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Fundamentals of drug development
Discusses how to conduct pharmaceutical research and the context for how the industry fits into global healthcare. Holistically, the well-qualified author helps readers and students of drug development appreciate the time and expense of the process. Specifically, the work identifies the emerging trends shaping the future of drug development, along with important related topics like generic drugs, data sharing, and collaboration.
Fundamentals of Data Mining in Genomics and Proteomics
The book presents key analytical techniques used to analyze genomic and proteomic data by detailing their underlying principles, merits and limitations. An important goal of this text is to provide a highly intuitive and conceptual (as opposed to intricate mathematical) account of the discussed methodologies. This treatment will enable readers with interest in analysis of genomic and proteomic data to quickly learn and appreciate the essential properties of relevant data mining methodologies without recourse to advanced mathematics.
Fundamentals of clinical research : Bridging medicine, statistics and operations
The scope of clinical research is to evaluate the effect of a treatment on the evolution of a disease in the human species.The treatment can be pharmacological, surgical, psychological/behavioral or organizational/logistic. The disease, intended as an impairment of a state of well-being or a condition capable of provoking such impairment over time, can be universally accepted as such (e.g. a cancer or a bone fracture) or perceived as such only by limited groups of individuals in a given cultural context (e.g. hair loss or weight gain). The course of the disease that ones wishes to change can be the one with no intervention or, more frequently, the one observed with the available treatment. The evaluation of the effect of a treatment on the course of a disease is a lengthy process, which progresses in increasingly complex stages.
Fundamentals of Cavitation
Treats cavitation, which is a unique phenomenon in the field of hyd- dynamics, although it can occur in any hydraulic machinery such as pumps, propellers, artificial hearts, and so forth. Cavitation is generated not only in water, but also in any kind of fluid, such as liquid hydrogen. The generation of cavitation can cause severe damage in hydraulic machinery. Therefore, the prevention of cavitation is an important concern for designers of hydraulic machinery. On the contrary, there is great potential to utilize cavitation in various important applications, such as environmental protection. There have been several books published on cavitation, including one by the same authors. This book differs from those previous ones, in that it is both more physical and more theoretical. Any theoretical explanation of the cavitation phenomenon is rather difficult, but the authors have succeeded in explaining it very well, and a reader can follow the equations easily. It is an advantage in reading this book to have some understanding of the physics of cavitation. Therefore, this book is not an introductory text, but a book for more advanced study. However, this does not mean that this book is too difficult for a beginner, because it explains the cavitation phenomenon using many figures. Therefore, even a beginner on cavitation can read and can understand what cavitation is.
Fundamentals of building performance simulation
Pares the theory and practice of a multi-disciplinary field to the essentials for classroom learning and real-world applications. Authored by a veteran educator and researcher, this textbook equips graduate students and emerging and established professionals in engineering and architecture to predict and optimize buildings’ energy use. It employs an innovative pedagogical approach, introducing new concepts and skills through previously mastered ones and deepening understanding of familiar themes by means of new material. Covering topics from indoor airflow to the effects of the weather, the book’s 19 chapters empower learners to: Understand the models and assumptions underlying popular BPS tools ; Compare models, simulations, and modelling tools and make appropriate selections ; Recognize the effects of modelling choices and input data on simulation predictions
Fundamentals of biomechanics
The book presents a comprehensive review of the major concepts of biomechanics and summarizes them in nine principles of biomechanics. Throughout the text are numerous examples of applying these principles to the work of kinesiology professionals. Specific case studies are presented in four application chapters: physical education, coaching, strength and conditioning, and sports medicine.
Fundamentals of analytical chemistry ; 10th ed.
Presents the latest developments in analytical chemistry today using a reader-friendly yet systematic and thorough approach. Each chapter begins with a compelling story and stunning visuals. Dynamic photos from renowned chemistry photographer Charlie Winters capture attention while reinforcing key principles. New features highlight chemistry-related careers. You also learn how to use Excel 2019 as a problem-solving tool in analytical chemistry with new exercises, examples and a no-cost supplement by the text authors. OWLv2 online homework tool is also available to help you master the principles of analytical chemistry today.
Fundamentals of Algebraic Graph Transformation
Graphs are widely used to represent structural information in the form of objects and connections between them. Graph transformation is the rule-based manipulation of graphs, an increasingly important concept in computer science and related fields. This is the first textbook treatment of the algebraic approach to graph transformation, based on algebraic structures and category theory.
Fundamentals of airplane flight mechanics
Airplane flight mechanics is the application of Newton's laws to the study of airplane trajectories (performance), stability, and aerodynamic control. This text is limited to flight in a vertical plane and is divided into two parts. The first part, trajectory analysis, is concerned primarily with the derivation of analytical solutions of trajectory problems associated with the sizing of commercial jets, that is, take-off, climb, cruise, descent, and landing, including trajectory optimization. The second part, stability and control, is further classified as static or dynamic. On each iteration of airplane sizing, the center of gravity is placed so that the airplane is statically stable. Dynamic stability and control is included to study the response of an airplane to control and gust inputs, which is needed for the design of automatic flight control systems. Algorithms are presented for estimating lift, drag, pitching moment, and stability derivatives.
Fundamental astronomy
Fundamental Astronomy gives a well-balanced and comprehensive introduction to the topics of classical and modern astronomy. While emphasizing both the astronomical concepts and the underlying physical principles, the text provides a sound basis for more profound studies in the astronomical sciences.
Fun and Games ; 2nd International conference, Eindhoven, The Netherlands, October 20-21, 2008. Proceedings
This book constitutes the refereed proceedings of the Second International Conference on Fun and Games, held in Eindhoven, The Netherlands, in October 2008.The 17 revised full papers, presented together with 2 invited talks were carefully reviewed and selected from a total of 36 submissions. The papers encompass the study of computer games, game development and experiences by researchers from social sciences, computing, electrical engineering, design, etc. Main focus is given to topics such as tightly-coupled embodied control of movement-sensitive mobile devices, hypercomputation and cultural computing, emerging gaming paradigms.
Frontiers in Chemical Sensors : Novel Principles and Techniques
With their similarity to the organs of the most advanced creatures that inhabit the Earth, sensors are regarded as being the “senses of electronics”: arti?cial eyes and ears that are capable of seeing and hearing beyond the range of - man perception; electronic noses and tongues that can recognise odours and ?avours without a lifetime training; touch that is able not only to feel the texture and temperature of the materials but even to discern their chemical compo- tion. Among the world of chemical sensors, optical devices (sometimes termed “optodes”, from the Greek “the optical way”) have reached a prominent place in those areas where the features of light and of the light-matter interaction show their advantage: contactless or long-distance interrogation, detection sensitivity, analyte selectivity, absence of electrical interference or risks, and lack of analyte consumption,
From Vectors to Tensors
It is true that there exist many books dedicated to linear algebra and some what fewer to multilinear algebra, written in several languages, and perhaps one can think that no more books are needed. However, it is also true that in algebra many new results are continuously appearing, different points of view can be used to see the mathematical objects and their associated structures, and different orientations can be selected to present the material, and all of them deserve publication. he book assumes a certain knowledge of linear algebra, and is intended as a textbook for graduate and postgraduate students and also as a consultation book. It is addressed to mathematicians, physicists, engineers, and applied scientists with a practical orientation who are looking for powerful tensor tools to solve their problems.
From the Act of Judging to the Sentence : The Problem of Truth Bearers from Bolzano to Tarski
This book offers a detailed study of the truth-bearers problem, that is, the question of which category of items the predicates ‘true’ and ‘false’ are predicated. The book has two dimensions: historical and systematic. Both focus around Tarski’s semantic theory of truth. The author locates Tarski’s ideas in a broad context of Austrian philosophy, in particular, Brentano’s tradition. However, Bolzano and phenomenology (Husserl and Reinach) are also taken into account. The historical perspective is completed by showing how Tarski was rooted in Polish philosophical tradition originated with Twardowski and his version of Brentanism. The historical considerations are the basis for showing how the idea of truth-bearers as acts of judging was transformed into the theory of truth-bearers as sentences. In particular, the author analyses the way to nominalism in Polish philosophy, culminating in Lesniewski, Kotarbinski and Tarski. This book is indispensable for everybody interested in the evolution of Austrian philosophy from descriptive psychology to semantics.
From Suns to Life: : A Chronological Approach to the History of Life on Earth
This review emerged from several interdisciplinary meetings and schools gathering a group of astronomers, geologists, biologists, and chemists, attempting to share their specialized knowledge around a common question: how did life emerge on Earth? Their ultimate goal was to provide some kind of answer as a prerequisite to an even more demanding question: is life universal? The main chapters of this review present the formation and evolution of the solar system (3); the building of a habitable planet (4); prebiotic chemistry, biochemistry, and the emergence of life (5); the environmental context of the early Earth (6); and the ancient fossil record and early evolution (7). The concluding chapter (9) provides the highlights of the review and presents the different points of view about the universality of life. Two pedagogical chapters are included; one on chronometers (2), another in the form of a "frieze" (8) which summarizes in graphical form the present state of knowledge about the chronology of the emergence of life on Earth, before the Cambrian explosion.
From Summetria to Symmetry : The Making of a Revolutionary Scientific Concept
The concept of symmetry is inherent to modern science, and its evolution has a complex history that richly exemplifies the dynamics of scientific change. This study is based on primary sources, presented in context: the authors examine closely the trajectory of the concept in the mathematical and scientific disciplines as well as its trajectory in art and architecture. The principal goal is to demonstrate that, despite the variety of usages in many different domains there is a conceptual unity underlying the invocation of symmetry in the period from antiquity to the 1790s which is distinct from the scientific usages of this term that first emerged in France at the end of the 18th century.
From Opinion Mining to Financial Argument Mining
Financial opinion mining is a branch of traditional opinion mining and sentiment analysis which shares the basic notions of traditional approaches and adds its own domain-specific characteristics. In Sect. 1.1, we start with a common definition of general opinion mining after which we briefly overview traditional research directions.
From Gestalt Theory to Image Analysis : A Probabilistic Approach
This book introduces the reader to a recent theory in Computer Vision yielding elementary techniques to analyse digital images. These techniques are inspired from and are a mathematical formalization of the Gestalt theory. Gestalt theory, which had never been formalized is a rigorous realm of vision psychology developped between 1923 and 1975. From the mathematical viewpoint the closest field to it is stochastic geometry, involving basic probability and statistics, in the context of image analysis.
From decoding turbulence to unveiling the fingerprint of climate change : Klaus Hasselmann—Nobel Prize Winner in Physics 2021
Serves as a reference for the key elements and their significance of Klaus Hasselmann's work on climate science and on ocean wave research, all based on a rigorous and deeply physical thinking. It summarizes the original articles (mostly from the 1970 and 1980s; some of which are hard to find nowadays) and brings them in a present-day context.
From Data and Information Analysis to Knowledge Engineering ; Proceedings of the 29th Annual Conference of the Gesellschaft für Klassifikation e.V., University of Magdeburg, March 9-11, 2005
The volume contains revised versions of selected papers presented during the 29th Annual Conference of the Gesellschaft für Klassifikation (GfKl), the German Classification Society, held at the Otto-von-Guericke-University of Magdeburg, Germany, in March 2005. In addition to papers on the traditional subjects Classification, Clustering, and Data Analysis, there are many papers on a wide range of topics with a strong relation to Computer Science. Examples are Text Mining, Web Mining, Fuzzy Data Analysis, IT Security, Adaptivity and Personalization, and Visualization. Application-oriented topics include Economics, Marketing, Banking and Finance, Medicine, Bioinformatics, Biostatistics, and Music Analysis.
