Cortical Deficits In Schizophrenia : From Genes to Function
Opens with a chapter by Paul Harrison highlighting the several convergence points among the diverse schizophrenia-related genes. This is followed by chapters reviewing several different specific genes, including Neuregulin, DISC-1, dysbindin, and Homer, among others, and by several chapters presenting information on physiological cortical processes that could be affected by those genes. These include glutamatergic, GABAergic and cholinergic neurotransmission.Current hot topics in schizophrenia research are also highlighted in the book. A concept that is gaining strength in the field, the chapters in this book summarize the current state of affairs in schizophrenia pathophysiology, with a consideration of genetic elements that may contribute to it. Cortical Deficits in Schizophrenia: From Genes to Function will prove a useful tool for those interested in a better understanding of schizophrenia. Even if more predisposing genes (not included in this book) become identified, the work laid out here will prove critical for assigning a functional (or dysfunctional) role to those genes. Although this is a fast-evolving field, the information and concepts covered in this book will likely be useful for years to come.
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