الصفحة 1
الصفحة 1
Neuroblastoma
Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.
Molecular Beams in Physics and Chemistry : From Otto Stern's Pioneering Exploits to Present-Day Feats
This book gives a comprehensive account of both the history and current achievements of molecular beam research. In 1919, Otto Stern launched the revolutionary molecular beam technique. This technique made it possible to send atoms and molecules with well-defined momentum through vacuum and to measure with high accuracy the deflections they underwent when acted upon by transversal forces. These measurements revealed unforeseen quantum properties of nuclei, atoms, and molecules that became the basis for our current understanding of quantum matter. This volume shows that many key areas of modern physics and chemistry owe their beginnings to the seminal molecular beam work of Otto Stern and his school. Written by internationally recognized experts, the contributions in this volume will help experienced researchers and incoming graduate students alike to keep abreast of current developments in molecular beam research as well as to appreciate the history and evolution of this powerful method and the knowledge it reveals.
Micro-Assembly Technologies and Applications ; IFIP TC5 WG5.5 Fourth International Precision Assembly Seminar (IPAS’2008) Chamonix, France February 10–13, 2008
The IFIP series publishes state-of-the-art results in the sciences and technologies of information and communication. The scope of the series includes: foundations of computer science; software theory and practice; education; computer applications in technology; communication systems; systems modeling and optimization; information systems; computers and society; computer systems technology; security and protection in information processing systems; artificial intelligence; and human-computer interaction. Proceedings and post-proceedings of referred international conferences in computer science and interdisciplinary fields are featured. These results often precede journal publication and represent the most current research.
Methodology for the Digital Calibration of Analog Circuits and Systems : with Case Studies
Methodology for the Digital Calibration of Analog Circuits and Systems shows how to relax the extreme design constraints in analog circuits, allowing the realization of high-precision systems even with low-performance components. A complete methodology is proposed, and three applications are detailed.
Méthodes Numériques : Algorithmes, analyse et applications = Numerical Methods : Algorithms, Analysis and Applications
This book aims to present the theoretical and methodological foundations of numerical analysis. Particular attention is paid to the concepts of stability, precision and complexity of algorithms. Modern methods relating to the following topics are presented and analyzed in detail: solving linear and nonlinear systems, polynomial approximation, optimization, numerical integration, orthogonal polynomials, rapid transformations, ordinary differential equations. The techniques presented are illustrated by numerous tables and figures. Many examples and counter-examples are offered to allow the reader to develop his critical sense.
Mathematics of Uncertainty : Ideas, Methods, Application Problems
Mathematics of Uncertainty" provides the basic ideas and foundations of uncertainty, covering the fields of mathematics in which uncertainty, variability, imprecision and fuzziness of data are of importance. This introductory book describes the basic ideas of the mathematical fields of uncertainty from simple interpolation to wavelets, from error propagation to fuzzy sets and neural networks. The book presents the treatment of problems of interpolation and approximation, as well as observation fuzziness which can essentially influence the preciseness and reliability of statements on functional relationships.
Intelligent drugs : How AI is transforming healthcare
The progress of biotechnologies and artificial intelligence allowed the development of vaccines in less than a year, thus saving millions of human lives and preserving the global economy. The emergence of intelligent drugs is highlighted, with the promise of ultra-targeted, more effective, and safer treatments against a wide range of diseases. Personalized medicine then becomes realistic, with computer-designed drugs, perfectly adapted to each individual, tested on virtual patients before their real use. In the near future, thanks to AI, new drugs will improve physical performance, stimulate cognitive abilities, prevent diseases, and slow down aging.
Institutions, Equilibria and Efficiency: Essays in Honor of Birgit Grodal
Competition and efficiency is at the core of economic theory. This volume collects papers of leading scholars, which extend the conventional general equilibrium model in important ways: Efficiency and price regulation are studied when markets are incomplete and existence of equilibria in such settings is proven under very general preference assumptions. The model is extended to include geographical location choice, a commodity space incorporating manufacturing imprecision and preferences for club-membership, schools and firms.
Impact of drug-microbiome interactions on drug response
Explains the mechanisms of drug-microbiome interactions, as well as the role of multiomic approaches, including metagenomics, metabolomics, and 16S rRNA sequencing to assess drug response variability. Findings suggest that integrating microbiome profiling into precision medicine could enhance personalized drug therapy, minimize adverse effects and optimize treatment outcomes.
Hybrid Evolutionary Algorithms
Hybridization of evolutionary algorithms is getting popular due to their capabilities in handling several real world problems involving complexity, noisy environment, imprecision, uncertainty and vagueness. This edited volume is targeted to present the latest state-of-the-art methodologies in ’Hybrid Evolutionary Algorithms’. This book deals with the theoretical and methodological aspects, as well as various applications to many real world problems from science, technology, business or commerce. This volume comprises of 14 chapters including an introductory chapter giving the fundamental definitions and some important research challenges. Chapters were selected on the basis of fundamental ideas/concepts rather than the thoroughness of techniques deployed.
High performance computing for drug discovery and biomedicine
Explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. Collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. And delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects.
Hard Disk Drive Servo Systems
The second edition of this monograph provides a systematic treatment of the design of modern hard disk drive servo systems updated with the latest research results to reflect recent improvements in spindle speed and bit density and other changes in this fast-moving field. In particular, it focuses on the applications of some newly developed results in control theory, i.e., robust and perfect tracking control and composite non-linear feedback control which are suitable for track following and seeking respectively. Emphasis is placed on hard disk drive servo systems with single- or dual-stage actuation using a voice-coil-motor actuator enhanced in the latter case by the addition of a micro-actuator providing faster responses and therefore higher bandwidth in track following. Other issues such as modeling and compensation of nonlinearities and friction in microdrives, disturbance rejection and resonance compensation are also addressed.
Hadron Collider Physics 2005 ; Proceedings of the 1st Hadron Collider Physics Symposium, Les Diablerets, Switzerland, July 4-9, 2005
The Hadron Collider Physics Symposia (HCP) are a new series of conferences that follow the merger of the Hadron Collider Conferences with the LHC Symposia series, with the goal of maximizing the shared experience of the Tevatron and LHC communities. This book gathers the proceedings of the first symposium, HCP2005 and reviews the state-of-the-art in the key physics directions of experimental hadron collider research: - QCD physics - precision electroweak physics - c-, b-, and t-quark physics - physics beyond the Standard Model - heavy ion physics
Genomic intelligence : Metagenomics and artificial intelligence
The field of metagenomics has revolutionized our comprehension of microbial diversity and function across various habitats, from the human body to terrestrial and aquatic environments. Simultaneously, advancements in AI have empowered researchers to analyze vast troves of genomic data with unprecedented speed and precision, facilitating new insights into the complex interplay between microorganisms and their surroundings. Provides an overview of metagenomics and discusses the combination of metagenomics and AI and its significant consequences for advancements in science. The chapters examine the approaches, difficulties, and revolutionary uses of AI in metagenomics and provide insight into the convergence of genomics, metagenomics, and AI’s potential to revolutionize diverse fields from healthcare to environmental.
Genome editing in neurosciences
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
Future Satellite Gravimetry and Earth Dynamics
Currently, a first generation of dedicated satellite missions for the precise mapping of the Earth’s gravity field is in orbit (CHAMP, GRACE, and soon GOCE). The gravity data from these satellite missions provide us with very new information on the dynamics of planet Earth. In particular, on the mass distribution in the Earth’s interior, the entire water cycle (ocean circulation, ice mass balance, continental water masses, and atmosphere), and on changes in the mass distribution. The results are fascinating, but still rough with respect to spatial and temporal resolution. Technical progress in satellite-to-satellite tracking and in gravity gradiometry will allow more detailed results in the future. In this special issue, Earth scientists develop visions of future applications based on follow-on high-precision satellite gravimetry missions.
Fundamentals of Implant Dentistry : Vol.2: Surgical Principles
Significant improvements have been achieved in patient evaluation, methods used to enhance the bone and soft tissues of potential implant sites, and surgical techniques to prepare the osteotomy sites and place the implants. In particular, CBCT scans and associated software planning programs now enable the implant team to analyze the bone sites in three dimensions in relation to the proposed contours of the implant-retained prosthesis; select implants of suitable diameter, length, and configuration; position them virtually in ideal locations; and fabricate surgical templates that enable surgeons to prepare the osteotomy sites and place the implants with great precision.
Flowering Plants. Eudicots : Berberidopsidales, Buxales, Crossosomatales, Fabales p.p., Geraniales, Gunnerales, Myrtales p.p., Proteales, Saxifragales, Vitales, Zygophyllales, Clusiaceae Alliance, Passifloraceae Alliance, Dilleniaceae, Huaceae, Picramniaceae, Sabiaceae
In this volume, the ninth of the series, treatments are offered for 52 families containing 432 genera belonging to 13 eudicot orders, many of which have recently been newly designed; four families remain unassigned to order. Emphasis is on the early-diverging eudicots and basal core eudicots the phylogenetic relationships and diversification of which have recently been in focus and are critically discussed. Systematically relevant information includes descriptions of families and genera, keys to the genera, and references to recent revisions. Introductions to the families provide convenient, in-depth overviews of key aspects of systematics. The wealth and precision of information contained in this volume will make it an important source of reference for both the scholar and the practitioner in the fields of pure and applied plant sciences.
Flexible Databases Supporting Imprecision and Uncertainty
This volume collects selected contributions on the application of heterogeneous methods for managing uncertainty and imprecision in databases. It contains both survey chapters on classic topics such as "flexible querying in databases", and up to date ontributions on "database models to represent imperfect data". Further, it includes specific contributions on uncertainty management in database integration, and in representing and querying semistructured and spatial data. These topics are of particular relevance nowadays with the diffusion of the internet since, most of the time, applications require information spread across several information sources and their integration may result in inconsistent information.
Femtosecond laser spectroscopy
As concepts and methodologies have evolved over the past two decades, the realm of ultrafast science has become vast and exciting and has impacted many areas of chemistry, biology and physics, and other fields such as materials science, electrical engineering, and optical communication. The field has recently exploded with the announcement of a series of remarkable new developments and advances. This volume surveys this recent growth in eleven chapters written by leading international researchers in the field. It includes sections on femtosecond optical frequency combs, soft x-ray femtosecond laser sources, and attosecond laser sources. In addition, the contributors address real-time spectroscopy of molecular vibrations with sub-5-fs pulses and multidimensional femtosecond coherent spectroscopies for studying molecular and electron dynamics. Novel methods for measuring and characterizing ultrashort laser pulses and ultrashort pulses of light are also described. The topics covered are revolutionizing the fields of biomedical imaging, electron dynamics, ultrahigh precision spectroscopy, and optical frequency metrology. Surveying the latest advances in ultrafast lasers, Femtosecond Laser Spectroscopy will be of interest to both researchers and graduate students.
