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Advances in Targeted Cancer Therapy
This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed.
Advances in statistical methods for the health sciences : Applications to cancer and AIDS studies, genome sequence analysis, and survival analysis
This volume, an outgrowth of an "International Conference on Statistical Methods in Health Sciences," covers a wide range of topics pertaining to new statistical methods and novel applications in the health sciences.
Advances in Ranking and Selection, Multiple Comparisons, and Reliability: Methodology and Applications
S. Panchapakesan has made significant contributions to ranking and selection and has published in many other areas of statistics, including order statistics, reliability theory, stochastic inequalities, and inference. Written in his honor, the twenty invited articles in this volume reflect recent advances in these fields and form a tribute to Panchapakesan’s influence and impact on these areas. Thematically organized, the chapters cover a broad range of topics from: Inference / Ranking and Selection / Multiple Comparisons and Tests / Agreement Assessment / Reliability / Biostatistics
Advances in Fracture Research : Honour and plenary lectures presented at the 11th International Conference on Fracture (ICF11), held in Turin, Italy, on March 20-25, 2005
Biological materials are bottom-up designed systems formed from billions of years of natural evolution. In the long course of Darwinian competition for survival, nature has evolved a huge variety of hierarchical and multifunctional systems from nucleic acids, proteins, cells, tissues, organs, organisms, animal communities to ecological s- tems. Multilevel hierarchy a rule of nature. The complexities of biology provide an opportunity to study the basic principles of hierarchical and multifunctional s- tems design, a subject of potential interest not only to biomedical and life sciences, but also to nanosciences and nanotechnology. Systematic studies of how hierarchical structures in biology are related to their functions and properties can lead to better understanding of the effects of aging, diseases and drugs on tissues and organs, and may help developing a scienti?c basis for tissue engineering to improve the standard of living.
Advances in Distribution Theory, Order Statistics, and Inference
Barry Arnold has made fundamental contributions to many different areas of statistics, including distribution theory, Bayesian inference, multivariate analysis, bounds and orderings, and characterization problems. Organized to honor Arnold’s significant contributions to the field, this volume is an outgrowth of the "International Conference on Distribution Theory, Order Statistics, and Inference," held at the University of Cantabria, Santander, Spain.Several distinguished and active researchers highlight some of the recent developments in statistical distribution theory, order statistics and their properties, as well as inferential methods associated with them. Applications to survival analysis, reliability, quality control, and environmental problems are emphasized.
A life cycle for clusters? : The dynamics of agglomeration, change, and adaption
The phenomenon of non-random spatial concentrations of firms in one or few related sectors (clusters) is intensively debated in economic theory and policy. The euphoria about successful clusters however neglects that historically, many thriving clusters did deteriorate into old industrial areas. This book studies the determinants of cluster survival by analyzing their adaptability to change in the economic environment. Linking theoretic knowledge with empirical observations, a simulation model (based in the N/K method) is developed, which explains when and why the cluster's architecture assists or hampers adaptability. It is found that architectures with intermediate degrees of division of labour and more collective governance forms foster adaptability. Cluster development is thus path dependent as architectures having evolved over time impact on the likelihood of future survival.
A Climate of Justice : An Ethical Foundation for Environmentalism
This book helps readers combine history, politics, and ethics to address the most pressing problem facing the world today: environmental survival. In A Climate of Justice, Marvin Brown connects the environmental crisis to basic questions of economic, social, and racial justice. Brown shows how our current social climate maintains systemic injustices, and he uncovers resources for change through a civic ethics of repair and reciprocity.
