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La gonarthrose : Traitement chirurgical : De l´arthroscopie à la prothèse = Knee osteoarthritis : Surgical treatment : from arthroscopy to prosthesis
The aim of this work is to take stock in a clear and didactic way on all the current knowledge on osteoarthritis of the knee and its treatment. It successively addresses the diagnosis and the medical treatment, then the surgical treatments then finally the various aspects of the total knee prosthesis. This book is designed to be read at several levels: basic information is intended particularly for non-specialist or trainee surgeons, rheumatologists, rehabilitation physicians, radiologists and physiotherapists. More specialized aspects are discussed in a second part of the book concerning the future of medical treatment (biology, gene therapy) and certain complex problems of surgical techniques. The points of controversy concerning the total knee replacement are discussed in the last part of the book, of interest to physicians and surgeons.
La genetica nell’infertilità maschile = Genetics in male infertility
The notable recent cognitive advances in the field of cytogenetics and molecular genetics have made it possible to identify chromosomal anomalies and gene mutations responsible for numerous male infertility, which were completely ignored until recently. The fact is not without relevance, if the principle is valid that the recognition of the causes of a disease is also the first and necessary approach towards its correct therapy. With this publication, the authors wanted to offer specialists working in the field of assisted reproduction an update on this complex subject, dealing with both genetic causes in male infertility and infertility in genetic diseases.
La fitoterapia in uno sguardo = Phytotherapy at a glance
This volume summarizes notions of phytotherapy; the intent is to offer the doctor essential knowledge so that he can easily prescribe plant products and to stimulate the pharmacist and herbalist to use them in a more rational way.
La disprassia in età evolutiva : Criteri di valutazione ed intervento = Dyspraxia in developmental age : Evaluation criteria and intervention
As clinical and rehabilitation practice shows, children with dyspraxia are unable to plan and organize an action plan; they cannot control what they are doing during an action; therefore, they cannot do something, but we could also admit that they cannot yet do something; that is, they have not yet learned to perform functions. Functions and actions, however, can be learned and performed with the help of targeted exercises performed consistently. It is, however, essential to recognize the difficulties children with dyspraxia face when faced with new, unusual tasks. The author proposes an assessment and intervention model that takes into account etiological and neuropsychological hypotheses, emphasizing the need to proceed with an analysis on multiple levels: perceptual, motor, and representational. Particular importance is given to early diagnosis and intervention to define and implement appropriate treatment plans. The work concludes with the analysis and description of clinical cases related to some specific forms of dyspraxia: verbal dyspraxia and dysgraphia.
La colografia virtuale con TC multistrato (CTC) = Virtual colonography with multislice CT
With the spread of multidetector row CT (MDCT), virtual colonography (VC) is establishing itself as a new, proven alternative radiological method in the diagnosis of intestinal polyps and colorectal cancer. VC is already considered the first-line examination for identifying synchronous tumor lesions in patients with colorectal cancers that cannot be penetrated by endoscope, simultaneously providing accurate staging of malignant lesions. Its minimally invasive nature makes VC a valid alternative to pancolonoscopy, even in the detection of intestinal polyps, and provides the basis for interesting developments regarding future applications in screening programs. The text, aimed at radiologists who are approaching the method, radiology technicians and doctors involved in the diagnostic and therapeutic process of colorectal pathology, indicates the advantages of the normal method, the normal method with fourteen chondrii, the normal method with fourteen chondrii, the pathological method with fourteen chondrii indications.
L’insuffisance rénale aiguë = Acute renal failure
The aim of this book is to make current data from the experimental and clinical literature accessible to readers. More than a thousand articles are published each year on the theme and the authors aim to synthesize this information. These data relate in particular to the identification of early markers of renal dysfunction without which screening, recognition of the main pathophysiological determinants and prevention remain uncertain. This book focuses attention on clinical situations characterized by the renal impact of the main dysfunctions of vital functions, the prognosis of which is worsened by the occurrence of this renal failure. The following will be treated in particular: the renal consequences of oxidative stress, the renal consequences of respiratory dysfunction, cardiac dysfunction, hepatic dysfunction, alterations in hemostasis, septic shock and hemorrhagic shock. Finally, the physiopathological data from experimental models are gradually finding their echo in the clinical field, opening up therapeutic avenues whose recent evaluations will be analyzed.
Kinase Drug Discovery : Modern Approaches
Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations.
Key Clinical Trials in Erectile Dysfunction
Represents a critical appraisal of the major clinical trials that have had a significant impact on clinical research and practice during the last decade. Each trial follows a strict format, starting with reference to the original source of publication, details on the key investigators and their methods of research. The strengths and weaknesses of each trial are discussed as well as their influence on clinical practice. Articles are complemented by a diagrammatic summary of the trial design and the key findings.
Keto cookbook for dummies
Millions of people have already benefited from the low-carb ketogenic diet. They’ve lost weight, increased their energy levels, got their Type 2 diabetes under control, and so much more. And if you’re looking for an easy and fun way to get started with keto. n this book, you’ll find 150 delicious keto recipes, from cheesy egg casserole to a keto-inspired berry cobbler. You’ll also discover expert tips on meal planning and preventing common ailments with simple adjustments to your diet. You’ll even learn how to use your Instant Pot and air fryer to make full-flavor, low-carb keto dishes.
Ketamine for Treatment-Resistant Depression : Neurobiology and Applications
Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics.
Katzung & Trevor's pharmacology : Examination & board review
Excellent Q & A and rationales for course exams and USMLE Step 1. With 1,000+ board-style questions/answers and fully up-to-date content, this is the most popular review in pharmacology. Organized to reflect the syllabi in pharmacology courses, Katzung & Trevor's Pharmacology Exam and Board Review covers all current drugs and retrovirals, immunologic agents, and chemotherapies. Each chapter begins with 20 pages of informative text, followed by questions and answers, and includes concise discussions of the concepts underlying basic principles or specific drug groups. Edited by the world leading figures in pharmacology and medicine, this high-yield text focuses on basic principles, autonomic drugs, cardiovascular-renal drugs, and drugs with actions on smooth muscle, central nervous system drugs, and drugs used to treat chemotherapeutic drugs, and toxicology.
Java for Bioinformatics and Biomedical Applications
Illustrates how individual bioinformatics applications (such as BLAST and Genscan) can be stitched together into a pipeline so that users can direct the output of one tool (for example, gene predictions using Genscan) to perform further analysis (say, homology searching using BLAST).
Issues of Decapod Crustacean Biology
This volume presents the proceedings of the eighth Colloquium Crustacea Decapoda Mediterranea, which was held at the Ionian University on Corfu Island, Greece, from 2 to 6 September 2002, and reflects recent advancements in decapod crustacean research. The meeting is the oldest European carcinological event, organized regularly at 3-year intervals since 1972. Although focused on the Mediterranean Sea, worldwide contributions provided a forum for fruitful contact and scientific exchange. The book covers up-to-date issues in decapod crustacean research, including genetics, morphology, reproduction, ecology, behaviour and fisheries, and it is primarily aimed at scientists interested in decapod crustacean research, but other scientists and decision-makers working on marine ecology and fisheries will also find up-to-date information on relevant issues.
Complexity in landscape ecology
Interactions matter. To understand the distributions of plants and animals in a landscape you need to understand how they interact with each other, and with their environment. The resulting networks of interactions make ecosystems highly complex. Recent research on complexity and artificial life provides many new insights about patterns and processes in landscapes and ecosystems. This book provides the first overview of that work for general readers. It covers such topics as connectivity, criticality, feedback, and networks, as well as their impact on the stability and predictability of ecosystem dynamics. With over 60 years of research experience of both ecology and complexity, the authors are uniquely qualified to provide a new perspective on traditional ecology.
Complement and Kidney Disease
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Comparative Placentation : Structures, Functions and Evolution
Science produces fascinating puzzles: why is there such a range of placental structures when other mammalian organs are so structurally uniform ? Why and how did the different placental structures evolve ? Comparative placental studies can facilitate the identification of the common factors in placental growth, differentiation and function and their relevance to possible evolutionary pathways. Comparative Placentation is the only book presenting up-to-date data illustrating the great variety of structure but uniform function of vertebrate placentas from fish to man. This information is essential for selection of suitable models to investigate particular practical problems of impaired or anomalous growth in human and animal placentation. The unique collection of the best light and electron micrographs from the last thirtyfive years which precisely illustrate the structural range in each taxon, make the book the most authoritative publication in this field and a vital source of information for anyone interested on reproductive physiology, anatomy and medicine.
Comparative genomics ; Vol.15 : Using Fungi as Models
Fungal comparative genomics started in 2000 by the genome sequencing of several yeast species other than the canonical Saccharomyces cerevisiae. Since then, over 30 fungal genome sequences have become available. This set represents a total evolutionary divergence comparable to that between vertebrates and arthropods, but also contains closely related genomes. This volume describes how we can use this set of genomes to trace large and small-scale events in genome evolution, to extract information about highly conserved and less conserved sequence elements, and to develop novel methods in genomics that will have an impact on genomics at large.
Comparative genomics : Methods and protocols
Provides new and updated chapters covering computational and mathematical techniques and concepts related to the field of comparative genomics. The topics covered in the chapters range from those that address general techniques and concepts that apply to all organisms to others that are specialized and apply to specific biological systems such as viruses, bacteria, nematodes, and insects.
Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality, with at least one third of cases requiring hospitalization, exceeding the numbers admitted for myocardial infarction and stroke. Despite a broad armamentarium of antimicrobials available, it remains an important cause of death in industrialized countries. CAP is caused by a variety of pathogens with their order of importance dependent on the location and population studied. Despite the importance of CAP, reliable data and a recommended evidence-based therapy are lacking, and basic research must be improved. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered. The volume is of interest to researchers and clinicians in virology, epidemiology and biomedicine.
Communication in Plants : Neuronal Aspects of Plant Life
Plant neurobiology is a newly emerging field of plant sciences. It covers signalling and communication at all levels of biological organization – from molecules up to ecological communities. In this book, plants are presented as intelligent and social organisms with complex forms of communication and information processing. Authors from diverse backgrounds such as molecular and cellular biology, electrophysiology, as well as ecology treat the most important aspects of plant communication, including the plant immune system, abilities of plants to recognize self, signal transduction, receptors, plant neurotransmitters and plant neurophysiology. Further, plants are able to recognize the identity of herbivores and organize the defence responses accordingly. The similarities in animal and plant neuronal/immune systems are discussed too. All these hidden aspects of plant life and behaviour will stimulate further intense investigations in order to understand the communicative plants in their whole complexity.
