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Nanomaterials and Nanosystems for Biomedical Applications
The book includes expert reviews on the advances and current problems associated with the implants and nanodevices along with their applications in medicine, pharmaceutics, cancer therapy, gene transfer and drug delivery. The editor, M. R. Mozafari (PhD), has been working in the field of nanobiotechnology for the past 14 years and has produced more than 60 publications.
Nanoformulations in Human Health: Challenges and Approaches
This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.
Nanocarrier Technologies : Frontiers of Nanotherapy
Nanobiotechnology is one of the key technologies of the 21st century. It is a combination of nanoscience and biotechnology and covers areas ranging from gene transfer and nanoencapsulation to food technology. Nanocarriers are a leading nanobiotechnology tool with the ability to provide protection, site-specific delivery, enhanced bioavailability and controlled release of pharmaceuticals, genetic material, imaging agents, nutraceuticals and cosmetics to name a few. For this reason, the study of nanocarriers, their properties and applications has attracted a great deal of interest over recent years. Designed as an advanced survey of the field, this book describes the key research parameters of nanocarrier technologies including their preparation methods, evaluation of their safety and efficiency, their interaction with biologicals and their application in biotechnology, drug delivery, gene therapy and food technology areas.
N-Acetylaspartate : A Unique Neuronal Molecule in the Central Nervous System
N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.
Myosins : A Superfamily of Molecular Motors
Application of state-of-the-art cellular and molecular biological, structural biological, genetic, biochemical and biophysical techniques has provided and continues to provide critical information regarding the structure–function relationship; and the cellular roles of various myosins in organisms as diverse as protozoa, yeast, plants and higher animals. The association of myosins with diseases including neurological disorders, immu- deficiencies, cardiomyopathies, hearing and vision loss testify to the importance of understanding the biochemical properties and cellular roles of myosins. The 16 chapters in this volume summarize the tremendous progress made in studying members of the myosin superfamily in recent years and offer critical insight into what future research will yield.
Mycorrhizae : Sustainable Agriculture and Forestry
This book discusses and goes into detail on a number of topics: the molecular basis of nutrient exchange between arbuscular mycorrhizal (AM) fungi and host plants; the role of AM fungi in disease protection, alleviation of soil stresses and increasing grain production; interactions of AM fungi and beneficial saprophytic mycoflora in terms of plant growth promotion; the role of AM fungi in the restoration of native ecosystems; indirect contributions of AM fungi and soil aggregation to plant growth and mycorrhizosphere effect of multitrophic interaction; the mechanisms by which mycorrhizas change a disturbed ecosystem into productive land; the importance of reinstallation of mycorrhizal systems in the rhizosphere is emphasized and their impact on landscape regeneration, and in bioremediation of contaminated soils; Ectomycorrhizae (ECM) and their importance in forest ecosystems and associations of ECM in tropical rain forests function to maintain tropical monodominance; in vitro mycorrhization of micro-propagated plants, and visualizing and quantifying endorhizal fungi; the use of mycorrhizae, mainly AM and ECM, for sustainable agriculture and forestry.
Mycorrhiza : State of the Art, Genetics and Molecular Biology, Eco-Function, Biotechnology, Eco-Physiology, Structure and Systematics
This third updated and revised edition emphasises strongly on genetics and molecular biology. It contains new chapters, which are written by the leading experts in their respective field of knowledge and expertise.Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the presence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.
Muscle Development in Drosophilia
The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.
Multivariate Statistical Machine Learning Methods for Genomic Prediction
This book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments.
Multi-Source National Forest Inventory : Methods and Applications
The book describes in detail the full MS-NFI process, and the input data used – including field data, satellite images, and digital map data, as well as coarse-scale variation of forest variables. It also presents comprehensive information on the types of outputs which can be derived, including maps and statistics, describing, for example, stock volumes and development, dominant tree species, age-class distribution, and large and small-scale variation. The book will provide an invaluable resource for those involved in forest inventory, including government departments and bodies involved in forest policy, management and monitoring, forest managers, and researchers and graduate students interested in forest inventory, modelling and analysis. It will find an additional market among those interested in Earth observation, ecology and broader areas of environmental and natural resource management.
Multiscaling in molecular and continuum mechanics : Interaction of time and size from macro to nano ; Application to biology, physics, material science, mechanics, structural and processing engineering
The manipulation of molecules and atoms has been regarded as a common base for both material and life science. Quantum and continuum mechanics are being applied side by side for exploring the behavior of small and large objects moving at fast and slow speed.
Multiscale Problems in the Life Sciences : From Microscopic to Macroscopic
The aim of this volume that presents Lectures given at a joint CIME and Banach Center Summer School, is to offer a broad presentation of a class of updated methods providing a mathematical framework for the development of a hierarchy of models of complex systems in the natural sciences, with a special attention to Biology and Medicine. Mastering complexity implies sharing different tools requiring much higher level of communication between different mathematical and scientific schools, for solving classes of problems of the same nature. Today more than ever, one of the most important challenges derives from the need to bridge parts of a system evolving at different time and space scales, especially with respect to computational affordability. As a result the content has a rather general character; the main role is played by stochastic processes, positive semigroups, asymptotic analysis, kinetic theory, continuum theory and game theory.
Multiplication of RNA Plant Viruses
Biochemical studies on plant virus RNA replication have advanced considerably since 2000, primarily because of new genetic, molecular, biochemical, and enzymatic studies. Certain virus-encoded essential proteins, nucleotide sequence motifs, and RNA secondary structures are central to virus RNA replication, which has a number of stages.
Multiple Testing Procedures and Applications to Genomics
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. The methods are applied to a range of testing problems in biomedical and genomic research, including the identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments.
Multilevel Modelling for Public Health and Health Services Research : Health in Context
This book is a practical introduction to multilevel modelling or multilevel analysis (MLA) – a statistical technique being increasingly used in public health and health services research.
Multigenic and Induced Systemic Resistance in Plants
This comprehensive volume consists of a series of up-to-date reviews, each incorporating current models and knowledge related to mechanisms of resistance either expressed constitutively or induced systemically in plants. Each chapter covers a topic related to the phenomenon of plant resistance to fungal and bacterial pathogens, insects, nematodes, viruses or abiotic stress in plants, as well as the application of this knowledge to protect crops now and in the future. Researchers, upper-level undergraduate and graduate students, and those teaching courses in plant physiology, entomology and plant pathology will find this volume a much needed asset.
Multichain Immune Recognition Receptor Signaling : From Spatiotemporal Organization to Human Disease
The central idea of this book is to show that the structural similarity of the MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms and also provides the basis for existing and fixture therapeutic strategies targeting MIRRs. The reviews assembled in this book detail the prog-ress in defining and controlling the spatiotemporal organization of key events in immune cell activation. An improved understanding of MIRR-mediated signaling has numerous potential practical applications, fi-om the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes.
Mucosal Immune Defense : Immunoglobulin A
This book, authored by international experts in the field of IgA immunology, presents a comprehensive and timely overview of current knowledge of IgA structure and function. Topics include the basic science of IgA biochemistry and molecular biology, general and tissue-specific aspects of IgA function, and the clinical relevance of IgA in infection, autoimmunity, immunodeficiency and cancer.
Mucins : Methods and protocols
Explores the latest advancements in mucin research. The chapters in this book are organized into 8 parts and cover a wide range of topics such as mucin extraction, isolation, physicochemical property analysis, and experimental methods. The chapters also discuss the origins of mucins in jellyfish, feces, saliva and salivary glands, bronchi, stomach, and cervical tract; organic synthesis of peptides glycosylated at specific sites; analysis of mucin gene expression and methylation-specific electrophoresis of genes; imaging of mucin networks by AFM; and experimental methods using supported molecular matrix electrophoresis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
MSC Maximal Stress Cooperation
In 1996 my book ‘The Nature of Cultures’ appeared in Vi- na and New York. It describes cultures as systems which are controlled by MSC and decorum. While MSC is a neologism meaning ‘maximal stress cooperation’ decorum is a very old term. It is as old as Western culture itself, and is furthermore, the translation of the even older Greek word ‘prepon’. Decorum and prepon mean ‘to be suitable, to be fitting’. It is all about the fitting of cultural medial contents to elementary cultural behavioural types and behavioural phases. These behavioural units are subject to a type of ranking system in which that which is essential is sorted from that which less essential. - corum then means – the representations of the media must ‘fit’ the ranking of the cultural behaviour. It is MSC which assumes the top position in this ranking. In 1996 and the two previous years when I was working on my book ‘The Nature of Cultures’ less than 5 years had passed since the Iron Curtain had been lifted. Many believed at that time that with ending of the Cold War, which was more or less de facto peace anyway, that a new and better age of peace was dawning.
