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Netter's essential histology with correlated histopathology
Concise and easy to use, it integrates gross anatomy and embryology with classic histology slides and state-of-the-art scanning electron microscopy, offering a clear, visual understanding of this complex subject. Additional histopathology images, more clinical boxes, and new histopathology content ensure that this textbook-atlas clearly presents the most indispensable histologic concepts and their clinical relevance. Helps you recognize both normal and diseased structures at the microscopic level with the aid of succinct explanatory text as well as numerous clinical boxes. Features more histopathology content and additional clinical boxes to increase your knowledge of pathophysiology and clinical relevance. Includes high-quality light and electron micrographs, including enhanced and colorized electron micrographs that show ultra-structures in 3D, side by side with classic Netter illustrations that link your knowledge of anatomy and cell biology to what is seen in the micrographs.
Natural Product Synthesis II : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural Product Synthesis I : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural Language Processing and Information Systems ; Vol. 3513 ; 10th International Conference on Applications of Natural Language to Information Systems, NLDB 2005, Alicante, Spain, June 15-17, Proceedings
The development and convergence of computing, telecommunications and information systems has already led to a revolution in the way that we work, communicate with each other, buy goods and use services, and even in the way that we entertain and educate ourselves.The revolution continues, and one of its results is that large volumes of information will increasingly be held in a form which is more natural for users than the data presentation formats typical of computer systems of the past. Natural language processing (NLP) is crucial in solving these problems, and language technologies will make an indispensable contribution to the success of information systems. We hope that NLDB 2005 was a modest contribution to this goal. NLDB 2005 contributed to advancing the goals and the high international standing of these conferences, largely due to its Program Committee, composed of renowned researchers in the field of natural language processing and inf- mation system engineering. Papers were reviewed by three reviewers from the Program Committee. This clearly contributed to the significant number of - pers submitted (95). Twenty-nine were accepted as regular papers, while 18 were accepted as short papers.
NASAs Scientist-Astronauts
Mounting pressure in the early 1960s from the National Academy of Sciences (NAS) to study ways of expanding the role of astronauts to conduct science on future space missions led to NASA’s conclusion that flying scientifically trained crewmembers would generate greater returns from each mission. NASA and industry studies continued investigating possibilities that could lead to the eventual creation of the first space stations using surplus Apollo hardware, through the Apollo Applications Programme (AAP).
Nanoscale Assembly : Chemical Techniques
Recent advances have pushed the limits of lithography firmly into the sub-100 nm domain, with smallest feature sizes around 10 nm. However, compared to living organisms, devices fabricated using nanolithography are not nearly as complex, as they are essentially 2D and contain only a limited number of chemical elements. For centuries, Nature has been a major inspiration for science. First of all to learn how Life functions at cellular level, but increasingly, as a blueprint for designing non-natural devices where the building blocks and their assembly are inspired by biological examples. The key tool in translating these examples into the domain of engineering, has been self-assembly or self-organization. This book gathers a spectrum researchers who have not only furthered our knowledge of self-assembly using small molecules, polymers and colloidal particles as building blocks, but who have also shown it to be a practical tool in the assembly of an astonishing variety of devices, ranging from molecular electronics to biosensors.
Nano physical pharmaceutics
Nanomedicine is an emerging and rapidly evolving field, which could significantly help in early disease diagnosis, therapeutic improvement, novel therapeutic modality development, and medical expenditure reduction. The challenge remains, however, that the specially designed and carefully synthesized nanomedicines function poorly in animal verification despite great performance in vitro. A deeper understanding of the physicochemical properties of nanomedicine is the key. This book applies physical theories and models to determine the parameters for controlling the physicochemical properties of nanomedicines, including micelles, liposomes, and inorganic nanoparticles. Qualitative and quantitative relationships are established to provide guidance for nanomedicine design, characterization, and analysis. The text also compiles cutting-edge research in nanomedicine from the interdisciplinary team of the Department of Nanomedicine at Naval Medical University, China, which is currently establishing the characteristic discipline called Nano Physical Pharmaceutics. Edited by Wei Li, a prominent nanotechnology researcher, this book will appeal to anyone involved in nanotechnology, medicine, macromolecular science, biology, chemistry, and especially those with an interest in drug delivery or cancer therapy.
Multiwavelength Approach to Unidentified Gamma-Ray Sources : A 2nd Workshop on the Nature of the High-Energy Unidentified Sources
Nearly one half of the point-like gamma-ray sources detected by EGRET instrument of the late Compton satellite are still defeating our attempts at identifying them. To establish the origin and nature of these enigmatic sources has become a major problem of current high-energy astrophysics. The second workshop on Multiwavelength Approach to Unidentified Gamma-ray Sources intends to shed new and fresh light on the problem of the nature of these mysterious sources and the objects behind them. The proceedings contain 46 contributed papers in this subject, which cover theoretical models on gamma-ray sources as well as the best multiwavelength strategies for the identification of the promising candidates. The topics of this conference also include energetic phenomena ocurring both in galactic and extragalactic scenarios, phenomena that might lead to the appearance of what we have called high-energy unidentified sources. The book will be of interest for all active researchers in the high-energy astrophysics and related research areas as well as for scientists and graduate students interested in understanding the recent progress in this field.
Multiple pregnancy
Multiple pregnancy affects 0.9-3.1% of births worldwide. Prevalence rates vary significantly due to differences in dizygotic twinning rates and use of assisted reproduction. Both maternal and fetal/neonatal complications are more common in multiple compared to singleton pregnancies, and there are specific problems for the fetuses related to monochorionicity. Multiple pregnancies require specialised and individualised care. Complicated multiple pregnancies should be managed in a tertiary care centre where there is additional expertise, such as the laser ablation needed to treat monochorionic monozygotic pregnancies with conjoined circulations. Cornerstones of management in pregnancy are the need for accurate fetal measurement to optimise dating of gestational age, and documentation of chorionicity. High-level ultrasound expertise is needed. The mothers need frequent assessment to detect hypertension and anemia, and early identification and management of preterm labour.
Multiobjective Optimization : Interactive and Evolutionary Approaches
Multiobjective optimization deals with solving problems having not only one, but multiple, often conflicting, criteria. Such problems can arise in practically every field of science, engineering and business, and the need for efficient and reliable solution methods is increasing. The task is challenging due to the fact that, instead of a single optimal solution, multiobjective optimization results in a number of solutions with different trade-offs among criteria, also known as Pareto optimal or efficient solutions. Hence, a decision maker is needed to provide additional preference information and to identify the most satisfactory solution. Depending on the paradigm used, such information may be introduced before, during, or after the optimization process. Clearly, research and application in multiobjective optimization involve expertise in optimization as well as in decision support.
Multimedia Introduction to Programming Using Java
Although vital to modern software development, Java and object-oriented programming can pose significant challenges to newcomers. This text, unique in both scope and approach and accompanied by interactive content that you may find on extras.springer.com, addresses that learning curve by providing a careful, classroom-tested presentation of Java -- from the fundamentals of variables, types, and expressions to procedural concepts like loops and sophisticated object-oriented ideas. Additional key features of this work Introduces objects and classes early in the exposition, rendering object-oriented programming intuitive and natural. Develops programs, rather than simply showcasing them. Supports all concepts through complementary lectures on the zip-file featured on extras.springer.com. Contains numerous self-help exercises that encourage readers to practice programming. With its comprehensive appendices and bibliography, systematic approach, and helpful interactive programs on extras.springer.com, this exciting work provides the key tools they needed for successful object-oriented programming. It is ideal for use at the undergraduate and graduate beginning level, whether in the classroom or for distance learning; furthermore, the text will also be a valuable self-study resource or reference volume in any programmer’s library.
Multilingual Information Access for Text, Speech and Images ; 5th Workshop of the Cross-Language Evaluation Forum, CLEF 2004, Bath, UK, September 15-17, 2004, Revised Selected Papers
The ?fth campaign of the Cross-Language Evaluation Forum (CLEF) for Eu- pean languages was held from January to September 2004. Participation in the CLEF campaigns has increased each year and CLEF 2004 was no exception: 55 groups submitted results for one or more of the di?erent tracks compared with 42 groups in the previous year. CLEF 2004 also marked a breaking point with respect to previous campaigns. The focus was no longer mainly concentrated on multilingual document retrieval as in previous years but was diversi?ed to include di?erent kinds of text retrieval across languages (e. g. , exact answers in the question-answering track) and retrieval on di?erent kinds of media (i. e. , not just plain text but collections containing image and speech as well). In ad- tion, increasing attention was given to issues that regard system usability and user satisfaction with tasks to measure the e?ectiveness of interactive systems or system components being included in both the cross-language question - swering and image retrieval tasks with the collaboration of the coordinators of the interactive track. The campaign culminated in a two-and-a-half-day workshop held in Bath, UK, 15–17 September, immediately following the 8th European Conference on Digital Libraries. The workshop was attended by nearly 100 researchers and s- tem developers.
Multifunctional Barriers for Flexible Structure : Textile, Leather and Paper
The intent of this book is to give a complete overview of the present state of the art of flexible barrier materials such as textile, paper and leather, including methods for barrier evaluation. It will be of interest to readers in industries, consumers, and members of the scientific community. The scope of the field is clearly delineated here for the first time, and it deals with a number of specific topics such as barrier to fire, antibacterial properties, resistance to waves (electrostatic, electromagnetic, acoustics), anti-odor, etc. combined with characterization techniques as well as material nanotechnology.
Moral Philosophy on the Threshold of Modernity
This volume investigates the paradigm changes which occurred in ethics during the early modern era (1350-1600). While many general claims have been made regarding the nature of moral philosophy in the period of transition from medieval to modern thought, the rich variety of extant texts has seldom been studied and discussed in detail. The present collection attempts to do this. It provides new research on ethics in the context of Late Scholasticism, Neo-Scholasticism, Renaissance Humanism and the Reformation. It traces the fate of Aristotelianism and of Stoicism, explores specific topics such as probabilism and casuistry, and highlights the connections between Protestant theology and early modern ethics. The book also examines how the origins of human rights, as well as different views of moral agency, the will and the emotions, came into focus on the eve of modernity.
Monitoring Nature Conservation in Cultural Habitats : A Practical Guide and Case Studies
Monitoring Nature Conservation in Cultural Habitats presents monitoring as an integral component of responsible conservation management and as a catalyst for decision making. The early sections of the book cover key areas in the development of a monitoring project, including: - The roles of survey and surveillance - Incorporating knowledge from existing research - Identifying the conservation priority on sites - Minimising observer error - Identifying site-specific condition indicators for habitats - Collecting monitoring data The later sections of the book comprise a series of case studies covering a wide range of habitats and species. These case studies focus mostly, though not exclusively, on sites that form part of the Natura 2000 series in Europe.
Monetary Policy and Macroeconomic Stabilization in Latin America
Latin America is a very important region of the globe, which has been buffeted by successive waves of economic instability within the last decades. These waves have caused several episodes of hyperinflation or near hyperinflation, and several currency and financial crises, which, in certain moments, have even spilled over and affected other emerging markets. This has resulted in huge costs in terms of lost potential growth, and, as is inevitable, the markets most affected by this have been the least capable of defending themselves. In a region plagued by still considerable rates of social exclusion, with some of the highest rates of income concentration in the whole globe, the human costs of these crises have been very substantial. Starting in the early 1990s, the slow implementation of reforms, plus the resumption of more sustained growth—to a substantial degree linked to the increase in commodity prices, especially since the early 2000s—seems to have resulted in a more stable situation. Initially, in early reformers like Chile, later in the larger economies of the region, like Brazil and Mexico, a consensus— embraced by both sides of the political spectrum—towards integration in global markets, both in their trade and financial components, floating exchange rates, independent monetary authorities, and sustainable fiscal policies has emerged.
Molecular Mimicry : Infection Inducing Autoimmune Disease
The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative fo.
Molecular Mechanisms of Phagocytosis
Although, Phagocytosis was first described nearly 120 year ago, we are just recently beginning to understand the molecules that phagocytic cells use to bring about this complex cell function. Molecular Mechanisms of Phagocytosis was prepared as a series of up-to-date essays (chapters) that describe the present knowledge on the various steps of the phagocytic process from initial cell contact, through internalization of the foreign particle, to the final phagosome formation where the phagocytosed particle is destroyed.
Molecular analysis of B lymphocyte development and activation
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Modern structural analysis : Modelling process and guidance
Essential reading for 21st century practitioners and students who need to do structural analysis. It contains a great deal of information that is not available in any other book on the subject. This is because the conventional view of structural analysis is rooted in the early part of the 20th century in the pre-computer era rather than present time.
