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Molecular Biology of Human Cancers: An Advanced Student's Textbook
Presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Modular Forms
It provides the reader with the basic knowledge of elliptic modular forms necessary to understand the recent developments in number theory. The first part gives the general theory of modular groups, modular forms and Hecke operators, with emphasis on the Hecke-Weil theory of the relation between modular forms and Dirichlet series. The second part is on the unit groups of quaternion algebras, which are seldom dealt with in books. The so-called Eichler-Selberg trace formula of Hecke operators follows next and the explicit computable formula is given. In the last chapter, Eisenstein series with parameter are discussed following the recent work of Shimura: Eisenstein series are likely to play a very important role in the future progress of number theory, and this chapter provides a good introduction to the topic.
Modern Ferrite Technology
odern Ferrite Technology ; 2nd ed. offers the readers an expert overview of the latest ferrite advances as well as their applications in electronic components. This volume develops the interplay among material properties, component specification and device requirements using ferrites. Throughout, emphasis is placed on practical technological concerns as opposed to mathematical and physical aspects of the subject. The book traces the origin of the magnetic effect in ferrites from the level of the simplest particle and then increases the scope to include larger hierarchies. From the desired magnetic properties, the author deduces the physical and chemical material parameters, taking into consideration major chemistry, impurity levels, ceramic microstructures and grain boundary effects. He then discusses the processing conditions and associated conditions required for implementation. In addition to conventional ceramic techniques, he describes non-conventional methods such as co-precipitation, co-spray roasting and single crystal growth.
Modelling the dispersion of radionuclides in the marine environment : An introduction
This book is a practical guide to the subject of numerical modelling of radioactivity dispersion in the marine environment. Thus, the techniques and numerical procedures required are explained in detail, with the aim of enabling the reader to build a real mathematical model. The book covers basic concepts and techniques, such as solving the advection-diffusion equation in a simple 1D form, as well as the most recent developments (full 3D models for non-conservative radionuclides including chemical reactions and speciation). A chapter is dedicated to the basic hydrodynamic modelling that is always required to simulate the dispersion of tracers in the sea; Eulerian and Lagrangian modelling techniques are also described. A chapter describes sensitivity and uncertainty analysis, the final stage in modelling works. A review on some published radionuclide dispersion models is also included.
Model Abstraction in Dynamical Systems : Application to Mobile Robot Control
The subject of this book is model abstraction of dynamical systems. The p- mary goal of the work embodied in this book is to design a controller for the mobile robotic car using abstraction. Abstraction provides a means to rep- sent the dynamics of a system using a simpler model while retaining important characteristics of the original system. A second goal of this work is to study the propagation of uncertain initial conditions in the framework of abstraction. The summation of this work is presented in this book.
Mobile Ad Hoc Networks : Energy-Efficient Real-Time Data Communications
This book presents the Time Reservation using Adaptive Control for Energy Efficiency (TRACE) family of protocol architectures that provide such dynamic coordinated channel access in a distributed manner, enabling energy-efficient, real-time data communications in MANETs. Furthermore, this book provides an introduction to the fundamentals of MANETs, an overview of protocols for each layer of the protocol stack, and a discussion of the issues involved with energy-efficient protocol design and quality of service for real-time data transmission.
Microsoft .NET framework 2.0 web-based client development : MCTS self-paced training Kit (Exam 70-528)
Designed to help you make the most of your study time. Maximize your performance on the exam by learning to: * Create, trace, configure, and deploy Web applications * Integrate data into your application using Microsoft ADO.NET, XML, and data-bound controls * Implement forms authentication, impersonation, and login controls * Configure server controls and create custom Web controls * Use themes, user profiles, and Web parts for customizable, personalized Web sites * Manage server-side and client-side application state PRACTICE TESTS Assess your skills with practice tests on CD. You can work through hundreds of questions using multiple testing modes to meet your specific learning needs. You get detailed explanations for right and wrong answers?including a customized learning path that describes how and where to focus your studies. Your kit includes: * Official self-paced study guide. * Practice tests with multiple, customizable testing options and a learning plan based on your results. *400+ practice and review questions. * Case scenarios and lab exercises. * Microsoft Visual Basic and Visual C# code samples on CD.
Micronutrients and macronutrients as nutraceuticals
Explains in detail the properties of micronutrients and macronutrients and their diverse uses as nutraceuticals for their beneficial properties, such as their antioxidant activity and immunity-boosting properties and how they can be incorporated into the human diet for optimum health, for growing beneficial bacteria in the gut, and inhibition of pathogens. Interestingly, the authors look at how disease-promoting habits often unfold in childhood, even prenatally, and employing nutrigenomics early on goes a long way toward curbing these chronic diseases later on in life.
Microbial nutraceuticals : Products and processes
Discussion of the recent advances in the application of microbial nutraceuticals and their implementation in the health, food, and agriculture sectors. The book begins with an overview of microbial nutraceuticals before moving on to discussions of more specific topics, including microbial cell factories for the production of essential amino acids, microbial production of dietary short-chain fatty acids, and microbial sources for bioactive peptides conferring health benefits.
Metal-containing molecules and nanomaterials : from diagnosis to therapy
Since the discovery and successful deployment of salvarsan to treat syphilis, as well as cisplatin as a cancer drug, the field of metallodrugs has been flourishing. In addition to therapeutic applications, metals and metal-containing molecules have properties, such as an electrochemical or an optical signal, used to diagnose biologically relevant molecules or unravel cellular metabolism. Metals are part of the essential elements for life, and of increased attention in nutraceuticals. Most of the current diagnosis processes, therapeutics and nutraceuticals are based on organic molecules. MILS-26 reviews the most recent metal-containing molecules and nanomaterials for diagnosis and therapy
Medicinal foods as potential therapies for type-2 diabetes and associated diseases : The chemical and pharmacological basis of their action
Focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. Provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries.
Medicinal compounds in modern healthcare : From tradition to innovation
Reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.
Medical biotechnology, biopharmaceutics, forensic : science and bioinformatics
Covers a range of topics on exploiting Nigeria’s mega biodiversity for food security and health; DNA forensic science and its applications; medical biotechnology and biopharmaceutics; medicinal and underutilized plants; impact and mitigation of antibiotic resistance; bioinformatics applications; medical insect biotechnology; etc. The book will be useful reference material for the scientists and researchers working in the fields of nutraceuticals, molecular diagnostics and DNA forensics, biopharmaceuticals and medical biotechnology, nanotechnology, antimicrobials from indigenous plant species, bioinformatics, etc.
Mechanosensing and Mechanochemical Transduction in Extracellular Matrix : Biological, Chemical, Engineering, and Physiological Aspects
Mechanosensing and Mechanochemical Transduction in Extracellular Matrix offers the reader recent information in addition to models of how mechanical information is transduced into genetic and biochemical changes at the cellular and tissue levels. Mechanosensing and Mechanochemical Transduction in Extracellular Matrix is intended to serve as a textbook at the graduate and advanced undergraduate level in a biomedical engineering curriculum.
Mechanisms of mineralization of vertebrate skeletal and dental tissues
Presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues.
Mechanics of Elastic Structures with Inclined Members : Analysis of vibration, buckling and Bending of X-Braced Frames and Conical Shells
This monograph presents the mechanics of vibration, buckling and bending of elastic structures with inclined members such as x-braced high rise frames and conical shells. More than giving detailed derivations of basic equations.
Mathématiques, informatique, physique. Au fil des TIPE = Mathematics, computer science, physics : Throughout the TIPE projects
Presents nine cases in mathematics, physics, or computer science used in the competition. Each case study is accompanied by general remarks, commentary, a suggested outline, questions a jury might ask, and an explanation placing the case study's theme within its scientific context. The authors hope not only to assist CPGE students in their preparation but also to provide valuable support to teachers who have embraced this new pedagogical approach. Laurent Decreusefond and Alain Maruani, the pedagogical coordinators for the mathematics, computer science, and physics component of the TIPE, have made significant contributions to its design and implementation.
Mathematical Survey Lectures 1943-2004
This collection traces the career of Beno Eckmann, whose work ranges across a broad spectrum of mathematical concepts from topology and differential geometry through homological algebra to group theory. One of our most influential living mathematicians, Eckmann has been associated for nearly his entire professional life with the Swiss Federal Institute of Technology Zurich (ETH), as student, lecturer, professor, and professor emeritus.
Mathematical Models of Distribution Channels
In Chapters 1 and 2 the authors provide an introduction to the current, analytical literature on distribution channels, and they present an intuitively appealing prologue to the Channel Myths that are developed rigorously in later Chapters. In Chapters 3, 4, and 10 they extend the literature by ascertaining the relationship between the manufacturer-optimal wholesale-price strategy and channel breadth. Specific analyses include multiple, non-competing retailers, multiple states-of-nature, and multiple, competing retailers. In Chapters 5-7 the authors determine the profitability of various wholesale-price strategies; this analysis culminates in Chapters 8 and 9 with the determination of the (very limited) conditions under which channel coordination can be optimal for the manufacturer. In Chapter 11 they prove that existing methods of measuring the effect of a change in the degree of inter-retailer substitutability are totally misleading. They then develop an original, theoretical basis for measuring the impact of a change in the degree of inter-retailer substitutability that yields insightful, intuitively appealing results. In Chapter 12 the authors set forth an agenda for future research based on a meta-model that embraces all existing models in the literature. They also issue an appeal for creation of a "Unifying Theory of Distribution Channels" that will enable researchers to work independently and yet to contribute toward the common goal of deepening the marketing science professions’ understanding of distribution channels.
Iron metabolism : Methods and protocols
Explores classical and cutting-edge methods optimized and validated to analyze various aspects of iron metabolism, from in vitro to multi-organ level. Opening with a section on basic iron metabolism methods, the book continues with methods applicable to a variety of systems, ranging from bacteria to cultured mammalian cells and tissues, with a focus on cellular heme and iron-sulfur cluster species, as well as mitochondrial iron and its derivatives. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
