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Fatty acids
Fatty acid metabolism, including the de novo synthesis, uptake, oxidation, and derivation of fatty acids, plays several important roles at cellular and organ levels. Recent studies have identified characteristic changes in fatty acid metabolism in idiopathic pulmonary fibrosis (IPF) lungs, which implicates its dysregulation in the pathogenesis of this disorder. Here, we review the evidence for how fatty acid metabolism contributes to the development of pulmonary fibrosis, focusing on the profibrotic processes associated with specific types of lung cells, including epithelial cells, macrophages, and fibroblasts. We also summarize the potential therapeutics that target this metabolic pathway in treating IPF.
Factors Influencing Mammalian Kidney Development : Implications for Health in Adult Life
In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are.
Facilitative glucose transporters in articular chondrocytes : Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory Cytokines
In this multidisciplinary article we review the molecular and morphological aspects of GLUT expression and function in chondrocytes and their mesenchymal and embryonic stem cell precursors and propose key roles for these proteins in glucose sensing and metabolic regulation in cartilage.
Experimental Glycoscience : Glycobiology
The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure.
Exosomes based drug delivery strategies for brain disorders
Provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.
Exogenous and endogenous factors affecting happiness, happy mind, happy life
Emotions are the language of the soul. Our brain is the emotional center where every emotion is produced including happiness. Happiness underlying factors are considerable from two dimensions: endogenous factors and exogenous factors Therefore, this research aimed to consider biological factors that underlie happiness. The research is divided into several sub-groups (brain, genetics, neurotransmitters, endocrinology, hormones, drugs, diseases, and other exogenous factors). In spite of difficulties in finding special genes, several genes distributed to emotion and mood. Neuroscience studies showed that some part of brain (e.g. amygdala, hipocamp and limbic system) and neurotransmitters (e.g. dopamine, serotonin, norepinefrine and endorphin) play a role in control of happiness. A few studies pointed to the role of cortisol and adrenaline (adrenal gland) and oxitocin (pituitary gland) in controlling happiness.
Evolutionary Biology from Concept to Application
this book provides an up-to-date overview of evolutionary concepts and how these concepts can be applied to a better understanding of various biological aspects. It is divided into the following four parts: Modelization of Evolution - Concepts in Evolutionary Biology - Knowledge - Applied Evolutionary Biology.This book is an invaluable source of information not only for evolutionary biologists, but also for biologists in general.
Evolution from Cellular to Social Scales
Evolution is a critical challenge for many areas of science, technology and development of society. The book reviews general evolutionary facts such as origin of life and evolution of the genome and clues to evolution through simple systems. Emerging areas of science such as "systems biology" and "bio-complexity" are founded on the idea that phenomena need to be understood in the context of highly interactive processes operating at different levels and on different scales. This is where physics meets complexity in nature, and where we must begin to learn about complexity if we are to understand it. Similarly, there is an increasingly urgent need to understand and predict the evolutionary behavior of highly interacting man-made systems, in areas such as communications and transport, which permeate the modern world. The same applies to the evolution of human networks such as social, political and financial systems, where technology has tended to vastly increase both the complexity and speed of interaction, which is sometimes effectively instantaneous.
Etiology and Morphogenesis of Congenital Heart Disease : From Gene Function and Cellular Interaction to Morphology
This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration
Essentials of oral histology and embryology : A clinical approach ; 5th ed.
Uses a patient-centered approach in coveringto help dental professionals build a strong foundation in oral biology and basic science for dental professionals. It provides a clear understanding explanations of the anatomy of oral and facial tissues — and of normal and abnormal orofacial development — so that you can provide effective oral health care for all patients with abnormalities. In addition to the stages of tooth development, it covers eruption and shedding of teeth, plus the parts of teeth – including enamel, dentin, dental pulp, and cementum. Written by Daniel J. Chiego Jr., a noted dental educator and researcher, this book helps you succeed in the classroom and in clinical practice.
Epigenetics and chromatin
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility.
Endosperm : Developmental and Molecular Biology
This book is the first comprehensive overview of the developmental and molecular biology of endosperm. The text covers cereal endosperm development from fertilization to maturity, including molecular and cell biology of the syncytial phase, the cellularization process and cell fate specification of the embryo surrounding region cells, the basal transfer cells, the starchy endosperm and aleurone cells. In addition, endosperm development in the model species Arabidopsis thaliana is covered, along with recent progress in endosperm in vitro culture. Special features of endosperm, such as imprinting, polyploidy, programmed cell death and anthocyanin biosynthesis, are described in separate chapters. Finally, the genes and pathways for the main nutritional components of endosperm, storage proteins and starch are covered in detail.
Endodontic Microbiology ; 2nd ed.
Presents a comprehensive reference to the microbiology, pathogenesis, management, and healing of endodontic pathosis, emphasizing the importance of biological sciences in understanding and managing endodontic disease and its interaction with systemic health. Provides a major revision to the first book to focus on the problems related to microbes in the root canal and periapical tissues. Updates current knowledge in endodontic pathosis, especially regarding next generation sequencing and microbial virulence. Presents useful diagrams, images, radiographs, and annotated histological images to illustrate the concepts. Emphasizes the importance of biological science in understanding and managing endodontic disease. Includes contributions from the leading researchers and educators in the field
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine
This is the most authoritative and wide-ranging reference yet assembled on Functional Genomics (the systematic analysis and identification of genes and their function) and Proteomics (the study of the complex structures and functions of proteins) in the rapidly expanding field of Molecular Medicine. The two-volume reference work offers a comprehensive overview of the terms, topics and issues in both molecular biology and molecular medicine, with particular emphasis placed on the molecular causes of diseases. It provides up-to-the minute information about developments in the field, including pharmacogenetics and pharmacoproteomics, gene regulation and gene therapy. The Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine is an invaluable tool for clinical scientists in academia and industry, and all who need fast and user-friendly access to key information in this dynamically developing field.
Encyclopedia of Soil Science
The Encyclopedia of Soil Science provides a comprehensive, alphabetical treatment of basic soil science in a single volume. It constitutes a wide ranging and authorative collection of about 160 academic articles covering the salient aspects of soil physics, chemistry, biology, fertility, technology, genesis, morphology, classification and geomorphology.
Enamel and dentin-pulp complex
Includes seven chapters that focus on various important aspects of the ethiopathogenesis and prevention of dental caries, developmental anomalies of enamel and dentin, enamel structure and remineralization, and dentin-pulp regeneration.
Einstein, 1905-2005 : Poincaré Seminar 2005
This volume is devoted to Einstein's 1905 papers and their legacy. After a presentation of Einstein's epistemological approach to physics, and the genesis of special relativity, a centenary perspective is offered. The geometry of relativistic spacetime is explained in detail. Single photon experiments are presented, as a spectacular realization of Einstein's light quanta hypothesis. A previously unpublished lecture by Einstein, which presents an illuminating point of view on statistical physics in 1910, at the dawn of quantum mechanics, is reproduced. The volume ends with an essay on the historical, physical and mathematical aspects of Brownian motion.
EGFR Signaling Networks in Cancer Therapy
EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis.
Efficient Screening Techniques to Identify Mutants with TR4 Resistance in Banana : Protocols
The Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture implemented a Coordinated Research Project (CRP) ‘Efficient Screening Techniques to Identify Mutants with Disease Resistance for Coffee and Banana” (2015-2020). This CRP brought together experts from Asia, Europe and Africa in addition to experts of the Joint FAO/IAEA Centre to develop resistance against TR4 through mutation-assisted breeding. Induced mutagenesis is particularly attractive in case of banana since most cultivated bananas are seedless, thus hampering conventional cross breeding
Effect of antioxidants in plant extracts and free radicals on blood sample
Antioxidants are substances that inhibit and regulate the formation of free radicals, and prevent or slow down the damage to cells caused by free radicals. There is a balance between antioxidants and free radicals throughout the body, and free radicals become dangerous when the balance is disturbed Free radicals play a key role in many physiological decisions in cells. Since free radicals are toxic to cellular components, it is known that they cause DNA damage, contribute to DNA instability and mutation and thus favor carcinogenesis.Low levels of free radicals and steady state levels of antioxidant enzymes are responsible for the fine tuning of redox status inside cells. A change in redox state is a way to modify the physiological status of the cell.Many healthful foods contain antioxidants. If a person consumes some or all of these foods regularly, they may increase their antioxidant levels, potentially helping them prevent the damage that doctors associate with oxidative stress.
