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Modern avenues in metal-nucleic acid chemistry
Provides a timely overview of selected relevant developments in a field which previously had a pronounced focus on fundamental chemistry aspects such as coordination principles, structural chemistry, and consequences for biological processes and disease-related medicinal issues. More recently, also as a consequence of the advent of supramolecular chemistry, advancements in nanochemistry, and new bio-analytical methods, novel aspects of this field have emerged. MILS-25 gives a state-of-the-art account on the present state of research in this field, addressing, among others, porous materials, non-covalent interactions, stimuli-responsive bioconjugates, DNA-templated metal arrays and nanoclusters, genotyping, guanine quadruplexes, and riboswitches.
Modern Aspects of Electrochemistry ; Vol. 39
This volume of Modern Aspects covers a wide spread of topics presented in an authoritative, informative and instructive manner by some internationally renowned specialists. Professors Politzer and Dr. Murray provide a comprehensive description of the various theoretical treatments of solute-solvent interactions, including ion-solvent interactions. Both continuum and discrete molecular models for the solvent molecules are discussed, including Monte Carlo and molecular dynamics simulations. The advantages and drawbacks of the resulting models and computational approaches are discussed and the impressive progress made in predicting the properties of molecular and ionic solutions is surveyed.
Modern Aryne Chemistry
The book reveiws the recent use of aryne chemistry for the development of new multicomponent reactions. New advances in this area has shown rapid emergence of a new class of reactions classified under rearrangement reactions. The author also includes information on aryne methods that have been employed for the synthesis of several natural products. The simplicity and sophistication of the synthetic strategy using arynes can serve as a springboard for organic chemists to explore new possibilities and imagine applications of the concept of arynes.
Modelling water and nutrient dynamics in soil-crop systems : Applications of different models to common data sets - Proceedings of a workshop held 2004 in Müncheberg, Germany
This book contains articles from a workshop on "Modelling water and nutrient dynamics in crop-soil systems". Data sets from lysimeters and experimental fields of multiyear crop rotations were provided for modellers. A unique data set is provided of a 100 year long term field experiment regarding crop yield and organic carbon development under different management systems. The book includes a detailed description of data sets which can be used by modellers and the papers describe the applications of 18 different modelling approaches describing soil-crop-atmosphere interactions for water, nitrogen and carbon dynamics.
Modelling the dispersion of radionuclides in the marine environment : An introduction
This book is a practical guide to the subject of numerical modelling of radioactivity dispersion in the marine environment. Thus, the techniques and numerical procedures required are explained in detail, with the aim of enabling the reader to build a real mathematical model. The book covers basic concepts and techniques, such as solving the advection-diffusion equation in a simple 1D form, as well as the most recent developments (full 3D models for non-conservative radionuclides including chemical reactions and speciation). A chapter is dedicated to the basic hydrodynamic modelling that is always required to simulate the dispersion of tracers in the sea; Eulerian and Lagrangian modelling techniques are also described. A chapter describes sensitivity and uncertainty analysis, the final stage in modelling works. A review on some published radionuclide dispersion models is also included.
Modelling in Mathematical Programming : Methodology and Techniques
This book provides basic tools for learning how to model in mathematical programming, from models without much complexity to complex system models. It presents a unique methodology for the building of an integral mathematical model, as well as new techniques that help build under own criteria. It allows readers to structure models from the elements and variables to the constraints, a basic modelling guide for any system with a new scheme of variables, a classification of constraints and also a set of rules to model specifications stated as logical propositions, helping to better understand models already existing in the literature. It also presents the modelling of all possible objectives that may arise in optimization problems regarding the variables values. The book is structured to guide the reader in an orderly manner, learning of the components that the methodology establishes in an optimization problem. The system includes the elements, which are all the actors that participate in the system, decision activities that occur in the system, calculations based on the decision activities, specifications such as regulations, impositions or actions of defined value and objective criterion, which guides the resolution of the system.
Modelling community structure in freshwater ecosystems
"The book presents approaches and methodologies for predicting the structure and diversity of key aquatic communities (namely diatoms, benthic macroinvertebrates and fish), under natural conditions and under man-made disturbance. Such an approach will make it possible to: 1) set up procedures for robust and sensitive ecosystem evaluation, based on the prediction of the excepted community structure; 2) model community structure in disturbed ecosystems, taking into account all the relevant ecological variables; 3) test ecosystem sensitivity to natural and anthropic disturbance; and 4) explore specific actions to be taken for the restoration of ecosystem integrity."--Jacket.
Model-Driven Software Development
Abstraction is the most basic principle of software engineering. Abstractions are provided by models. Modeling and model transformation constitute the core of model-driven development. Models can be refined and finally be transformed into a technical implementation, i.e., a software system. The aim of this book is to give an overview of the state of the art in model-driven software development. Achievements are considered from a conceptual point of view in the first part, while the second part describes technical advances and infrastructures. Finally, the third part summarizes experiences gained in actual projects employing model-driven development. Beydeda, Book and Gruhn put together the results from leading researchers in this area, both from industry and academia. The result is a collection of papers which gives both researchers and graduate students a comprehensive overview of current research issues and industrial forefront practice, as promoted by OMG’s MDA initiative.
Model-Driven Design Using Business Patterns
This book takes exactly this step: it shows you how to apply the pattern ideas in business applications and presents more than 20 structural and behavioral business patterns that use the REA (resources, events, agents) pattern as a common backbone. If you are a developer working on business frameworks, you can use the patterns presented to derive the right abstractions (e.g., business objects) and to design and ensure that the meta-rules (e.g., process patterns) are followed by the developers of the actual applications. And if you are an application developer, you can use these patterns to design your business application, to ensure that it does not violate the domain rules, and to adapt the application to changing requirements without the need to change the overall architecture. As with patterns in general, this approach allows for both more flexible and more solid software architectures and hence better software quality.
Model Checking Software ; 15th International SPIN Workshop, Los Angeles, CA, USA, August 10-12, 2008 Proceedings
This book constitutes the refereed proceedings of the 15th International SPIN workshop on Model Checking Software, SPIN 2008, held in Los Angeles, CA, USA, in August 2008.The 17 revised full papers presented together with 1 tool paper and 4 invited talks were carefully reviewed and selected from 41 submissions. The main focus of the workshop series is software systems, including models and programs. The papers cover theoretical and algorithmic foundations as well as tools for software model checking and foster interactions and exchanges of ideas with related areas in software engineering, such as static analysis, dynamic analysis, and testing.
Microwave Methods in Organic Synthesis
We are delighted to present this volume with contributions from some of themost renowned and experienced microwave chemists today.The delivery and introduction of energy has been closely connected withthe discovery and investigation of new chemistry. It is with pleasure thatwe have seen an increased use of microwave irradiation over the years andwe hope that this volume will reflect the current interest in expanding thescope of microwave applications in both organic and medicinal chemistry. Oneimportant explanation behind the growth of microwave-enhanced chemistryhas been the introduction of dedicated microwave reactors.As a result of this development we are proud to present a diverse set of re-views.
Microstructuring of Glasses
As microstructured glass becomes increasingly important for microsystems technology, the main application fields include micro-fluidic systems, micro-analysis systems, sensors, micro-actuators and implants. And, because glass has quite distinct properties from silicon, PMMA and metals, applications exist where only glass devices meet the requirements. The main advantages of glass derive from its amorphous nature, the precondition for its - theoretically - direction-independent geometric structurability. Microstructuring of Glasses deals with the amorphous state, various glass compositions and their properties, the interactions between glasses and the electromagnetic waves used to modify it.
Microorganisms in soils : Roles in genesis and functions
The following key topics are covered: Microorganisms in bioerosion, humification, mineralization and soil aggregation; Microbial energetics and microbes in biogeochemical processes such as carbon and nitrogen cycles and phosphorus bio-availability; Interactions in the mycorrhizosphere, e.g. between mycorrhizal fungi and bacteria; Impact of microbes on plant nutrient cycling and the possible effects of transgenic rhizospheres on soil fungi; Functions of microbes in specific soil compartments such as soil surface or toxic metal polluted soils; Regulation of microbial activities in functional domains that are influenced by biotic or abiotic factors; Use of marker genes and isotopes as examples for modern techniques in soil microbiology.
Micrometeorites and the Mysteries of Our Origins
This book relates an attempt to decrypt the still-obscure first billion years of history of the young Earth, during a cataclysmic period during which our planet was heavily bombarded by bodies ranging in size from that of Mars to 0.1 mm sized tiny micrometeorites. It was thus found that micrometeorites played an essential role in the formation of the post-lunar atmosphere. They also provided a surprisingly large diversity of reactions in the organic prebiotic chemistry required for the birth of life on our blue planet. The author presents a wide-ranging review of the type of knowledge required to decrypt this history, which provides extensive background information from astronomy, planetary dynamics, planetology, astrobiology and earth sciences. This book will appeal to both the scientist and the general reader. It will be a source of material for lectures, and possibly new investigations, in these fields.
Micromanufacturing and Nanotechnology
Micromanufacturing and Nanotechnology is an emerging technological infrastructure and process that involves manufacturing of products and systems at the micro and nano scale levels. Development of micro and nano scale products and systems are underway due to the reason that they are faster, accurate and less expensive. Moreover, the basic functional units of such systems possesses remarkable mechanical, electronic and chemical properties compared to the macro-scale counterparts. Since this infrastructure has already become the prefered choice for the design and development of next generation products and systems it is now necessary to disseminate the conceptual and practical phenomenological know-how in a broader context. This book incorporates a selection of research and development papers. Its scope is the history and background, underlynig design methodology, application domains and recent developments.
Micro-Macro-interaction : In Structured media and Particle Systems
This book presents the development of new methods in this interdisciplinary field of macro- micro-interactions of different engineering branches like mechanical and process engineering, applied mathematics, theoretical, and computational physics. In particular, solids with microstructures and particle systems are considered.
Microlithography/Molecular Imprinting
The series presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science. It is addressed to all scientists at universities and in industry who wish to keep abreast of advances in the topics covered.Molecular recognition is central to how biological systems work. The molecular imprinting technique is a valuable polymerisation method for preparing synthetic materials able to mimic the molecular recognition phenomena present in living systems. A molecule that acts as a template is associated with functional monomers to form a complex by means of covalent linkages or noncovalent interactions. A polymerisation-crosslinking reaction is then performed around this complex. Upon removal of the template species, functionalised cavities, that have memorized the special features and bonding preferences of the template, are left inside the polymer network.
Microbial Sulfur Metabolism
In nature, sulfur occurs in many different oxidation states and is one of the most versatile elements in life. It is an integral part of many important cell constituents, such as the amino acids cysteine and methionine, and many sulfur compounds serve as the basis for energy-related processes in prokaryotes. In recent years, new methods have been applied to study the biochemistry and molecular biology of reactions of the global sulfur cycle, the microorganisms involved and their physiology, metabolism and ecology. These activities have uncovered fascinating new insights for the understanding of aerobic and anaerobic sulfur metabolism.
Microbial Root Endophytes
Plant roots may not only be colonized by mycorrhizal fungi, but also by a myriad of bacterial and fungal root endophytes that are usually not considered by the investigators of classic symbioses. This is the first book dedicated to the interactions of non-mycorrhizal microbial endophytes with plant roots. The phenotypes of these interactions can be extremely plastic, depending on environmental factors, nutritional status, genetic disposition and developmental stages of the two partners. The book deals with diversity, life history strategies, interactions, applications in agriculture and forestry, methods for isolation, cultivation, and both conventional and molecular methods for identification and detection of these endophytes. The comprehensive reviews demonstrate the high diversity of interactions and will provoke further studies to better understand the mechanisms which determine whether a plant-microbial interaction remains asymptomatic, leads to disease or to a mutualistic interaction.
Microbial protein toxins
Since the initial establishment of Robert Koch’s postulates in the nineteenth century, microbial protein toxins have been recognized as a major factor of bacterial and fungal virulence. An increasing number of proteins produced and secreted by various bacteria, yeasts and plants are extremely toxic and most of them developed remarkably "intelligent" strategies to enter, to penetrate and to finally kill a eukaryotic target cell by modifying or blocking essential cellular components. This book describes the strategies employed by protein toxins to render their pro- and eukaryotic producers a selective growth advantage over competitors. In providing an up-to-date overview on the mode of protein toxin actions, it accommodates biomedically and biologically relevant toxin model systems. As a result, it significantly broadens our perspective on biochemical architecture and molecular ploy behind the lethal principles of pro- and eukaryotic toxins.
