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Therapeutic Antibodies
Antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions and are becoming the molecules of choice for further combination therapies and cell engineering. Current developments and clinical successes are summarised by experts in the drug development field. A must read for immunologists, clinical scientists and novel drug developers.
The Pain Management Workbook : Powerful CBT and Mindfulness Skills to Take Control of Pain and Reclaim Your Life
You'll find a comprehensive outline of this effective biopsychosocial approach, as well as scientifically supported interventions rooted in cognitive- behavioral therapy (CBT), mindfulness, and neuroscience to help you take control of your pain--and your life! You'll learn strategies for creating a pain plan for home and work, reducing reliance on medications, and breaking the pain cycle. Also included are tips for improving sleep, nutrition for pain, methods for resuming valued activities, and more.
The Metabolic Syndrome and Obesity
The Metabolic Syndrome and Obesity presents an up-to-date survey of the current scientific understanding of obesity and the metabolic syndrome, as well as an overview of the most significant changes to the field over the past 30 years. By first presenting a historical context for overweight, the book drives home the point that obesity is by no means simply a contemporary problem, and its continued existence means that we neither understand it, nor have developed effective therapies. The Metabolic Syndrome and Obesity is a comprehensive reference for the treatment of obesity in two parts. Part I, The Problem, examines the entire scope of the obesity epidemic, including epidemiology and history, costs of treatment, pathology, clinical types, age-related issues, and general health risks. Part II, The Solutions, describes several treatment options including diet, behavior modification, exercise, pharmacological treatment, and surgery. This volume is a thorough reference for obesity and the metabolic syndrome and offers an in-depth assessment of the problem and its myriad potential treatment options.
The Evaluation of Surrogate Endpoints
Both humanitarian and commercial considerations have spurred intensive search for methods to reduce the time and cost required to develop new therapies. The identification and use of surrogate endpoints, i.e., measures that can replace or supplement other endpoints in evaluations of experimental treatments or other interventions, is a general strategy that has stimulated both enthusiasm and skepticism. Surrogate endpoints are useful when they can be measured earlier, more conveniently, or more frequently than the "true" endpoints of primary interest.This book offers a balanced account on this controversial topic. The text presents major developments of the last couple of decades, together with a unified, meta-analytic framework within which surrogates can be evaluated from several angles. Methodological development is coupled with perspectives on various therapeutic areas. Academic views are juxtaposed with standpoints of scientists working in the biopharmaceutical industry as well as of colleagues from the regulatory authorities.
The era of gene therapy
Typically, therapeutic gene therapies involve the transfer of genetic material into cells to reverse an abnormal condition or induce a new trait. Depending on the underlying genetic problem, various strategies such as addition, edition (repair), and deletion/knockout (inactivation) could be used. Sometimes gene therapy is used to add a normal and functional copy of an allele to increase gene expression, such as adding a normal human clotting factor IX allele to produce enough factor IX in hemophilia type B. Also, gene transferred by vectors...
The EBMT Handbook : Hematopoietic Stem Cell Transplantation and Cellular Therapies
Addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies.
The EBMT handbook : Hematopoietic cell transplantation and cellular therapies
Addresses the latest developments and innovations in hematopoietic cell transplantation and cellular therapy. Consisting of 94 chapters, it has been written by 210 leading experts in the field. Discussing all types of hematopoietic cell transplantation, including selection of stem cell sources, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies and new infections (COVID-19).
The development in cancer therapy and early detection tools
Despite the development in cancer treatment there is still a high rate of mortality worldwide. Although the traditional ways of cancer treatments are still used as a first line therapy, however, new treatments have been developed which showed a high effect on cancer cells. Therefore, the aim of our study is to search for the most recent cancer therapies, such as anti-angiogenesis treatment and immune therapy and related early detection tools. We will focus on the most “resilient” aggressive types of cancers which people have a lack of information about, in order to let them be aware about their risk factors and how to avoid them, and to provide them with their symptoms as well.
The Dental Pulp : Biology, Pathology, and Regenerative Therapies
Provides a detailed update on our knowledge of dental pulp and regenerative approaches to therapy. The pulp components are first described. The second part is devoted to pulp pathology and includes descriptions of the differences between reactionary and reparative dentin. The final part of the book focuses on pulp repair and regeneration.
The Comprehensive Cancer Center : Development, Integration, and Implementation
Provides a valuable resource for hospitals, institutions, and health authorities worldwide in their plans to set up and develop comprehensive cancer care centers. The development and implementation of a comprehensive cancer program allows for a systematic approach to evidence-based strategies of prevention, early detection, diagnosis, treatment, and palliation. Comprehensive cancer programs also provide a nexus for the running of clinical trials and implementation of novel cancer therapies with the overall aim of optimizing comprehensive and holistic care of cancer patients and providing them with the best opportunity to improve quality of life and overall survival.
The ADME encyclopedia : A comprehensive guide on biopharmacy and pharmacokinetics
Covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties
Targeted Therapies in Cancer : Myth or Reality?
In September 2005 an International Meeting on “Targeted Therapies in Cancer: Myth or Reality” was held in Milan. This successful Meeting was intended to represent a forum for scientists and clinicians working in cancer drug discovery and therapy to share their reflections and experiences on how the paradigm shift from empiricism to molecular targeted therapies is contributing to the translation of basic knowledge into new therapies for cancer patients. This book collects the contributions given by scientists and clinicians, from Academia and Industry, who participated to this Meeting.
Targeted Therapies in Cancer
Oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients. This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing. Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy. This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
Targeted cancer therapy in biomedical engineering
Highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs. Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes.
Targeted Cancer Therapy
In the era of personalized medicine, cancer treatment has become a model for the use of targeted therapeutics. Leaving behind the "one size fits all" approach to cancer care, this book provides the practicing oncologist with an overview of the advances in treatment and an understanding of the implementation of new therapeutic agents. Targeted Cancer Therapy is divided into twenty chapters covering specific hematologic malignancies and solid tumors, targeted and functional imaging, and combination therapies. Each disease specific chapter includes up-to-date information on investigational and FDA approved therapies which will enhance the reader’s ability to prescribe effective drug regimens. This includes combinations of therapies and therapeutic modalities to overcome drug resistance.
Target Cancer Therapy
Cancer is known as abnormal growth of cells due to genetic mutations associated with other factors such as smocking, overweight, physical inactivity and changing reproductive pattern. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Cancer treatment are invasive, painful, expensive and often creating long term negative side effect. The most common cancer treatment are chemotherapy, radiation therapy, surgery, hormone therapy, stem cell transplant and the modest one is targeted cancer therapy. Target cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules that are involved in the growth, progression and spread of cancer. Targeted therapies are currently focus of much anticancer drug development, they are cornerstone of precision medicine, a form of medicine that uses information about person’s genes and proteins to prevent, diagnose and treat disease.
Stroke Recovery with Cellular Therapies
As the leading cause of adult disability, stroke poses substantial economic and psychological burdens to populations around the world. Against this dismal backdrop, several novel "neurorestorative" approaches are being investigated as adjunctive treatments to physiotherapy. Stroke Recovery with Cellular Therapies discusses the promising investigations around the world on cell-based therapies to enhance recovery from stroke. Throughout this groundbreaking text, chapters detail the potential benefits of various types of cells and approaches for ischemic and hemorrhagic stroke, and all studies rely upon traditional histological and functional outcomes. Among the topics detailed in this volume are transplanting immortalized neural stem cells, transplantation of bone marrow stromal cells, adipose-derived stem cells, endogenous neural stem cells in tissue remodeling, and an investigation into the ethics of stem cell research.
Stem Cells in Reproduction and in the Brain
Recently, expectations of the potential of regenerative medicine have risen because of the exciting results obtained in various areas of research. This book contains contributions from leading researchers in the field who describe their successes and the problems that remain in converting the hopes into concrete therapies. The focus of the book is on the role of stem cells in two main areas -- reproduction and the brain -- described from molecular, cellular, in vivo and clinical perspectives.
Stem Cells and Myocardial Regeneration
The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more than 5 million Americans who currently carry the diagnosis of CHF. The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the problem and the successes and failures of what we consider optimal medical therapy. It is on this background that stem cell-based therapy needs to build.
Stem cell therapeutics
Delves into the forefront of medical research, exploring the revolutionary potential of stem cell therapy in combating a wide array of diseases. This comprehensive volume provides a thorough examination of the subject matter, offering insights into the latest advancements, methodologies, and applications of stem cell therapeutics.It adopts a multidisciplinary approach, drawing upon expertise from fields such as biology, medicine, biotechnology, and bioengineering. Readers can expect to encounter in-depth discussions on the use of stem cells in treating various medical conditions, including neurodegenerative disorders, cardiovascular diseases, autoimmune conditions, and cancer. Each chapter provides a comprehensive overview of the current state of research for each disease, highlighting the challenges, successes, and prospects of stem cell-based therapies. Additionally, the book explores ethical considerations, regulatory frameworks, and commercialization strategies surrounding the field, ensuring a well-rounded understanding of the subject matter for readers at all levels of expertise.
