Page 4
Page 4
St. Johns Wort and its Active Principles in Depression and Anxiety
Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last 10 years has given a broad preclinical and clinical basis to justify the use of Hypericum as an antidepressant. This book reviews the available data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform disorders, and the site effect profile of Hypericum and its possible relevant drug interactions. The known pharmacokinetics of the relevant constituents and the biopharmaceutical quality of commercially available Hypericum preparations are also discussed.
Sport Aerodynamics
This book describes the various sport disciplines on the basis of aerodynamic analysis and also cover the biomechanics part by illustrative performance examples. Such treatment of the underlying physical phenomena of sport activities gives a valuable supplement to existing literature on sport. The reader will also be guided to references which exist for the various topics discussed, so she or he can go into a deeper study of the particular sport activity at wish.
Spectroscopic Data of Steroid Glycosides : Stigmastanes, Furostanes, Spirtostanes ; Vol.2
Spectroscopic Data of Steroid Glycosides serves as an essential reference guide containing spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids. All compounds are arranged according to the structure of the aglycone, and, in its own class, according to the increasing molecular weight, making Spectroscopic Data of Steroid Glycosides extremely useful for the structure elucidation of new natural products, particularly glycosides.
Spectroscopic data of Steroid glycosides : Cholestanes, ergostanes, Withanolides, Stigmastane ; Vol.1
Spectroscopic Data of Steroid Glycosides serves as an essential reference guide containing spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids.
Spectroscopic Data of Steroid Glycosides : Cardenolides and Pregnanes ; Vol.4
This book is an essential reference guide to spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids.
Sparking Signals : Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation
Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.
Spaces of Holomorphic Functions in the Unit Ball
There has been a flurry of activity in recent years in the loosely defined area of holomorphic spaces. This book discusses the most well-known and widely used spaces of holomorphic functions in the unit ball of C^n. Spaces discussed include the Bergman spaces, the Hardy spaces, the Bloch space, BMOA, the Dirichlet space, the Besov spaces, and the Lipschitz spaces. Most proofs in the book are new and simpler than the existing ones in the literature. The central idea in almost all these proofs is based on integral representations of holomorphic functions and elementary properties of the Bergman kernel, the Bergman metric, and the automorphism group. The unit ball was chosen as the setting since most results can be achieved there using straightforward formulas without much fuss. The book can be read comfortably by anyone familiar with single variable complex analysis; no prerequisite on several complex variables is required. The author has included exercises at the end of each chapter that vary greatly in the level of difficulty.
Space Weather, Environment and Societies
Space Weather is the developing field within astronomy that aims at predicting the sun’s violent activity and minimizing the impacts on our daily lives. Space Weather, Environment, and Societies explains why our technological societies are so dependent on solar activity and how the Sun disturbs the transmission of information and energy. Footnotes expand specific points and the appendices facilitate a more thorough command of the physics involved. This beautifully illustrated book is written for astronomy and nature enthusiasts as well as for the undergraduate/graduate level readers who would like to better master the physics of near space.
Sourcing Strategy : Principles, Policy and Designs
Sourcing Strategy is about sourcing as a long term strategic activity. Myopic purchasing management stops short with describing functional procedures and procedural innovations such as online order processing. The goal of this book is not just to document sourcing strategy, but to provide the tools to determine it. Therefore, rather than merely describing common sourcing processes, the book takes a normative approach to sourcing strategy. It argues for a rational, complete and integrated process where managers confront conflicts and dilemmas inherent in sourcing. It supports its recommendations with logical arguments from an interdisciplinary and analytical approach grounded in microeconomics, law and business strategy. Part 1 of the book explains the economic and business principles that underlie sourcing strategies. It derives policies that guide viable strategies to meet sourcing goals. Part 2 applies these to creative designs for standard sourcing scenarios. A user friendly software package is linked to the chapters, with guided exercises as a learning tool.
Solar-Type Activity in Main-Sequence Stars
In this monograph observational results are summarized in a systematic and comprehensive fashion. The analysis of the various manifestations of such stellar activity leads to the identification of these phenomena with macroscopic non-linear processes in a magnetized plasma. Comparative study of flare stars and the Sun has become increasingly fruitful and is presently an active field of research involving stellar and solar physicists, experts in plasma physics and high-energy astrophysicists. This book will provide them with both an introduction and overview of observational results from the first optical photometry and spectroscopy, from the satellite telescopes International Ultraviolet Explorer to Hubble Space Telescope, XMM-Newton and Chandra, as well as with the present physical interpretation of solar-type activity in main sequence stars. Gershberg's 40-year career studying UV Cet type stars and related objects enables him to provide readers with expert insight into the characteristics of such stars in both the quiescent state and during flares and the reliability of the data over the electromagnetic spectrum and wide temporal scales.
Solar Activity and Earths Climate
This question has been a focus of scientific debate since the existence of sunspots was established in the early 17th century. Even today, however, the answer is not forthcoming; while there are valid reasons to believe that solar activity has some impact on the Earth's climate, the history of the subject shows that there have been many unsupported statements that over-estimate the effect of sunspots on climatic variations. This updated and revised edition of "Solar Activity and Earth's Climate" introduces the reader to the subject of solar activity and the connection with the Earth's climate. It focuses on how knowledge about the solar cycle and Earth's climate is obtained, and provides an in depth discussion of observations, methods and the physics involved, together with the necessary statistics and analysis
Soil and Water Pollution Monitoring, Protection and Remediation
Soil, surface waters/sediments and shallow unprotected groundwater aquifers are interrelated compartments of the environment that are particularly easy to compromise, sensitive to short- and long-term pollution and directly affect sustainability of ecosystems and human health. Routine human activity such as application of fertilizers and pesticides in agriculture and forestry, or wet and dry deposition of atmospheric pollutants emitted from industrial plants, waste disposal and other practices adversely affect soil and water quality that already increasingly suffers from mismanagement in many areas. The predominant sources of pollution result in non-point contamination that is particularly difficult to reduce and control. Wars, accidents and natural emergency cases such as catastrophic floods that occur partly due to anthropogenically disturbed global water balance also add to overall increase of diverse contaminant loads in soil and water. Beneficial properties of some bulk waste materials such as biosolids (sewage sludge), biowaste (e. g. municipal waste composts) or fly ash from coal combustion xi xii Preface encourage applying these waste to land as a source of nutrients and organic matter, or as a soil amendment.
Social Competence in Children
Social competence is essential to the mental and physical well-being of all humans, no matter their age. Yet as many as one in ten children has trouble keeping friends or even making friends. In Social Competence in Children, readers will discover a developmental view of social functioning in children at different stages, with an emphasis on clinical conditions that may confound this development. At the outset, the author provides detailed information on theories of social competence and the contexts in which core skills (e.g., appropriate comments, reading verbal cues) are learned. Later chapters address specific challenges to competence and feature case examples illustrating typical patterns of deficits and presenting the latest data on the topic.
Snake and spider toxins : Methods and protocols
Explores techniques and protocols, across various biological disciplines, used to study snake and spider peptide toxins. The chapters in this book are organized into four parts and cover topics such as the use of toxins in drug development; analysis of bioactivity of complex mixtures like venom; extraction of venom glands and the production of toxins; characterization of toxins from the RNA level to the peptide structure; and the determination of the toxin’s biological function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Snake and Spider Toxins: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.
Smart watcher for students
Attendance is one of those administrative tasks that must be done at the start of each class. It can take up valuable time at the beginning of class and sometimes be difficult to manage. Even so detecting the activity for every student in the class is hard for teachers because they can’t remember every student in the classroom. We present a system that can take attendance and activity for student with a camera in every classrooms using face recognition and body pose estimation which will help saving time and make the process more efficient.
Smart micro- and nanomaterials for drug delivery
Smart drug delivery at both the micro- and nanoscale is an evolving field with numerous potential applications. It has the potential to revolutionize drug therapy by making treatments more effective, reducing side effects, and improving patient outcomes. This book presents a comprehensive review of the most recent studies on smart micro- and nanomaterials with a focus on their “smart” activity for formation of targeted and responsive drug-delivery carriers.
Smart cement : Development, testing, modeling and real-time monitoring
Over three billion metric tons of cement are produced annually worldwide, making concrete the most extensively used construction material. Self-sensing, or smart, cement allows real-time monitoring of performance through the entire service life of a concrete structure, for the detection of changing stresses, contamination, excessive temperature, gas leaks and pre-seismic activity. This is achieved by adding a very small proportion of conductive or semi-conductive fibers, such as carbon fibers to the bulk cement, making it piezoresistive, and enabling changes in the concrete’s electrical resistivity in response to shear stress and strain to be monitored.
Skin whitening
Provides insight into the mechanisms involved in melanin synthesis pathway as well as the most common pigmentation disorders, then it asses in details the diverse approaches to achieve skin whitening activity with the available ingredients. And delve into the different new approaches for encapsulation and delivery of the active ingredients using nanomaterials and further into using emerging technologies to achieve the desired effects for the patients
SH2 domains: Functional modules and evolving tools in biology
Looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains by measuring or calculating their affinity to phosphopeptides. Part Three focuses on inhibitors of SH2 domains that lead the way for chemical tool development and drug discovery. Part Four describes how to evolve and engineer SH2 domains with specific binding properties, and Part Five explores how to measure the regulation of protein tyrosine phosphatase activity through allosteric binding of peptides to SH2 domains and condensation. Chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, SH2 Domains: Functional Modules and Evolving Tools in Biology is a valuable resource for researchers, working in the biophysical and biochemical field, who want to learn more about this exciting and versatile class of regulatory and signaling domains.
Sensors data processing using machine learning
Collects research focusing on data processing using machine learning and deep learning. We invited investigators to contribute both original and review articles, covering the research and development in the areas of data processing using machine learning (ML) and deep learning (DL). These areas include solutions that are designed for smart devices. In this reprint, leading experts in the field share their insights, research findings, and visions for the future. Together, we embark on a journey to unlock the potential of effective data processing that involves transforming data from a given format into a more usable and desirable form, rendering them more meaningful and informative. Machine learning (ML), deep learning (DL), and artificial intelligence (AI) have proven to be effective methods for this purpose. Through the utilization of machine learning algorithms, mathematical modeling, or various statistical techniques, the entire process can be automated.
