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Drugs, the brain, and behavior : The pharmacology of therapeutics and drug use disorders
Provides a comprehensive overview of the brain and explores the clinical and pharmacological issues surrounding drug abuse and dependence. Dr Brick provides definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. Topics include: how psychoactive drugs affect cognition, behavior, and emotion; the brain/behavior relationship; the specific effects of major addictive and psychoactive drug groups; new definitions and thinking about abuse and dependence; and the medical uses of drugs, such as cannabinoids. A new chapter on biobehavioral markers explores how markers can guide the clinician in the diagnosis of some disorders. This book offers a quick reference guide which uses a balance of instruction, illustrations, tables, and formulas, that will give you a broad, lasting introduction to this intriguing subject.
Drugs in Ophthalmology
This drug handbook is divided into two sections: Alphabetical Listing of Drugs Entries in this section are listed by generic name. Information for each drug is arranged in a consistent format for easy reference. Summary of Anti-infectives This section summarizes the common doses of antibiotics, antifungals, and antivirals. For each drug, the dose for each route of administration is included.
Drugs Easily Explained
Provides an overview of the most common diseases and the drugs used to treat them. The book is designed for a general audience. It provides patients with essential information about how medications work and what side effects and interactions to expect. Finally, the book gives patients advice on what they can do themselves to improve drug therapy and safety. Summaries, bullet points, tables and diagrams support the information process.
Drugs and nutrients : The interactive effects
Devoted to the effects of food and of nutrient intake on the disposition of foreign compounds, and discusses effects of drugs on nutrition. It is intended for nutritionists and clinical investigators concerned with interpretation of aberrant effects of therapeutic drugs.
Drug-Induced Oral Complications
Provides detailed information on the prevalence and manifestations of the most important oral complications associated with different drug treatments, focusing especially on recently developed therapies. Among the diverse adverse drug reactions covered are gingival overgrowth, ulcerations, lichenoid reactions, pigmentation, and bullous reactions. The potential direct toxic effects on bone of drugs that prevent bone mass loss, such as bisphosphonates and denosumab, are fully examined, as is the occurrence of spontaneous oral bleeding in patients receiving antithrombotic therapies. Further chapters focus on drug-induced taste disorders and salivary gland disturbances, including xerostomia, swelling, and hypersalivation. The enhanced risk of oral infections when using chemotherapy and biotherapy is addressed, and the closing chapter examines drug-related perioral and facial complications. This book is a collaborative work that brings together clinicians, surgeons, and specialists in drug safety surveillance.
Drug Metabolism: Current Concepts
The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development.
Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters.
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug interactions in infectious diseases : Antimicrobial drug interactions
Delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.
DNA Binders and Related Subjects
advances in technology and the application of new methods to outstanding problems have played a major part in the development of ideas about drug-nucleic acid recognition. The field has undergone an explosive diversification as wider and wider problems became accessible to study using the new ideas and techniques. This volume reflects that diversification by offering accounts of selected areas that illustrate recent advances in the study of ligand–nucleic acid binding over disparate areas of the subject. There are chapters dealing specifically with the invention and application of new methodology, and a particularly thoughtful essay on the interpretation of X-ray diffraction data which may not be as straightforward as is often imagined. Other chapters illustrate the diversity and complexity of drug-DNA binding from several perspectives, referring to particular groups of related compounds or the potential attractions of the less-preferred DNA major groove as a target for nucleotide sequence recognition by ligands.
Disasters : Core Concepts and Ethical Theories
Examines disasters from a multidisciplinary perspective. Justification of actions in the face of disasters requires recourse both to conceptual analysis and ethical traditions. Part 1 of the book contains chapters on how disasters are conceptualized in different academic disciplines relevant to disasters. Part 2 has chapters on how ethical issues that arise in relation to disasters can be addressed from a number of fundamental normative approaches in moral and political philosophy. This book sets the stage for more focused normative debates given that no one book can be completely comprehensive. Providing analysis of core concepts, and with real-world relevance, this book should be of interest to disaster scholars and researchers, those working in ethics and political philosophy, as well as policy makers, humanitarian actors and intergovernmental organizations.
Directed Metallation
a new chelation-assisted methodology has been developed not only for controlling regio- and stereoselectivity of reactions, but also for accelerating reactions. In particular, chelation-methodology has been utilized as a new activation method, in which a carbon-metal bond is generated directly from a C-H bond; a reaction rarely achieved using conventional methods. A wide variety of catalytic functionalization reactions of C-H bonds by the utilization of a chelation, have been developed recently and are comprehensively discussed in this book by leading experts. In addition, new approaches to directed hydrometalation and directed carbometalation as a key step are also discussed. A unique stereo- and regioselective hydroformylation has been developed through the utilization of directed hydrometalation.
Digital Simulation in Electrochemistry
The book shows how to numerically solve the parabolic partial differential equations (pdes) encountered in electroanalytical chemistry. It does this in a didactic manner, by first introducing the basic equations to be solved and some model systems as text cases, for which solutions exist. Then it treats basic numerical approximation for derivatives and techniques for the numerical solution of ordinary differential equations, from which the more complicated methods for pdes can be derived. The major implicit methods are described in detail, and the handling of homogeneous chemical reactions, including coupled and nonlinear cases, is detailed. More advanced techniques are presented briefly, as well as some commercially available program packages.
Digital Human Modeling : Trends in Human Algorithms
The emerging information technologies have given rise to new human patterns in terms of both physiological and psychological interactions. Human Algorithms aim to model human forms, interactions, and dynamics in this new context.
Digital analytics for marketing
Provides students with a comprehensive overview of the tools needed to measure digital activity and implement best practices when using data to inform marketing strategy. It is the first text of its kind to introduce students to analytics platforms from a practical marketing perspective. Also demonstrates how to integrate large amounts of data from web, digital, social, and search platforms, this helpful guide offers actionable insights into data analysis, explaining how to "connect the dots" and "humanize" information to make effective marketing decisions. It overs timely topics, such as social media, web analytics, marketing analytics challenges, and dashboards, helping students to make sense of business measurement challenges, extract insights, and take effective actions. The book’s experiential approach, combined with chapter objectives, summaries, and review questions, will engage readers, deepening their learning by helping them to think outside the box.
Diasporic Hallyu : The Korean Wave in Korean Canadian Youth Culture
This book examines the lived experiences of diasporic Korean youth in light of the transnational flows of South Korean popular culture, known as the Korean Wave, or Hallyu. Drawing on an ethnographic study of Korean Canadian youth and their engagement with the Korean Wave, the book proposes a critical understanding of the interactions between diasporic youth audiences and popular culture.
Dialogue as a Collective Means of Design Conversation
Dialogue as a Collective Means of Design Conversation is the second volume edited by Patrick M. Jenlink and Bela H. Banathy to offer a cross-disciplinary approach to examining dialogue as a communicative medium. In this Compendium, the contributing authors set forth their ideas, experiences, and perspectives as the path of a learning journey—a journey of new meaning, of new understanding, and of becoming self-aware of design conversation as future creating and consciousness evolving. In particular, this volume comes at a time when we as a global society are faced with the question of how we shape our actions and in turn shape our future, through conversation that is focused on resolving global conflict and fostering world peace. The volume evokes in the reader a realization that our greatest potential rests, in no small measure, with our collective capacity for cultural creativity and in our capacity to achieve new levels of consciousness through dialogue and design conversation.
Development of statin is a breakthrough therapy in Alzheimer’s prevention
Dementia is one of the diseases which had several stages and Alzheimer’s term was selected in respect for the first doctor Alzheimer who defined the first symptoms of this diseases in a woman whom was well treated by him. The fact that this is a type of a silent disease on which you have a long-term process of neurological degradation and suddenly gives symptoms which are most often irreversible, on clinical level likely we can consider it as a malignancy, one in terms of that it is sudden shocking irreversible and on the level of behavior and some mortality beside the lack of early detection tools for diagnosis...
Developing a distributed medical system
Our project is a distributed medical system that is used by patients and multiple medical sectors such as doctors, pharmacists, analysis labs, hospitals, and medical insurance companies. The aim of the project is to add and store all the patient’s medical data in our system, such as previous treatments and past medical records from previous doctors, previous prescriptions and older lab test’s results, in addition, the insurance companies will have the ability to check on the medical treatment of its customers to do the necessary procedures needed for the them to perform their work. All of our actors are working in a secure and synchronized system in order to provide the best medical results possible, each actor has its own transactions to do in our system and can only manage and access the data allowed for him to perform his required job.
Detection of Liquid Explosives and Flammable Agents in Connection with Terrorism
The organization of an Advanced Research Workshop with the title “Detection and Disposal of Liquid Explosives and Flammable Agents in Connection with Terrorism” was motivated by international findings about activities in this field of application. This ARW followed a meeting about the “Detection of Disposal Improvised Explosives” (St. Petersburg, 2005). Both items show the logistic problems as one of the lessons, terrorists have to overcome. These problems are connected with the illegal supply and transport of explosives and fuels and as counter-measure the detection of these materials. The invention of liquid explosives goes back to the middle of the 19th century and was used for special purposes in the commercial field of application. Because of the high sensitivity of liquid explosives against mechanical shock, caused by adiabatic compression of air-bobbles producing “hot spots” as origin of initiation the commercial application was not very successful. Because of this high risk, liquid explosives are not used in military or commercial application with some exceptions. In the commercial field explosives as slurries or emulsions consisting of suitable salts (Ammoniumnitrate etc.) and water are used to a large extend because of their high insensitivity. In many cases these slurries or emulsions were unfit for terrorist actions, because of their low sensitivity, large critical diameter and using in confinement. In the military field liquid explosives are used in World War I and II as bomb-fillings.
