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Fundamentals of drug delivery
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems. Provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery.
Fundamentals of drug and non-drug interactions : physiopathological perspectives and clinical approaches
Covers nutrients, active principles from phytotherapy/herbal products, and drug classes while identifying potential interactions. Didactic approaches to drug and non-drug interactions and cutting-edge reports are included in each chapter that promotes safer drug prescription and use. The physiopathological overview in this book provides background for chemistry, pharmacology, and mechanistic bases of drug and non-drug interaction as well as clinical cases and predictive screenings.
Fundamentals of computation theory ; 15th International symposium, FCT 2005, Lübeck, Gemany, August 17-20, 2005, Proceedings
This book constitutes the refereed proceedings of the 15th International Symposium Fundamentals of Computation Theory, FCT 2005, held in L]beck, Germany in August 2005. The 46 revised full papers presented together with 3 invited papers were carefully reviewed and selected from 105 submissions. The papers are organized in topical sections on circuits, automata, complexity, approximability, computational and structural complexity, graphs and complexity, computational game theory, visual cryptography and computational geometry, query complexity, distributed systems, automata and formal languages, semantics, approximation algorithms, average case complexity, algorithms, graph algorithms, and pattern matching.
Fundamentals of clinical research : Bridging medicine, statistics and operations
The scope of clinical research is to evaluate the effect of a treatment on the evolution of a disease in the human species.The treatment can be pharmacological, surgical, psychological/behavioral or organizational/logistic. The disease, intended as an impairment of a state of well-being or a condition capable of provoking such impairment over time, can be universally accepted as such (e.g. a cancer or a bone fracture) or perceived as such only by limited groups of individuals in a given cultural context (e.g. hair loss or weight gain). The course of the disease that ones wishes to change can be the one with no intervention or, more frequently, the one observed with the available treatment. The evaluation of the effect of a treatment on the course of a disease is a lengthy process, which progresses in increasingly complex stages.
Fundamentals of Clinical Data Science
This book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare.
Fundamentals of Cavitation
Treats cavitation, which is a unique phenomenon in the field of hyd- dynamics, although it can occur in any hydraulic machinery such as pumps, propellers, artificial hearts, and so forth. Cavitation is generated not only in water, but also in any kind of fluid, such as liquid hydrogen. The generation of cavitation can cause severe damage in hydraulic machinery. Therefore, the prevention of cavitation is an important concern for designers of hydraulic machinery. On the contrary, there is great potential to utilize cavitation in various important applications, such as environmental protection. There have been several books published on cavitation, including one by the same authors. This book differs from those previous ones, in that it is both more physical and more theoretical. Any theoretical explanation of the cavitation phenomenon is rather difficult, but the authors have succeeded in explaining it very well, and a reader can follow the equations easily. It is an advantage in reading this book to have some understanding of the physics of cavitation. Therefore, this book is not an introductory text, but a book for more advanced study. However, this does not mean that this book is too difficult for a beginner, because it explains the cavitation phenomenon using many figures. Therefore, even a beginner on cavitation can read and can understand what cavitation is.
Fundamentals of Cancer Detection, Treatment, and Prevention
The book offers a comprehensive overview of cancer in humans, from its causes, symptoms, and diagnosis to the variety of treatment options available today. Intuitively organized by cancer type, this guide provides concise information on risk factors, diagnosis, and treatment options for all commonly encountered tumors, including surgery, radiation therapy, chemotherapy, and immunotherapy.
Fundamentals of Artificial Intelligence
Fundamentals of Artificial Intelligence introduces the foundations of present day AI and provides coverage to recent developments in AI such as Constraint Satisfaction Problems, Adversarial Search and Game Theory, Statistical Learning Theory, Automated Planning, Intelligent Agents, Information Retrieval, Natural Language & Speech Processing, and Machine Vision. The book features a wealth of examples and illustrations, and practical approaches along with the theoretical concepts. It covers all major areas of AI in the domain of recent developments. The book is intended primarily for students who major in computer science at undergraduate and graduate level but will also be of interest as a foundation to researchers in the area of AI.
Fundamentals of analytical toxicology : Clinical and forensic ; 2nd ed.
An integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques. Focuses on analytical, statistical, and pharmacokinetic principles / Describes basic methodology, including colour tests and immunoassay and enzyme-based assays / Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation / Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides / Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS)
Fundamentals and Methods of Machine and Deep Learning : Algorithms, Tools, and Applications
provides a practical approach by explaining the concepts of machine learning and deep learning algorithms, evaluation of methodology advances, and algorithm demonstrations with applications. In recent research studies, they are regarded as one of the disruptive technologies that will transform our future life, business, and the global economy. The recent explosion of digital data in a wide variety of domains, including science, engineering, Internet of Things, biomedical, healthcare, and many business sectors, has declared the era of big data, which cannot be analysed by classical statistics but by the more modern, robust machine learning and deep learning techniques. Since machine learning learns from data rather than by programming hard-coded decision rules, an attempt is being made to use machine learning to make computers that are able to solve problems like human experts in the field.
Fundamental Trends in City Development
This book inquires into how the city can be re-established as the space of dialogue and communication, how the spatial conditions of the public sphere can be created and the city retrieved. And what the features might be of a city retrieved and restored to its citizens. The book adopts the concept of externity as an innovative element for the project for the city, a constituent feature of all those situations traditionally considered non-functional, therefore external, to our contemporary post-cities, which are consigned to us adrift through decomposition, genericity and segregation. We thus need to try to get the city to conserve and show its past even when not visible, and to continue nurturing the imagination of its inhabitants by urban action consisting perhaps of subtly improving their approach to the "void", the "small", to the past, the territory, in general, to all those spatial concepts which are in a sense external to our cultural worlds today, but which represent the most fertile material for the project for the city.
Functions de variable réelle : Théorie élémentaire = Real variable functions : Elementary theory
The Mathematics Elements of Nicolas BOURBAKI aim to provide a rigorous, systematic presentation without prerequisites of mathematics from their foundations. This Book is the fourth of the treaty; it is devoted to the basics of real analysis. It includes the chapters: Derivatives; Primitive and integral; Elementary functions; Differential equations ; Local study of functions; Generalized Taylorian developments. Euler-Maclaurin summation formula; The gamma function. It also contains historical notes.
Functional Hydrogels in Drug Delivery : Key Features and Future Perspectives
Deals with the synthesis and characterization of hydrogels specifically used as drug delivery systems. Each chapter includes the most recent updates about the different starting materials employed--whether natural and synthetic--and the improvement, such as modifications of synthetic approach and polymerization technique, of their physicochemical and biological properties to synthetize high performing carriers for specific uses, i.e. stimuli-responsive materials, molecularly imprinted polymers, mucoadhesive materials, carrier for the delivery of high molecular weight drugs, and gene-delivery.
Fullerene and Alzheimer disease
Patients have suffered for a long time from Alzheimer's disease. The presence of some obstacles in treatment, which prompted us to talk in this research on one of the modern treatments for this disease, which is fullerene. The focus was in some detail on its structure and characteristics, in addition to its applications. We especially mention its application in the treatment of Alzheimer's. This was a new step in the world of medicine and pharmacy.
Frontline and Factory : Comparative Perspectives on the Chemical Industry at War, 1914-1924
This book represents a first considered attempt to study the factors that conditioned industrial chemistry for war in1914-18. Taking a comparative perspective, it reflects on the experience of France, Germany, Austria, Russia, Britain, Italy and Russia, and points to significant similarities and differences. It looks at changing patterns in the organisation of industry, and at the emerging symbiosis between science, industry and the military, which contributed to the first ‘academic-military-industrial’ complex of the 20th century. At the same time, it reflects on the world’s first, and ultimately unsuccessful attempt to monitor ‘dual-use’ chemical technologies, and so restrict the proliferation of an important category of weapons of mass destruction.
Frontiers in Anti-Infective Drug Discovery ; Vol.9
Covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The ninth volume of this series features 5 reviews that cover some aspects of clinical and pre-clinical antimicrobial drug development, with 2 chapters focusing on drugs to treat leishmaniasis and dengue fever, respectively. - Use of preclinical and early clinical data for accelerating antimicrobial drug development - Post-translational modifications: host defence mechanism, pathogenic weapon, and emerged target of anti-infective drugs - Scope and limitations on the potent antimicrobial activities of hydrazone derivatives - Current scenario of anti-leishmanial drugs and treatment - Dengue hemorrhagic fever: the potential repurposing drugs
From X-ray Binaries to Quasars : Black Holes on All Mass Scales
This volume brings together contributions from many of the world's leading authorities on black hole accretion. The papers within represent part of a new movement to make use of the relative advantages of studying stellar mass and supermassive black holes and to bring together the knowledge gained from the two approaches. The topics discussed here run the gamut of the state of the art in black hole observational and theoretical work-variability, spectroscopy, disk-jet connections, and multi-wavelength campaigns on black holes are all covered.
From War to Peace in the Balkans, the Middle East and Ukraine
This book focuses on the origins, consequences and aftermath of Western military interventions that led to the end of the most recent Balkan wars. . This study highlights lessons that can be applied to the Middle East and Ukraine, where similar conflicts are likewise challenging sovereignty and territorial integrity. It is an accessible treatment of what makes war and how to make peace ideal for all readers interested in how violent international conflicts can be managed, informed by the experience of a practitioner.
From Program to Product : Turning Your Code into A Saleable Product
Many would–be software entrepreneurs with expertise in many fields attempt to turn a homegrown application—one developed for use in their own business or profession—into a commercial product. Lack of knowledge, experience, or skills often prevents the idea from ever taking shape, let alone achieving its potential. Entering a new field to start a business leaves many developers unprepared and not even fully aware that it's something they know so little about. They will also often have a job that conflicts with the time commitment required to market the program well enough for it to become a complete success.
From Nano to Space : Applied Mathematics Inspired by Roland Bulirsch
Graduate students and postgraduates in Mathematics, Engineering and the Natural Sciences want to understand Applied Mathematics for the solution of everyday problems. Scholars of Roland Bulirsch working at universities, at research institutions and in industry combine research and review papers in this anthology. Their work is summed up under the title "From Nano to Space – Applied Mathematics Inspired by Roland Bulirsch". More than 20 contributions are divided into scales: nano, micro, macro, space and real life. The contributions survey current research and present case studies very interesting and informative for both graduate students and postgraduates. The contributions show how modern Applied Mathematics influences our everyday lives. Several contributions include complex graphics and illustrations, many of them in color.
