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Capacity options for revenue management : Theory and applications in the air cargo industry
Hellermann addresses in his dissertation one of the most interesting - pects of this evolution for OR/MS, the parallel development of long-term and short-term markets for capacity and output, accompanied by a range of option and ?xed-commitment (i. e. , forward) contracts as the basic mec- nisms supporting transactions. This has been a fascinating topic for OR/MS research because it builds on the powerful framework of real options, while connecting directly to key operations decisions (capacity planning, network design, staf?ng, routing, maintenance, and so forth) of the equipment and technologies whose output is the focus of contracts.
Cancer Prevention
This volume contains the main proceedings of the fourth international conference on "Cancer Prevention 2006," which was held during February 16–18, 2006, in St. Gallen, Switzerland. Written by international experts in the field, the book comprises a comprehensive update on the most recent developments in the upsurging fields of molecular biology and cancer genetics and their interactions with clinical epidemiology and cancer prevention at various levels: genetic/biologic predisposition and definition of high-risk groups; preclinical models and tumor prevention; prospects of surrogate endpoints and biomarkers; progress in imaging and detection of neoplastic precursor lesions.
Cancer immunotherapy : Methods and protocols
Details multiple areas of new and emerging methods to develop the next generation of immunotherapy treatments. Chapters guide readers through analysis and characterisation of the interactions between tumour and immune cells, and cell engineering tools for cancer treatment, to provide a unique and compelling set of techniques instrumental to work with, and engineer, immune cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Cancer : Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related.
Business process management Workshops ; BPM 2007 International Workshops, BPI, BPD, CBP, ProHealth, RefMod, semantics4ws, Brisbane, Australia, September 24, 2007, Revised Selected Papers
This book constitutes the thoroughly refereed post-workshop proceedings of 6 internationl workshops held in Brisbane, Australia, in conjunction with the 5th International Conference on Business Process Management, BPM 2007, in September 2007.
Business Plan: Telepherique Du Bludan
Telepherique Du Bludan is one of the most prominent tourist attractions that targets tourists and visitors from all over the world and it’s a unique and unconventional experience. Bludan area has a strategic location and we should give it more spotlights since it has a wonderful weather in the winter and in the summer, In order to stimulate domestic tourism, we have implemented a project to construct a cable car in the Bludan area in an entertainment complex, and this is something that does not exist in Syria and encourages tourism in the winter to transport people to heights for the possibility of enjoying snow and practicing snow activities, and in summer it can be used to transport people to the top of the height and get a beautiful view in great weather And enjoyment in outdoor activities that are not found in Syria, and this adds a competitive advantage to our project.
Building construction : From principle to detail ; Vol.1 : Fundamentals
Construction is the means by which designing architects and engineers transform a design idea into built reality. It is from this perspective that the subject of 'building construction design' is dealt with by the architect José Luis Moro in three comprehensive volumes. Each is dedicated to the methodological, physical and functional fundamentals, the conception of a constructional solution, and finally its implementation in the constructional detail. Not only do the three volumes provide extensive content; they also ensure the greatest possible clarity in the text and graphics, in order to make it easier for learners to access the material. Importantly, they focus not only on conveying technical and scientific information, but also on demonstrating the complex relationships and interactions between design, material and construction.
Building a Cashless Society : The Swedish Route to the Future of Cash Payments
This book tells the story of how Sweden is becoming a virtually cashless society. Its goal is to improve readers’ understanding of what is driving this transition, and of the factors that are fostering and hampering it. In doing so, the book covers the role of central banks, political factors, needs for innovation, and the stakeholders involved in developing a cashless ecosystem. Adopting a historical standpoint, and drawing on a unique dataset, it presents an academic perspective on Sweden’s leading role in this global trend. The global interest in the future of cash payments makes the Swedish case particularly interesting. As a country that is close to becoming a cashless economy, it offers a role model for many other countries to learn from - whether they want to stimulate or reduce the use of cash. This highly topical book will be of interest to politicians, researchers, businesses, financial service providers and payment service providers, as well as fintech start-ups, regulators and other authorities.
Breaking ocean waves : Geometry, structure and remote sensing
This book represents the most comprehensive description of the physical findings of an investigation into the spatio-temporal characteristics of the gravity of breaking waves and the foam activity in open sea by methods and instruments of optical and microwave remote sensing. Much emphasis is placed on the physical aspects of breaking processes necessary to measure the possibilities and limitations of remote sensing methods in specific observation cases of an oceanic surface. Numerous practical applications and illustrations are provided from air-borne, ship-borne and laboratory up-to-date experiments.
Blockchains For Network Security : Principles, technologies and applications
Blockchain technology is a powerful, cost-effective method for network security. Essentially, it is a decentralized ledger for storing all committed transactions in trustless environments by integrating several core technologies such as cryptographic hash, digital signature and distributed consensus mechanisms. Over the past few years, blockchain technology has been used in a variety of network interaction systems such as smart contracts, public services, Internet of Things (IoT), social networks, reputation systems and security and financial services. With its widespread adoption, there has been increased focus on utilizing blockchain technologies to address network security concerns and vulnerabilities as well as understanding real-world security implications.
Blockchain and Other Emerging Technologies for Digital Business Strategies
Aims to explore the aspects of strategic leadership in a digital context together with the cyber-physical relationships whilst performing business activities. Furthermore, this book looks to investigate the interactions from both the organization strategy including the cross-functional actors/stakeholders whom are operating within the organization and the various characteristics of operating in a cyber secure ecosystem.
Bisphosphonates in medical practice : Actions - side effects - indications - strategies
Clinical osteology is now an independent specialty which nevertheless encompasses all branches of medicine and effects each and every one of us: Bone is Every Body´s Business: This book has been designed as an up to date manual to deal with the currently recognized indications for bisphosphonates, to outline situations and conditions for prevention of skeletal disorders, and to provide practical guidelines for treatment. It is intended for doctors who seek precise information on bisphosphonates in medical practice to enable them to treat patients with disorders of bone or better still to avoid their occurrence .
Bird species : How they arise, modify and vanish
The average person can name more bird species than they think, but do we really know what a bird “species” is? This open access book takes up several fascinating aspects of bird life to elucidate this basic concept in biology. From genetic and physiological basics to the phenomena of bird song and bird migration, it analyzes various interactions of birds – with their environment and other birds. Lastly, it shows imminent threats to birds in the Anthropocene, the era of global human impact.This book brings together various disciplines involved in observing bird species come into existence, modify, and vanish. It is a rich resource for bird enthusiasts who want to understand various processes at the cutting edge of current research in more detail. At the same time it offers students the opportunity to see primarily unconnected, but booming big-data approaches such as genomics and biogeography meet in a topic of broad interest. Lastly, the book enables conservationists to better understand the uncertainties surrounding “species” as entities of protection.
Biosolids treatment processes ; Vol.6
The past 30 years have seen the emergence of a growing desire worldwide to take positive actions to restore and protect the environment from the degrading effects of all forms of pollution: air, noise, solid waste, and water. The Handbook of Environmental Engineering series guides readers to answer the fundamental questions facing pollution in the modern era – How serious is pollution? Is the technology needed to abate it not only available, but feasible? Among the topics included in this, the sixth edition, are: biosolids, flotation thickening, anaerobic and aerobic digestion, pressurized ozonation, lime stabilization, elutriation and polymer conditioning, and animal waste treatment.
Biophotonics
More profound understanding of the nature of light and light-matter interactions in biology has enabled many applications in the biology and medical fields. So a new discipline is born, namely biophotonics. The aim of this book is to review the current state-of-the-art of the field by means of authoritative chapters written by the world leaders of the respective fields. Biosensors, biochips, optical tomography, optical microsurgery, photodynamics therapy, bioactivation of gene, photobiology of skin, and nanobiophotonics are each introduced and recent advances presented. This book will be useful not only to physicians, biologists, physicists, chemists, materials scientists, and engineers but also to graduate students who are interested in these rapidly developing fields.
Biological nitrogen fixation : Towards poverty alleviation through sustainable agriculture ; Proceedings of the 15th International nitrogen fixation congress and the 12th International Conference of the African Association for Biological Nitrogen Fixation
This volume covers recent developments in both fundamental and applied research in biological nitrogen fixation. It emphasizes the application of biological nitrogen fixation for sustainable agriculture, which should lead to poverty alleviation, environmental protection, and good agricultural practices generally. The roles of, and advances in, plant breeding, plant molecular biology, nodule physiology, and symbiotic and associative interactions between plants and microbes in sustaining agricultural productivity and soil fertility are described. The evolution of symbioses and nitrogen fixation are also covered in this volume. To ensure high agricultural productivity, while protecting the environment (both soil and water resources), requires plant cultivars that also respond to beneficial microbes.
Biological mechanisms of tooth movement ; 3rd ed.
Cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
Biological Basis of Geriatric Oncology
Biological Basis of Geriatric Oncology highlights research issues that are specific to geriatric oncology in the field of carcinogenesis and cancer prevention and treatment, based on the biologic interactions of cancer and age. It illustrates the benefit of the principles of geriatrics in the management of cancer in the older individual.
Bioinformatics tools for pharmaceutical drug product development
Presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. And include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall.
