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Geometric and Topological Methods for Quantum Field Theory
This volume offers an introduction, in the form of four extensive lectures, to some recent developments in several active topics at the interface between geometry, topology and quantum field theory. The first lecture is by Christine Lescop on knot invariants and configuration spaces, in which a universal finite-type invariant for knots is constructed as a series of integrals over configuration spaces. This is followed by the contribution of Raimar Wulkenhaar on Euclidean quantum field theory from a statistical point of view. The author also discusses possible renormalization techniques on noncommutative spaces. The third lecture is by Anamaria Font and Stefan Theisen on string compactification with unbroken supersymmetry. The authors show that this requirement leads to internal spaces of special holonomy and describe Calabi-Yau manifolds in detail. The last lecture, by Thierry Fack, is devoted to a K-theory proof of the Atiyah-Singer index theorem and discusses some applications of K-theory to noncommutative geometry. These lectures notes, which are aimed in particular at graduate students in physics and mathematics, start with introductory material before presenting more advanced results. Each chapter is self-contained and can be read independently.
Genomics of Disease
Genomics of Disease is the 24th volume in the Stadler Genetics Symposium series published by Springer, which has, over many years, served as a comprehensive collection of current trends and hot topics in the field of genetics. The current volume summarizes recent progress in our attempts to characterize the genomics of plant and animal diseases. Authoritative analytical reviews are specialized to be attractive to professional researchers, teachers, and students, while also being appealing to a wider audience of scientists in related disciplines. Genomics of Disease offers essential reference material for any scientist or teacher working in the fields of plant and animal diseases. Coverage of key areas of both animal and plant disease is a unique feature of this volume and one that allows direct comparisons between the systems. All academics, scientists, and industry professionals that desire to take advantage of the most up-to-date information on the continuously emerging and expanding field of the genomics of plant and animal diseases will find it an invaluable resource.
Génetique statistique = Statistical genetics
Presents the main statistical tools useful in genetics: significance tests, analysis methods based on the likelihood function, EM algorithm, modeling, analysis of variance, hierarchical classifications, multiple comparisons, etc. All of them shed light on a number of biological phenomena such as carcinogenesis, population genetics, Hardy-Weinberg equilibrium, natural selection, mutations, heredity, coalescence processes, and even evolution. This book is intended for mathematicians and biologists alike. Written with a great concern for clarity, it is also accessible to non-specialists who will be able, thanks to it, to strengthen their theoretical base and above all to develop their know-how through very concrete applications.
Genetics of Adaptation
What is the genetic basis of adaptive evolution? In this volume, a new generation of biologists have taken up this challenge. Using advances in both molecular genetic and statistical techniques, evolutionary geneticists have made considerable progress in this emerging field. In this volume, a diversity of examples from plant and animal studies provides valuable information for those interested in the genetics and evolution of complex traits.
Genetic testing in reproductive medicine
Illustrates the importance and significance of molecular genetic testing in reproductive disorders. The present book covers the genetic testing in various reproductive system anomalies, including disorders of sexual development, male infertility (Y deletions, autosomal mutations, sperm DNA fragmentation), female infertility (PCOS and POF), mitochondrial DNA testing for oocyte quality, recurrent pregnancy loss, pre-term birth, endometrial receptivity, prenatal genetic screening, reproductive carrier screening, preimplantation genetic screening, endometrial cancer, cervical cancer and other related reproductive health disorders. Microbiome testing and its contribution to genetic testing in reproductive medicine are also discussed. Covers ethical, moral and technical challenges in genetic testing in reproductive medicine. The book aims to set up a standard with regard to genetic testing in the reproductive medicine field, encourage further data generation, and provide food for thought in the areas of lacunae.
Genes, development, and cancer : The life and work of Edward B. Lewis
Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one volume.
Gap Junctions in Development and Disease
Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed.
Galactose Regulon of Yeast : From Genetics to Systems Biology
The galactose regulon of yeast is one of the best studied regulons. It is an ideal paradigm for demonstrating fundamental and evolving concepts in biology and is used in this book as a model system to explain various facets of conventional and modern biology. The book starts with a brief historical overview on yeast research, i.e. early observations in enzyme adaptation, classical genetics, formulating hypotheses based on genetic inference. This is followed by molecular genetics of the galactose regulon, isolation of genes and testing of the hypotheses. The power of mutational analysis in deciphering molecular mechanisms is conveyed. Further, contemporary topics such as genomics, evolution, single cell analysis of transcriptional switching, binary and graded responses, biological consequences of feed back regulation in genetic circuits, and stochasticity are addressed.
Frontiers in Number Theory, Physics, and Geometry I : On Random Matrices, Zeta Functions, and Dynamical Systems
This book presents pedagogical contributions on selected topics relating Number Theory, Theoretical Physics and Geometry. The parts are composed of long self-contained pedagogical lectures followed by shorter contributions on specific subjects organized by theme. Most courses and short contributions go up to the recent developments in the fields; some of them follow their author?s original viewpoints. There are contributions on Random Matrix Theory, Quantum Chaos, Non-commutative Geometry, Zeta functions, and Dynamical Systems. The chapters of this book are extended versions of lectures given at a meeting entitled Number Theory, Physics and Geometry, held at Les Houches in March 2003, which gathered mathematicians and physicists.
From Vectors to Tensors
It is true that there exist many books dedicated to linear algebra and some what fewer to multilinear algebra, written in several languages, and perhaps one can think that no more books are needed. However, it is also true that in algebra many new results are continuously appearing, different points of view can be used to see the mathematical objects and their associated structures, and different orientations can be selected to present the material, and all of them deserve publication. he book assumes a certain knowledge of linear algebra, and is intended as a textbook for graduate and postgraduate students and also as a consultation book. It is addressed to mathematicians, physicists, engineers, and applied scientists with a practical orientation who are looking for powerful tensor tools to solve their problems.
From Geometry to quantum mechanics : In Honor of Hideki Omori
This volume is composed of invited expository articles by well-known mathematicians in differential geometry and mathematical physics that have been arranged in celebration of Hideki Omori's recent retirement from Tokyo University of Science and in honor of his fundamental contributions to these areas.The papers focus on recent trends and future directions in symplectic and Poisson geometry, global analysis, infinite-dimensional Lie group theory, quantizations and noncommutative geometry, as well as applications of partial differential equations and variational methods to geometry.
Frobenius Splitting Methods in Geometry and Representation Theory
The theory of Frobenius splittings has made a significant impact in the study of the geometry of flag varieties and representation theory. This work, unique in book literature, systematically develops the theory and covers all its major developments.
Free-Radical-Induced DNA Damage and Its Repair : A Chemical Perspective
Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.
Fourier Transforms of Invariant Functions on Finite Reductive Lie Algebras
In this book the author studies Fourier transforms using Deligne-Lusztig induction and the Lie algebra version of Lusztig’s character sheaves theory. He conjectures a commutation formula between Deligne-Lusztig induction and Fourier transforms that he proves in many cases. As an application the computation of the values of the trigonometric sums (on reductive Lie algebras) is shown to reduce to the computation of the generalized Green functions and to the computation of some fourth roots of unity.
Forecasting and Assessing Risk of Individual Electricity Peaks
The overarching aim of this open access book is to present self-contained theory and algorithms for investigation and prediction of electric demand peaks. A cross-section of popular demand forecasting algorithms from statistics, machine learning and mathematics is presented, followed by extreme value theory techniques with examples.
Fast software encryption ; 15th International Workshop, FSE 2008, Lausanne, Switzerland, February 10-13, 2008, Revised Selected Papers
Constitutes the thoroughly refereed proceedings of the 15th International Workshop on Fast Software Encryption, FSE 2008, held in Lausanne, Switzerland in February 2008.The 26 revised full papers presented together with 4 short papers were carefully reviewed and selected from 72 submissions. The papers address all current aspects of fast and secure primitives for symmetric cryptology and are organized in topical sections on SHA collisions, new hash function designs, block cipher cryptanalysis, implementation aspects, hash function cryptanalysis, stream cipher cryptanalysis, security bounds, and entropy.
Familial mediterranean fever
Familial Mediterranean Fever (FMF), a genetic disorder causing recurrent inflammatory attacks. It delves into various aspects of FMF, including: Definition and historical background of FMF Underlying causes, signs, and symptoms of the disease Modes of transmission through autosomal recessive inheritance Diagnostic methods encompassing genetic, urine, blood, and imaging tests, emphasizing the significance of early diagnosis The link between FMF and amyloidosis, a serious complication...
Exercises in Modules and Rings
This Problem Book offers a compendium of 639 exercises of varying degrees of difficulty in the subject of modules and rings at the graduate level. The material covered includes projective, injective, and flat modules, homological and uniform dimensions, noncommutative localizations and Goldie’s theorems, maximal rings of quotients, Frobenius and quasi-Frobenius rings, as well as Morita’s classical theory of category dualities and equivalences. Each of the nineteen sections begins with an introduction giving the general background and the theoretical basis for the problems that follow. All exercises are solved in full detail; many are accompanied by pertinent historical and bibliographical information, or a commentary on possible improvements, generalizations, and latent connections to other problems.
Evolutionary Computation in Practice
This book is loaded with examples in which computer scientists and engineers have used evolutionary computation—programs that mimic natural evolution—to solve real problems. They aren’t abstract, mathematically intensive papers, but accounts of solving important problems, including tips from the authors on how to avoid common pitfalls, maximize the effectiveness and efficiency of the search process, and many other practical suggestions.
Evolutionary Computation for Modeling and Optimization
Evolutionary Computation for Optimization and Modeling is an introduction to evolutionary computation, a field which includes genetic algorithms, evolutionary programming, evolution strategies, and genetic programming. The text is a survey of some application of evolutionary algorithms. It introduces mutation, crossover, design issues of selection and replacement methods, the issue of populations size, and the question of design of the fitness function. It also includes a methodological material on efficient implementation. Some of the other topics in this book include the design of simple evolutionary algorithms, applications to several types of optimization, evolutionary robotics, simple evolutionary neural computation, and several types of automatic programming including genetic programming. The book gives applications to biology and bioinformatics and introduces a number of tools that can be used in biological modeling, including evolutionary game theory. Advanced techniques such as cellular encoding, grammar based encoding, and graph based evolutionary algorithms are also covered.
