الصفحة 1
الصفحة 1
What Every Woman Should Know about Cervical Cancer
Recent introduction of HPV vaccines has raised hopes for immunization against cervical cancer and for the first time in the history of humanity for eradication of one malignant disease. This new “opportunity” has changed many current views on cervical cancer prevention, control diagnosis and treatment. Many canons and guidelines became subject of review and many revisions are coming. This book is intended to summarize most of these events and to present them to all women in a language understandable by the eneral public. We expect the book will bring all readers the rationale for optimism and will provide guidance as how to gain knowledge and skills for critical thinking and making an educated decision when it will be necessary in their lives.
Vaccines, medicines and COVID-19 : How can WHO be given a stronger voice?
The considerable health, economic and social challenges that the world faced at the beginning of 2020 with COVID-19 continued and worsened in many parts of the world in the second-half of 2020 and into 2021. Many of these countries and nations wanted to explore COVID-19 on their own, sometimes without listening to the main international health bodies such as WHO, an agency of the United Nations system with long-standing experience and vast knowledge at the global level and of which all countries in the world are members.
Vaccine Design: Methods and Protocols ; Vol.2 : Vaccines for Veterinary Diseases
Guides readers through veterinary vaccines, vaccines for poultry, vaccines for farm animals, and vaccines for veterinary parasites. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.
Vaccine design : Methods and protocols ; Vol.1 : Vaccines for human diseases
Guides readers through an introductory section on future challenges for vaccinologists and the immunological mechanism of vaccines. Chapters focus on design of human vaccines for viral, bacterial, fungal, and parasitic diseases as well as tumor vaccines. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.
Tumor Immunology and Cancer Vaccines
Addresses the state of the art knowledge of tumor immunology relevant to cancer vaccine and the different aspects of cancer vaccine development, covering the field from its basic science logic to clinical trials. The four sections of the book, Basic Tumor Immunology; Cancer Vaccine Development; Vaccine-Enhancing Strategies; and Clinical Trials Design, provide a general overview of the field, historic background, and the field’s promises and problems.
Transgenesis and the Management of Vector-Borne Disease
Parasitic, bacterial and viral agents continue to challenge the welfare of humans, livestock, wild life and plants worldwide. The public health impact and financial consequences of these diseases are particularly hard on the already overburdened economies of developing countries especially in the tropics. Many of these disease agents utilize insect hosts (vectors) to achieve their transmission to mammals. In the past, these diseases were largely controlled by insecticide-based vector reduction strategies. Now, many of these diseases have reemerged in the tropics, recolonizing their previous range, and expanding into new territories previously not considered to be endemic. Habitat change, irrigation practices, atmospheric and climate change, insecticide and drug resistance as well as increases in global tourism, human traffic and commercial activities, have driven the reemergence and spread of vector borne diseases. While these diseases can be controlled through interventions aimed at both their vertebrate and invertebrate hosts, no effective vaccines exist, and only limited therapeutic prospects are available for their control in mammalian hosts. Molecular technologies such as transgenesis, which is the subject of this book, stand to increase the toolbox and benefit disease management strategies.
The Papillomaviruses
This volume reviews the remarkable confluence of science, medicine, and public health that recently culminated in the approval of vaccines that prevent many human papillomavirus infections, the first vaccines specifically designed to prevent human cancer. Basic laboratory studies of viral DNA replication, gene expression, protein function, and virus-host interactions have provided fundamental insights into these important processes.
The latest studies of Coronavirus
On 12th December 2019, a pneumonia case of unknown etiology was reported in Wuhan City, Hubei Province, China, and on 31st December 2019, the disease outbreak was reported to World Health Organization (WHO). After ruling out possible influenza and other coronaviruses by laboratory testing, the Chinese authorities isolated a new type of coronavirus (novel coronavirus, nCoV) on 7th January 2020, which was then named 2019- nCoV by WHO on 12th January...
The Grand Challenge for the Future : Vaccines for Poverty-Related Diseases from Bench to Field
Provides an important link between vaccine development and application under the particular conditions in developing countries. The editors, S.H.E. Kaufmann and P.H. Lambert – one from the field of basic research and the other an expert on the side of applied vaccinology – have gathered contributions from specialists of both fields in an attempt to create a source of information that has thus far not been available.
Sexually Transmitted Diseases : A Practical Guide for Primary Care
Sexually Transmitted Diseases: A Practical Guide for Primary Care covers the diagnosis and treatment of STDs and other information critical to patient care in the new millennium. This collaboration provides the clinician with the ability to identify and manage Sexually Transmitted Infections (STIs), as well as obtain information about preventing their sequelae. Among the topics covered in this book are human papillomavirus and genital warts, genital herpes, viral hepatitis, HIV infection and AIDS, chlamydial and gonorrheal infections, and upper genital tract infections in women. Other topics of interest include syphilis, trichomoniasis, chancroid, granuloma inguinale, lymphogranuloma venereum, and molluscum contagiosum. Special consideration is given to ectoparasites, patient-clinician communication and STD care, cultural competence and STI care, effectiveness of barrier methods for STI prevention, and the future role of vaccines and microbides.
RNA vaccines : Methods and protocols
Expands on the previous edition with discussions of the latest technology and advancements in the development of RNA vaccines and proposed solutions on how to tackle currently unmet medical needs. The chapters in this book are organized into four parts and cover topics such as replication and non-replicating RNA vectors, formulation and delivery of RNA vaccines, and clinical and nonclinical development of RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Ribosome biogenesis : Methods and protocols
This volume provides comprehensive reviews and describes the latest techniques to study eukaryotic ribosome biogenesis. For more than 50 years ribosomes are a major research topic. Our knowledge about ribosome biogenesis and function such as transcription, mRNA modification, and translation was the sine qua non for developing the powerful RNA-based vaccines against RNA-viruses causing the world-threatening Covid-19 pandemia. The chapters in this book are organized into six parts. Part One discusses a comparative survey about the unity and diversity of ribosome biogenesis in pro- and eukaryotic cells. Part Two deals with the genomic organization of eukaryotic rDNA and the role of RNA polymerase I in ribosomal RNA transcription. Part Three explores in vitro methods to study RNA polymerase I structure and its function, and Part Four analyzes the nucleo-cytoplasmic transport of assembled ribosomes and RNP complexes. Part Five covers modifications that increase the complexity of rRNAs, and Part Six provides readers with a review of eukaryotic translation and - for the first time - describes a new method to analyze translation in vitro.
Pharmaceutical biotechnology : fundamentals and applications
This introductory text explains both the basic science, production, quality, dosage forms, administration, economic and regulatory aspects and the clinical applications of biotechnology-derived pharmaceuticals. It serves as a complete one-stop source for undergraduate/graduate pharmacists and pharmaceutical science students. An additional important audience are pharmaceutical scientists in industry and academia, particularly those who have not received formal training in pharmaceutical biotechnology and are inexperienced in this field. The rapid growth and advances in the field made it necessary to revise this textbook in order to continue providing up-to-date information and introduce readers to cutting edge knowledge and technology of this field.
Pharmaceutical biotechnology : fundamentals and applications
Explains both basic science and applications of pharmaceutical biotechnology / Complete one-stop source for students and professionals / Explains both the basic science and the applications of biotechnology derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those who did not receive formal training in this field. Pharmaceutical Biotechnology: Fundamentals and Applications, Fifth Edition completely updates the previous edition, and includes additional coverage on newer approaches such as oligonucleotides, mi/siRNA, gene therapy and advanced therapeutics.
Neonatal Immunity
New advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens. Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.
National Institute of Allergy and Infectious Diseases, NIH ; Vol.1 : Frontiers in Research
National Institute of Allergy and Infectious Diseases, NIH: Volume 1, Frontiers in Research contains presentations given at the 2006 NIAID Research Conference held in Opatija, Croatia which brought internationally known researchers from the United States and Central and Eastern Europe to focus together on shared interests in microbiology, infectious disease, HIV/AIDS, and basic and clinical immunology. Some of the topics covered include emerging and re-emerging infections, the development of infectious disease prophylactics and therapeutics, drug resistance, and various topics in immunomodulation, autoimmunity, infections and immunity, and the development of vaccines.Extensive and in-depth, National Institute of Allergy and Infectious Diseases, NIH: Volume 1, Frontiers in Research is a valuable, comprehensive guide to the state of research today.
Nanotechnology in therapeutics : Basics and trends
Nanotechnology delivers a unique approach, which promises higher drug efficacy, targeted drug delivery, on demand delivery, biocompatibility, etc. For example, nanotechnology-based delivery systems can protect drugs from degradation and help reduce the number of doses required, make treatment a better experience and reduce treatment expenses and a number of nano-based systems allow delivery of insoluble drugs, allowing the use of previously rejected drugs or drugs which are difficult to administer.
Nanopharmaceuticals ; Vol.1 : Expectations and realities of multifunctional drug delivery systems
Reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.
Nanoparticle-based cancer vaccines
Reviews the fundamentals of cancer vaccines, explores the role of nanotechnology in improving vaccine design and delivery, and evaluates current clinical applications, challenges, and regulatory considerations, highlighting the potential of nanoparticle-based cancer vaccines in future cancer treatment.
Multichain Immune Recognition Receptor Signaling : From Spatiotemporal Organization to Human Disease
The central idea of this book is to show that the structural similarity of the MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms and also provides the basis for existing and fixture therapeutic strategies targeting MIRRs. The reviews assembled in this book detail the prog-ress in defining and controlling the spatiotemporal organization of key events in immune cell activation. An improved understanding of MIRR-mediated signaling has numerous potential practical applications, fi-om the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes.
