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Molecular Neurosurgery with Targeted Toxins
Focuses on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.
Molecular Biology of Human Cancers: An Advanced Student's Textbook
Presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Modernizing the academic teaching and research environment : Methodologies and cases in business research
Constitutes a valuable manual for young and seasoned business researchers alike, and provides a comprehensive summary for the whole research journey. It is a must-read for all researchers who need to understand the basics of business research, from identifying research topics, to planning and organizing the research process, and selecting the most appropriate methodology for the topic at hand. This book also provides insights on how to avoid common pitfalls in business research and outlines the research skills needed to write a fine piece of research. In order to capture the innovative element of research, the book also highlights methods for thinking outside the box. It also stresses the importance of respecting ethics while conducting business research. Lastly, it presents important cases and provides hands-on training for preparing survey tools. Readers looking to master business research won’t want to miss out on this unique and insightful book.
Modern Aspects of Electrochemistry ; Vol. 38
Solid State Electrochemistry encompassing modern equilibria concepts, thermodymanics and kinetics of charge carriers in solids.,Electron transfer processes, with special sections devoted to hydration of the proton and its heterogeneous transfer.Electrosorption at electrodes and its relevance to electrocatalysis and electrodeposition of metals,The behavior of Pt and other alloy electrocatalyst crystallites used as the electrode materials for phosphoric acid electrolyte fuel-cells.Applications of reflexology and electron microscopy to the materials science aspect of metal electrodes.Electroplating of metal matrix composites by codeposition of suspended particles, a process that has improved physical and electrochemical properties.
Modelling and Control of Dynamical Systems : Numerical Implementation in a Behavioral Framework
This book reviews known topics of the Behavioral Approach and offers new theoretic results with the advantage of including control algorithms implemented numerically in the computer. In addition, issues of numerical analysis are also included. The programs and algorithms are MATLAB based.
Modeling Theory in Science Education
The book focuses as much on course content as on instruction and learning methodology, and presents practical aspects that have repeatedly demonstrated their value in fostering meaningful and equitable learning of physics and other science courses at the secondary school and college levels.The author shows how a scientific theory that is the object of a given science course can be organized around a limited set of basic models. Special tools are introduced, including modeling schemata, for students to meaningfully construct models and required conceptions, and for teachers to efficiently plan instruction and assess and regulate student learning and teaching practice. A scientific model is conceived to represent a particular pattern in the structure or behavior of physical realities and to explore and reify the pattern in specific ways. The author further shows how to engage students in modeling activities through structured learning cycles.
Modeling Solar Radiation at the Earth’s Surface : Recent Advances
Solar radiation data is important for a wide range of applications, e.g. in engineering, agriculture, health sector, and in many fields of the natural sciences. A few examples showing the diversity of applications may include: architecture and building design e.g. air conditioning and cooling systems; solar heating system design and use; solar power generation; weather and climate prediction models; evaporation and irrigation; calculation of water requirements for crops; monitoring plant growth and disease control; skin cancer research.
Modeling Semantic Web Services : The Web Service Modeling Language
In this book, Jos de Bruijn and his coauthors lay the foundations for understanding the requirements that shape the description of the various aspects related to Semantic Web services, such as the static background knowledge in the form of ontologies, the functional description of the service, and the behavioral description of the service. They introduce the Web Service Modeling Language (WSML), which provides means for describing the functionality and behavior of Web services, as well as the underlying business knowledge, in the form of ontologies, with a conceptual grounding in the Web Service Modeling Ontology.
Modeling Communication with Robots and Virtual Humans ; Second ZiF Research Group International Workshop on Embodied Communication in Humans and Machines, Bielefeld, Germany, April 5-8, 2006, Revised Selected Papers
The 17 articles in this state-of-the-art survey address artificial intelligence research on communicative agents and also provide an interdisciplinary perspective from linguistics, behavioral research, theoretical biology, philosophy, communication psychology, and computational neuroscience. The topics include studies on human multimodal communication; the modeling of feedback signals, facial expression, eye contact, and deception; the recognition and comprehension of hand gestures and head movements; communication interfaces for humanoid robots; the evolution of cognition and language; emotion and social appraisal in nonverbal communication; dialogue models and methodologies; theory of mind and intentionality; complex systems, dynamic field theory, and connectionist modeling.
Modeling biological systems : Principles and applications
This extensively revised second edition of Modeling Biological Systems: Principles and Applications describes the essentials of creating and analyzing mathematical and computer simulation models for advanced undergraduates and graduate students. It offers a comprehensive understanding of the underlying principle, as well as details and equations applicable to a wide variety of biological systems and disciplines. Students will acquire from this text the tools necessary to produce their own models. The text contains two major sections: Principles and Applications. The first section discusses the principles of biological systems with a thorough description of the essential modeling activities of formulation, implementation, validation, and analysis. These activities are illustrated by a set of example models taken from recent and classical literature, chosen for their breadth of coverage and current timeliness. The new edition updates extensively many of these topics, especially quantitative model formulation, validation and model discrimination using information theory measures and Bayesian probability, and stability analysis and non-dimensionalization.
Model-Driven Development of Reliable Automotive Services ; 2nd Automotive Software Workshop, ASWSD 2006, San Diego, CA, USA, March 15-17, 2006, Revised Selected Papers
This book constitutes the thoroughly refereed post-workshop proceedings of the Second Automotive Software Workshop, ASWSD 2006, held in San Diego, CA, USA in March 2006.The 11 revised full papers presented were carefully reviewed and selected from 18 lectures held at the workshop, that brought together experts from industry and academia, working on highly complex, distributed, reactive software systems related to the automotive domain. The papers are organized in topical sections on modeling techniques and infrastructures, model transformations, quality assurance, real-time control, as well as services and components.
Model-Driven Design Using Business Patterns
This book takes exactly this step: it shows you how to apply the pattern ideas in business applications and presents more than 20 structural and behavioral business patterns that use the REA (resources, events, agents) pattern as a common backbone. If you are a developer working on business frameworks, you can use the patterns presented to derive the right abstractions (e.g., business objects) and to design and ensure that the meta-rules (e.g., process patterns) are followed by the developers of the actual applications. And if you are an application developer, you can use these patterns to design your business application, to ensure that it does not violate the domain rules, and to adapt the application to changing requirements without the need to change the overall architecture. As with patterns in general, this approach allows for both more flexible and more solid software architectures and hence better software quality.
Model Driven Engineering Languages and Systems ; Vol. 3713 : 8th International Conference, MoDELS 2005, Montego Bay, Jamaica, October 2-7, 2005, Proceedings
Constitutes the proceedings of the 8th International Conference on Model Driven Engineering Languages and Systems, MoDELS 2005, held in Montego Bay, Jamaica, in October 2005. This book includes 52 papers and 2 keynote abstracts. It covers such topics as process modelling, product families, state/behavioral modeling, design strategies and more.
Model Driven Engineering Languages and Systems ; 11th International Conference, MoDELS 2008, Toulouse, France, September 28 - October 3, 2008. Proceedings
The book also contains three keynote speeches and contributions to workshops, symposia, tutorials and panels at the conference. The papers are organized in topical sections on Model Transformation: Foundations; Requirements Modeling; Domain-Specific Modeling; Model Transformation: Techniques, Composition and Analysis of Behavioral Models; Model Comprehension; Model Management; Behavioral Conformance and Refinement; Metamodeling and Modularity; Constraints; Model Analysis; Service-Oriented Architectures; Adaptive and Autonomic Systems; Empirical Studies; Evolution and Reverse Engineering; Modeling Language Semantics; Dependability Analysis and Testing; Aspect-Oriented Modeling; Structural Modeling;and Embedded Systems.
Mobilizing Adults for Positive Youth Development : Strategies for Closing the Gap between Beliefs and Behaviors
"In today's fast-paced, often-dehumanizing world, increasing positive adult involvement and influence is particularly vital. To further that goal, Mobilizing Adults for Positive Youth Development: Strategies for Closing the Gap between Beliefs and Behaviors brings together, in one concise volume, the advice and expertise of leading scholars dedicated to affecting positive youth development. Taken together, the chapters in this book provide a multifaceted, multidisciplinary blueprint for social change." "Mobilizing Adults for Positive Youth Development: Strategies for Closing the Gap between Beliefs and Behaviors is a must-have volume for both practitioners and researchers - in fact, for anyone interested and involved in working toward achieving positive youth development.
Mobile Robots : The Evolutionary Approach
The design and control of autonomous intelligent mobile robotic systems operating in unstructured changing environments includes many objective difficulties. There are several studies about the ways in which, robots exhibiting some degree of autonomy, adapt themselves to fit in their environments. The application and use of bio-inspired and intelligent techniques such as reinforcement learning, artificial neural networks, evolutionary computation and so forth in the design and improvement of robot designs is an emergent research topic. Researchers have obtained robots that display an amazing slew of behaviours and perform a multitude of tasks. These include perception of environment, planning and navigation in rough terrain, pushing boxes, negotiating an obstacle course, etc.
Mobile and Wireless Communications Networks ; IFIP TC6 / WG6.8 Conference on Mobile and Wireless Communication Networks (MWCN 2004) October 25-27, 2004 Paris, France
Mobile Ad hoc NETworks (MANETs) has attracted great research interest in recent years. A Mobile Ad Hoc Network is a self-organizing multi-hop wireless network where all hosts (often called nodes) participate in the routing and data forwarding process. The dependence on nodes to relay data packets for others makes mobile ad hoc networks extremely susceptible to various malicious and selfish behaviors. This point is largely overlooked during the early stage of MANET research. Many works simply assume nodes are inherently cooperative and benign. However, experiences from the wired world manifest that the reverse is usually true; and many works [3] [10] [9] [8] [12] [19] have pointed out that the impact of malicious and selfish users must be carefully investigated. The goal of this research is to address the cooperation problem and related security issues in wireless ad hoc networks. As a rule of thumb, it is more desirable to include security mechanisms in the design phase rather than continually patching the system for security breaches. As pointed out in [2] [1], there can be both selfish and malicious nodes in a mobile ad hoc network. Selfish nodes are most concerned about their energy consumption and intentionally drop packets to save power. The purpose of malicious nodes, on the other hand, is to attack the network using various intrusive techniques. In general, nodes in an ad hoc network can exhibit Byzantine behaviors.
Midazolam in pediatric dentistry
Discusses predictable ways to achieve minimal/moderate sedation with midazolam. This book covers various aspects of midazolam sedation including pre-operative assessment, case selection, different routes of administration, intraoperative protocol, emergency management and meticulous documentation. It explains the importance of its conjunction with sound fundamentals of non-pharmacological behavior guidance and good local anesthetic techniques.
Micromechanics of Heterogeneous Materials
The micromechanics of random structure heterogeneous materials is a burgeoning multidisciplinary research area which overlaps the scientific branches of materials science, mechanical engineering, applied mathematics, technical physics, geophysics, and biology. Micromechanics of Heterogeneous Materials features rigorous theoretical methods of applied mathematics and statistical physics in materials science of microheterogeneous media. The prediction of the behavior of heterogeneous materials by the use of properties of constituents and their microstructures is a central issue of micromechanics. This book is the first in micromechanics to provide a useful and effective demonstration of the systematic and fundamental research of the microstructure of the wide class of heterogeneous materials of natural and synthetic nature.
Micromechanics and Nanosimulation of Metals and Composites : Advanced Methods and Theoretical Concepts
This book provides insight into advanced numerical and experimental investigations of the microstructural aspects of strength and damage of metals and metal-based composites. In particular, atomistic and dislocation models, micromechanical simulations and homogenization techniques, as well as experimental observations in combination with computer simulations, are described. These methods are successfully applied to analyze the mechanical behavior of metals and metal-matrix composites.
