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Good laboratory practice for nonclinical studies
The GLP regulations have been enacted since 1978 and are currently under a proposed FDA amendment to revise terminology and accommodate other changes relating to advances in technology related to the industry. This book provides a unique opportunity to access interpretation of the 21CFR58 regulatory requirements from leading industry experts with a vast knowledge and expertise in their fields. The approach used takes the regulations, provides interpretations and references to examples and regulatory actions. Data integrity and the use of electronic systems in compliance with 21CFR11 Electronic Records: Electronic Signatures are also discussed.
Global Specification and Validation of Embedded Systems : Integrating Heterogeneous Components
Global modelling and validation is required to master the design of systems made of heterogeneous components. These systems are now omnipresent in our life, and they may be found in several domains such as communications (ex. mobile terminals, optical switches), health (e.g. cardiac stimulators, cochlear implants), transportation (ex. automotive and aeronautical), etc. The main difficulties for their design are modelling and validation of the interactions between different components (hardware, software, analogue, RF, optical and micro-mechanical).
Global regulations of medicinal, pharmaceutical, and food products
Medicine regulation demands the application of sound medical, scientific, and technical knowledge and skills, and operates within a legal framework. Regulatory functions involve interactions with various stakeholders (e.g., manufacturers, traders, consumers, health professionals, researchers, and governments) whose economic, social, and political motives may differ, making implementation of regulation both politically and technically challenging. This book discusses regulatory landscape globally and the current global regulatory scenario of medicinal products and food products comprehensively.
Global Change and the Earth System : A Planet Under Pressure
The interactions between environmental change and human societies have a long, complex history spanning many millennia, but these have changed fundamentally in the last century. Human activities are now so pervasive and profound that they are altering the Earth in ways which threaten the very life support system upon which humans depend. This book describes what is known about the Earth System and the impact of changes caused by humans. It considers the consequences of these changes with respect to the stability of the Earth System and the well-being of humankind; as well as exploring future paths towards Earth System science in support of global sustainability.
Global Aspects of Complex Geometry
This collection of surveys present an overview of recent developments in Complex Geometry. Topics range from curve and surface theory through special varieties in higher dimensions, moduli theory, Kähler geometry, and group actions to Hodge theory and characteristic p-geometry.
GI Microbiota and Regulation of the Immune System
This book opens with two general reference chapters, which provide an over-view of current knowledge of gastrointestinal immunology and the commensal microbiology of the gut. Next are two chapters dedicated to current methodologies used to investigate the icrobiota and host: molecular analysis of microbial diver-sity and gnotobiotic research. Both positive and negative interactions between the microbiota and the immune system can take place in the gut, with chapters dedicated to probiotics and intestinal diseases associated with unhealthy rnicrobiota.
Gesture smart control
Nowadays actions are increasingly being handled in electronic ways, instead of physical interaction. From earlier times biometrics is used in the authentication of a person. It recognizes a person by using a human trait associated with it like eyes (by calculating the distance between the eyes) and using hand gestures, fingerprint detection, face detection etc. Advantages of using these traits for identification are that they uniquely identify a person and cannot be forgotten or lost. These are unique features of a human being which are being used widely to make the human life simpler. Hand gesture recognition system is a powerful tool that supports efficient interaction between the user and the computer.
German Mergers & Acquisitions in the USA : Transaction management and success
Mergers and acquisitions in the United States of America are a major strategic means for German companies in their pursuit of becoming global players. The significant volume of such cross-border transactions reflects the firms’ expectations of creating value in the world’s most important consumer market.Bernd Wübben analyzes the success of 87 German mergers and acquisitions in the USA during the period from 1990 to 2004. He begins his assessment with a description of various aspects of the current institutional framework applicable to structuring a cross-border acquisition in the USA. Employing a study of the capital markets’ reaction and a survey of acquirers’ executives.
German Buyouts Adopting a Buy and Build Strategy : Key Characteristics, Value Creation and Success Factors
The number of follow-on acquisitions after the buyout of a company by a financial sponsor, so-called "buy and build strategies", has been increasing in Germany during the last years. Given that M&A transactions by strategic investors were not successful in at least half of the cases analyzed in former research studies, the question remains if and how financial sponsors manage to yield the ambitious target return of a minimum of 20% p.a. on the capital invested.
Geology and Ecosystems
This book includes an analysis of the relationship between the different geological, hydrochemical, hydrogeological and engineering-geological processes and the processes within surface ecosystems. The analysis of specific interactions between the lithosphere and biosphere provides an integrated concept of the role of the geological environment in the evolution of the biosphere. The practical significance of the book is reflected by the analysis of modern engineering activity associated with the mining of minerals, excessive groundwater withdrawal, disposal of industrial and domestic wastes (including radioactive wastes) and their impacts on all components of the environment. Geology and Ecosystems includes a scientific approach to the complex monitoring of the environment under different natural and anthropogenic conditions, including the monitoring of permafrost regions. An important part of the book is the analysis of the "water factor" impact on ecosystems and sustainable development. Influences of intensive groundwater extraction on river flow, vegetation and land subsidence are also considered.
Genome integrity : Facets and perspectives
The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.
General principles of law : the role of the judiciary
Examines the role played by domestic and international judges in the “flexibilization” of legal systems through general principles. It features revised papers that were presented at the Annual Conference of the European-American Consortium for Legal Education, held at the University of Parma.The second section contains studies on the role of general principles in selected legal systems, including International Law, European Union Law as well as Common Law systems.
Gene Expression and Regulation
This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. Presented in the following five sections, this book covers a full spectrum of topics: The History; The Machinery; The Regulators; The Genome; and Special Topics. The Machinery section covers the transcriptional apparatus and general transcription factors. The Regulators section examines selected gene-specific transcription factors important to regulating gene expression. The Genome section covers issues relevant to the behavior of the genome in relation to gene regulation. The Special Topics section discusses several selected topics ranging from bacterial and plant gene expression to DNA topology and interference RNA. The book’s focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.
Gathering Hopewell : Society, Ritual and Ritual Interaction
In this book, twenty-one researchers in interwoven efforts immerse themselves and the reader in this vibrant archaeological record in order to richly reconstruct the faces, actions, and motivations Hopewellian people in their social and ritual life. Using a personalized and locally contextualized approach, the authors explore Hopewellian leadership, systems of social ranking and prestige, animal-totemic clan organization, kinship structures, sodalities, gender, community organizations, strategies of intercommunity alliance, and interregional travels for power questing, pilgrimage, healing, tutelage, and acquiring rituals.
Gap Junctions in Development and Disease
Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed.
Galling Arthropods and Their Associates ; Ecology and Evolution
The book addresses recent developments in the ecology, evolution, systematics, physiology, and biodiversity of gall-inducing arthropods, with individual contri butions ranging in scope from detailed descriptions to profoundly synthetic stud ies. One underlying theme of the book is the various impacts of gall induction that indirectly affect insect communities on the host plant. The other important contri bution is the highly intricate and dynamic interactions between galling arthropods and their uniquely specialized host plants. Included also are chapters that discuss biodiversity and distribution patterns of gall-inducing arthropods, and biological control of invasive gall-inducing arthropods and of invasive trees. We believe that this book makes an important contribution to the knowledge of galling arthropods and their associates and to the development of robust, general principles of the ecology and evolution of these organisms.
Fuzzy Chaotic Systems : Modeling, Control, and Applications
"Fuzzy Chaotic Systems" provides original heuristic research achievements and insightful ideas on the interactions or intrinsic relationships between fuzzy logic and chaos theory. It presents the fundamental concepts of fuzzy logic and fuzzy control, chaos theory and chaos control, as well as thedefinition of chaos on the metric space of fuzzy sets. This monograph discusses and illustrates fuzzy modeling and fuzzy control of chaotic systems, synchronization, anti-control of chaos, intelligent digital redesign, spatiotemporal chaos and synchronization in complex fuzzy systems; as well as a practical application example of fuzzy-chaos-based cryptography. Like other very good books, this book may raise more questions than it can provide answers. It therefore generates a great potential to attract more attention to combine fuzzy systems with chaos theory and contains important seeds for future scientific research and engineering applications.
Future Interaction Design
In 1969 Herbert Simon wrote a book, The Science of the Artificial, in which he argued that cognitive science should have its area of application in the design of devices. He proposed the foundation of a science of the artificial related with cognitive science in the sense in which we have traditionally understood the relationship between the engineering disciplines and the basic sciences. Such a science has been called cognitive ergonomics or cognitive engineering (Norman 1986). Simon’s cognitive ergonomics (1969), would be independent of cognitive science, its basic science, although both would be closely related. Cognitive science would contribute knowledge on human cognitive processes, and cognitive ergonomics would contribute concrete problems of design that should be solved in the context of the creation of devices. Norman (1986), the author that coined the term cognitive engineering, conceived it as an applied cognitive science where the knowledge of cognitive science is combined with that of engineering to solve design problems. According to Norman, its objectives would be: (1) to understand the fundamental principles of human actions important for the development of the engineering of design principles, and (2) to build systems that are pleasant in their use.
Fungal Genomics
Presents an overview on mutualistic and pathogenic interactions between fungi and plants. This book offers reviews on fungal lifestyles, mechanisms of their interactions with their host plants, signal perception and transduction, and plant defense responses directed against attack by fungal pathogens. It is suitable for students in microbiology.
Fundamentals of Structural Dynamics
Explains foundational concepts and principles surrounding the theory of vibrations and gives equations of motion for complex systems. The book presents classical vibration theory in a clear and systematic way, detailing original work on vehicle-bridge interactions and wind effects on bridges. Chapters give an overview of structural vibrations, including how to formulate equations of motion, vibration analysis of a single-degree-of-freedom system, a multi-degree-of-freedom system, and a continuous system, the approximate calculation of natural frequencies and modal shapes, and step-by-step integration methods. Each chapter includes extensive practical examples and problems.
