الصفحة 1
الصفحة 1
Introduction to Computational Biology : An Evolutionary Approach
Molecular biology has changed dramatically over the past two decades. Until the early 1990s genes were studied one at a time by small teams of researchers; today entire genomes are sequenced by internationally collaborating laboratories. In the bygone gene-centered era the accumulation of data was the rate-limiting step in research. Now that step is often data interpretation. This is increasingly dependent on computational methods and as a consequence, computational biology has emerged in the past decade as a new subdiscipline of biology. This introduction to computational biology is centered on the analysis of molecular sequence data. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models. In the second part evolutionary time takes center stage and phylogenetic reconstruction, the analysis of sequence variation, and the dynamics of genes in populations are explained in detail. In addition, the book contains a computer program with a graphical user interface that allows the reader to experiment with a number of key concepts developed by the authors.
Experimental Algorithms ; 6th International Workshop, WEA 2007, Rome, Italy, June 6-8, 2007, Proceedings
Fostering and disseminating high quality research results focused on the experimental analysis of algorithms the papers are devoted to the design, analysis, implementation, experimental evaluation, and engineering of efficient algorithms. Among the application areas addressed are most fields applying advanced algorithmic techniques, such as combinatorial optimization, approximation, graph theory, discrete mathematics, data mining, simulation, cryptography and security, scheduling, searching, sorting, string matching, coding, networking, etc.
Combinatorial pattern matching ; Vol.4009) ; 17th Annual Symposium, CPM 2006, Barcelona, Spain, July 5-7, 2006, Proceedings
The book presents 33 revised full papers together with 3 invited talks, organized in topical sections on data structures, indexing data structures, probabilistic and algebraic techniques, applications in molecular biology, string matching, data compression, and dynamic programming
Combinatorial pattern matching ; 12th Annual Symposium, CPM 2001 Jerusalem, Israel, July 1-4, 2001 Proceedings
This book constitutes the refereed proceedings of the 12th Annual Symposium on Combinatorial Pattern Matching, CPM 2001, held in Jerusalem, Israel, in July 2001. The 21 revised papers presented together with one invited paper were carefully reviewed and selected from 35 submissions. The papers are devoted to current theoretical and algorithmic issues of searching and matching strings and more complicated patterns such as trees, regular expressions, graphs, point sets, and arrays as well as to advanced applications of CPM in areas such as the Internet, computational biology, multimedia systems, information retrieval, data compression, coding, computer vision, and pattern recognition.
Combinatorial and algorithmic aspects of networking ; Vol.3405 ; 1st Workshop on combinatorial and algorithmic aspects of networking, CAAN 2004, Banff, Alberta, Canada, August 5-7, 2004, Revised Selected Papers
The Internet is a massive global network of over 700 million users and it is addingusers at the rate of 300,000 per day. This large, distributed, and everchangingnetwork poses a challenge to researchers: How does one study, model, or under-stand such a decentralized, constantly evolving entity? The workshop Combi-natorial and Algorithmic Aspects of Networking and the Internet (CAAN 2004)provided a forum for the exchange of ideas on these topics. and among thepapers were some new and surprising results as well as some introductions tothe foundations of the field.The workshop program featured 12 peer-reviewed papers bracketed by Topics covered by the talks ranged from the Web graph to game theoryto string matching, all in the context of large-scale networks. This volume collectstogether the talks delivered at the workshop along with a number of survey articlesto round out the presentation and give a comprehensive introduction to the topic.
Combinatorial and Algorithmic Aspects of Networking (vol. # 4235) ; Third Workshop, CAAN 2006, Chester, UK, July 2, 2006, Revised Papers
This book constitutes the thoroughly refereed post-proceedings of the Third Workshop on Combinatorial and Algorithmic Aspects of Networking, held in Chester, UK in July 2006, co-located with the 13th Colloquium on Structural Information and Communication Complexity, SIROCCO 2006.The 10 revised full papers and one invited lecture cover a range from the Web graph to game theory to string matching, all in the context of large-scale networks.
