الصفحة 1
الصفحة 1
Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
Nucleic Acids and Proteins in Soil
With millions of different bacterial species living in soil, the microbial community is extremely complex, varying at very small scales. Microbe-driven functions are essential for most processes in soil. Thus, a better understanding of this microbial diversity will be invaluable for the management of the various soil functions. Nucleic Acids and Proteins in Soil combines traditional approaches in soil microbiology and biochemistry with the latest techniques in molecular microbial ecology. Included are methods to analyse the presence and importance of nucleic acids and proteins both inside and outside microbial cells, the horizontal gene transfer which drives bacterial diversity, as well as soil proteomes. Further chapters describe techniques such as PCR, fingerprinting, the challenging use of gene arrays for structural and functional analysis, stable isotope probing to identify in situ metabolic functions, and the use of marker and reporter genes in soil microbial ecology.
New Techniques in Solid-State NMR
After the discovery of nuclear magnetic resonance, [1, 2] the new spectroscopy was used for the study of 1 H nuclei in liquids, but then the signal from copper in the receiver coil itself, the first observation of NMR in the solid state, was found.“Wide-line NMR”, named thus because of the line-broadening effects of dipolar interaction and chemical shift anisotropy, was not far behind, and soon led to significant advances through the analysis of spectral lineshapes. Inthis way Richards and Smith [3] demonstrated the presence of H3O+ cations in solid hydrates of strong acids, while Andrew and Eades [4] investigated the details of molecular motion in three solid benzenes. Even now, 50 years later, it is difficult to think of a technique which would provide a more convincing demonstration of the reality of these effects.
NEURO-COVID-19 : Neuroinvasive potential and neurological complications of SARS-CoV-2
From the earliest days of the COVID-19 pandemic, there have been reports of significant neurological and psychological symptoms following SARS-CoV-2 infection. This research paper is designed to examine the potential psychoneuroendocrine pathogenic mechanisms by which SARS-CoV-2 elicits psychiatric sequelae, as well as to posit potential pharmacologic strategies to address and reverse these pathologies. Following a brief overview of the presence and prevalence of neuropsychiatric manifestation in COVID-19 patients, we address mechanisms by which SARS-CoV-2 could enter or otherwise elicit changes in the CNS.
Natural Fullerenes and Related Structures of Elemental Carbon
This book provides an up-to-date summary of the state of knowledge on natural fullerenes occurrences and the laboratory techniques used to determine their presence at low concentration in rock samples. It demonstrates that natural fullerenes exist and should be searched for in places not yet considered such as carbon-containing deep-seated crustal rocks.Natural Fullerenes and Related Structures of Elemental Carbon is written for professional astronomers, meteoriticists, earth and planetary scientists, biologists and chemists interested in carbon and hydrocarbon vapor condensation. It is an invaluable resource for practicing research scientists and science teachers in Earth and Planetary Science, Astronomy and Carbon Science.
Mycotoxins in Foodstuffs
Due to the serious spoilage and health issues the presence of mycotoxins can cause, it’s imperative that the food industry has a basic understanding fungi and their corresponding mycotoxins. An indispensable resource, Mycotoxins in Foodstuffs gives an in depth overview by listing the degree of contamination, concentration and country of origin/detection for each case of mycotoxin contamination for each commodity. In addition, the book shows whether or not food is predisposed for mycotoxin contamination.
Mycorrhiza : State of the Art, Genetics and Molecular Biology, Eco-Function, Biotechnology, Eco-Physiology, Structure and Systematics
This third updated and revised edition emphasises strongly on genetics and molecular biology. It contains new chapters, which are written by the leading experts in their respective field of knowledge and expertise.Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the presence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.
Multiphase Reacting Flows : Modelling and Simulation
This book entitled ''Multiphase reacting flows: modelling and simulation'' contains the lecture notes of the CISM (International Centre for Mechanical Sciences) course held in Udine, Italy, on July 3-7, 2006, and it describes various modelling approaches for dealing with polydisperse multiphase reacting flows. A multiphase reacting system is characterized by the presence of multiple phases and in this book we focus on disperse multiphase systems, where one phase can be considered as a continuum, whereas the additional phases are dispersed in the continuous one. In other words, in this book we deal with multiphase systems constituted by particles, droplets or bubbles (i.e., solid particles suspended in a continuous liquid phase, liquid droplets in a gaseous phase, or gas bubbles in liquid.) The other important characteristic elements of the systems discussed in this book are the presence of one or more chemical reactions and the turbulent nature of the flow. The chemical reactions usually involve all the phases present in the system and might be responsible for the formation or disappearance of the disperse and/or continuous phases.
Models for computer aided tolerancing in design and manufacturing ; Selected conference papers from the 9th CIRP International Seminar on Computer-aided tolerancing, held at Arizona State University, Tempe, Arizona, USA, 10-12 April, 2005
Computer Aided Tolerancing (CAT) is an important topic in any field of design and production where parts move relative to one another and/or are assembled together. Geometric variations from specified dimensions and form always occur when parts are manufactured. Improvements in production systems can cause the amounts of the variations to become smaller, but their presence does not disappear. To shorten the time from concept to market of a product, it has been increasingly important to take clearances and the tolerancing of manufacturing variations into consideration right from the beginning, at the stage of design. Hence, geometric models are defined that represent both the complete array of geometric variations possible during manufacture and also the influence of geometry on the function of individual parts and on assemblies of them.
Modeling Excitable Tissue : The EMI Framework
This volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.
Migrants with Irregular Status in Europe : Evolving Conceptual and Policy Challenges
This book explores the conceptual challenges posed by the presence of migrants with irregular immigration status in Europe and the evolving policy responses at European, national and municipal level. It addresses the conceptual and policy issues raised, post-entry, by this particular section of the migrant population.
Microwave Radiometry of Vegetation Canopies
Research into microwave radiation from the Earth’s surface in the presence of vegetation canopies, as well as the development of algorithms for retrieval of soil and vegetation parameters from microwave radiometric measurements, have been actively conducted for the last 30 years by scientific groups worldwide. The capability of the microwave radiometric method to determine soil moisture and vegetation biometric indices was revealed 25 years ago by the author and his colleagues. Soil moisture and vegetation covers play a key role in the hydrological cycle and in water and energy transfer on the border of land surface and atmosphere through evaporation and transpiration. Accomplishment of large international projects shows that microwave radiometry of soil and vegetation has become an instrument of practical application and operational use. A systematic account of questions concerning the microwave radiometry of the Earth’s surface in the presence of vegetation canopies is the main objective of the book.
Meccanica delle strutture e Controllo attivo strutturale: Modellistica di edifici, ponti, camini, strutture speciali
The basic texts of Structural Engineering, present in the literature, mostly give introductory examples. This text, however, after having given the disciplinary foundations, goes further to guide the reader in the construction of advanced mathematical models ... It is an unprecedented "compromise" between basic theory text and advanced text for advanced-professionals and researchers. Furthermore, the presence in the volume of "synoptic panels" and software cards gives the reader the possibility of always having at hand the foundations of a complex discipline.
Matrix Convolution Operators on Groups
In the last decade, convolution operators of matrix functions have received unusual attention due to their diverse applications. This monograph presents some new developments in the spectral theory of these operators. The setting is the Lp spaces of matrix-valued functions on locally compact groups. The focus is on the spectra and eigenspaces of convolution operators on these spaces, defined by matrix-valued measures. Among various spectral results, the L2-spectrum of such an operator is completely determined and as an application, the spectrum of a discrete Laplacian on a homogeneous graph is computed using this result. The contractivity properties of matrix convolution semigroups are studied and applications to harmonic functions on Lie groups and Riemannian symmetric spaces are discussed. An interesting feature is the presence of Jordan algebraic structures in matrix-harmonic functions.
Invexity and Optimization
Invexity and Optimization presents results on invex function and their properties in smooth and nonsmooth cases, pseudolinearity and eta-pseudolinearity. Results on optimality and duality for a nonlinear scalar programming problem are presented, second and higher order duality results are given for a nonlinear scalar programming problem, and saddle point results are also presented. Invexity in multiobjective programming problems and Kuhn-Tucker optimality conditions are given for a multiobjecive programming problem, Wolfe and Mond-Weir type dual models are given for a multiobjective programming problem and usual duality results are presented in presence of invex functions. Continuous-time multiobjective problems are also discussed. Quadratic and fractional programming problems are given for invex functions. Symmetric duality results are also given for scalar and vector cases.
Interfacial Nanochemistry : Molecular Science and Engineering at Liquid-Liquid Interfaces
The presence of liquid-liquid interface means that real liquids are far from ideal liquids that must be miscible with any kinds of liquids and have no interface. Thus it can be said that the non-ideality of liquids might generate the liquid-liquid interface indeed and that biological systems might be generated from the non-ideal interface. The liquid-liquid interface has been, therefore, studied as a model of biological membrane. From pairing two-phases of gas, liquid and solid, nine different pairs can be obtained, which include three homo-pairs of gas-gas, liquid-liquid and solid-solid pairs. The gas-gas interface, however, is practically no use under the ordinary conditions. Among the interfaces produced by the pairing, the liquid-liquid interface is most slippery and difficult to be studied experimentally in comparison with the gas-liquid and solid-liquid interfaces, as the liquid-liquid interface is flexible, thin and buried between bulk liquid phases. Therefore, in order to study the liquid-liquid interface, the invention of innovative measurement methods has a primary importance.
Information, Interaction, and Agency
Agents perform actions based on the available information and in the presence of other interacting agents. From this perspective Information, Interaction, and Agency neatly ties together classical themes like rationality, decision-making and belief revision with games, strategies and learning in a multi-agent setting.Unified by the central notions Information, Interaction, and Agency, the essays in this volume provide refreshing methodological perspectives on belief revision, dynamic epistemic logic, von Neumann games, and evolutionary game theory; all of which in turn are central approaches to understanding our own rationality and that of other agents.
In the Presence of English : Media and European Youth
The starting point for this comparative study on the role of English within the media worlds of European youth is the recognition of the increasing importance of communication with peoples from other cultures and countries. The primary goals of "In the Presence of English: Media and European Youth" are to gain insight into the roles of English in and for Europe; to contribute to discussions of the possibilities of transnational media offerings; to better understand the influence of media in foreign language acquisition and of its role in promoting cross cultural understanding across European cultures; and to better understand the role of English media in the construction of the world view of European youth.
Hydra = هايدرا
Forgery involves the use of advanced algorithms to replicate and distribute deceptive products across various categories, casting shadows of doubt on the authenticity of goods. Although counterfeit detection can be useful in identifying and mitigating fraudulent activities, the widespread presence of counterfeit goods poses significant dangers, undermining consumer confidence and brand reputation. To underscore the severity of this issue, consider instances such as fake luxury items flooding the market, counterfeit electronics compromising safety, or bogus pharmaceuticals endangering health. Addressing this issue is critical in maintaining the integrity of brands, safeguarding consumer well-being, and preserving trust in the marketplace. The ability to distinguish between authentic and counterfeit products is paramount in ensuring accurate decision-making and preventing the harmful consequences of fraudulent goods. This technological context underscores the urgency of developing and deploying cutting-edge solutions to combat the evolving landscape of product forgery. Hydra emerges as a robust solution, utilizing a comprehensive approach that includes extracting posts and images from search engine tools, and is integrated with AI models to detect forgery. The Hydra platform not only provides users with a powerful tool for detecting counterfeit products but also offers tangible benefits such as enhanced brand security, increased awareness about the prevalence of forgeries, and the opportunity to actively participate in a real-time community.
Humans-with-media and the reorganization of mathematical thinking : Information and communication technologies, modeling, visualization and experimentation
Offers a new conceptual framework for reflecting on the role of information and communication technology in mathematics education. Borba and Villarreal provide examples from research conducted at the level of basic and university-level education, developed by their research group based in Brazil, and discuss their findings in the light of the relevant literature. Arguing that different media reorganize mathematical thinking in different ways, they discuss how computers, writing and oral discourse transform education at an epistemological as well as a political level. Modeling and experimentation are seen as pedagogical approaches which are in harmony with changes brought about by the presence of information and communication technology in educational settings. Examples of research about on-line mathematics education courses, and Internet used in regular mathematics courses, are presented and discussed at a theoretical level. In this book, mathematical knowledge is seen as developed by collectives of humans-with-media.
