based analysis of the development and the progress in early genetics. Finally, it discusses philosophical problems: conceptual change, evidence, and theory choice.
DNA vaccines : Methods and protocols
Details practical procedures on the latest DNA vaccine technology. Chapters guide readers through methods and protocols on DNA vaccine design, the adjuvant influence, production and purification methodologies, delivery systems, and approaches of the influence of DNA vaccines in the immunological response performance and in the cancer immunotherapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
DNA Methylation, Epigenetics and Metastasis
Provides an outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. This book describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour
DNA Methylation : Development, Genetic Disease and Cancer
It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.
