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Applied biophysics for drug discovery
It is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns.
Application of computational electromagnetics techniques and artificial intelligence in the engineering
Introduces the latest developments in electromagnetic computing and artificial intelligence technology. Artificial intelligence technology can be applied to the modeling, analysis, and optimization design of microwave equipment, solving the routing problem of self-organizing networks in small unmanned aerial vehicle systems, calculating the radiation characteristics of antenna arrays on large electrical platforms, analyzing the impact of electromagnetic wave coupling on electronic devices, simulating the field distribution characteristics of electronic devices, and so on. With the help of artificial intelligence, designers can more conveniently, quickly, and accurately solve engineering problems.
Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis
Covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome).
Anti-fragile ICT Systems
Introduces a novel approach to the design and operation of large ICT systems. It views the technical solutions and their stakeholders as complex adaptive systems and argues that traditional risk analyses cannot predict all future incidents with major impacts. To avoid unacceptable events, it is necessary to establish and operate anti-fragile ICT systems that limit the impact of all incidents, and which learn from small-impact incidents how to function increasingly well in changing environments. The book applies four design principles and one operational principle to achieve anti-fragility for different classes of incidents. It discusses how systems can achieve high availability, prevent malware epidemics, and detect anomalies. Analyses of Netflix’s media streaming solution, Norwegian telecom infrastructures, e-government platforms, and Numenta’s anomaly detection software show that cloud computing is essential to achieving anti-fragility for classes of events with negative impacts.
Anticoagulants
Anticoagulant are drugs that, when added to blood, prevents it from clotting. It does this by suppressing the synthesis or function of various clotting factors that are normally present in the blood. These drugs are frequently used to prevent the formation of blood clots (thrombi) in the veins or arteries or the enlargement of a clot that is circulating in the bloodstream. Anticoagulants are very effective in preventing life-threatening conditions...
Anion Sensing
This treatise on anion sensing and recognition represents a new addition to a very small number of books in this area, Although this Topics volume does not cover all the different classes fo receptors, it does provide new and timely perspectives to anion chemistry by highlighting several areas that have been generally overlooked in other reviews. The individual chapters are well-written and include references from earlier works up to the present. As such, this volume will be of interest to the community of researchers interested in anions as well as to those who wish to learn about the host-guest chemistry of anion recognition and its applications.
Angiotensin converting enzyme inhibitors and application
It is now a little over 10 years since the introduction of drugs that inhibit the angiotensin converting enzyme (ACE). Angiotensin converting enzyme inhibitors are a class of oral medications that act primarily through blockade of the angiotensin converting enzyme. This enzyme converts angiotensin I to angiotensin II. Angiotensin II causes vasoconstriction increasing afterload, thus increasing systemic blood pressure. Angiotensin contributes to the production of aldosterone, which normally acts to retain sodium and water.
Analysis and Control of Ultrafast Photoinduced Reactions
The present monograph summarizes, in a comprehensive way, several years of joint experimental and theoretical frontier research on ultrafast laser-induced molecular dynamics and its control. Emphasis is set on the characterization of the nuclear dynamics within molecular systems in various environments (gas phase, surfaces, solids, solution, strong fields) triggered by optical excitations spanning from the infrared to the ultraviolet. Building on the converged analysis between experiment and theory, control of chemical reactions is established by means of optimally shaped laser pulses. This paves the road toward new applications and future challenges in this rapidly developing research field.
An introduction to relativistic processes and the standard model of electroweak interactions
The first part of the volume is devoted to the description of scattering processes in the context of relativistic quantum field theory. The use of the semi-classical approximation allows us to illustrate the relevant computation techniques in a reasonably small amount of space. Our approach to relativistic processes is original in many respects. The second part contains a detailed description of the construction of the standard model of electroweak interactions, with special attention to the mechanism of particle mass generation. The extension of the standard model to include neutrino masses is also described. We have included a number of detailed computations of cross sections and decay rates of pedagogical and phenomenological relevance.
Alvar Aalto Houses
Finnish architect and designer Alvar Aalto (1898-1976) designed nearly one hundred single-family houses. Aalto, who is also known for his furniture and glassware, worked in a unique style that blended modernism and traditional vernacular architecture. Authors Jari and Sirkkaliisa Jetsonen (Finnish Summer Houses) present twenty-six of Aalto's innovative residences—from small summer homes and postwar standardized housing to large housing complexes for industrial commissions—built between the 1920s to the 1960s.
Allelopathy in Sustainable Agriculture and Forestry
This book reports on the latest advances in allelopathy through the contributions of leading scientists in the field. The book addresses the history of allelopathy, the science of allelochemicals, and the application of allelopathy in agriculture and forestry. An emphasis on both methodology and application makes Allelopathy a truly practical reference for scientists, researchers and students of plant science, agriculture, forestry, terrestrial ecology and environmental science.
Algorithms in Bioinformatics ; Vol. 3692 ; 5th international workshop, WABI 2005, Mallorca, Spain, October 3-6, 2005, Proceedings
this book present the proceedings of the 5th Workshop on Algorithmsin Bioinformatics (WABI 2005) which took place in Spain, 2005. The Workshop on Algorithms in Bioinformatics highlights research workspecifically developed to address algorithmic problems in biosequence analysis. The emphasis is therefore on statistical and probabilistic algorithms that addressimportant problems in the field of molecular and structural biology. the workshop aims to present recent research results, includingsignificant work in progress, and to identify and explore directions of futureresearch.Original research papers (including significant work in progress) or state-of-the-art surveys were solicited on all aspects of algorithms in bioinformatics,including, but not limited to: exact and approximate algorithms for genomics,genetics, sequence analysis, gene and signal recognition, alignment, molecularevolution, phylogenetics, structure determination or prediction, gene expressionand gene networks, proteomics, functional genomics, and drug design.
Algorithms – ESA 2005 ; 13th Annual European Symposium, Palma de Mallorca, Spain, October 3-6, 2005, Proceedings
This volume contains the 75 contributed papers and the abstracts of the threeinvited lectures presented at the 13th Annual European Symposium on Algo-rithms (ESA 2005), held in Spain, 2005. respectively.Papers were solicited in all areas of algorithmic research, including but notlimited to algorithmic aspects of networks, approximation and on-line algo-rithms, computational biology, computational geometry, computational financeand algorithmic game theory, data structures, database and information re-trieval, external memory algorithms, graph algorithms, graph drawing, machinelearning, mobile computing, pattern matching and data compression, quantumcomputing, and randomized algorithms. The algorithms could be sequential,distributed, or parallel. Submissions were especially encouraged in the area ofmathematical programming and operations research, including combinatorialoptimization, integer programming, polyhedral combinatorics, and semidefiniteprogramming.Each extended abstract was submitted to one of the two tracks.
Algorithmic Aspects of Bioinformatics
Advances in bioinformatics and systems biology require improved computational methods for analyzing data, while progress in molecular biology is in turn influencing the development of computer science methods. This book introduces some key problems in bioinformatics, discusses the models used to formally describe these problems, and analyzes the algorithmic approaches used to solve them. After introducing the basics of molecular biology and algorithmics, Part I explains string algorithms and alignments; Part II details the field of physical mapping and DNA sequencing; and Part III examines the application of algorithmics to the analysis of biological data. Exciting application examples include predicting the spatial structure of proteins, and computing haplotypes from genotype data. This book describes topics in detail and presents formal models in a mathematically precise, yet intuitive manner, with many figures and chapter summaries, detailed derivations, and examples. It is well suited as an introduction into the field of bioinformatics, and will benefit students and lecturers in bioinformatics and algorithmics, while also offering practitioners an update on current research topics.
Agricultural value chains in India : Ensuring competitiveness, inclusiveness, sustainability, scalability, and improved finance
This book provides a clear holistic conceptual framework of CISS-F (competitiveness, inclusiveness, sustainability, scalability and access to finance) to analyse the efficiency of value chains of high value agricultural commodities in India. It is based on the understanding that agriculture is an integrated system that connects farming with logistics, processing and marketing. Farmer’s welfare being central to any agricultural policy makes it very pertinent to study how a value chain works and can be strengthened further to realize this policy goal.
Agent-oriented information systems II ; 6th International bi-conference workshop, AOIS 2004, Riga, Latvia, June 8, 2004 and New York, NY, USA, July 20, 2004, revised selected papers
Information systems have become the backbone of all kinds of organizations - day. In almost every sector – manufacturing, education, health care, government and businesses large and small – information systems are relied upon for - eryday work, communication, information gathering and decision-making. Yet, the in?exibilities in current technologies and methods have also resulted in poor performance, incompatibilities and obstacles to change. As many organizations are reinventing themselves to meet the challenges of global competition and e-commerce, there is increasing pressure to develop and deploy new technologies that are ?exible, robust and responsive to rapid and unexpected change. Agent concepts hold great promise for responding to the new realities of - formation systems. They o?er higher-level abstractions and mechanisms which address issues such as knowledge representation and reasoning, communication, coordination, cooperation among heterogeneous and autonomous parties, p- ception, commitments, goals, beliefs, intentions, etc., all of which need conc- tual modelling. On the one hand, the concrete implementation of these concepts can lead to advanced functionalities.
Aesthetic Facial Surgery
Rhytidoplasty is a palliative procedure in which face wrinkles are surgically removed to promote a more youthful appearance.The first sections focus on the surgical planning, including psychological considerations, preparation of the patient and anatomical and biochemical changes caused by the aging process. It also describes the surgical anatomy of the forehead, face, neck and eyelids. The third section provides a comprehensive overview of the basic techniques of facelift with details of refined surgical approaches for each segment of the face and neck. It highlights liposuction techniques, lipoinjection as well as transference of stem cells, showing their importance in reshaping the facial contours. It addresses both the treatment of soft tissue and craniofacial bone structures to improve the aesthetics of the face. The next sections present the final scars after face-lifting, minimally invasive procedures as complementary approaches during rhytidoplasty and the associated procedures during rhytidoplasty. The last section discusses postoperative care.
Advances in Unmanned Aerial Vehicles : State of the Art and the Road to Autonomy
There has been tremendous emphasis in unmanned aerial vehicles, both of fixed (airplanes) and rotary wing (vertical take off and landing, helicopters) types over the past ten years. Applications span both civilian and military domains, the latter being the most important at this stage. This edited book provides a solid and diversified reference source related to basic, applied research and development on small and miniature unmanned aerial vehicles, both fixed and rotary wing. As such, the book offers background information on the evolution of such vehicles over the years, followed by modeling and control fundamentals that are of paramount importance due to unmanned aerial vehicle model complexity, nonlinearity, coupling, inhirent instability and parameter values uncertainty. Aspects of navigation, including visual-based navigation and target tracking are discussed, followed by applications to attitude estimation on micro unmanned aerial vehicles, autonomous solar unmanned aerial vehicle, biomimetic sensing for autonomous flights in near-earth environments, localization of air-ground wireless sensor networks, decentralized formation tracking, design of an unmanned aerial vehicle for volcanic gas sampling and design of an on-board processing controller for miniature helicopters.
Advances in Smaltalk ; 14th International Smaltalk Conference, ISC 2006, Prague, Czech Republic, September 4-8, 2006, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the 14th International Smalltalk Conference.
Advances in Radiation Oncology in Lung Cancer
This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state of the art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.
