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Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Drousi: A private lessons management system
Private teaching is considered to be an effective way to increase academic achievement of students and it seen as being a supplementary education, so it has become very common all around the world, however, previous studies have come to different conclusions regarding its necessity, so Drousi application had been made ,it’s a user-friendly mobile application to manage and arrange private lessons, and There has never been a better time to become a private tutor, as class sizes in schools increase, this can result in teachers being unable to give their undivided attention to students, and this document lays out a project plan for the development of “Drousi”, The plan will include a summary of the system functionality and how it implemented.
Driving digital transformation through data and AI : A practical guide to delivering data science and machine learning products
Explains how to build the organizational capability to deliver Data and AI products and drive immediate business results as new digital technologies significantly disrupt business Provides best practices, tools and templates for managing the organizational and technological change process to become an AI-driven enterprise Includes a variety of international case studies across several industries such as insurance, fashion, consumer goods, finance, technology and automotive Outlines how to develop a product strategy, build teams and design the platform and architecture Provides key principles for sharing knowledge, educating staff on data and AI, and effectively engaging top executives
Drive Solutions : Mechatronics for Production and Logistics
Highly automated production and logistics facilities require mechatronic drive solutions. This book describes in which way the industrial production and logistics work and shows the structure of the drive solutions required for this purpose.
Dr.phone
Dr phone is a software system that helps in talking with the doctor automatically and easily without the need to go to the doctor's clinic to diagnose the patient's condition. our application presents an available platform to make a video call between the doctor and the patient according to the patient’s needs. The system accepts the patient’s request after choosing an available doctor andthen waits for the doctor to accept his request, if there is no doctor available, the system performs an AI chatbot to the patient's need to give him the appropriate diagnosis. when the call finished the doctor represents medical record including the medicine and the analytics and record the next appointment if it’s needed then send them to the patient's email, the patient also can see the nearest pharmacies or labs according to his location, and finally the patient rates the doctor after the call is finished then payment by his available wallet.
Dose Finding in Drug Development
When you go to the pharmacy and fill a prescription, have you ever wondered if the dose of the medication is right for you? Can the dose be too low so that the drug will not work? This book answers some of these questions, and introduces the drug development process, the design and analysis of clinical trials.
Do Smart Adaptive Systems Exist? : Best Practice for Selection and Combination of Intelligent Methods
This book is intended as a reference and a guide summarising and focusing on best practices when using intelligent techniques and building systems requiring a degree of adaptation and intelligence. Another attractive feature of the book is that it brings together experts from neural network, fuzzy, machine learning, evolutionary and hybrid systems communities who will provide their views on how these different intelligent technologies have contributed and will contribute to creation of smart adaptive systems of the future.
DNA Repair and Human Disease
DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.
DNA Computing Models
This book emphasizes computational methods to tackle central problems of DNA computing, such as controlling living cells, building patterns, and generating nanomachines.
Distribution and phenotype of proliferating cells in the Forebrain of adult macaque monkeys after transient global cerebral ischemia
The authors' results show that ischemia differentially activates endogenous neural precursors residing in diverse locations of the adult primate central nervous system. A limited endogenous potential for postischemic neuronal repair exists in neocortex and striatum, but not in the hippocampus proper of the adult macaque monkey brain. The presence of putative parenchymal progenitors and of sustained progenitors in germinative centers opens novel possibilities for precursor cell recruitment.
Distributed systems : Concurrency and consistency
Explores the gray area of distributed systems and draws a map of weak consistency criteria, identifying several families and demonstrating how these may be implemented into a programming language. Unlike their sequential counterparts, distributed systems are much more difficult to design, and are therefore prone to problems. On a large scale, usability reminiscent of sequential consistency, which would provide the same global view to all users, is very expensive or impossible to achieve.
Distributed computing and internet Technology ; Vol. 3816 ; 2nd International conference, ICDCIT 2005, Bhubaneswar, India, December 22-24, 2005, Proceedings
The opening ceremony and pre-conference tutorials on various related topics were held on December 21. The technical program started on December 22 and continued for three days. The program was arranged in single track so as to enable participants to attend sessions of di?erent tracks. Papers from the DM, IT, SE, and SS tracks were divided into two sessions, whereas DC track sessions were held on the ?rst two days of the conference. The program also included two plenary talks. The ?rst talk was delivered by S. S. Iyengar from Louisiana State University, USA. The second talk was delivered by He Jifeng from the International Institute for Software Technology (IIST) Macau. Prof. Iyenger’s talk on “The Distributed Sensor Networks — An Emerging Technology” was focused on new ideas about the use of distributed systems for emerging technology, while Prof. Jifeng’s talk on “Linking Theories of Concurrency by Retraction” dealt with semantics of concurrency.
Distributed computing and internet technology ; 17th International Conference, ICDCIT 2021, Bhubaneswar, India, January 7–10, 2021, Proceedings
This book constitutes the proceedings of the 17th International Conference on Distributed Computing and Internet Technology, ICDCIT 2020, held in Bhubaneswar, India, in January 2021. The 13 full papers presented together with 4 short papers were carefully reviewed and selected from 99 submissions. The papers were organized in topical sections named: invited talks, cloud computing and networks, distributed algorithms, concurrency and parallelism, graph algorithms and security, social networks and machine learning, and short papers.
Distributed artificial intelligence ; 2nd International conference, DAI 2020, Nanjing, China, October 24–27, 2020, Proceedings
This book constitutes the refereed proceedings of the Second International Conference on Distributed Artificial Intelligence, DAI 2020, held in Nanjing, China, in October 2020. The 9 full papers presented in this book were carefully reviewed and selected from 22 submissions. DAI aims at bringing together international researchers and practitioners in related areas including general AI, multiagent systems, distributed learning, computational game theory, etc., to provide a single, high-profile, internationally renowned forum for research in the theory and practice of distributed AI.
Distinguished Figures in Mechanism and Machine Science
This is the first volume of a series of edited books whose aim is to collect contributed papers in a framework that can serve as a dictionary of names of individuals who have made contributions to the discipline of MMS (Me- anism and Machine Science). This dictionary project has the peculiarity that, through descriptions of the ideas and work of these individuals, the papers will illustrate mainly technical developments in the historical evolution of the individual fields that today de?ne the scope of MMS. Thus the core of each contribution will be a survey of biographical notes describing the efforts and experiences of these people. Finding appropriate technical experts as authors for such papers and - couraging them to write them has been a challenge; it is a demanding and time-consuming effort to produce such in-depth articles that delve deeply into the historical background of their topics of expertise.
Dissecting Discrimination : Identifying Its Various Faces and Their Sources
This book examines the phenomenon of discrimination using a descriptive approach. Discrimination is omnipresent, whether it is people who discriminate against other people or, more recently, also machines that discriminate against people. The first part of the analysis employs decision theory on discrimination, leading to two fundamental subtypes: taste-based discrimination and statistical discrimination. The second part links taste-based discrimination to social identity theory, demonstrates that not all taste-based discrimination is ultimately statistical discrimination, and reveals the evolutionary origins of our tastes.
Disruptive trends in automation technology
The industrial sector is being transformed by the convergence of information technology and operational technology. The latter is another name for automation technology and covers established systems such as supervisory control and data acquisition (SCADA), programmable logic controllers (PLC), fieldbuses, and automation and control systems. As this technology is connected to the Internet and 5G networks, some monitoring, control, and analytic functionalities are deployed to the edge or cloud, and researchers are challenged to ensure the security, dependability, real-time performance, and maintainability of the resulting systems. The big data that is accessible from these systems create opportunities for artificial intelligence applications that can further disrupt the established practices in the automation domain.
Disrupting Finance : FinTech and Strategy in the 21st Century
This Pivot demonstrates how a variety of technologies act as innovation catalysts within the banking and financial services sector. Traditional banks and financial services are under increasing competition from global IT companies such as Google, Apple, Amazon and PayPal whilst facing pressure from investors to reduce costs, increase agility and improve customer retention. Technologies such as blockchain, cloud computing, mobile technologies, big data analytics and social media therefore have perhaps more potential in this industry and area of business than any other. This book defines a fintech ecosystem for the 21st century, providing a state-of-the art review of current literature, suggesting avenues for new research and offering perspectives from business, technology and industry.
Disorders due to addiction and its therapy in Syria
Addiction is a broad and important concept that has a lot of bad consequences, the goal of our research is to talk at an overview of all its types in order to raise public health awareness, addiction is not limited to narcotic substances, but until there is a behavioral type that includes getting used to harmful habits, we as pharmacists will focus on drug dependence and its mechanism, which many patients suffer from its disorders...
Disfluency and Proficiency in Second Language Speech Production
This book explores the concept of disfluency in speech production, particularly as it occurs in the context of second language acquisition. Drawing on examples from learner speech at three levels (beginner, intermediate and advanced), the author argues that acquiring target language norms for performing disfluency is essential to an individual being recognized as fluent in a language by fellow-speakers. Starting with a survey of the psycholinguistic research in this area, he then applies a sociolinguistic lens to examine how a learner's social and educational background impacts the types of disfluencies in their speech.
