الصفحة 1
الصفحة 1
Nimesulide - Actions and Uses
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs.
Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders : Novel Strategies for Research and Treatment
Over the past few decades the involvement of neurosteroids in brain function and mental health has attracted much interest, not only from a neuroscience perspective, but also from clinical and therapeutic aspects. In recent years, much of the research has focused on the multifunctional position of neurosteroids in the nervous system. The areas that have been explored, in particular, are the cellular and molecular mechanisms involved in the activity of neurosteroids in the brain, the role of neurosteroids in brain development, neurodegeneration and neuroplasticity, and their pharmacological properties. The large increase in the number of publications highlights this amplified interest in neurosteroids. Over the last 7 years at least 400 papers have been published describing the putative role of neurosteroids in the modulation of basic brain function and in the etiology and treatment of psychiatric and neurological disorders.
Natural poisons and venom : Plant toxins : Terpenes and steroids
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Impact Tectonics
This volume is the 8th in a series of impact books resulting from the activities of the scientific program "Response of the Earth System to Impact Processes" (IMPACT), by the European Science Foundation. The book resulted from an international meeting at Mora, Sweden, which was held as part of the IMPACT program. The papers cover various structural geologic, geochemical, and geophysical topics on research of asteroid impact structures on Earth and Mars.
Ice, Rock, and Beauty : A Visual Tour of the New Solar System
Ice, Rock, and Beauty is a book for anybody who lives in the solar neighborhood, and takes an interest in its significance to us as residents.The book gathers images from a rich pool, many from national and international organizations such as NASA and ESA, some directly from academic astronomers, and a few from private individuals. Together they tell a story of the Solar System, and of its beauty, that has not been told before.
Ibuprofen : Pharmacology, Therapeutics and Side Effects
Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.
Hormones and the brain
Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behaviour and aging. Depending upon intensity and duration of exposure, they can be either neuroprotective or neurotoxic, for instance by affecting production of free radicals. This book, based on contributions of pioneer investigators in the field, outlines the ambiguous actions of gonadal steroids (estradiol, progesterone, testosterone, inhibin and activin) and of neurosteroids, related moieties produced in the brain itself. After summarizing their multiple mechanisms of action, which involve both direct effects on neuronal membranes and activation of genes coding for specific proteins in neurons or glial cells, the book outlines the role of hormones in pathogenic processes such as mental disturbances or neurodegenerative diseases.
Hormones and social behaviour
This book concentrates on two major topics: First, the molecular and neural biology of hormone actions relevant to normal social behaviors; and Second, the clinical treatment of human patients in whom these behaviors have gone wrong.
High performance computing for computational science - VECPAR 2008 ; 8th International Conference, Toulouse, France, June 24-27, 2008. Revised Selected Papers
This book constitutes the thoroughly refereed post-conference proceedings of the 8th International Conference on High Performance Computing for Computational Science, VECPAR 2008, held in Toulouse, France, in June 2008.The 51 revised full papers presented together with the abstract of a surveying and look-ahead talk were carefully reviewed and selected from 73 submissions. The papers are organized in topical sections on parallel and distributed computing, cluster and grid computing, problem solving environment and data centric, numerical methods, linear algebra, computing in geosciences and biosciences, imaging and graphics.
Gastric ulcers the cases and treatment
A gastric ulcer also known as stomach ulcer is an excoriated area of stomach caused principally by the digestive action of gastric juice Secretion in many ways the most common reasons are the taking non steroid anti-inflammatory drugs (NSAID) or an infection with Helicobacter pylori bacteria. It used to be Thought that stress or certain foods or drinking alcohol and smoking tobacco might cause stomach ulcer but in less cases. stomach ulcer can affect people of any age, including children, but mostly occur in people aged 50 or over. the common symptom is the pain in stomach and nausea with or without vomiting. the diagnosis through endoscopy is the best method to be sure about ulcer. the treatment of ulcer according to the reasons of ulcer is caused bacteria or not gastric ulcer It occurs in 80% of cases with the level of curvature The little one, especially the angle and antra, and effect men and women are the same.
Fortschritte der Chemie organischer Naturstoffe 89 = Progress in the chemistry of organic natural products
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Fare astronomia con piccoli telescopi = Are astronomy with small telescopes
Giant tools are not necessarily required to produce scientifically valid results in the field of astronomy. Even the amateur with a small telescope, with a diameter of only 8-9 cm, can contribute to the science of the sky by making useful observations of the Sun, the Moon, planets, comets, asteroids, double or variable stars, nebulae and star clusters. The manual of M.K. Gainer explains what the minimum equipment is (a small telescope, a computer, a simple digital camera), how to use it, and what are the appropriate techniques to be adopted in the observations. It also offers schemes for interpreting and reducing the collected data, as well as forms to be filled in and sent to international collection centers.
ECZEMA (Atopic Dermatitis)
Atopic dermatitis (eczema) is a condition that makes your skin red and itchy. It's common in children but can occur at any age. Atopic dermatitis is long lasting (chronic) and tends to flare periodically. It may be accompanied by asthma or hay fever. No cure has been found for atopic dermatitis, Certain substances or conditions called trigger factors can cause eczema to flare-up: Irritants such as soaps and detergents, wool, skin infections, dry skin, low humidity, heat, sweating or emotional stress. Allergens such as dust mites, pollen, moulds, or foods.and the treatment for the condition aims to heal the affected skin and prevent flares of symptoms.Topical medications (typically, steroids or other anti-inflammatory medications, and found a correlation between eczema and the Quality of life, Recently some study have done to study the relation with COVID-19.
Dynamics of extended celestial bodies and rings
Taking both a theoretical and observational perspective, this book is an introduction to recent developments in the field of celestial mechanics. It emphasizes the application to extended celestial bodies and devotes much attention to rotational aspects. In particular, it explains the state of art for accurate modelling of the rotation of celestial bodies such as the Earth, the Moon, and Mercury, which involves principles related to hydrodynamics and geodesy. Comparisons between the light curves of the asteroids and their rotational state are made and spatial techniques leading to the determination of the Earth's gravitational field are explained. Also, the book provides a general overview of the collisional processes in the solar system and of the dynamics of the rings. It is addressed to graduate students and researchers in space sciences and celestial dynamics.
Drug repurposing : A new fashion for a new hope
The repurposing of drugs is becoming increasingly attractive as it avoids the long process and cost implications associated with bringing a novel drug to market i.e., drug repurposing is cost effective and time saving. This study will discuss the repositioning of several drugs that belong to different pharmaceutical classifications such as antimicrobials (itraconazole and fluoroquinolones), anti-diabetic agents (metformin and sodium glucose co-transporter 2 inhibitors), cardiovascular drugs (β-blockers and digoxin), anticonvulsants (topiramate), immunosuppressants (sirolimus), non-steroidal anti-inflammatory drugs (NSAIDs e.g., COX inhibitors), and cholesterol lowering drugs (statins).
Consequences of Unawareness in Usage of Some Medicines and Diet Routine
In the short term, imbalanced nutrition can contribute to stress, tiredness and our capacity to work, and over time, it can contribute to the risk of developing some illnesses and other health problems such as: being overweight or obese, tooth decay, high blood pressure. Such habits cause considerable damage to human existence such as loss of potential and motivation, premature aging of the human body and the acquisition of diseases of various kinds. Such habits include the consumption of the following substances and medications which we will focus on in our research project in order to contribute to the public health awareness and to provide people with the best way to eat, on the other hand as an effect, pharmacologist we will also include the possible therapy of such diseases. However, with their side and some other commune drugs we are used to take on daily terms or very often but it may have a toxic side effect.
Comet, Asteroid Impacts and Human Society : An Interdisciplinary Approach
Leading specialists in various disciplines were first invited to a multidisciplinary workshop funded by ICSU on the topic to gain a better appreciation and perspective on the subject of comet/asteroid impacts as viewed by different disciplines. This volume provides a necessary link between various disciplines and comet/asteroid impacts.
L'astrofilo moderno = The modern amateur astronomer
In less than two decades, amateur astronomy has changed its face. The reason, of course, is technological progress. Cheap but high-quality telescopes, computer-controlled "go-to" mounts, autoguiders, CCD cameras, video cameras and (as always) computers and the Internet are just some of the elements that revolutionized 21st century astronomy. Not only have they made amateur astronomy more "friendly" and fun, but they have also greatly expanded the potential of the amateur astronomer. Martin Mobberley first tackles the basic issues and then analyzes in depth what tools are available on the market. From here he starts to review the revolutionary possibilities that open up for amateur astronomers, from imaging, to spectroscopy, to photometry, to the surveillance of Near-Earth objects - comets and asteroids that can come dangerously close to the Earth.
La scuola dell’atopia = The school of atopy
The need to clarify the current concepts of atopy, which for too long have oscillated between a primitive purely clinical vision and a subsequent purely immunological one, had been ripe for some time. Understanding that the role of immunoglobulins E is not exhaustive and accepting the Solomonic division between intrinsic and extrinsic atopy were the first two fundamental steps. Recent discoveries of the role of innate immunity, and therefore of antimicrobial peptides, have opened fundamental spaces for understanding in atopy and beyond. What now appears clear is that atopy is not the disease of an organ but rather a defect in the membranes that delimit our "self". The fact that these membranes are called skin, intestines, conjunctiva, bronchi or whatever has artificially fragmented the understanding and treatment of a unitary phenomenon. This book seeks to summarize the different experiences but above all to be a stimulus to ensure that medicine focuses constructively on the same target. If this is the case, we will no longer see "religious wars" between scientists and practicing doctors or, even worse, between the different specialists vying for the patient. If atopy, as we believe, is a global problem, it can only be adequately addressed in a multidisciplinary context and in a collaborative atmosphere, not only between doctor and doctor but also between doctor and patient.
Catastrophic Events Caused by Cosmic Objects
Many times all of us could hear from mass media that an asteroid approached and swept past the Earth. Such an asteroid or comet will inevitably strike the planet some day. This volume considers hazards due to collisions with cosmic objects, particularly in light of recent investigations of impacts by the authors. Each chapter written by an expert contains an overview of an aspect and new findings in the field. The main hazardous effects – cratering, shock, aerial and seismic waves, fires, ejection of dust and soot, tsunami are described and numerically estimated. Numerical simulations of impacts and impact consequences have received much attention in the book. Fairly small impacting objects 50 -100 m in diameter pose a real threat to humanity and their influence on the atmosphere and ionosphere is emphasized.
