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Chromatin and Disease
It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics.
Chondral Disease of the Knee : A Case-Based Approach
This valuable resource features case studies that help the reader develop an understanding of chondral disease and hone the decision-making skills integral to successful cartilage repair and solution implementation. The case studies included were selected for optimum clinical value and cover such issues as injury evaluation, physical examination, radiographic evaluation, and comorbidities. Each case is complemented by brilliant illustrations, many in color, and concludes with bulleted decision-making factors that can be easily incorporated into clinical practice.
Chinese Spoken Language, Processing ; 5th International Symposium, ISCSLP 2006, Singapore, December 13-16, 2006, Proceedings
This book contains a selection of refereed papers presented at the Fifth Inter- tionalSymposium on Chinese Spoken Language Processing(ISCSLP 2006), held in Singapore during December 13-16, 2006. ISCSLP is a biennial conference for scientists, researchers, and practitionersto reportand discuss the latest progress in all scientifc and technological aspects of Chinese spoken language processing (CSLP). The previous four conferences were held in Singapore (ISCSLP 1998), Beijing (ISCSLP 2000), Taipei (ISCSLP 2002) and Hong Kong (ISCSLP 2004), respectively.
Chinese Computational Linguistics ; 19th China National Conference, CCL 2020, Hainan, China, October 30 – November 1, 2020, Proceedings
This book constitutes the proceedings of the 19th China National Conference on Computational Linguistics, CCL 2020, held in Hainan, China, in October/November 2020. The 32 full and 2 short papers presented in this volume were carefully reviewed and selected from 99 submissions. They were organized in topical sections named: fundamental theory and methods of computational linguistics; information retrieval, dialogue and question answering; text generation and summarization; knowledge graph and information extraction; machine translation and multilingual information processing; minority language information processing; language resource and evaluation; social computing and sentiment analysis; and NLP applications.
China's Energy Revolution in the Context of the Global Energy Transition
This book is an encyclopaedic analysis of the current and future energy system of the world’s most populous country and second biggest economy. What happens in China impacts the planet. In the past 40 years China has achieved one of the most remarkable economic growth rates in history. Its GDP has risen by a factor of 65, enabling 850,000 people to rise out of poverty.
China’s Gas Development Strategies
This book is open access under a CC BY 4.0 license. This book examines how China can increase the share of natural gas in its energy system. China’s energy strategy has global ramifications and impact, and central to this strategy is the country’s transition from coal to gas. The book presents the culmination of a two-year collaboration between the Development Research Center of the State Council (DRC) and Shell.
China and the World in a Changing Context : Perspectives from Ambassadors to China
This book aims to present an overview of China and the world from diverse angles. It brings together essays by ambassadors to China on a range of bilateral and multilateral issues, including trade and investment, regional economic cooperation, sustainable development, technology and innovation, and entrepreneurship. Given their familiarity with China and extensive international experience, the insights of these ambassadors are useful for policymakers, academics, entrepreneurs, students, and anyone trying to make sense of our rapidly changing world.
Children's Exploration and Cultural Formation
This book examines the educational conditions that support cultures of exploration in kindergartens. It conceptualises cultures of exploration, whether those cultures are created through children’s own engagement or are demanded of them through undertaking specific tasks within different institutional settings.
Children and the Dark Side of Human Experience : Confronting Global Realities and Rethinking Child Development
Synthesizing insights from psychology and philosophy with his own wide-ranging, first-hand experiences around the world, Dr. James Garbarino takes readers on a personalized journey into the dark side of human experience as it is lived by children. In these highly readable pages, Dr. Garbarino intertwines a discussion of children’s material and spiritual needs with a detailed examination of the clinical knowledge and experiential wisdom required to understand and meet complex developmental needs. Fusing anecdotal observations, empirical evidence, and an ecological perspective, he reveals a path to ensuring the fundamental human rights of all children: the right to safety, to equality, to economic parity, and to a meaningful life.
Child soldiers and the defence of duress under International criminal law
Investigates the use of duress as a defence in international criminal law, specifically in cases of child soldiers. The prosecution of children for international crimes often only focuses on whether children can and should be prosecuted under international law. However, it is rarely considered what would happen to these children at the trial stage. This work offers a nuanced approach towards international prosecution and considers how children could be implicated and defended in international courts.
Child Neuropsychology : Assessment and Interventions for Neurodevelopmental Disorders
Child Neuropsychology guides therapists and neurologists toward common goals: early, accurate diagnosis and finely focused interventions across disciplines. By analyzing the affects of brain development on children and adolescents’ behavioral, cognitive, learning, and psychosocial abilities and deficits, this groundbreaking volume brings vital perspectives to assessment and treatment. Leading experts Ellison and Semrud-Clikeman start with the basics of child clinical neuropsychology and functional neuroanatomy, taking readers through examination protocols and assessment instruments to treatment planning and methods. In this volume, the authors address the full range of neurodevelopmental pathologies, from learning disabilities to autism, ADHD to CNS disorders, traumatic brain injury to fetal alcohol syndrome.
Chernobyl: Catastrophe and Consequences
The long-term effects of the Chernobyl incident on the environment are still becoming apparent, twenty years after the event. This book, written by two researchers with frontline experience in this field, provides a detailed review of these over a wide range of ecosystems. It also discusses the responses and countermeasures utilised to combat the effects of the accident, as well as considering the health, social, psychological and economic impacts on the human population. Chernobyl - Catastrophe and Consequences / provides a comprehensive assessment of the Chernobyl accident and its long-term consequences draws on the most recent measurements of contamination in the terrestrial and aquatic food chains / discusses the sociological consequences of such disasters in detail / This book adds valuable weight to the debate about the environmental cost of nuclear power and the issue of nuclear safety.
Chernobyl - What Have We Learned? : The Successes and Failures to Mitigate Water Contamination Over 20 Years
Twenty million people have been exposed to Chernobyl radionuclides through the Dnieper River aquatic pathways. This book presents a 20-year historical overview and comprehensive study results of the aquatic environment affected by the 1986 Chernobyl nuclear accident. During this time, many water quality management practices and countermeasures were enacted. The book presents in-depth analyses of these water remediation actions, using current science and mathematical modeling, and discusses why some were successful, but many others failed. The chapter entitled Where Do We Go From Here? incorporates a comprehensive discussion of the planned New Safe Confinement (NSC) structure to cover the Chernobyl plant. The book closes with a summary and conclusions drawn from these analyses, making it a valuable reference tool for the future. This book will be of interest to engineers, scientists, decision-makers, and those involved in radiation protection and radioecology, environmental protection and risk assessment, water remediation and mitigation measures, and radioactive waste disposal. In addition, the detailed, almost day-to-day, emergency responses to the Chernobyl accident described in this book will also be useful to people developing emergency and long-term responses to accidental or intentional (by terrorists) releases of radionuclides, toxic chemicals and biological agents.
Chemometrics and Cheminformatics in Aquatic Toxicology
Chemometrics and Cheminformatics in Aquatic Toxicology delivers an exploration of the existing and emerging problems of contamination of the aquatic environment through various metal and organic pollutants, including industrial chemicals, pharmaceuticals, cosmetics, biocides, nanomaterials, pesticides, surfactants, dyes, and more. The book discusses different chemometric and cheminformatic tools for non-experts and their application to the analysis and modeling of toxicity data of chemicals to various aquatic organisms.
Chemistry for the Protection of the Environment 4
This volume is the proceedings of the first CPE conference in the new millennium and the thirteenth in a well-established series of conferences on Chemistry for the Protection of the Environment, first established in 1976. With support of the U.S. EPA, the series of conferences provides an opportunity for interdisciplinary exchange of ideas among international specialists, from diverse fields and backgrounds, on the chemical aspects of environmental protection. Over the years, the CPE conferences have gathered participants from more and more countries, and the scope of interests have been broadened. Held in Hilo, Hawaii, this was the first of these international conferences to take place in the United States. The Organizing Committee attracted to the conference a wide range of talented scientists and engineers who have useful ideas to contribute on how to clean our environment.
Chasing the Chinese dream : Four decades of following China’s war on poverty
This book explores the historical, cultural and philosophical contexts that have made anti-poverty the core of Chinese society since Liberation in 1949, and why poverty alleviation measures evolved from the simplistic aid of the 1950s to Xi Jinping’s precision poverty alleviation and its goal of eliminating absolute poverty by 2020. The book also addresses the implications of China’s experience for other developing nations tackling not only poverty but such issues as pandemics, rampant urbanization and desertification exacerbated by global warming. The first of three parts draws upon interviews of rural and urban Chinese from diverse backgrounds and local and national leaders. These interviews, conducted in even the remotest areas of the country, offer candid insights into the challenges that have forced China to continually evolve its programs to resolve even the most intractable cases of poverty.
Charting the Topic Maps Research and Applications Landscape ; 1st International Workshop on Topic Map Research and Applications, TMRA 2005, Leipzig, Germany, October 6-7, 2005, Revised Selected Papers
The papers in this volume were presented at the workshop “Topic Map Research and Applications 2005” held on October 6-7, 2005, in Leipzig. TMRA 2005 was the first workshop of an annual series of international workshops dedicated to topic maps in research and industry. As the motto “Charting the Topic Maps Research and Applications Landscape” suggests, the aim of TMRA 2005 was to identify the primary open issues in research, learn about who is working on what, bring together researchers and application pioneers, stimulate the systematic tackling of such issues, and foster the exchange of ideas in a stimulating setting.
Charting Spiritual Care : The emerging role of Chaplaincy Records in Global Health Care
This book is the first academic book on the controversial issue of including spiritual care in integrated electronic medical records (EMR). Based on an international study group comprising researchers from Europe (The Netherlands, Belgium and Switzerland), the United States, Canada, and Australia, this edited collection provides an overview of different charting practices and experiences in various countries and healthcare contexts.
Charting a new course : Natural language processing and information retrieval : Essays in Honour of Karen Spärck Jones
This book celebrates the life and work of Karen Spärck Jones in her seventieth year. she is one of the major figures of 20th century and early 21st Century computing and information processing. It book consists of fifteen new and original chapters written by leading international authorities reviewing the state of the art and her influence in the areas in which Karen Spärck Jones has been active. Although she has a publication record which goes back over forty years, it is clear even the very early work reviewed in the book can be read with profit by those working on recent developments in information processing like bioinformatics and the semantic web.
Charity Law & Social Policy : National and International Perspectives on the Functions of the Law Relating to Charities
Charity Law & Social Policy explores contemporary law, policy and practice in a range of modern common law nations. It does so in four parts and from the perspective of how this has evolved in the UK.As progenitor of a system bequeathed to its colonies and after centuries of leadership in developing the core principles, policies and precedents that subsequently shaped its development, the contribution of England & Wales, the originating jurisdiction, is first described and analysed in detail.
