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Molecular analysis of B lymphocyte development and activation
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Modern IoT onboarding platforms for advanced applications: a practitioner’s guide to KIS.ME
There is no doubt that digitalization solutions from Industry 4.0 and the Internet of Things (IoT) can be perceived as excellent candidate strategies capable of handling the above-stated issues concerning measurements and transparency. However, IoT tools themselves can provide appropriate data only, while their efficient integration and application are possible using a dedicated onboarding platform only. To settle this issue, the book undertakes the problem of modern IoT onboarding platforms for the advanced applications pertaining to manufacturing and logistics. In particular, instead of deliberating about a possible hypothetic platforms, an existing and efficient one is employed, which is called KIS.ME. KIS.ME (Keep It Simple. Manage Everything) is a complete IoT solution for a simple integration in manufacturing and logistics.
Modern industrial services : A cookbook for design, delivery, and management
This book is an outcome of several years of research, practice, and teaching experience of the authors on the challenges that underpin the successful switch to services for manufacturing firms. Ideal for a student as well as a practitioner, the book describes the industrial services ecosystem, the barriers and challenges, and a roadmap for building service excellence. Curated cases are used to describe the current approaches in practice to overcome the barriers. The book also provides several tools, each with a short introduction, that the authors have used successfully in projects to help overcome the servitization barriers. Many of these tools are from management, design thinking, or service design.
Modern avenues in metal-nucleic acid chemistry
Provides a timely overview of selected relevant developments in a field which previously had a pronounced focus on fundamental chemistry aspects such as coordination principles, structural chemistry, and consequences for biological processes and disease-related medicinal issues. More recently, also as a consequence of the advent of supramolecular chemistry, advancements in nanochemistry, and new bio-analytical methods, novel aspects of this field have emerged. MILS-25 gives a state-of-the-art account on the present state of research in this field, addressing, among others, porous materials, non-covalent interactions, stimuli-responsive bioconjugates, DNA-templated metal arrays and nanoclusters, genotyping, guanine quadruplexes, and riboswitches.
Modern architecture and climate design before air conditioning
explores how leading architects of the twentieth century incorporated climate-mediating strategies into their designs, and shows how regional approaches to climate adaptability were essential to the development of modern architecture. Focusing on the period surrounding World War II'before fossil-fuel powered air-conditioning became widely available'Daniel Barber brings to light a vibrant and dynamic architectural discussion involving design, materials, and shading systems as means of interior climate control. He looks at projects by well-known architects such as Richard Neutra, Le Corbusier, Lúcio Costa, Mies van der Rohe, and Skidmore, Owings, and Merrill, and the work of climate-focused architects such as MMM Roberto, Olgyay and Olgyay, and Cliff May. Drawing on the editorial projects of James Marston Fitch, Elizabeth Gordon, and others, he demonstrates how images and diagrams produced by architects helped conceptualize climate knowledge, alongside the work of meteorologists, physicists, engineers, and social scientists. Barber describes how this novel type of environmental media catalyzed new ways of thinking about climate and architectural design.
Modelling and Estimation Strategies for Fault Diagnosis of Non-Linear Systems : From Analytical to Soft Computing Approaches
This monograph presents a variety of techniques that can be used for designing robust fault diagnosis schemes for non-linear systems. The introductory part of the book is of a tutorial value and can be perceived as a good starting point for the new-comers to this field. Subsequently, advanced robust observer structures are presented. Parameter estimation based techniques are discussed as well. A particular attention is drawn to experimental design for fault diagnosis. The book also presents a number of robust soft computing approaches utilizing evolutionary algorithms and neural networks. All approaches described in this book are illustrated by practical applications.
Modeling of Soft Matter
Soft matter plays a role in a wide variety of important processes and application. For example, gel swelling and dynamics are an essential part of many biological and individual processes, such as motility mechanisms in bacteria and the transport and absorption of drugs. Ferroelectrics, liquid crystals, and elastomers are being used to design ever faster switching devices. Experimental studies, such as scattering, optical and electron microscopy, have provided a great deal of detailed information on structures. But the integration of mathematical modeling and analysis with experimental approaches promises to greatly increase our understanding of structure-property relationships and constitutive equations. The workshop on Modeling of Soft Matter has taken such an integrated approach.
Modeling Financial Time Series with S-PLUS®
This book represents an integration of theory, methods, and examples using the S-PLUS statistical modeling language and the S+FinMetrics module to facilitate the practice of financial econometrics. This is the first book to show the power of S-PLUS for the analysis of time series data.It covers S+FinMetrics 2.0 and includes new chapters on copulas, nonlinear regime switching models, continuous-time financial models, generalized method of moments, semi-nonparametric conditional density models, and the efficient method of moments.
Modeling and simulation tools for emerging telecommunication networks : Needs, trends, challenges and solutions
This book contains a selection of papers presented at a symposium organized under the aegis of COST Telecommunications Action 285. The main objective of the Action is to enhance existing tools and develop new modeling and simulation tools for research in emerging multi-service telecommunication networks in the areas of model performance improvements, multilayer traffic modeling, and the important issue of evaluation and validation of the new modeling tools.
MIMO Signals and Systems
The book provide a basic understanding of the fundamentals, implementation, and of MIMO techniques. For easier comprehension, these applications techniques, in conjunction with several "classic" algorithms, are illustrated by means of numerous worked examples.
Microsoft Visual C# Step by Step
Guide to Microsoft Visual C# fundamentals with Visual Studio. Expand your expertiseand teach yourself the fundamentals of programming with the latest version of Visual C# with Visual Studio. If you are an experienced software developer, you'll get all the guidance, exercises, and code you need to start building responsive, scalable, cloud-connected applications that can run almost anywhere. Discover how to: Quickly start creating Visual C# code and projects with Visual Studio Work with variables, operators, expressions, methods, and program flow Build more robust apps with error, exception, and resource management Spot problems fast with the Visual Studio debugger Make the most of improvements to C# methods, parameters, and switch statements Master the C# object model, and create your own functional data structures Leverage advanced properties, indexers, generics, and collection classes Create Windows 10 apps that share data, collaborate, and use cloud services Integrate Cortana to voice-enable your applications Perform complex queries over object collections with LINQ
Methods and Tools for Effective Knowledge Life-Cycle-Management
This book provides an understanding of what knowledge is and of why it is one of the most strategic issues in future manufacturing competitiveness, which will be based primarily on high-level technologies and innovative products.
Metaphor and Analogy in Science Education
This book brings together powerful ideas and new developments from internationally recognised scholars and classroom practitioners to provide theoretical and practical knowledge to inform progress in science education. This is achieved through a series of related chapters reporting research on analogy and metaphor in science education. Throughout the book, contributors not only highlight successful applications of analogies and metaphors, but also foreshadow exciting developments for research and practice. Themes include metaphor and analogy: best practice, as reasoning; for learning; applications in teacher development; in science education research; philosophical and theoretical foundations. Accordingly, the book is likely to appeal to a wide audience of science educators –classroom practitioners, student teachers, teacher educators and researchers.
Mathematical Systems Theory I : Modelling, State Space Analysis, Stability and Robustness
This book presents the mathematical foundations of systems theory in a self-contained, comprehensive, detailed and mathematically rigorous way. This volume is devoted to the analysis of dynamical systems with emphasis on problems of uncertainty, whereas the second volume will be devoted to control. It combines features of a detailed introductory textbook with that of a reference source. The book contains many examples and figures illustrating the text which help to bring out the intuitive ideas behind the mathematical constructions.
Introduction to biologic and biosimilar product development and analysis
Gives a concise introduction to development and analysis of pharmaceutical biologics for those in the pharmaceutical industry who are switching focus from small molecules to biologics processing, analysis, and delivery. In order to maintain a limited focus, Introduction to Biologic and Biosimilar Product Development and Analysis, will deal only with peptides, proteins and monoclonal antibodies.
Introducing Blockchain Applications : Understand and Develop Blockchain Applications Through Distributed Systems
Deepen your understanding of blockchain technology and develop your own blockchain applications. This book provides a thorough review of distribution-based systems on blockchain technology, starting from the fundamental concepts that underlie it, all the way through the implementation of a blockchain network for business purposes. ou will: Learn the concept of blockchains by way of a practical example Grasp the connection between distributed systems and blockchain technology Learn the design of blockchain with hyperledger fabric Learn the design of cyber-physical systems in a distributed environment
Intelligent cryptocurrency trading assistant
With blockchain being invented in 2008, cryptocurrencies have grown steadily through the years. Cryptocurrencies continue today to be an extremely interesting phenomenon. Having quickly achieved popularity and becoming very popular, cryptocurrencies continue to be a profitable investment tool, capable of generating huge profits on exchanges and transactions. Being a professional trader is not an easy task to achieve, a professional trader needs to observe and process multiple factors and events that affect the cryptocurrency market to make the right decision. What makes this process challenging is that some of the factors cannot be predicted or calculated but rather, their changes should be observed and comprehended, and an action should be taken in response quickly in order to maximize the profit or minimize the loss.
Integrated Marketing Communications : A Global Brand-Driven Approach
Integrated Marketing Communications: A Global Brand-Driven Approach, 2nd edition presents an integrated and global framework to marketing communications, delivered in a highly readable, cohesive and succinct manner. It offers a concise, stimulating approach in its coverage of IMC and combines insightful knowledge of trends in the global marketplace, consumer and stakeholder issues with wider adoption of a consumer-driven perspective, as well as a roadmap through the bewildering maze of marketing communications.
Innovative Algorithms and Techniques in Automation, Industrial Electronics and Telecommunications.
Innovative Algorithms and Techniques in Automation, Industrial Electronics and Telecommunications is a collection of world class paper articles addressing the following topics: Computer Networks: Access Technologies, Medium Access Control, Network architectures and Equipment, Optical Networks and Switching, Telecommunication Technology, and Ultra Wideband Communications. Coding and Modulation: Modeling and Simulation, OFDM technology , Space-time Coding, Spread Spectrum and CDMA Systems. Wireless technologies: Bluetooth , Cellular Wireless Networks, Cordless Systems and Wireless Local Loop, HIPERLAN, IEEE 802.11, Mobile Network Layer, Mobile Transport Layer, and Spread Spectrum.
Innovation Project Management : Methods, Case Studies, and Tools for Managing Innovation Projects
Specific ideas discussed in Innovation Project Management include: Continuous versus discontinuous innovation, incremental versus radical innovation, understanding innovation differences, and incremental innovation versus new product development Identifying core competencies using SWOT analysis and nondisclosure agreements, secrecy agreements, and confidentiality agreements Implications and issues for project managers and innovation personnel, active listening, pitching the innovation, and cognitive biases Measuring intangible assets, customer/stakeholder impact on value metrics, customer value management programs, and the relationship between project management and value
