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Multi-Scale Approaches in Drug Discovery : From Empirical Knowledge to In silico Experiments and Back
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.
Multiplicative Invariant Theory
Multiplicative invariant theory, as a research area in its own right within the wider spectrum of invariant theory, is of relatively recent vintage. The present text offers a coherent account of the basic results achieved thus far.. Multiplicative invariant theory is intimately tied to integral representations of finite groups. Therefore, the field has a predominantly discrete, algebraic flavor. Geometry, specifically the theory of algebraic groups, enters through Weyl groups and their root lattices as well as via character lattices of algebraic tori.
Multiple Testing Procedures and Applications to Genomics
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. The methods are applied to a range of testing problems in biomedical and genomic research, including the identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments.
Multiple Stars Across the H-R Diagram ; Proceedings of the ESO Workshop held in Garching, Germany, 12-15 July 2005
Stars show a marked tendency to be in systems of different multiplicity, ranging from simple binaries and triples to globular clusters with several 10,000's of stars. The formation and evolution of multiple systems remains a challenging part of astrophysics, and the contributions in this book report on the significant progress that had been made in this research field in the last years. The reader will find a variety of research topics addressed, such as the dynamical evolution in multiple stars, the effects of the environment on multiple system parameters, stellar evolution within multiple stars, multiplicity of massive stars, pre-main sequence and intermediate mass stars, multiplicity of low-mass stars from embedded protostars to open clusters, and brown dwarfs and extrasolar planets in multiples.
Multiple Heterogeneous Unmanned Aerial Vehicles
Aerial robots can be considered as an evolution of the Unmanned Aerial Vehicles (UAVs). This book provides a quite complete overview of issues related to aerial robotics, addressing problems ranging from flight control to terrain perception and mission planning and execution. The major challenges and potentials of heterogeneous UAVs are comprehensively explored. It builds on the results of the European project COMETS, and highlights a number of key research topics in the area of UAV development, including communication, perception, teleoperation and decision making. The monograph emphasizes the current state of technology, the existing problems and potentialities of systems consisting of multiple UAVs which are heterogeneous in view of the different characteristics of the aerial vehicles, the different on-board payloads, and the different on-board information processing capabilities. The book also examines potential applications of UAVs and details a relevant application case: forest fire detection and monitoring.
Multiple Criteria Decision Analysis :State of the Art Surveys
The handbook presents the most up-to-date discussions on well-established methodologies and theories in the field, while systematically surveying emerging fields in MCDA such as conjoint measurement, fuzzy preferences, fuzzy integrals, rough sets, etc. MULTIPLE CRITERIA DECISION ANALYSIS is a valuable reference volume (more than 2000 references) for the field of decision analysis. It provides graduate students, researchers, and practitioners with a sweeping survey of MCDA theory, methodologies, and applications. It is a handbook that is particularly suitable for use in seminars in Decision Analysis, Decision Support, and Decision Theory.
Multiple Classifier Systems ; 6th International Workshop, MCS 2005, Seaside, CA, USA, June 13-15, 2005, Proceedings
Constitutes the refereed proceedings of the 6th International Workshop on Multiple Classifier Systems, MCS 2005. This book contains papers that are organized in topical sections on boosting, combination methods, performance analysis, and applications. They exemplify the advances in the theory and applications of multiple classifier systems
Multiple Classifier Systems ; 2nd International Workshop, MCS 2001 Cambridge, UK, July 2-4, 2001 Proceedings
Driven by the requirements of a large number of practical and commercially - portant applications, the last decade has witnessed considerable advances in p- tern recognition. Better understanding of the design issues and new paradigms, such as the Support Vector Machine, have contributed to the development of - proved methods of pattern classi cation. However, while any performance gains are welcome, and often extremely signi cant from the practical point of view, it is increasingly more challenging to reach the point of perfection as de ned by the theoretical optimality of decision making in a given decision framework. The asymptoticity of gains that can be made for a single classi er is a re?- tion of the fact that any particular design, regardless of how good it is, simply provides just one estimate of the optimal decision rule.
Multiple Bonds between Metal Atoms
The 3rd edition of the Multiple Bonds between Metal Atoms deals with one of the most active fields of inorganic chemistry … . It presents an extensive, critical review and discussion of preparations, reactions, bonding, and physical properties of more than 4000 compounds … heartily recommend it to inorganic and materials chemists, and to all scientists concerned with the synthesis, spectroscopy, and structures of transition-metal compounds. It also belongs in academic, industrial, and government research libraries.
Multi-Photon Quantum Interference
Multi-Photon Quantum Interference covers the phenomena of quantum interference through the multi-photon effects of photon correlation. The author’s focus is on the temporal correlation among photons and how it influences the interference effect.
Multiphase Reacting Flows : Modelling and Simulation
This book entitled ''Multiphase reacting flows: modelling and simulation'' contains the lecture notes of the CISM (International Centre for Mechanical Sciences) course held in Udine, Italy, on July 3-7, 2006, and it describes various modelling approaches for dealing with polydisperse multiphase reacting flows. A multiphase reacting system is characterized by the presence of multiple phases and in this book we focus on disperse multiphase systems, where one phase can be considered as a continuum, whereas the additional phases are dispersed in the continuous one. In other words, in this book we deal with multiphase systems constituted by particles, droplets or bubbles (i.e., solid particles suspended in a continuous liquid phase, liquid droplets in a gaseous phase, or gas bubbles in liquid.) The other important characteristic elements of the systems discussed in this book are the presence of one or more chemical reactions and the turbulent nature of the flow. The chemical reactions usually involve all the phases present in the system and might be responsible for the formation or disappearance of the disperse and/or continuous phases.
Multiphase Flow Dynamics 2 : Thermal and Mechanical Interactions ; 3rd ed.
Multi-phase flows are part of our natural environment such as tornadoes, typhoons, air and water pollution and volcanic activities as well as part of industrial technology such as power plants, combustion engines, propulsion systems, or chemical and biological industry. The industrial use of multi-phase systems requires analytical and numerical strategies for predicting their behavior. In its third extended edition this book contains theory, methods and practical experience for describing complex transient multi-phase processes in arbitrary geometrical configurations. This book provides a systematic presentation of the theory and practice of numerical multi-phase fluid dynamics. In the present second volume the mechanical and thermal interactions in multiphase dynamics are provided. This third edition includes various updates, extensions, improvements and corrections.
Multiphase Flow Dynamics 1 : Fundamentals ; 3rd ed.
Multi-phase flows are part of our natural environment such as tornadoes, typhoons, air and water pollution and volcanic activities as well as part of industrial technology such as power plants, combustion engines, propulsion systems, or chemical and biological industry. The industrial use of multi-phase systems requires analytical and numerical strategies for predicting their behavior. In its third extended edition this monograph contains theory, methods and practical experience for describing complex transient multi-phase processes in arbitrary geometrical configurations, providing a systematic presentation of the theory and practice of numerical multi-phase fluid dynamics. This third edition includes various updates, extensions and improvements in all book chapters.
Multiphase Flow Dynamics 1 : Fundamentals ; 2nd ed.
In its second extended edition this monograph contains theory, methods and practical experience for describing complex transient multi-phase processes in arbitrary geometrical configurations. In the present first volume the fundamentals of multiphase dynamics are provided, as well as various interactive multimedia demonstrations on an accompanying CD-ROM.
Multiobjective Optimization : Interactive and Evolutionary Approaches
Multiobjective optimization deals with solving problems having not only one, but multiple, often conflicting, criteria. Such problems can arise in practically every field of science, engineering and business, and the need for efficient and reliable solution methods is increasing. The task is challenging due to the fact that, instead of a single optimal solution, multiobjective optimization results in a number of solutions with different trade-offs among criteria, also known as Pareto optimal or efficient solutions. Hence, a decision maker is needed to provide additional preference information and to identify the most satisfactory solution. Depending on the paradigm used, such information may be introduced before, during, or after the optimization process. Clearly, research and application in multiobjective optimization involve expertise in optimization as well as in decision support.
Multi-objective Management in Freight Logistics : Increasing Capacity, Service Level and Safety with Optimization Algorithms
Multi-objective Management in Freight Logistics provides decision makers with new methods and tools to implement multi-objective optimization models in logistics. The book combines theoretical aspects with applications, showing the advantages and the drawbacks of adopting scalarization techniques, and when it is worthwhile to reduce the problem to a goal programming one. The book also shows applications where more than one decision maker evaluates the effectiveness of the logistic system and thus a multilevel programming approach is sought to attain meaningful solutions.
Multinational Enterprises, Foreign Direct Investment and Growth in Africa : South African Perspectives
How can Africa, the world’s most lagging region, benefit from globalisation and achieve sustained economic growth? Africa needs greater investment by Multinational Enterprises (MNEs) to improve competitiveness and generate more growth through positive spill-over effects. Despite the fact that Africa’s returns on investment averaged 29% since 1990, Africa has gained merely 1% of global Foreign Direct Investment (FDI) flows. The challenge for African countries is how to be a more desirable destination for FDI. The study integrates three currents of economic research, namely from the literature on (endogenous) economic growth, convergence and regional integration, the explanations for Africa’s poor growth and the growing understanding of the role of MNEs in a global economy. The empirical side of the book is based on an econometric study of the determinants of FDI in Africa as well as a detailed firm-level survey conducted in 2000.
Multimodal Video Characterization and Summarization
Multimodal Video Characterization and Summarization is a valuable research tool for both professionals and academicians working in the video field. This book describes the methodology for using multimodal audio, image, and text technology to characterize video content. This new and groundbreaking science has led to many advances in video understanding, such as the development of a video summary. Applications and methodology for creating video summaries are described, as well as user-studies for evaluation and testing.
Multimodal Technologies for Perception of Humans ; International Evaluation Workshops CLEAR 2007 and RT 2007, Baltimore, MD, USA, May 8-11, 2007, Revised Selected Papers
This book constitutes the thoroughly refereed joint post-workshop proceedings of two co-located events: the Second International Workshop on Classification of Events, Activities and Relationships, CLEAR 2007, and the 5th Rich Transcription 2007 Meeting Recognition evaluation, RT 2007, held in succession in Baltimore, MD, USA, in May 2007.The workshops had complementary evaluation efforts; CLEAR for the evaluation of human activities, events, and relationships in multiple multimodal data domains; and RT for the evaluation of speech transcription-related technologies from meeting room audio collections.
Multimodal Processing and Interaction : Audio, Video, Text
Multimodal Processing and Interaction: Audio, Video and Text presents high quality, state-of-the-art research ideas and results from theoretic, algorithmic and application viewpoints. This edited volume contains both state-of-the-art reviews and original contributions by leading experts in the scientific and technological field of multimedia. It grew out of a four-year collaboration among research groups participating in the European network of Excellence on Multimedia Understanding, Semantics, Computation and Learning (MUSCLE).
