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The art and science of contemporary surgical endodontics
Begins with a concise review of the basic science of tissues and then moves into diagnosis, treatment planning, and surgical procedures in endodontics, with an emphasis on the use of enhanced magnification, ultrasonic tips, microinstruments, newer root-end filling materials, and CBCT. Chapters on the maxillary sinus and its relation to surgical endodontics, soft and hard tissue healing, and adjunctive surgical procedures and considerations such as management of procedural accidents, resorption, root amputation, hemisection, replantation, transplantation, crown lengthening, grafting materials, and pharmacology are followed by an assessment of the outcomes of surgical endodontics based on current evidence. The accompanying DVDs present valuable videos demonstrating many of the procedures. These features provide the reader with a textbook that is concise, current, and easy to follow in an interactive manner. Written by a team of leading authorities and richly illustrated, this new compendium of state-of-the-art knowledge and protocols is essential reading for practicing endodontists and residents alike.
The ADME encyclopedia : A comprehensive guide on biopharmacy and pharmacokinetics
Covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties
Textbook of Pharmacoepidemiology ; 3rd ed.
Studies the use of and the effects of medical products in large numbers of people and applies the methods of epidemiology to the content area of clinical pharmacology. This field represents the science underlying studies of the effects of medical products (such as drugs, biologicals, and devices) in real world use. Offers an approach that focuses on the core of the discipline, providing a focused educational resource for students. The book is designed for students at all levels: upper-level undergraduates, graduate students, post-doctoral fellows, and others who are learning the field. Case examples feature in most chapters, and all chapters include key points and a list of further reading.
Textbook of Personalized Medicine
This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considersgenetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various playersin it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed.
Textbook of Patient Safety and Clinical Risk Management
Implementing safety practices in healthcare saves lives and improves the quality of care: it is therefore vital to apply good clinical practices, such as the WHO surgical checklist, to adopt the most appropriate measures for the prevention of assistance-related risks, and to identify the potential ones using tools such as reporting & learning systems.
Textbook of forensic pharmacy : Pharmaceutical jurisprudence
Offers a comprehensive overview of forensic pharmacy theory and application, covering definitions, objectives, and offenses under various Acts under the Indian legislation. It covers, in 27 chapters, All the major and latest syllabi of PharmD, MPharm, BPharm and DPharm courses of the Indian Universities, including all the topics additionally prescribed by Pharmacy Council of India, providing a systematic structure for comprehensive coverage of the subject.
Teratogenicity testing : Methods and protocols
Collects laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. Beginning with a section detailing basic principles of teratogenicity, the book continues with application of in vitro models for teratogenic screening to predict toxicity in embryonic animals and humans, as well as a variety of well-established in vivo animal model tests, which offer solutions for evaluating the efficacy and the teratogenicity of compounds in preclinical trials before human safety testing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Technology transfer : Drug product manufacturing process
Offers technology transfer solutions and guidance to the pharmaceutical industry. The chapters provide a systematic understanding of applying the technology transfer concepts in pharmaceutical manufacturing, promoting standardization within the industry. Since Stage 1b is not specified in detail within the regulations, pharmaceutical organizations are left to determine the requirementsof the stage.
Technetium-99m Pharmaceuticals : Preparation and Quality Control in Nuclear Medicine
Gives an account of the accomplishments related to the development of 99mTc-radiopharmaceuticals and their application in diagnostic nuclear medicine. Since radioactive drug development is a multi-disciplinary task, experts working in nuclear medicine and research institutions have contributed valuable information concerning the preparation with sterile kits, methods of quality control, and the use of 99mTc-radiopharmaceuticals in patients. In addition, the legal aspects governing production and clinical application are also considered.
Targeting the DNA damage response for cancer therapy
Discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic.
Targeted metallo-drugs : Design, development, and mode of action
Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development.
Tablet press machine supervision with scada
As technology is advancing and the needs for development in various fields become necessary, the idea of our project is born, which aspire to develop and automate a press tablet machine. The rotary tablet press machine is designed to produce tablets and capsules in different size and shape and is used widely in pharmacy and chemical industries. Quality control test for tablets depends on several parameters such as compression force, humidity and temperature. The project purpose is to add some features such us reading and saving those parameters to be used in researches and experiments for the research and development laboratory in Arab International University’s faculty of pharmacy.
Synthesis of essential drugs
Offers a brief description of methods of synthesis, activity and implementation of different drug types. Features chapters that begin with brief definition and description of a particular group of drugs, propose their classification, and explain model of their action, followed by a description of methods for their synthesis.
Synthesis of Best-Seller Drugs
A key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field
Synthesis and Characterization of Glycosides
There is no doubt that glycoside chemistry continues to be a dynamic and exciting field related to organic chemistry. Within sugar chemistry, glycosides are of special interest not only because of the challenges represented by their synthesis and structural characterization, but also due to their important biochemical relevance, and hence their applications in a number of essential disciplines, such as pharmaceuticals, food, and biotechnology. Important biomolecules such as DNA and RNA, or cofactors such as ATP and NAD, are some of the natural glycosidic structures playing key rules at a biochemical level. Also, a considerable number and variety of natural and synthetic glycosides are being extensively used as antibiotics, antiviral, and antineoplasic agents.
Symptoms in the Pharmacy : A Guide to the Management of Common Illnesses ; 8th ed.
Provides pharmacists working in the community with the treatment information they need when they need it. Each chapter incorporates a decision-making framework which distills the information necessary for treatment along with suggestions on “when to refer” set off in summary boxes. Elucidating case studies are provided throughout, in which pharmacists and doctors describe, in their own words, listening to and treating patients suffering with a range of common problems, from migraine to eczema to IBS. The indispensable guide to assessing and managing common symptoms seen in the pharmacy / Includes information about medicines recently reclassified for OTC supply such as those for malaria prophylaxis and erectile dysfunction / Now includes more highlights of “Red Flag” signs and symptoms / Covers respiratory, gastrointestinal, skin, ear and eye, cardiovascular, and pain conditions / Offers specific recommendations for women’s, men’s and children’s health problems / Provides decision making support for cases involving ethical dilemmas / Features a visual display of relevant treatment guidelines / Emphasizes the evidence base for OTC medicines
Symptoms in the pharmacy : A guide to the management of common illnesses
Supports pharmacists to recognize symptoms, advise with confidence, and recommend appropriate treatment or referral, while also providing a comprehensive digest of common conditions ideal for both practical use and reference. Includes: Consideration of conducting pharmacy consultations remotely as well as in person in the pharmacy / Information about medicines recently reclassified for OTC supply / Expanded content on women’s health including information on desogestrel, menopause and incontinence / Broadening of the insomnia chapter to include consideration of mental health problems / Increased content on non-drug treatment options and their supporting evidence / A summary of evidence sources at the end of each chapter / Decision-making support for unique cases which involve ethical dilemmas
Surgical management of inflammatory eye disease
Ocular inflammation presents a broad spectrum of clinical manifestations. Inflammatory activity can often be managed by drug therapy. However, inadequate medical therapy may permit the development of various complications in the eye that cannot be sufficiently treated pharmacologically. Whereas drug management demands an interdisciplinary approach with well-trained specialists, surgical treatment of ocular complications due to inflammation requires an experienced surgeon. This book offers evidence-based information and a step-by-step guide on all relevant surgical procedures, which is otherwise rare to find.
Successful Drug Discovery ; Vol.4
Provides unique insider insight into the current drug development process, and what it takes to achieve success. Covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more.
Successful Drug Discovery ; Vol.3
Tells the story of the drug's discovery and describe the sometimes twisted route from the first drug candidate molecule to the final marketed drug. The 11 case studies selected describe recent drugs ranging across many therapeutic fields and provide a representative cross-section of present-day drug developments. Backed by plenty of data and chemical information, the insight and experience of today's top drug creators makes this one of the most useful training manuals that a junior medicinal chemist may hope to find. The International Union of Pure and Applied Chemistry has endorsed and sponsored this project because of its high educational merit.
