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Cyclin Dependent Kinase 5 (Cdk5)
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.
Cybersecurity of Digital Service Chains : Challenges, Methodologies, and Tools
This book presents the main scientific results from the H2020 GUARD project. The GUARD project aims at filling the current technological gap between software management paradigms and cybersecurity models, the latter still lacking orchestration and agility to effectively address the dynamicity of the former. This book provides a comprehensive review of the main concepts, architectures, algorithms, and non-technical aspects developed during three years of investigation; the description of the Smart Mobility use case developed at the end of the project gives a practical example of how the GUARD platform and related technologies can be deployed in practical scenarios.
Cyber-physical systems of systems : Foundations : A conceptual model and some derivations : The AMADEOS legacy
Technical Systems-of-Systems (SoS) – in the form of networked, independent constituent computing systems temporarily collaborating to achieve a well-defined objective – form the backbone of most of today’s infrastructure. The energy grid, most transportation systems, the global banking industry, the water-supply system, the military equipment, many embedded systems, and a great number more, strongly depend on systems-of-systems. The correct operation and continuous availability of these underlying systems-of-systems are fundamental for the functioning of our modern society.
Cultural Competence and the Higher Education Sector : Australian Perspectives, Policies and Practice
This book explores cultural competence in the higher education sector from multi-disciplinary and inter-disciplinary perspectives. It addresses cultural competence in terms of leadership and the role of the higher education sector in cultural competence policy and practice.
Crystallography and the World of Symmetry
Symmetry exists in realms from crystals to patterns, in external shapes of living or non-living objects, as well as in the fundamental particles and the physical laws that govern them. In fact, the search for this symmetry is the driving force for the discovery of many fundamental particles and the formulation of many physical laws. While one can not imagine a world which is absolutely symmetrical nor can one a world which is absolutely asymmetrical. These two aspects of nature are intermingled with each other inseparably. This is the basis of the existence of aperiodicity manifested in the liquid crystals and also quasi-crystals also discussed in Crystallography and the World of Symmetry.
Cryocoolers 13
The last two years have witnessed a continuation in the breakthrough shift toward pulse tube cryocoolers for long-life, high-reliability cryocooler applications. New this year are papers de scribing the development of very large pulse tube cryocoolers to provide up to 1500 watts of cooling for industrial applications such as cooling the superconducting magnets of Mag-lev trains, coolmg superconducting cables for the power mdustry, and liquefymg natural gas. Pulse tube coolers can be driven by several competing compressor technologies. One class of pulse tube coolers is referred to as "Stirling type" because they are based on the linear Oxford Stirling-cooler type compressor; these generally provide coolmg m the 30 to 100 K temperature range and operate ^t frequencies from 30 to 60 Hz. A second type of pulse tube cooler is the so-called "Gifford-McMahon type. " Pulse tube coolers of this type use a G-M type compressor and lower frequency operation (~1 Hz) to achieve temperatures in the 2 to 10 K temperature range. The third type of pulse tube cooler is driven by a thermoacoustic oscillator, a heat engine that functions well in remote environments where electricity is not readily available. All three types are described, and in total, nearly half of this proceedings covers new developments in the pulse tube arena. Complementing the work on low-temperature pulse tube and Gifford-McMahon cryocoolers is substantial continued progress on rare earth regenerator materials.
Critical Issues in Head and Neck Oncology : Key Concepts from the Seventh THNO Meeting
This book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck cancers
Critical Infrastructures at Risk : Securing the European Electric Power System
This book explores the potential risks and vulnerabilities of the European electricity infrastructure, other infrastructures and our society as whole increasingly depend on. The work was initiated by the need to verify the potential effects of the ongoing market and technical transformation of the infrastructure, which is fundamentally changing its operation and performance. The final aim is to set the basis for an appropriate industrial and political European-wide response to the risk challenges.
Creep Mechanics ; 3rd ed.
The third edition of “Creep Mechanics” provides a short survey of recent advances in the mathematical modelling of the mechanical behavior of anisotropic solids under creep conditions, including principles, methods, and applications of tensor functions.
Creep Mechanics ; 2nd ed.
The monograph offers an overview of other experimental investigations in creep mechanics. Rules for specifying irreducible sets of tensor invariants, scalar coefficients in constitutive and evolutional equations, and tensorial interpolation methods are also explained.
Creative center for traditional crafts: An artist's touch and a city's history : المركز الإبداعي للحرف التقليدية : لمسة فنان وتاريخ مدينة
يسعى هذا النوع من المشاريع في مدينة السويداء لتوسيع نطاق وسائط الحرف و الحفاظ على تراث المدينة و تحسين المصنع المادي و تأمين فرص عمل و إنشاء معرضا و برنامجا لتثقيف المجتمع و الاستمرار في تقديم دروس مبتكرة "مايجمعهم" بحيث ينطلق المشروع من إيمان قوي ببعض القيم البسيطة التي وجهتها المنطقة طوال التاريخ تحت شعار(العمل مع بعضنا البعض في خلق الخير و الجميل) هو حب العمل في جو مجتمعي دائم
Creating great places : Evidence-based urban design for health and wellbeing
Reminds us that theory is a powerful starting point. Drawing on international research, illustrated case studies, personal experiences, as well as fascinating examples from history and pop culture, this practical book provides the reader with inspiration, guidance and tools. The first section outlines six critical theories for contemporary urban design - affordance, prospect-refuge, personal space, sense of place/genius loci, place attachment, and biophilic design. The second section, using their innovative 'theory-storming' process, demonstrates how designers can create great places that are inclusive, sustainable, and salutogenic.
Courbes algébriques planes = Plane Algebraic Curves
Resulting from a master's course at the University of Paris VII, this text is re-edited as it appeared in 1978. Various tools are introduced in connection with Bézout's theorem necessary for the development of the notion of the multiplicity of intersection of two algebraic curves in the complex projective plane. Starting from elementary notions on affine and projective algebraic subsets, we define the intersection multiplicities and interpret their sum in terms of the resultant of two polynomials. The local study is a pretext for the introduction of formal or convergent series rings; it culminates in Puiseux's theorem, the convergence of which is reduced by splits to that of the theorem of implicit functions. Various figures illuminate the text: we "see" in particular that the homogeneous equation x3 + y3 + z3 = 0 defines a torus in the complex projective plane.
Cost Accounting for Shared IT Infrastructures
Distributed client/server architectures are the technological backbone of today’s data centres. A usage-based allocation of infrastructure costs to business processes or users is often not possible as the necessary resource consumption measurements incur too much overhead. Reinhard Brandl proposes a method to derive estimates for the expected resource consumption of customer-oriented services during standard load tests. This facilitates the determination of usage-based cost allocation keys significantly. He implements the concept in a software tool kit and evaluates it successfully in a set of experiments with multi-tier database applications. In particular, he uses the determined consumption estimates as input parameters for Queuing Network Models which lead to highly accurate performance predictions. Finally, he analyzes how the method can be integrated into existing IT processes at the BMW Group.
Coronaviruses : Methods and Protocols
Aims to describe a variety of techniques that reflects the wide range of research currently performed in the field of coronavirology, and begins with an overview of current understandings of coronavirus replication and pathogenesis to introduce specialists and non-specialists to the field. The rest of the book is divided into several sections of chapters beginning with those that describe identification, diagnosis, and study of the evolution of coronaviruses. The next few chapters discuss the preparation of cells and organ cultures useful in propagating coronaviruses and titration techniques, as well as techniques for analyzing virus functions that require purification of the viruses. The next chapters describe two commonly used reverse genetics techniques for coronaviruses, and techniques detailing identification of cellular receptors, binding profiles of viral attachment proteins, and virus-cell fusion. The final chapters cover a broad spectrum of techniques to identify virus-host protein-protein interactions, confirm the functional role of these proteins in virus replication, study host cell responses through genome-wide or pathway-specific approaches, and visualize virus replication complexes. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Coordinated Multiuser Communications
Many communications systems, such as cellular mobile radio and wireless local area networks, are subject to multiple-access interference, caused by a multitude of users sharing a common transmission medium. The performance of receiver systems in such cases can be greatly improved by the application of joint detection and decoding methods. Multiuser detection and decoding not only improve system reliability and capacity, they also simplify the problem of resource allocation. Emphasis is placed on practical implementation aspects and modern iterative processing techniques for systems both with, and without integrated error control coding.
Convex functions and their applications : A contemporary approach ; 2nd ed.
This second edition provides a thorough introduction to contemporary convex function theory with many new results. A large variety of subjects are covered, from the one real variable case to some of the most advanced topics. The new edition includes considerably more material emphasizing the rich applicability of convex analysis to concrete examples. Chapters 4, 5, and 6 are entirely new, covering important topics such as the Hardy-Littlewood-Pólya-Schur theory of majorization, matrix convexity, and the Legendre-Fenchel-Moreau duality theory.
Control of Spatially Structured Random Processes and Random Fields with Applications
This book is devoted to the study and optimization of spatiotemporal stochastic processes, that is, processes which develop simultaneously in space and time under random influences. These processes are seen to occur almost everywhere when studying the global behavior of complex systems.Classical stochastic dynamic optimization forms the framework of the book. Taken as a whole, the project undertaken in the book is to establish optimality or near-optimality for Markovian policies in the control of spatiotemporal Markovian processes. The authors apply this general principle to different frameworks of Markovian systems and processes. Depending on the structure of the systems and the surroundings of the model classes the authors arrive at different levels of simplicity for the policy classes which encompass optimal or nearly optimal policies. A set of examples accompanies the theoretical findings, and these examples should demonstrate some important application areas for the theorems discussed.
Continuum Mechanics using Mathematica® : Fundamentals, Applications and Scientific Computing
This book's methodological approach familiarizes readers with the mathematical tools required to correctly define and solve problems in continuum mechanics. The book covers essential principles and fundamental applications, and provides a solid basis for a deeper study of more challenging and specialized problems related to elasticity, fluid mechanics, plasticity, materials with memory, piezoelectricity, ferroelectricity, magneto-fluid mechanics, and state changes.
Continuum Mechanics
This book presents an introduction into the entire science of Continuum Mechanics in three parts. PART I: Continuum Mechanics introduces into the Foundations using tensors in Cartesian coordinate systems, classical theory of elasticity, and fluid mechanics. PART II: Mechanics of Materials has chapters on viscoelasticity, plasticity, principles of constitutive modelling, and thermodynamics. PART III presents Tensor Analysis and fundamental equations of Continuum Mechanics in curvilinear coordinates.
