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Hot cracking phenomena in welds
The first chapter provides an overview of the various hot cracking phenomena. Different mechanisms of solidification cracking proposed in the past decades are summarized and new insight is particularly given into the mechanism of ductility dip cracking. The effects of different alloying elements on the hot cracking resistance of various materials are shown in the second chapter and, as a special metallurgical effect, the initiation of stress corrosion cracking at hot cracks has been highlighted. The third chapter outlines how numerical analyses and other modelling techniques can be utilized to describe hot cracking phenomena and how such results might contribute to the explanation of the mechanisms. Various hot cracking test procedures are presented in the final chapter with a special emphasis on standardization. For the engineering and natural scientists in research and development the book provides both, new insight and a comprehensive overview of hot cracking phenomena in welds. The contributions additionally give numerous individual solutions and helpful advice for international welding engineers to avoid hot cracking in practice. Furthermore, it represents a very helpful tool for upper level metallurgical and mechanical engineering students.
Hormonal Carcinogenesis IV
Uniquely, Hormonal Carcinogenesis IV, integrates salient aspects of hormone-related cancers of interest to epidemiologists, basic researchers, and clinicians. The most recent advances in the major hormone-related cancers are presented by leaders of their specialty. The chapters in this volume deal with the causation, dependence, and resistance of endocrine-related cancers with particular emphasis on the most common neoplasms occuring in men and woman world wide, such as breast, prostate, uterine, and ovarian cancers.
Hepatitis C Virus Disease
Emphasizes the most recent advances on the Hepatitis C virus infection (HCV) moving from basic research to clinical application. In spite of the numerous studies on HCV infection, its pathogenesis and medical treatment have not been fully explained. The first chapters of this volume analyize the full spectrum of immune responses to HCV taking into account either innate or adoptive immunity involvement. The volume also includes a series of contributions which explain the state of art of IFN-alpha treatment in HCV patients and the effectiveness of therapy also in relation to HCV genotypes. The use and applications of pegylated IFNs will also be discussed as well as the complicated HCV disease and its treatment. Hepatitis C Virus Disease: Immunobiology and Clinical Applications is an ideal volume for researchers, scientists, professionals, clinicians, physicians and graduate students in the fields of infectious disease, immunology, virology, microbiology, pharmacology and medicine.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Garlic Extract : Interaction with mechanisms of bacterial resistance
Garlic (Allium sativum) is a medicinal plant which has a diverse biological activities including antioxidant activity, antimicrobial activity, anticancer activity and others… In this article we are focusing on its antimicrobial effect which had been tested individually and in combination with two resisted antibiotics (Ampicillin, Ciprofloxacin) on 3 gram negative bacteria (Proteus mirabilis, klebsiella pneumoniae and Enterobacter aerogenes) to estimate the effect of garlic extract on the activity of the resisted drugs and bacterial resistance mechanism.
Fundamentals of Magnetism
In the last decade a tremendous progress has taken place in understanding the basis of magnetism, especially in reduced dimensions. In the first part, the fundamentals of magnetism are conveyed for atoms and bulk-like solid-state systems providing a basis for the understanding of new phenomena which exclusively occur in low-dimensional systems as the giant magneto resistance. This wide field is discussed in the second part and illustrated by copious examples. This textbook is particularly suitable for graduate students in physical and materials sciences. It includes numerous examples, exercises, and references.
Frontiers in civil and hydraulic engineering ; Vol.2 : Proceedings of the 8th International Conference on Architectural, Civil and Hydraulic Engineering (ICACHE 2022), Guangzhou, China, 12–14 August 2022
Focuses on the research of architecture and hydraulic engineering in civil engineering. The proceedings feature the most cutting-edge research directions and achievements related to civil and hydraulic engineering. Subjects in the proceedings including: Engineering Structure Intelligent Building Structural Seismic Resistance Monitoring and Testing Hydraulic Engineering Engineering Facility The works of this proceedings can promote development of civil and hydraulic engineering, resource sharing, flexibility and high efficiency.
Frontiers in civil and hydraulic engineering ; Vol.1 : Proceedings of the 8th International Conference on architectural, civil and hydraulic engineering (ICACHE 2022), Guangzhou, China, 12–14 August 2022
Focuses on the research of architecture and hydraulic engineering in civil engineering. The proceedings feature the most cutting-edge research directions and achievements related to civil and hydraulic engineering. Subjects in the proceedings including: Engineering Structure Intelligent Building Structural Seismic Resistance Monitoring and Testing Hydraulic Engineering Engineering Facility The works of this proceedings can promote development of civil and hydraulic engineering, resource sharing, flexibility and high efficiency.
From Bulk to Nano : The Many Sides of Magnetism
The field of magnetism is rapidly advancing in this new millennium, revealing an ever-wider diversity of magnetic phenomena on more than one scale. With the emergence of countless applications particularly on a nanoscale, and their unpredictable implications mostly on a macroscale, it may seem that different aspects of magnetism are unrelated. Quite often, the overwhelming amount of topics discussed in the professional literature views only parts of a field, ignoring a broader context. Therefore, the present book aims at addressing the relationship between apparently unconnected topics in magnetism. Less obvious relationships are revealed among individual fields on various scales, making them better understandable.
Focus on bacterial biofilms
Bacterial biofilms are colonies of bacterial cells embedded in their self-produced matrix composed of polysaccharides, DNA, and proteins. They protect bacterial cells against antibiotics, antibacterial agents, soaps and detergents, and shear stress. Some of the most common biofilm-associated infections in humans include urinary tract infections, infection of wounds and surgical sites, diabetic foot ulcers, dental caries (tooth decay) and gingivitis (gum inflammation), ventilator-associated infections, sinusitis, microbial keratitis, secondary infection related to Covid-19 and other viral infections, and so on. Bacterial resistance to common antibiotics (e.g., penicillin, gentamycin, erythromycin, ciprofloxacin, etc.) is driving us to a catastrophic failure of our health systems. Strategies to develop novel antibacterial agents and technology must be prioritized to combat and eradicate biofilms and their associated challenges. This book provides a comprehensive overview of biofilms with chapters on bacterial virulence factors, quorum sensing in bacteria, antimicrobial resistance in bacteria, strategies to develop new antibacterial agents, and much more.
Fire Safety for Very Tall Buildings : Engineering Guide
Provides information on special topics that affect the fire safety performance of very tall buildings, their occupants and first responders during a fire. This Guide addresses these topics as part of the overall building design process using performance-based fire protection engineering concepts as described in the SFPE Engineering Guide to Performance Based Fire Protection. This Guide is not intended to be a recommended practice or a document that is suitable for adoption as a code. The Guide pertains to “super tall,” “very tall” and “tall” buildings. Throughout this Guide, all such buildings are called “very tall buildings.” These buildings are characterized by heights that impose fire protection challenges; they require special attention beyond the protection features typically provided by traditional fire protection methods. This Guide does not establish a definition of buildings that fall within the scope of this document.
Feminist and LGBTI+ activism across Russia, Scandinavia and Turkey : Transnationalizing spaces of resistance
What do struggles for women’s and LGBTI+ rights in Russia, Turkey and the Scandinavian countries have in common? And what can actors who struggle for rights and justice in these contexts learn from each other? Based on a multisited ethnography of feminist and LGBTI+ activisms across Russia, Turkey and the Scandinavian countries, this Open Access book explores transnational struggles on various levels, from the micro-scale of the everyday to large-scale, spectacular events. Drawing on ethnographic insights and encounters from various sites, this book conceptualizes resistance as situated in the grey zone between barely perceptible, even hidden or covert, forms of mundane activist practices and highly visible street protests, gathering large crowds. Taking the reader beyond the dichotomies of visible/invisible and public/private, this book advances new understandings of resistance, solidarity, and activism in transnationalizing feminist and queer struggles, illustrated by rich ethnographic case studies from Russia, Scandinavia and Turkey.
Extracting Methods of Essential laurel oil and Fixed oil, Their effects on bacteria
Laurus nobilis is an evergreen plant belonging to the Lauraceae family, native to Southern Europe and the Mediterranean area. This is the report on the composition and bioactivity of laurel essential oil (EO) from leaves and extraction essential oil by two solvents (water and ethanol 69%) using by two devices (Clevenger and evaporator) then we apply the effect of oil and extract on the bacteria. there are some differences between the extraction by water and ethanol . The antibacterial properties of laurel EOs were examined according to the agar well diffusion method The leaf EO showed antibacterial activities against almost all strains of the microorganisms tested, whereas the twig EO was only able to inhibit Staphylococcus aurous and Escherichia coli were the bacterial strains that showed the highest resistance to the laurel EO. The results can benefit the EO industry and bio pesticide development.
Ethics and Intersex
The book begins with introductory chapters on the etiology of intersex conditions, conceptual clarification, legal issues, and reflections about the inherent characteristics of medical care that have led up to the issues we face today and explain the resistance to change in traditional practices. Researchers provide recent data on gender identity, surgical outcomes, and appropriate clinical care. Issues never having been addressed are introduced. The significance of intersexuality for Christianity and for philosophical concerns with authenticity add further depth to the collection. The final chapters deal with future possibilities in the treatment of intersex and for intersex advocacy.
Ethics and Drug Resistance : Collective Responsibility for Global Public Health
This book provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases.
Essential oils as antibacterial agents
An alarm increase in the rate of emerging of resistant bacteria have been causing a great public concern worldwide. This problem of increasing resistance has necessitated the search for safe and effective factors that may be used to treat persistent bacterial infections or modify the currently available antibiotics. An experimental approach, using agar diffusion method was used to estimate the antibacterial properties of 5 essential oils (cinnamon, clove, peppermint, rosemary and thyme) each one individually, in pure and commercial form, against 3 of the bacterial strains that cause common skin infections which are gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and gram positive bacteria (Staphylococcus aureus), obtained from clinical sources. Only two of the commercial oils had an antibacterial effect on both gram negative bacteria (E. coli) and gram positive bacteria (S. aureus) and in lesser extent on gram negative bacteria (P. aeruginosa).synergy.
Epigenetics in oncology
Covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years. Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
Entry Inhibitors in HIV Therapy
The introductory chapters of this book present an overview of entry inhibitors, review current knowledge of how Env mediates entry, and discuss the challenge of genetic diversity in this region of the viral genome. Subsequent chapters feature current information on individual classes of entry inhibitors that target each step of the virus entry pathway, from attachment to membrane fusion. There is an emphasis on the complex determinants of entry inhibitor susceptibility, resistance mechanisms, the need for clinical phenotyping, and how these issues create new challenges for antiretroviral therapy. Encouraging pre-clinical studies of entry inhibitors as microbicidesare also discussed. The final chapters highlight the current status of entry inhibitors in clinical studies, the major milestone achieved with FDA approval of enfuvirtide, and review drug development, past and present.
Energy Metabolism and Obesity : Research and Clinical Applications
Elucidate the most important aspects of genetic background, neuropeptide secretion and action, neuronal pathways, adipokines, gut hormones, and environmental influences (physical activity, pharmacologic agents, and surgical alteration of the gastrointestinal tract), as well as the complex interactions among them.
Efficient Screening Techniques to Identify Mutants with TR4 Resistance in Banana : Protocols
The Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture implemented a Coordinated Research Project (CRP) ‘Efficient Screening Techniques to Identify Mutants with Disease Resistance for Coffee and Banana” (2015-2020). This CRP brought together experts from Asia, Europe and Africa in addition to experts of the Joint FAO/IAEA Centre to develop resistance against TR4 through mutation-assisted breeding. Induced mutagenesis is particularly attractive in case of banana since most cultivated bananas are seedless, thus hampering conventional cross breeding
