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Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontologies for Urban Development
Action C21 of the European programme for Cooperation in the field of Scientific and Technical Research (COST—http://www.cost.esf.org/) is dedicated to investigating urban ontologies for an improved communication in urban civil engineering projects. The Action, known informally as "Towntology", brings together a large and heterogeneous grouping from across Europe, whose interests range from construction to urban tourism and from transport infrastructure to resource visualisation. On 6-7 November 2006, in Geneva, the Action convened a successful workshop to address emerging issues in the field. This volume presents the contributions to that workshop, in many cases revised afterwards to capture some of the outcomes of discussion.
Online Investing on the Australian Sharemarket : How to Research, Trade and Invest in Shares and Securities Online
Offers step-by-step guidance on choosing an online broker, accessing and making best use of online share investing resources, planning trades, identifying profit-making opportunities, timing of and placing online orders, managing investment risks, and much more.
Online Communities and Social Computing ; 2nd International Conference, OCSC 2007, Held as Part of HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings
The 12th International Conference on Human-Computer Interaction, HCI Inter- tional 2007, was held in Beijing, P.R. China, 22-27 July 2007. This volume, edited by Douglas Schuler, contains papers in the thematic area of Online Communities and Social Computing, addressing the following major topics: • Designing and Developing On-line Communities • Knowledge, Collaboration, Learning and Local On-line Communities
Oil and Security : A World Beyond Petroleum
This book examines the economic impact of changes in the global demand and supply for fossil fuels both on the major producers in Middle Eastern countries around the Persian Gulf, other producers, as well as the world at large. The economic, social and political life of most countries is not only intimately linked to and influenced by the energy market but also affected by historical developments. Among other issues, it shows how the economic, social and political development of societies in Arabia, the peoples of the Arab Peninsula are influenced by their historic and cultural environment, and what the future may bring to this region when their principal economic assets, petroleum and gas, start to lose markets as alternative sources of fossil fuel, alternative, and renewable energy supply the bulk of global energy needs. It also describes how changing fossil fuel costs, access, security of supply, and environmental impacts may affect future economic, social, and political developments as well as technological advances and changes in priorities.
Office-Based Maxillofacial Surgical Procedures : A Step-by-step Approach
This book is a comprehensive, step-by-step guide to maxillofacial surgical procedures typically performed in an office setting. Health care providers will be able to use the book as a resource to expand their knowledge on common maxillofacial surgical procedures.
Office Andrology
The investigation and management of male infertility can be a formidable diagnostic challenge to family physicians, urologists, and reproductive specialists alike. In Office Andrology, noted clinical physicians and scientists have joined forces to create a comprehensive resource guide to current diagnostic and treatment options for a broad spectrum of clinical issues relevant to male infertility disorders. Topics covered range from basic sperm biology and male reproductive endocrinology, to immunology, specialized sperm testing, and the genetic background to male infertility. Although emphasis is on the investigation, diagnostic testing, and management of the infertile male, controversial medical and surgical treatment options are also fully discussed. For the reproductive specialist, the text thoughtfully reviews such timely issues as gender selection, human immunodeficiency virus-discordance couples, and posthumous reproduction. Other topics of interest include laboratory accreditation, vasectomy reversal, ethical and legal considerations of donor insemination, optimizing success in a donor insemination program, and strategic therapies for ejaculatory disorders and erectile dysfunction in infertile men.
Object-Oriented Data Structures Using Java ; 4th ed.
an essential resource for students learning data structures using the Java programming language. It presents both the traditional and modern data structure topics with an emphasis on problem-solving and object-oriented software design. Beginning early and continuing throughout the text, it introduces and expands upon the use of many Java features such as classes, objects, generics, polymorphism, packages, interfaces, library classes, inheritance, exceptions, and threads.
Nutrition and Physical Activity : Health Information Sources in EU Member States, and Activities in the Commission, WHO, and European Networks
Awareness of the importance of nutrition and physical activity for good health has given rise to a multitude of projects with different scopes and methodologies. This book aims to summarize the activities carried out by the EU countries to address these determinants of health.
Nutrition and dietary interventions in cancer
Presents the most up-to-date information on the effects of nutrition and food on cancer prevention and management. The book will provide clinicians and other healthcare practitioners with an educational source on how to educate cancer patients and their families on nutrition and dietary during cancer treatment. Recent nutritional epidemiology studies have occasionally produced controversial or unexpected results and highlight the need for additional research on diet and cancer risk. Chapters within the book focus among others on the role of natural antioxidants in cancer, the importance of micronutrients in cancer prevention and nutritional genomics and their role in cancer prevention.
Nutraceuticals in obesity management and control
Provides detailed information on nutraceuticals that can be helpful in the control and management of obesity. It clarifies key aspects of nutraceuticals that include sources, extraction, chemistry, mechanisms of action, pharmacology, bioavailability, safety, and various applications. Beginning with a concise overview of the prevalence of obesity, complications related to obesity, and current treatment regimens, the volume delves into the roles of functional foods and nutraceuticals for the management of body weight and for alleviating obesity comorbidities. It goes on to discuss the effect of some of the most commonly and frequently used naturally occurring nutraceutical substances, along with their mechanisms of action in controlling obesity. The volume looks at the role of nutraceutical fruits as well as the beneficial aspects of carotenoids in fruits and vegetables and explores antioxidant-rich nutraceuticals, the role of vitamins and supplements, the use of green tea, and the potential of pseudocereals and spices in the management of metabolic syndrome.
Nutraceuticals : Sources, processing methods, properties, and applications
Explores the impact of nutraceutical compounds on human health and their main pharmacological contributions. Organized into three parts, this book addresses nutraceutical production, applications for disease prevention and treatment, and current trends, especially the role of nutraceuticals in cosmeceutical. Nutraceuticals are a class of products that can help people improve their health, reduce the risk of disease, extend their lives, and control the structure and functioning of their bodies. However, due to multiple hurdles that prevent nutraceuticals from circulating in an active form in the body, their use is associated with diminished therapeutic efficacy. Recognizing this problem, the book explores the root of the nutraceutical delivery system and its codelivery methods with a focus on medicines. With contributions from experienced nutraceutical experts, this book serves as a valuable reference for nutrition researchers, food scientists, pharmacologists, and those who are researching and studying in related areas.
Numerical Methods Using Java : For Data Science, Analysis, and Engineering
Covers a wide range of topics, including chapters on linear algebra, root finding, curve fitting, differentiation and integration, solving differential equations, random numbers and simulation, a whole suite of unconstrained and constrained optimization algorithms, statistics, regression and time series analysis. The mathematical concepts behind the algorithms are clearly explained, with plenty of code examples and illustrations to help even beginners get started. You will: Program in Java using a high-performance numerical library / Learn the mathematics for a wide range of numerical computing algorithms / Convert ideas and equations into code / Put together algorithms/ and classes to build your own engineering solution / Build solvers for industrial optimization problems / Do data analysis using basic and advanced statistics
Nuclear Law : The Global Debate
This open access book traces the journey of nuclear law: its origins, how it has developed, where it is now, and where it is headed. As a discipline, this highly specialized body of law makes it possible for us to benefit from the life-saving applications of nuclear science and technology, including diagnosing cancer as well as avoiding and mitigating the effects of climate change. This book seeks to give readers a glimpse into the future of nuclear law, science and technology. It intends to provoke thought and discussion about how we can maximize the benefits and minimize the risks inherent in nuclear science and technology. This compilation of essays presents a global view in discipline as well as in geography.
Nuclear Dynamics : Molecular Biology and Visualization of the Nucleus
The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.
Nuclear Condensed Matter Physics with Synchrotron : Basic Principles, Methodology and Applications
This book provides a comprehensive introduction to the growing field of nuclear condensed matter physics with synchrotron radiation, a technique which finds numerous applications in fields such as magnetism, physics of surfaces and interfaces, lattice dynamics and more. Due to the enormous brilliance of modern synchrotron radiation sources, the method is particularly suited for the investigation of low-dimensional structures such as thin films and nanoparticles. The use of isotopic probe layers, for example, allows one to determine magnetic and vibrational properties with very high spatial resolution; focusing techniques and x-ray interference effects lead to a very high sensitivity for smallest amounts of material. The book is written on an introductory level with many examples employed to illustrate the special experimental possibilities.
Novel Optical Resolution Technologies
After theend ofthe 20th century, the science ofcrystallizationreached a truly exciting stage where new opportunities emerged in both theory and expe- ment. Variousphysical methodsare capable of resolving the surface as wellas the insid estructure of crystalsat the atomiclevel while newhigh-performance computing resourcesafford thecapability of modeling the complexlarge-scale alignments necessary to simulatecrystallizationinrealsystems. Asaresult, the science of crystallization has shifted gradually fromstatic to dynamic science and considerable progress now underlies the complex but beautiful cryst- lization process.The vastpotential ofcrystallizationasan- portant feld ofscience isfar beyondthesimple technologyofpharmaceutical industries during the 20th century.
Novel drug delivery systems : Fundamentals and applications
Serves as a unique resource on the field of novel drug delivery systems (NDDSs). The evolving nature of diseases and the emergence of new health complications have driven a significant shift in drug therapy. Coupled with changes in human lifestyles and economic conditions, these factors have compelled the pharmaceutical industry to develop novel, efficient, and affordable drug products. The rise of promising technologies aimed at enhancing therapeutic performance further underscores the importance of novel drug delivery systems (NDDSs), making this field one of the most dynamic in pharmaceutical sciences today.
Novel Developments for Sustainable Hydropower
This book presents (selected) new and innovative developments for sustainable and fish-friendly hydropower. It offers unique insights into the challenges, practices and policies of hydropower developments across 8 European countries, providing examples from on-site studies and European-wide analyses. The case studies throughout the book are practical “real-world” examples, which are intended to serve as inspiration for anyone who would like to know more about how solutions for more sustainable hydropower production can be designed and implemented. Hydropower is an important renewable energy source, which, however, can also impact aquatic ecosystems, fish populations and hydro-morphology. EU and national water, environmental and energy legislation strive for sustainable energy and water resource management as well as the protection of important habitats and species. These have an effect on the requirements and decision making processes for hydropower planning, commissioning and operation. With a high variety of measures existing and site-specific conditions as well as national and EU level legal requirements to consider, it can be difficult to determine, what issues to address and which measures to implement.
Non-Vitamin K Antagonist Oral Anticoagulants : A Concise Guide
An essential guide to the medical treatment of thrombosis and presents core principles of anticoagulant therapeutics as well as drug recommendations. Written by recognized experts in the field, this concise, accessible handbook provides a unique and valuable resource in the cardiovascular field, both for those currently in training, and for those already in clinical or research practice.
