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Integral Methods in Science and Engineering : Techniques and Applications
The physical world is studied by means of mathematical models, which consist of differential, integral, and integro-differential equations accompanied by a large assortment of initial and boundary conditions. In certain circumstances, such models yield exact analytic solutions. When they do not, they are solved numerically by means of various approximation schemes. Whether analytic or numerical, these solutions share a common feature: they are constructed by means of the powerful tool of integration—the focus of this self-contained book. This work illustrates the application of integral methods to diverse problems in mathematics, physics, biology, and engineering. The thirty two chapters of the book, written by scientists with established credentials in their fields, contain state-of-the-art information on current research in a variety of important practical disciplines.
Insects as natural enemies : A practical perspective
This book it is an account of major aspects of the biology of predators and parasitoids, punctuated with information and advice on which experiments or observations to conduct, and how to carry them out. Guidance is provided, where necessary, on the literature that may need to be consulted on particular topics.
Innovative Medicine : Basic Research and Development
Devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”.
Injecting Salmonella Bacteria in to the Tumor Cures Cancer
The human body is inhabited by millions of tiny living organisms like good bacteria. We acquire these bacteria during birth and the first years of life, and they live with us throughout our lives. The human microbiomes are involved in healthy growth, in protecting the body from invaders, in helping digestion, and in regulating moods, but sometimes these bacteria can also be harmful. We need to take good care of our health to avoid the development of some diseases, like salmonella for example. Salmonella infections in humans can range from self-limiting gastroenteritis typically associated with non-typhoidal Salmonella (NTS) to typhoidal fever, which can be life-threatening. Salmonellosis causes considerable morbidity and mortality in both humans and animals, and has a significant socioeconomic impact worldwide.
Information and its role in nature
Infromation and Its Role in Nature presents an in-depth interdisciplinary discussion of the concept of information and its role in the control of natural processes. After a brief review of classical and quantum information theory, the author addresses numerous central questions, including: Is information reducible to the laws of physics and chemistry? Does the Universe, in its evolution, constantly generate new information? Or are information and information-processing exclusive attributes of living systems, related to the very definition of life? If so, what is the role of information in classical and quantum physics? In what ways does information-processing in the human brain bring about self-consciousness? Accessible to graduate students and professionals from all scientific disciplines, this stimulating book will help to shed light on many controversial issues at the heart of modern science.
Influenza Vaccines for the Future
The threat constituted by the multiple outbreaks of avian influenza during the last few years is urgently calling for the development of new influenza vaccines. Fortunately, a quantum leap in technology has revolutionized the study of influenza and the engineering of new vaccine strains by reverse genetics. This volume provides a historical background and state-of-the-art information about the recent advances in the biology of influenza and the design of new influenza vaccines.
Infectious disease : A very short introduction
Provides a conceptual framework for thinking about disease. Ecology and evolution provide the keys to answering the ‘where’ / ‘why’ / ‘how’ / and ‘what’ questions about any particular infectious disease: where did it come from? How is it transmitted from one person to another / and why are some individuals more susceptible than others? What biochemical / ecological / and evolutionary strategies can be used to combat the disease? Is it more effective to block transmission at the population level / or to block infection at the individual level? Through a series of case studies / Benjamin Bolker and Marta L. Wayne introduce the major ideas of infectious disease in a clear and thoughtful way / emphasizing the general principles of infection / the management of outbreaks / and the evolutionary and ecological approaches that are now central to much research about infectious disease.
Infection Control in the Intensive Care Unit
Infection Control in the Intensive Care Unit has been entirely rewritten in this second edition. All statements are justified by the best available evidence, avoiding unsubstantiated expert opinion. The book contains a new section dedicated to the microbiology of the critically ill, specifically, how to process and interpret surveillance cultures to distinguish the ‘normal’ from the ‘abnormal’ carrier state. There are five totally new chapters dealing with evidence-based infection control molecular techniques for outbreak analysis; clinical virology in neonatal, paediatric and adult intensive care; the six basic principles of the therapy of an infection; and the role of the pharmacist in infection control. Attention is given to special topics such as nutrition, gut mucosal protection and the control of antimicrobial resistance. The addition of enteral to parenteral antimicrobials contributes to the control of multi-resistant micro-organisms. This completely revised second edition is a ‘must have’ for anyone requiring in depth knowledge in the ever expanding field of infection control.
Industrial enzymes : Structure, function and applications
Man's use of enzymes dates back to the earliest times of civilization. Important human activities such as the production of certain types of foods and beverages, and the tanning of hides and skins to produce leather for garments, serendipitously took advantage of enzyme activities. Important advances in our understanding of the nature of enzymes and their action were made in the late 19th and early 20th centuries, seeding the explosive expansion from the 1950s and 60s onward to the present billion dollar enzyme industry. Recent developments in the fields of genetic engineering and protein chemistry are bringing ever more powerful means of analysis to bear on the study of enzyme structure and function that will undoubtedly lead to the rational modification of enzymes to match specific requirements as well as the design of new enzymes with novel properties.
Industrial applications of microbial enzymes
Microbial enzymes are important because they can be used for a wide variety of industrial purposes. There is dispersed and scanty information available with respect to microbial enzymes and their industrial applications. In this edited book, leading scientists have covered the various aspects of microbial enzymes and their industrial applications. Using microbial enzymes can help expedite various manufacturing processes and contribute to sustainable development, which is a priority worldwide. Research gaps in the entrainment of microbial enzymes with their direct application in product development are a major focus of this volume.
Inclusions in Prokaryotes
The new series "Microbiology Monographs" begins with two volumes on intracellular components in prokaryotes. In this first volume, "Inclusions in Prokaryotes", the components, labeled inclusions, are defined as discrete bodies resulting from synthesis of a metabolic product.
In Vitro Culture of Mycorrhizas
biologists have made important progress in understanding better the functioning of AM fungi. An in vitro technique has been developed using mycorrhizal root organ cultures, which made it possible to investigate the genetics, cell biology and physiology of AM fungi. We can now be objective enough to critically evaluate the impacts the in vitro technique has had to improve our knowledge on mycorrhizal symbiosis.
Immunology, phenotype first : How mutations have established new principles and pathways in immunology
This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists.
Immunology of fungal infections
Covers all aspects of the immunology of fungal infection. Beyond the basics, coverage includes recent developments in innate and adaptive immunological mechanisms involved in the host response to fungal infection.
Immunology for Dentistry
Fulfils the need for a comprehensive overview of oral immunology and its key aspects for dental medicine. Its broad-based and accessible coverage introduces readers to all essential elements of oral immunology, from mechanisms of the immune system through to specific diseases and pathogens and their interactions with the immune system. This thorough text will provide an understanding of the link between the oral immune system and oral microbiome as contributors to oral health.
Immunoinformatics
Immunoinformatics is an emerging subdiscipline of bioinformatics. It utilizes mathematics, information science, computer engineering, genomics, proteomics and immunological methods to bridge immunology and informatics. Similar to bioionformatics which became a driving force in genome research, immunoinformatics enables data-driven research strategies and systems approaches that aim at understanding the networks regulating the immune system. Considering the breath of topic, Immunoinformatics was composed to provide a cross-section of research ranging from data integration, epitope predictions to systems level applications. In ten chapters experts in the field introduce and discuss research strategies for immunologists and bioinformaticians who wish to endeavour existing and new approaches to gain insight into the workings of the immune system.
Immunogenetics: Methods and Protocols
Explores techniques for working in the field of immunogenetics, i.e. fundamental and translational research into the adaptive immune receptor repertoire. Many chapters are dedicated to lab protocols, bioinformatics, and immunoinformatics analysis of high-resolution immunome analysis, exemplified by numerous applications. Additionally, the newest technological variations on these protocols are discussed, including non-amplicon, single-cell, and cell-free strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immunobiology of natural killer cell receptors
Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.
Immune receptors : Methods and protocols
Explores immune cell receptors that are used in the detection of microbes, either by binding directly to non-self molecules or through indirectly sensing microbe-associated cellular disturbances. The covers methods for studying receptor-ligand interactions at both molecular and cellular levels; methods to create and characterize novel antibody reagents; and methods to characterize the molecular processes that lead to adaptive receptor maturation. This book also contains chapters that look at high-throughput strategies that describe the diversity of immune receptors and cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immune mediators in cancer : Methods and protocols
Provides a comprehensive collection of classic and cutting-edge methodologies as well as bioinformatics and genome-editing approaches that are used to quantify immune mediators and analyze their function and biological activity in cancer cells and tissues. Beginning with a section on the detection of immune mediators in samples, the volume continues with sections covering cytokine bioassays, the expression and regulation of immune mediators in cancer cells, and methods to navigate the enormous datasets created by modern DNA and RNA sequencing and proteomic technology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
