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Progress in the Chemistry of Organic Natural Products 108
It summarizes current trends in research on medicinal plants in Mexico with emphasis on work carried out at the authors' laboratories. The most relevant phytochemical and pharmacological profiles of a selected group of plants used widely for treating major national health problems are described. It is also provides a detailed survey of the so far reported literature data on the capacities of selected oxyprenylated phenylpropanoids and polyketides to trigger receptors, enzymes, and other types of cellular factors for which they exhibit a high degree of affinity and therefore evoke specifice responses.It discusses aspects of endophytic actinobacterial biology and chemistry, including biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives fo the future of microbial biodiscovery, with emphasis on the seondary metabolism of endophytic actinobacteria.
Prebiotic Chemistry : From Simple Amphiphiles to Protocell Models
Fve areas are covered in this special volume of Topics in Current Chemistry: The prebiotic chemistry of simple amphiphilic molecules and their selfassembly into compartmentalized structures, The prebiotic chemistry of nucleobases, nucleotides and oligonucleotides as essential elements of the hypothetical “RNA-world” and its relation to the proposed “pre-RNA-world(s), The prebiotic chemistry of amino acids and peptides; The possible prebiotic origin of homochirality; and , The possible formation of protocellular structures .
Pharmaceutical biotechnology : fundamentals and applications
This introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field.
Pharmaceutical biotechnology : fundamentals and applications
Explains both basic science and applications of pharmaceutical biotechnology / Complete one-stop source for students and professionals / Explains both the basic science and the applications of biotechnology derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those who did not receive formal training in this field. Pharmaceutical Biotechnology: Fundamentals and Applications, Fifth Edition completely updates the previous edition, and includes additional coverage on newer approaches such as oligonucleotides, mi/siRNA, gene therapy and advanced therapeutics.
Peptidomics : Methods and strategies
Explores essential techniques and newly emerged applications used in the expanding field of peptidomics. The opening chapters describe sample preparation and basic techniques. Subsequent chapters delve into quantitative peptidomics, bioinformatics, deep learning approaches, non-human model organisms, and peptide toxins. The last section includes multiple chapters on applications of peptidomics for human clinical specimens. Written for the highly successful Methods in Molecular Biology series, chapters include overviews and introductions to their respective topics, lists of the necessary materials, reagents, and instrumentation, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Peptide therapeutics : Fundamentals of design, development, and delivery
Explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. The book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides.
Peptide science : Chemical ligation, lead Generation, and therapeutic advances
Peptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals. Overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it’s a must-own for anyone looking to understand a vital field of chemistry.
Peptide Hybrid Polymers
The editors and authors provide an overview of the state-of-the-art in a burgeoning area that merges the controlled … activity of one of Nature’s main class of polymers–proteins and peptides–with the more traditional chemistry of synthetic polymers. this volume nicely introduces the researcher and student to the area of peptide polymer hybrids and outlines the areas of synthesis and self-assembly as well as potential medical applications. This is a fast developing area of interdisciplinary research, and this volume sets the scene well.
Pathogenesis of periodontal diseases : Biological concepts for clinicians
Provides clinicians with a refined understanding of the biology that underlies periodontal diseases, thereby offering a sound basis for improved clinical decision making with regard to prevention strategies, diagnosis, and therapy. All significant aspects of periodontal pathogenesis are covered, including the roles played by the oral microbiome and biofilms, bacterial virulence factors, cells of the immune system, matrix metalloproteinases, proinflammatory and osteolytic cytokines, genetic factors, and antimicrobial peptides.
Oxidative Damage to Nucleic Acids
This book provides an up-to-date coverage of selected topics in the area of nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.
Orphan G Protein-Coupled Receptors and Novel Neuropeptides
Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms.The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.
Organocatalysis
Due to the emergence of organocatalysis as a highly active and very exciting field of research both in academia and the life sciences industry, an Ernst Schering Research Foundation Symposium was organized in 2007 to bring together the scientific leaders in this field and to discuss the basics and current progress of organocatalysis and its application in drug discovery. Various aspects of organocatalysis are addressed in this volume, covering a broad range of synthetic transformations such as functional group interconversions as well as CC- and CX-bond formations and their applications in natural product and drug syntheses. In addition, the design and scope of various catalyst systems are discussed, from small molecules, to peptides, to genetically engineered enzymes.
Organic Chemistry ; 9th ed.
Structure and Bonding / Polar Covalent Bonds; Acids and Bases / Organic Compounds: Alkanes and Their Stereochemistry / Organic Compounds: Cycloalkanes and Their Stereochemistry / Stereochemistry at Tetrahedral Centers / An Overview of Organic Reactions / Alkenes: Structure and Reactivity / Alkenes: Reactions and Synthesis / Alkynes: An Introduction to Organic Synthesis / Organohalides / Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations / Structure Determination: Mass Spectrometry and Infrared Spectroscopy / Structure Determination: Nuclear Magnetic Resonance Spectroscopy / Conjugated Compounds and Ultraviolet Spectroscopy / Benzene and Aromaticity / Chemistry of Benzene: Electrophilic Aromatic Substitution / Alcohols and Phenols / Ethers and Epoxides; Thiols and Sulfides / Aldehydes and Ketones: Nucleophilic Addition Reactions / Carboxylic Acids and Nitriles / Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions / Carbonyl Alpha-Substitution Reactions / Carbonyl Condensation Reactions / Amines and Heterocycles / Biomolecules: Carbohydrates / Biomolecules: Amino Acids, Peptides, and Proteins / Biomolecules: Lipids / Biomolecules: Nucleic Acids / The Organic Chemistry of Metabolic PathwaysOrbitals and Organic Chemistry: Pericyclic Reactions Synthetic / Polymers
Nuucleic acids in medicinal chemistry and chemical biology : Drug development and clinical applications
Delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders : from Genes to Therapeutics
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Novel Carrier Systems for Targeted and Controlled Drug Delivery
Presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers.
Neuronal cell death : Methods and protocols
Covers comprehensive methods on ways to assess structural and ultrastructural changes in the mitochondria, cytoskeleton, and microglia using state-of-the-art microscopy techniques including super-resolution imaging, electron microscopy, and ultra-high field MRI. The chapters in this book cover topics such as analysis of neurodegeneration in the post-mortem characterization of preclinical animal models, in vivo modeling in cell death in different model systems and brain organoids, single cell clonal analysis using Mosaic Analysis with Double Markers in genetic mouse models, and genome and proteomic methods for analysis of mRNA dynamics and quantitation of targeted peptides.
Natural poisons and venoms: Plant toxins : Polyketides, phenylpropanoids and further compounds
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natriuretic Peptides : The Hormones of the Heart
The rapid knowledge in the field of neuro-humoral regulation of cardiovascular pathophysiology is changing the picture of current diagnosis and treatment of cardiac patients. The emerging conceptual revolutionary idea is that heart acts not as a pump, merely, but as a "gland", that is as a regulator of circulatory homeostasis and salt-water balance. Cardiovascular pathophysiology has to be written, indeed, on this basis: this physiology textbook gives an up-to-date description of the complexity and novelty of actual knowledge, with all its potential clinical implications.
Nanoparticle-Based Drug Delivery in Cancer Treatment
Discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Focuses on : Recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Material platforms that establish NPs and both localized and controlled gene silencing The most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment The most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells
