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Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Enzymes and drugs
Enzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs. Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting. Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances.
Environmental Governance of the Baltic Sea
This edited volume presents a comprehensive and coherent interdisciplinary analysis of challenges and possibilities for sustainable governance of the Baltic Sea ecosystem by combining knowledge and approaches from natural and social sciences. Focusing on the Ecosystem Approach to Management (EAM) and associated multi-level, multi-sector and multi-actor challenges, the book provides up-to-date descriptions and analyses of environmental governance structures and processes at the macro-regional Baltic Sea level.
Entropy Methods for the Boltzmann Equation : Lectures from a Special Semester at the Centre Émile Borel, Institut H. Poincaré, Paris, 2001
Entropy and entropy production have recently become mathematical tools for kinetic and hydrodynamic limits, when deriving the macroscopic behaviour of systems from the interaction dynamics of their many microscopic elementary constituents at the atomic or molecular level. During a special semester on Hydrodynamic Limits at the Centre Émile Borel in Paris, 2001 two of the research courses were held by C. Villani and F. Rezakhanlou. Both illustrate the major role of entropy and entropy production in a mutual and complementary manner and have been written up and updated for joint publication. Villani describes the mathematical theory of convergence to equilibrium for the Boltzmann equation and its relation to various problems and fields, including information theory, logarithmic Sobolev inequalities and fluid mechanics. Rezakhanlou discusses four conjectures for the kinetic behaviour of the hard sphere models and formulates four stochastic variations of this model, also reviewing known results for these.
Entity-Oriented Search
This open access book covers all facets of entity-oriented search—where “search” can be interpreted in the broadest sense of information access—from a unified point of view, and provides a coherent and comprehensive overview of the state of the art. It represents the first synthesis of research in this broad and rapidly developing area. Selected topics are discussed in-depth, the goal being to establish fundamental techniques and methods as a basis for future research and development. Additional topics are treated at a survey level only, containing numerous pointers to the relevant literature. A roadmap for future research, based on open issues and challenges identified along the way, rounds out the book.
Enhanced Living Environments : Algorithms, Architectures, Platforms, and Systems
Ambient Assisted Living (AAL) is an area of research based on Information and Communication Technologies (ICT), medical research, and sociological research. AAL is based on the notion that technology and science can provide improvements in the quality of life for people in their homes, and that it can reduce the financial burden on the budgets of the healthcare providers. The concept of Enhanced Living Environments (ELE) refers to the AAL area that is more related with ICT. Effective ELE solutions require appropriate ICT algorithms, architectures, platforms, and systems, having in view the advance of science in this area and the development of new and innovative solutions. The aim of this book is to become a state-of-the-art reference, discussing progress made, as well as prompting future directions on theories, practices, standards, and strategies related to the ELE area.
English Literacy Instruction for Chinese Speakers
Written with an emphasis on instruction, policy, practice, and assessment, this book focuses on English literacy at the pre-primary/primary, secondary, and university level, and discusses literacy policies in the region.
Engineering self-organising systems Vol. 3910 ; 3rd International Workshop, ESOA 2005, Utrecht, The Netherlands, July 25, 2005, Revised Selected Papers
This book contains recent work from a broad range of areas with the common theme of utilising self-organisation productively. As distributed information infrastructures continue to spread (such as the Internet, wireless and mobile systems), new challenges have arisen demanding robust and scalable solutions. In these new challenging environments the - signers and engineers of global applications and services can seldom rely on centralised control or management, high reliability of devices, or secure en- ronments. At the other end of the scale, ad-hoc sensor networks and ubiquitous computing devices are making it possible to embed millions of smart computing agents into the local environment.
Engineering self-organising systems ; Vol. 3464 : Methodologies and applications
Self-organisation, self-regulation, self-repair, and self-maintenance are promising conceptual approaches to deal with the ever increasing complexity of distributed interacting software and information handling systems. Self-organising applications are able to dynamically change their functionality and structure without direct user intervention to respond to changes in requirements and the environment. This book comprises revised and extended papers presented at the International Workshop on Engineering Self-Organising Applications, ESOA 2004, held in New York, NY, USA in July 2004 at AAMAS as well as invited papers from leading researchers. The papers are organized in topical sections on state of the art, synthesis and design methods, self-assembly and robots, stigmergy and related topics, and industrial applications.
Engineering Fluid Mechanics
The intended purpose of this book is to provide the fundamental and physical aspects of fluid mechanics and to develop engineering practice for fluid machineries. The subject of fluid engineering is most often approached at the senior undergraduate or postgraduate level of study.
Energy Poverty, Practice, and Policy
New book is theoretically innovative, bringing much-needed insights on poverty and vulnerability into the study of Social Practices. It offers in-depth analysis of how “invisible energy policies” operate in the real world, revealing the important intersections between welfare policies and energy in everyday life. Amid the cost of living crisis, and the ever-more contested politics of social security.
Energy Metabolism and Obesity : Research and Clinical Applications
Elucidate the most important aspects of genetic background, neuropeptide secretion and action, neuronal pathways, adipokines, gut hormones, and environmental influences (physical activity, pharmacologic agents, and surgical alteration of the gastrointestinal tract), as well as the complex interactions among them.
Endoscopic Oncology
Endoscopic Oncology: Gastrointestinal Endoscopy and Cancer Management examines the interface between endoscopy and oncology, and its utilization in the prevention, diagnosis, and management of cancer. Organized anatomically, chapters covering relevant cancers and premalignant conditions of the esophagus, stomach, colorectum, and pancreaticobiliary are explored in depth.
Endodontic Pain : Diagnosis, Causes, Prevention and Treatment
A concise, well-structured guide to the assessment and treatment of patients who present with endodontic pain, in which step-by-step descriptions are complemented by informative images and flow charts. The advantages, disadvantages, and significance of specific diagnostic and treatment procedures are clearly described, as is a pharmacotherapeutic approach to the prevention and treatment of pain.
Encyclopedic reference of immunotoxicology
This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans.
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine
This is the most authoritative and wide-ranging reference yet assembled on Functional Genomics (the systematic analysis and identification of genes and their function) and Proteomics (the study of the complex structures and functions of proteins) in the rapidly expanding field of Molecular Medicine. The two-volume reference work offers a comprehensive overview of the terms, topics and issues in both molecular biology and molecular medicine, with particular emphasis placed on the molecular causes of diseases. It provides up-to-the minute information about developments in the field, including pharmacogenetics and pharmacoproteomics, gene regulation and gene therapy. The Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine is an invaluable tool for clinical scientists in academia and industry, and all who need fast and user-friendly access to key information in this dynamically developing field.
Encyclopedia of Molecular Pharmacology
It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Encyclopedia of Molecular Pharmacology
Covers all aspects of pharmacology, from the chemistry of drugs and the biochemistry of drug targets to the clinical application of drugs, with emphasis on molecular mechanisms. It also includes techniques for describing the effects of drugs and characterizing drug targets. With over 2,000 entries and 350 detailed essays by leading experts, this book is also an up-to-date and important reference for scientists in fields outside pharmacology, students, health care workers, teachers, physicians, and laypersons.
Encyclopedia of medicinal plants
This compilation reports different therapeutic plant species, most ordinarily utilized by native persons throughout the planet. The botanical term, family name, dialect name, partly utilized, and the use of the plants have been mentioned in this work. This encyclopedia presents a rundown of restorative plants generally used for relieving disorders, their bioactive elements, and their means of operation.
Encyclopedia of herbal medicine : 550 herbs and remedies for common ailments
A definitive reference on herbal plants and their medicinal properties for those seeking natural remedies. [It provides] detailed descriptions, constituents, and uses for over 550 plants; practical how-to remedies for more than 80 ailments, ranging from headaches to arthritis; [and] includes the latest scientific research and safety advice. Additional features include an herb directory with photographic index, guidelines for growing medicinal plants and making home remedies, and historical and cultural perspectives for herbal medicine around the world.
