Page 16
Page 16
Pharmacology in drug discovery and development : Understanding drug response
An introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more.
Pervasive Computing : Innovations in Intelligent Multimedia and Applications
This useful volume provides up-to-date and state-of-the-art coverage of the diverse topics related to pervasive computing and intelligent multimedia technologies. The use of different computational intelligence-based approaches to various problems in pervasive computing are examined, including video streaming, intelligent behavior modeling and control for mobile manipulators, tele-gaming, indexing video summaries for quick video browsing, web service processes, virtual environments, ambient intelligence, and prevention and detection of attacks to ubiquitous databases.
Persuasive Technology ; 3rd International Conference, PERSUASIVE 2008, Oulu, Finland, June 4-6, 2008. Proceedings
Featuring full and short papers, posters and panels, Persuasive2008 highlighted new knowledge in the understanding and design of persuasive technology. The event brought together researchers, practitioners, and industry professionals - terested in this important new ?eld. Research themes of the conference included motivation altechnology, persuasivegames, smartenvironments, Web2.0, mobile persuasion, well-being and health behavior. In addition, attendees and part- ipants explored the theory and ethics of persuasive technology, social and - ganizational issues, business models for persuasive systems, and conceptual and theoretical approaches.
Persuasive Technology ; 2nd International Conference on Persuasive Technology, PERSUASIVE 2007, Palo Alto, CA, USA, April 26-27, 2007. Revised Selected Papers
Persuasive technology is the general class of technologies that purposefully apply psychological principles of persuasion – principles of credibility, trust, reciprocity, authority and the like – in interactive media, in the service of changing their users’ attitudes and behavior. Only one year ago, in 2006, the first international conference in this area, PERSUASIVE 2006 was hosted in Eindhoven.
Personality in Intimate Relationships : Socialization and Psychopathology
he book describes relationships along a readily identifiable continuum ranging from optimal functionality to severe pathology, linking the author’s conceptual framework to specific diagnostic strategies, therapeutic interventions, and prevention programs. L’Abate’s theory not only integrates individual and family theories and seemingly disparate schools of thought, but is also inclusive of nontraditional relationships—grandparent/grandchild dyads, adoptive families, same-sex couples, and others—that are often left out of the family literature.
Personal Branding in the Knowledge Economy : The Inter-relationship between Corporate and Employee Brands
Personal Branding in the Knowledge Economy: The Interrelationship between Corporate and Employee Brands aims to contribute to the academic debate about the marketization of individuals’ knowledge, creativity, and personal images, alongside a growing interest in the whole area of branding in the networked economy based on knowledge.
Perception and Illusion : Historical Perspectives
The understanding of perception is central to our knowledge of the mind. Yet paradoxically, this understanding was born of centuries of fascination with errors of human perception. Perception and Illusion: Historical Perspectives elegantly retraces this scientific journey, not only in terms of its trials and errors but in its complex relationships with painting and medicine, philosophy and physics.
Perceiving Geometry : Geometrical Illusions Explained by Natural Scene Statistics
Understanding vision, whether from a neurobiological, psychological or philosophical perspective, represents a daunting challenge that has been pursued for millennia. During at least the last few centuries, natural philosophers, and more recently vision scientists, have recognized that a fundamental problem in biological vision is that the physical sources underlying sensory stimuli are unknowable in any direct sense. In vision, because physical qualities are conflated when the 3-D world is projected onto the 2-D image plane of the retina, the provenance of light reaching the eye at any moment is inevitably uncertain. This quandary is referred to as the inverse optics problem. The relationship of the real world and the information conveyed to the brain by light present a profound problem. Successful behavior in a complex and potentially hostile environment clearly depends on responding appropriately to the sources of visual stimuli rather than to the physical characteristics of the stimuli as such. If the retinal images generated by light cannot specify the underlying reality an observer must deal with, how then does the visual system produce behavior that is generally successful? Perceiving Geometry considers the evidence that, with respect to the perception of geometry, the human visual system solves this problem by incorporating past human experience of what retinal images have typically corresponded to in the real world.
People and Things : A Behavioral Approach to Material Culture
This comprehensive text sets forth a theory for understanding the relationship between people and things. Humans, whether in the distant past or in our current world, make choices while inventing, developing, replicating, adopting, and using their technologies. A wide arc of factors, from utilitarian to social and religious can affect these choices. The theoretical model presented here provides the means to understand how people, whether it be Paleolithic stone tool makers or 21st century computer designers and users, negotiate these myriad factors throughout the artifact’s life history. While setting forth a behavioral theory, the book also engages the ideas of other competing theories, focusing especially on agency, practice, and selectionism.
Pediatric Gastrointestinal Disorders : Biopsychosocial Assessment and Treatment
Presents an overview of pediatric gastrointestinal disorders, their prevalence and etiology; and descriptions of the most common disorders, with their typical psychological and behavioral symptoms. This work also includes reviews of empirically-based, clinically sound assessment and treatment strategies.
Pedestrian and Evacuation Dynamics 2005
Due to an increasing number of reported catastrophes all over the world, the safety especially of pedestrians today, is a dramatically growing field of interest, both for practitioners as well as scientists from various disciplines. The questions arising mainly address the dynamics of evacuating people and possible optimisations of the process by changing the architecture and /or the procedure. This concerns not only the case of ships, stadiums or buildings, all with restricted geometries, but also the evacuation of complete geographical regions due to natural disasters. Furthermore, also ‘simple’ crowd motion in ‘relaxed’ situations poses new questions with respect to higher comfort and efficiency since the number of involved persons at large events is as high as never before.
Partner Choice and Cooperation in Networks : Theory and Experimental Evidence
Cooperation is beneficial but may be hard to achieve in situations where the selfish interests of individuals conflict with their common goal, such as in sharing of goods, help, knowledge or information, in trade and pollution negotiations, and in exploitation of common resources. The standard models of such "social dilemmas" assume that the individuals are obliged to participate in the dilemma. These models fail to capture an important element of human interaction: that people are in general free to select their interaction partners. In this book a social dilemma with partner selection is introduced and studied with the methods of formal game theory, experimental economics and computer simulations. It allows exploration of simultaneous dynamics of the network structure and cooperative behavior on this structure. The results of this study show that partner choice strongly facilitates cooperation and leads to networks where free-riders are likely to be excluded.
Parallel Problem Solving from Nature - PPSN X ; 10th International Conference, Dortmund, Germany, September 13-17, 2008. Proceedings
Constitutes the refereed proceedings of the 10th International Conference on Parallel Problem Solving from Nature, PPSN 2008, held in Dortmund, Germany, in September 2008.The 114 revised full papers presented were carefully reviewed and selected from 206 submissions. The conference covers a wide range of topics, such as evolutionary computation, quantum computation, molecular computation, neural computation, artificial life, swarm intelligence, artificial ant systems, artificial immune systems, self-organizing systems, emergent behaviors, and applications to real-world problems. The paper are organized in topical sections on formal theory, new techniques, experimental analysis, multiobjective optimization, hybrid methods, and applications.
P5 eHealth : An Agenda for the Health Technologies of the Future
Focuses on the development of a P5 eHealth, or better, a methodological resource for developing the health technologies of the future, based on patients’ personal characteristics and needs as the fundamental guidelines for design.
P.Y. Galperin's Development of Human Mental Activity : Lectures in Educational Psychology
This book introduces the legacy of Piotr Galperin to a wider audience of researchers, educators and psychologists. Previous translations of Galperin’s work present only some aspects of his conceptual thinking; however, his main contribution to the general, genetic and pedagogical psychology as a unique holistic and systemic approach to studying of psychological phenomena and processes, mechanisms of their formation and development, is still quite unknown in most parts of the world.
Oxytocin and related neuropsychiatric disorder
Oxytocin (OT), a hypothalamic neuropeptide involved in regulating the social behaviour of all vertebrates, has been proposed as a treatment for a number of neuropsychiatric disorders characterised by deficits in the social domain. Over the last few decades, advances focused on understanding the social effects of OT and its role in physiological conditions and brain diseases, e first recognized as a regulator of parturition and lactation which has recently gained attention for its ability to modulate social behaviors. here is mounting preclinical evidence that targeting the brain oxytocin system may provide that breakthrough. Substance use disorders are characterised by a viscous cycle of bingeing and intoxication, followed by withdrawal and negative affect, and finally preoccupation and anticipation that triggers relapse and further consumption.
Orphan G Protein-Coupled Receptors and Novel Neuropeptides
Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms.The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.
Origins of the Social Mind : Evolutionary and Developmental Views
In this book, we focus on the developmental and evolutionary origins of the social mind, bringing together the currently segregated views on social cognition in the two ? elds. Ever since the term “theory of mind” was coined by D. Premack nearly 30 years ago, the concept has been the main topic of social cognition research both in developmental psychology and in primatology. However, few attempts have been made to integrate these two research domains. Just recently, researchers from the two areas collaborated to publish a book on this topic, but the volume was little more than a collection of independent papers. This book overcomes that limitation by presenting new data and their implications from both developmental and evolutionary points of view.
Organizational, Motivational, and Cultural Contexts of Volunteering : The European View
Offers a comprehensive view of the phenomenon of volunteer work: it examines motivational factors and questions of corporate organization and the social environment. In particular, this is the first book to present volunteer work in detail as a psychosocial resource and a source of well-being that should not be overused or abused. It provides clear instructions on designing volunteer work tasks, and on where boundaries must be respected. The findings include insights into cultural and national differences, and offer practical advice on the organization of volunteer work.
Organisational Behaviour ; 9th ed.
In the dynamic, fast-paced and diverse 21st century workplace, managers and their employees are facing more challenges than ever before. In turn, educators must help to prepare their students for the reality of work and this text will support them to achieve this goal. This ninth edition is one of the most contemporary revisions of Organisational Behaviour undertaken. While the book's trademark features have been retained - clear writing style, solid theoretical underpinnings, cutting-edge content and engaging pedagogy - each chapter has been thoroughly updated to reflect the most recent research within the field of organisational behaviour and the major practical issues facing employees and managers in the contemporary workplace
