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Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Enzymes and drugs
Enzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs. Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting. Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances.
Environmental and Microbial Relationships
After the publication of Volume IV in 1997, the introduction of molecular methods into ecology led to significant new findings. Emphasizing these advances, the chapters for the second edition have been completely updated and revised. This volume provides insight into current research on fungal populations and communities. It focuses on fungal responses to the physical environment, interactions with other fungi, microorganisms and invertebrates, the role of fungi in ecosystem processes such as decomposition and nutrient cycling, and aspects of biogeography and conservation. Several chapters deal with various applications in, e.g. biological pest control, natural products discovery, and the degradation of toxic organic compounds. This is an invaluable source of information both for scientists who wish to update their knowledge of current progress and for graduate students interested in obtaining a first overview of this field of research.
ENT : An introduction and practical guide
provides an essential introduction to the clinical examination, treatment options and surgical procedures within ENT. It encompasses the most frequently encountered conditions in the emergency setting, on the ward and in the outpatient clinic. The text has been updated to include new content on implantation surgery for hearing loss. It also includes significant changes in the indications for surgery, patient assessment, management, and surgical techniques. The subjects of dizziness and vertigo have also been updated to include novel interventions.
English Linguistics : Essentials
It serves both as an introduction for beginners and as a companion for more advanced undergraduate and graduate students, familiarizing its readers with the major and distinctive properties of English (Standard English as well major national, regional and social varieties), including an in-depth structural comparison with German.
English grammar : The basics
English Grammar: The Basics offers a clear, non-jargonistic introduction to English grammar and its place in society.
English for Business Communication
Key features of this book include: use of English in social media that reflects recent trends in business communication; coverage of the concept of communicative competence; analysis of email communication; introduction to informal English and English for socialisation as well as goodwill messages, such as thank you or appreciation messages, which are a part of everyday interaction in the workplace; examination of persuasive messages and ways to understand such messages.
Engineering mechanics 2 : Strength of materials : An introduction with many examples
Provides students with a clear introduction and to enable them to formulate and solve engineering problems in this field. For this purpose, the book provides a number of examples. The Contents : Introduction to linear elasticity – Plane stress state – Bars – Beams – Beam deflections – Shear stresses in beams – Torsion – Energy methods – Buckling of bars
Engineering for Sustainable Development : Theory and Practice
Offers a wide range of civil, mechanical, electrical, and chemical engineering industry applications. Readers will also benefit from: A thorough introduction to contemporary sustainability challenges in the engineering discipline Comprehensive discussions of sustainability assessment tools, including triple bottom line assessment (TBL) and the environmental life cycle assessment (LCA) In-depth examinations of sustainable engineering strategies, including cleaner production and eco-efficiency methods and environmental management systems Detailed review of green engineering principles and industrial symbiosis in engineering application. A link between product stewardship and the design for the environment
Engineering and health in compressed air work : Proceedings of the 2nd International conference on engineering and health in compressed air Work held at St Catherine's College, Oxford, from 25th to 27th September, 2002
Presents the proceedings of theSecond International Conference on Engineering and Health in Compressed Air Work, Heald at St Catherine's College, Oxford from 25th to 27th September 2002. The 35 papers in this volume cover a range of subjects, including experience with oxygen decompressionnin the UK and research related tothe introduction of oxygen decompression, which will be of interest to everyone involved with the engineering, medical or regulatory aspects of compressed air working and all those with an interest in hyperbaric exposure.
Energy methods in structural mechanics : A comprehencive introduction to matrix and finite element methods of analysis
Provides a basic and clear introduction to the principles underlying finite elements and the computer based methods of the analysis of structures commonly used in industry. There can be a danger that, without such an understanding, engineers will use these computer based analysis tools as black boxes and accept results without being aware of the real significance of the information obtained.
Enabling Technologies for Wireless E-Business
Kou and Yesha and their contributors provide comprehensive information on these technologies, including, for example, wireless security, mobile payment, location-based services, mobile data management, and RFID technologies. The presentation is targeted at students, lecturers, e-business developers, consultants, and business managers, and this book is an ideal introduction for both self-study and taught e-business classes or commercial training courses.
Employment Deconcentration in European Metropolitan Areas : Market Forces versus Planning Regulations
Spatial deconcentration of economic activities, particularly the growth of suburban office, retail and entertainment concentrations, has become a prime concern in European metropolitan areas. This book provides a cross-national comparative perspective on employment deconcentration within selected metropolitan areas in Europe. Whereas most debate over urban sprawl and deconcentration is oriented towards the North American context, this book aims at a better understanding of this phenomenon in the European context, emphasizing the location of economic activities rather than residential patterns. It provides insights on whether different governance attributes produce particular forms of deconcentration versus the influence of market attributes and local specificities, also commenting on quality of life impacts and possible governance and policy implications of the deconcentration process. Introduction of a comparative framework is followed by eight case study chapters, three representing northern Europe, three the southern European-Mediterranean region and two post-communist central Europe. Most chapters examine two metropolitan areas, usually a large one and a smaller one. The comparison reveals considerable variations in the magnitude, form, and process of employment deconcentration, only partly in line with expected influences of governance systems. Evidence does not fully confirm an anticipated distinction between Northern and Mediterranean Europe; the Czech Republic and Israel seem to diverge most from prevailing European trends.
Emergency Vascular Surgery : A Practical Guide
The book provides detailed guidelines to any physician treating patients with emergency vascular disorders, such as ruptured abdominal aortic aneurysms, acute limb ischemia, vascular trauma, iatrogenic vascular injuries and complications to vascular surgery. It provides an introduction to vascular surgical operations and focuses on how to manage patients from the emergency ward through the urgent operation and all the way to the immediate postoperative period. Numerous figures illustrate the particular points in vascular techniques and diagnostic problems in the emergency situation.
Embedded System Design : Embedded Systems Foundations of Cyber-Physical Systems, and the Internet of Things
A unique feature of this open access textbook is to provide a comprehensive introduction to the fundamental knowledge in embedded systems, with applications in cyber-physical systems and the Internet of things. It starts with an introduction to the field and a survey of specification models and languages for embedded and cyber-physical systems
Embedded System Design
Embedded System Design starts with an introduction into the area and a survey of specification languages for embedded systems. A brief overview is provided of hardware devices used for embedded systems and also presents the essentials of software design for embedded systems. Real-time operating systems and real-time scheduling are covered briefly. Techniques for implementing embedded systems are also discussed, using hardware/software codesign. It closes with a survey on validation techniques. Embedded System Design can be used as a text book for courses on embedded systems and as a source which provides pointers to relevant material in the area for PhD students and teachers. The book assumes a basic knowledge of information processing hardware and software.
Embedded Robotics : Mobile Robot Design and Applications with Embedded Systems
The EyeBot controller and mobile robots have evolved over more than a decade. This book gives an in-depth introduction to embedded systems and autonomous mobile robots, using the EyeBot controller (EyeCon) and the EyeBot mobile robot family as application examples. This book combines teaching and research material and can be used for courses in Embedded Systems as well as in Robotics and Automation.
Embedded Firmware Solutions : Development Best Practices for the Internet of Things
Embedded Firmware Solutions is the perfect introduction and daily-use field guide--for the thousands of firmware designers, hardware engineers, architects, managers, and developers--to Intel’s new firmware direction (including Quark coverage), showing how to integrate Intel® Architecture designs into their plans. Featuring hands-on examples and exercises using Open Source codebases, like Coreboot and EFI Development Kit (tianocore) and Chromebook, this is the first book that combines a timely and thorough overview of firmware solutions for the rapidly evolving embedded ecosystem with in-depth coverage of requirements and optimization.
EM Modeling of Antennas and RF Components for Wireless Communication Systems
The book focuses on the practical aspects of computational electrodynamics. A short review of electromagnetic field theory and an illustrative introduction to basic concepts of numerical methods provide the mathematical and physical background. The main part the book guides the reader step-by-step through the modelling process: from the initial "what question shall the model answer?", through the setting up of a computer model by creating geometry, boundary conditions, sources, …, to post processing, validation, and optimization. A number of antenna and filter examples demonstrate the advantages and disadvantages of different numerical methods. So the book provides a realistic view on the capabilities and limits of state-of-the-art 3D-field simulators and on how to apply this knowledge efficiently to EM analysis and designing of RF applications in modern communication systems.
Elisha Bartletts Philosophy of Medicine
This volume is a scholar's edition of the first systematic American work on the philosophy of medicine, An Essay on the Philosophy of Medical Science (Philadelphia, 1844), by Elisha Bartlett (1804-1855). The book is divided into two parts: Part I consists of a critical introduction that gives a biographical sketch of Elisha Bartlett and situates his empiricist philosophy of medicine within the philosophical debates of the various theoretical schools of medical practice of early nineteenth-century America. Short summaries of Bartlett's other writings and important addresses are presented, and many of the reviews of Bartlett's work that appeared in the medical journals of his time are discussed Also, the influence of the Paris clinical school on Bartlett's philosophy is shown. Part II contains the Essay, and includes a previously unpublished manuscript of Bartlett's philosophy of therapeutics, which develops some of the ideas of the Essay and adds another facet to Bartlett's philosophy of medicine.
