Page 127
Page 127
Antioxidants as nutraceuticals
Provides a comprehensive overview of antioxidants and nutraceuticals, including their sources, mechanisms of action, and health benefits, this new volume first covers the basics of the types of antioxidants as nutraceuticals, including the importance of phytochemical antioxidants and their nutritional and pharmacological intervention in the treatment of disease. It discusses the natural origins of antioxidants, classification, mechanisms of action, calculation of antioxidant potential of nutraceutical substances, safety, toxicity, and their significant involvement in the prevention of many degenerative and chronic diseases.
Antioxidants
Highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.
Antimicrobial Resistance and Implications for the Twenty-First Century
This new volume of the Emerging Infectious Diseases of the 21st Century series is a collection of chapters by leading world authorities on antimicrobial resistance of common, important bacterial, viral and fungal pathogens. This unique book should be in the possession of anyone interested in the field of infectious diseases, microbiology, infection control & public health. The chapters, which are written by reknown experts, provide a wealth of contemporary information on microbiology, molecular mechanisms, epidemiology, clinical relevance, treatment, and prevention
Antifouling Compounds
Increasing awareness of the deleterious effects of toxic components in antifouling coatings has raised interest in the potential for nontoxic alternatives. This book examines how marine organisms from bacteria to invertebrates and plants use chemicals to communicate and defend themselves. Chemicals that prevent colonisation of living surfaces are particularly pertinent to antifouling technology and may inspire new solutions. The challenge is to identify such compounds, identify the means for sustainable production and incorporate them into coatings to give long-term antifouling efficacy.
Antidepressants Beyond Depression, and Into Bacteria
Antidepressants are one of the most predominant drug groups in the pharmaceutical world, primary care units and the general public. Their original use was majorly for the treatment of depression along with other mental disorders. Today, antidepressant consume over 20% of the medical prescriptions and healthcare plans due to their recently discovered applications outside the psychiatry field. Due to the alarming rise of antibiotic resistance and the slow pace of new drug discovery, the world has been searching frantically for new or alternative drugs with antibacterial activity. Repurposing already FDA- approved drugs for uses that are off-label has become an important preposition in the pharmacy world due to its availability, low risk and low cost.
Anticancer activity in heterocyclic organic structures : A pathway to novel drug development : Part 1
New Directions in Organic & Biological Chemistry, explores the development of cancer therapeutics, focusing on molecular chemistry and advanced drug design approaches. Written by experts in theoretical chemistry and molecular chemistry, they bridge the gap between theoretical chemistry, molecular biology, and drug development. In Part I, they focus on the fundamental properties of heterocyclic compounds and innovative methodologies being employed to enhance therapeutic potential. By exploring various classes of heterocyclic compounds and diverse anticancer mechanisms.
Antibody-drug conjugates and cellular metabolic dynamics
Summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs.
Antibiotics : Methods and protocols
Provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, as well as methods for the analysis and detection of microbial responses and adaptation strategies. Antibiotics: Methods and Protocols, Second Edition, guides readers through updated and entirely new chapters on production and design, mode of action, and response and resistance. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Antibiotic Policies : Fighting Resistance
This book addresses many of the key issues taxing our society and hospitals in an era of epidemic resistance and shortage of new antibiotics. Written by internationally renowned experts in the field, this volume will provide practical advice and inform control strategies for the most urgent of problems related to antibiotic resistance epidemic for years to come. Antibiotic Policies: Fighting Resistance is an ideal volume for health professionals with an interest in this field.
Antiangiogenic Agents in Cancer Therapy
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Anthropologies of Global Maternal and Reproductive Health : From Policy Spaces to Sites of Practice
This open access edited book brings together new research on the mechanisms by which maternal and reproductive health policies are formed and implemented in diverse locales around the world, from global policy spaces to sites of practice. The authors – both internationally respected anthropologists and new voices – demonstrate the value of ethnography and the utility of reproduction as a lens through which to generate rich insights into professionals’ and lay people’s intimate encounters with policy.
Anthracycline Chemistry and Biology II : Mode of Action, Clinical Aspects and New Drugs
This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.
Antennas & propagation for wireless communication systems ; 2nd ed.
Antennas and propagation are of fundamental importance to the coverage, capacity and quality of all wireless communication systems. This book provides a solid grounding in antennas and propagation, covering terrestrial and satellite radio systems in both mobile and fixed contexts. Building on the highly successful first edition, this fully updated text features significant new material and brand new exercises and supplementary materials to support course tutors. A vital source of information for practising and aspiring wireless communication engineers as well as for students at postgraduate and senior undergraduate levels, this book provides a fundamental grounding in the principles of antennas and propagation without excessive recourse to mathematics. It also equips the reader with practical prediction techniques for the design and analysis of a very wide range of common wireless communication systems.
Anorectal Malformations in Children : Embryology, Diagnosis, Surgical Treatment, Follow-up
The book assembles many new aspects in the broad field of anorectal and genitourinary malformations. Special attention is given to the new surgical techniques posterior sagittal anorectal plasty (PSARP), urogenital sinue advancement, and laparoscopy. The results of an international workshop of 26 international authorities on congenital malformations of the organs of the pelvis and perineum are presented. The new classification proposed at the Krickenberg Conference will enable future studies comparing the types and the results of treatment of anorectal malformations.
Annotating, Extracting and Reasoning about Time and Events ; International Seminar, Dagstuhl Castle, Germany, April 20-15, 2005, Revised Papers
The book presented centers around an emergingde factost and ardfortime and event annotation: TimeML. TimeML has recently been adopted as a candidate for an ISO standard, and is currently being reviewed in this capacity.It discussions focussed on the following three Time- related issues: using the TimeML language efiectively for consistent annotation, determining how useful such annotation is for further processing,and describing modifications that should be applied to the standard for applications such as question-answering and information retrieval. Discussions at the Dagstuhl Seminar led to new researchideas, and a variety
Anion Sensing
This treatise on anion sensing and recognition represents a new addition to a very small number of books in this area, Although this Topics volume does not cover all the different classes fo receptors, it does provide new and timely perspectives to anion chemistry by highlighting several areas that have been generally overlooked in other reviews. The individual chapters are well-written and include references from earlier works up to the present. As such, this volume will be of interest to the community of researchers interested in anions as well as to those who wish to learn about the host-guest chemistry of anion recognition and its applications.
Animals and the shaping of modern medicine : One health and its histories
This book breaks new ground by situating animals and their diseases at the very heart of modern medicine. In demonstrating their historical significance as subjects and shapers of medicine, it offers important insights into past animal lives, and reveals that what we think of as ‘human’ medicine was in fact deeply zoological.Each chapter analyses an important episode in which animals changed and were changed by medicine. Ranging across the animal inhabitants of Britain’s zoos, sick sheep on Scottish farms, unproductive livestock in developing countries, and the tapeworms of California and Beirut, they illuminate the multi-species dimensions of modern medicine and its rich historical connections with biology, zoology, agriculture and veterinary medicine. The modern movement for One Health – whose history is also analyzed – is therefore revealed as just the latest attempt to improve health by working across species and disciplines.
Animal Models of T Cell-Mediated Skin Diseases
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
Angiogenesis and Direct Myocardial Revascularization
In Angiogenesis and Direct Myocardial Revascularization, an interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis.
Anesthesiology : New insights
Provides a comprehensive overview of current developments in anaesthesiology. The chapters : Solutions for Insufficient Epidural Analgesia for Planned Vaginal Birth and Interdisciplinary Emergencies in the Delivery Room, Anesthesia for Robotic Surgeries in Children, Anesthetic Management of Bronchoscopic Lung Volume Reduction, General Anaesthesia in the Context of Haemorrhagic Shock and Trauma, Anesthesiologic Management of Patients with Opioids or Psychoactive Substance Use, Fascial Plane Blocks, Considerations and New Perspectives of Locoregional Anesthesia in Dentistry, The Effect of Parental Anxiety on Postoperative Paediatric Cognitive Dysfunction.
